The network for 'negative regulation of intracellular transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of intracellular transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.

Danio rerio
Name Description Probability Func Analog Organism
rarga retinoic acid receptor gamma a 0.195
nf1a neurofibromin 1a 0.181
zgc:158138 zgc:158138 0.125
mapk6 mitogen-activated protein kinase 6 0.105
gdf6a growth differentiation factor 6a 0.102
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.090
ppp2r5d protein phosphatase 2, regulatory subunit B', delta 0.083
zgc:101761 zgc:101761 0.082
actr1 ARP1 actin-related protein 1, centractin (yeast) 0.081
ext2 exostoses (multiple) 2 0.074
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.074
plk1 polo-like kinase 1 (Drosophila) 0.071
capns1a calpain, small subunit 1 a 0.068
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.067
insrb insulin receptor b 0.067
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.065
cd63 Cd63 antigen 0.063
lef1 lymphocyte enhancer binding factor 1 0.063
akt2 v-akt murine thymoma viral oncogene homolog 2 0.062
lsm8 LSM8 homolog, U6 small nuclear RNA associated 0.059
tfe3a transcription factor binding to IGHM enhancer 3a 0.058
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.058
spry4 sprouty (Drosophila) homolog 4 0.058
ptprf protein tyrosine phosphatase, receptor type, F 0.057
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.056
zgc:73328 zgc:73328 0.055
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.054
echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 0.053
thraa thyroid hormone receptor alpha a 0.052
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.051
gro2 groucho 2 0.050
acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.050
vdra vitamin D receptor a 0.049
mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.049
clasp2 cytoplasmic linker associated protein 2 0.049
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.048
mmp9 matrix metalloproteinase 9 0.048
tll1 tolloid-like 1 0.047
LOC567452 G protein-coupled receptor kinase 5-like 0.047
igf1rb insulin-like growth factor 1b receptor 0.047
cdc20 cell division cycle 20 homolog 0.047
hmx2 H6 family homeobox 2 0.047
spry2 sprouty homolog 2 0.046
vps26bl vacuolar protein sorting 26 homolog B, like 0.046
atxn7l3 ataxin 7-like 3 0.046
nf1b neurofibromin 1b 0.045
ankrd6 ankyrin repeat domain 6 0.045
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.045
fkbp5 FK506 binding protein 5 0.045
mfn2 mitofusin 2 0.045
suz12b suppressor of zeste 12 homolog (Drosophila) b 0.045
prps1b phosphoribosyl pyrophosphate synthetase 1B 0.044
ppp2r1b protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform 0.044
cyp51 cytochrome P450, family 51 0.043
cyp1a cytochrome P450, family 1, subfamily A 0.043
wnt10a wingless-type MMTV integration site family, member 10a 0.043
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.043
hmcn1 hemicentin 1 0.042
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.042
lhx2b LIM homeobox 2b 0.042
arfgef1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.042
zgc:111961 zgc:111961 0.042
ldb1a LIM-domain binding factor 1a 0.042
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.042
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.042
wls wntless homolog (Drosophila) 0.041
zgc:92030 zgc:92030 0.040
si:ch211-89p1.1 si:ch211-89p1.1 0.040
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.040
cdh1 cadherin 1, epithelial 0.040
bmp2b bone morphogenetic protein 2b 0.039
aurkb aurora kinase B 0.039
kdm5c lysine (K)-specific demethylase 5C 0.039
zgc:92027 zgc:92027 0.039
rap1b RAS related protein 1b 0.039
birc5a baculoviral IAP repeat-containing 5a 0.038
fcho2 FCH domain only 2 0.038
wu:fa99c08 wu:fa99c08 0.038
cat catalase 0.038
axin1 axin 1 0.038
aplnra apelin receptor a 0.037
smn1 survival motor neuron 1 0.037
mtmr8 myotubularin related protein 8 0.037
ptpra protein tyrosine phosphatase, receptor type, A 0.037
sod2 superoxide dismutase 2, mitochondrial 0.037
clic1 chloride intracellular channel 1 0.036
stat3 signal transduction and activation of transcription 3 0.036
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.036
npnt nephronectin 0.036
ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.036
sox11b SRY-box containing gene 11b 0.036
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.035
tp53bp2 tumor protein p53 binding protein, 2 0.035
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.035
nnt nicotinamide nucleotide transhydrogenase 0.035
nr2f6b nuclear receptor subfamily 2, group F, member 6b 0.035
spred1 sprouty-related, EVH1 domain containing 1 0.035
zgc:172136 zgc:172136 0.035
anxa13 annexin A13 0.034
h1m linker histone H1M 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Int6 Int6 homologue 0.021
Eph Eph receptor tyrosine kinase 0.012
H Hairless 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.653
PML promyelocytic leukemia 0.458
CRYAB crystallin, alpha B 0.448
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.410
HSPB8 heat shock 22kDa protein 8 0.408
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.376
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.348
DTX3L deltex 3-like (Drosophila) 0.328
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.328
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.274
IGF1R insulin-like growth factor 1 receptor 0.267
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.255
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.236
BTRC beta-transducin repeat containing 0.229
MED15 mediator complex subunit 15 0.182
SP100 SP100 nuclear antigen 0.181
AXIN1 axin 1 0.168
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.154
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.146
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.143
CKAP5 cytoskeleton associated protein 5 0.120
MAPK1 mitogen-activated protein kinase 1 0.120
YAP1 Yes-associated protein 1 0.117
SMAD7 SMAD family member 7 0.107
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.106
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.105
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.097
FAS Fas (TNF receptor superfamily, member 6) 0.096
ACVR1B activin A receptor, type IB 0.095
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.093
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.092
ZNF260 zinc finger protein 260 0.092
CREBBP CREB binding protein 0.091
FBXW11 F-box and WD repeat domain containing 11 0.091
GSK3B glycogen synthase kinase 3 beta 0.088
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.087
AXL AXL receptor tyrosine kinase 0.085
DCAF7 DDB1 and CUL4 associated factor 7 0.083
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.081
ZNF263 zinc finger protein 263 0.080
POU3F2 POU class 3 homeobox 2 0.076
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.074
PGK1 phosphoglycerate kinase 1 0.073
TUBA1A tubulin, alpha 1a 0.072
APC adenomatous polyposis coli 0.068
MAPT microtubule-associated protein tau 0.066
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.065
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.064
IRS2 insulin receptor substrate 2 0.063
BCL3 B-cell CLL/lymphoma 3 0.063
TGFBR1 transforming growth factor, beta receptor 1 0.062
HSPB2 heat shock 27kDa protein 2 0.061
HIPK3 homeodomain interacting protein kinase 3 0.060
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.060
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.059
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.059
HIPK2 homeodomain interacting protein kinase 2 0.058
FADD Fas (TNFRSF6)-associated via death domain 0.057
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.057
POU5F1 POU class 5 homeobox 1 0.056
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.055
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.055
DAXX death-domain associated protein 0.054
PAX3 paired box 3 0.053
PRKCA protein kinase C, alpha 0.053
PRDX1 peroxiredoxin 1 0.053
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.053
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.053
LRRK2 leucine-rich repeat kinase 2 0.053
IFIH1 interferon induced with helicase C domain 1 0.052
GLI1 GLI family zinc finger 1 0.052
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.052
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.052
TRIM22 tripartite motif containing 22 0.052
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.051
C3orf15 chromosome 3 open reading frame 15 0.051
C1QA complement component 1, q subcomponent, A chain 0.049
TFF1 trefoil factor 1 0.049
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.049
TEK TEK tyrosine kinase, endothelial 0.048
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.048
SOCS1 suppressor of cytokine signaling 1 0.047
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.046
CSNK1E casein kinase 1, epsilon 0.046
RAB6A RAB6A, member RAS oncogene family 0.046
SKP1 S-phase kinase-associated protein 1 0.046
NCOA3 nuclear receptor coactivator 3 0.045
CFLAR CASP8 and FADD-like apoptosis regulator 0.045
SREBF2 sterol regulatory element binding transcription factor 2 0.044
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.043
ZNF84 zinc finger protein 84 0.043
DCTN1 dynactin 1 0.043
FYN FYN oncogene related to SRC, FGR, YES 0.043
SAE1 SUMO1 activating enzyme subunit 1 0.042
ELK1 ELK1, member of ETS oncogene family 0.041
C1QB complement component 1, q subcomponent, B chain 0.041
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.040
SOD1 superoxide dismutase 1, soluble 0.040
CALD1 caldesmon 1 0.039
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.039
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.968
Bcl2 B-cell leukemia/lymphoma 2 0.777
Ctnnb1 catenin (cadherin associated protein), beta 1 0.744
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.734
Rxra retinoid X receptor alpha 0.502
Rara retinoic acid receptor, alpha 0.475
Apc adenomatosis polyposis coli 0.432
Grb10 growth factor receptor bound protein 10 0.328
Ghr growth hormone receptor 0.316
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.313
Bax BCL2-associated X protein 0.297
Yap1 yes-associated protein 1 0.261
Il6st interleukin 6 signal transducer 0.253
Adam17 a disintegrin and metallopeptidase domain 17 0.205
Gli3 GLI-Kruppel family member GLI3 0.202
Invs inversin 0.187
Gli2 GLI-Kruppel family member GLI2 0.183
Dok1 docking protein 1 0.179
Bmp4 bone morphogenetic protein 4 0.171
Gopc golgi associated PDZ and coiled-coil motif containing 0.164
Pten phosphatase and tensin homolog 0.156
Fgfr2 fibroblast growth factor receptor 2 0.155
Meox2 mesenchyme homeobox 2 0.152
Smad3 MAD homolog 3 (Drosophila) 0.144
Axin1 axin 1 0.139
Fgfr1 fibroblast growth factor receptor 1 0.122
Zeb1 zinc finger E-box binding homeobox 1 0.119
Gbp7 guanylate binding protein 7 0.116
Wnt5a wingless-related MMTV integration site 5A 0.114
Vegfa vascular endothelial growth factor A 0.114
Rarg retinoic acid receptor, gamma 0.112
Mdm2 transformed mouse 3T3 cell double minute 2 0.110
Dlg4 discs, large homolog 4 (Drosophila) 0.108
Mefv Mediterranean fever 0.106
Pbx1 pre B-cell leukemia transcription factor 1 0.105
Pax8 paired box gene 8 0.100
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.094
Iigp1 interferon inducible GTPase 1 0.091
Gbp6 guanylate binding protein 6 0.089
Acvr1 activin A receptor, type 1 0.087
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.084
Vps29 vacuolar protein sorting 29 (S. pombe) 0.080
Dlg2 discs, large homolog 2 (Drosophila) 0.075
Mb myoglobin 0.074
Nf1 neurofibromatosis 1 0.073
Pkd1 polycystic kidney disease 1 homolog 0.070
Irgm2 immunity-related GTPase family M member 2 0.069
Fam96a family with sequence similarity 96, member A 0.069
Vps26a vacuolar protein sorting 26 homolog A (yeast) 0.068
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.067
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.066
Trem3 triggering receptor expressed on myeloid cells 3 0.062
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.061
Mcl1 myeloid cell leukemia sequence 1 0.061
Ret ret proto-oncogene 0.060
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.059
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.058
Mdm4 transformed mouse 3T3 cell double minute 4 0.057
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.057
Sox11 SRY-box containing gene 11 0.056
Ncoa3 nuclear receptor coactivator 3 0.055
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.054
Gpc3 glypican 3 0.052
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.052
Rb1 retinoblastoma 1 0.052
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.052
Kitl kit ligand 0.051
Kit kit oncogene 0.050
Vhl von Hippel-Lindau tumor suppressor 0.050
Nmi N-myc (and STAT) interactor 0.049
Mapk3 mitogen-activated protein kinase 3 0.046
Hes1 hairy and enhancer of split 1 (Drosophila) 0.046
Pax6 paired box gene 6 0.046
Bicc1 bicaudal C homolog 1 (Drosophila) 0.046
Dlg1 discs, large homolog 1 (Drosophila) 0.045
Tgtp2 T-cell specific GTPase 2 0.045
Parp9 poly (ADP-ribose) polymerase family, member 9 0.043
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.043
Rpgrip1l Rpgrip1-like 0.042
Setdb1 SET domain, bifurcated 1 0.041
Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 0.041
Sfrs18 serine/arginine-rich splicing factor 18 0.041
Fzd2 frizzled homolog 2 (Drosophila) 0.039
Tgfb2 transforming growth factor, beta 2 0.039
Rnf115 ring finger protein 115 0.038
Dusp1 dual specificity phosphatase 1 0.037
Vps26b vacuolar protein sorting 26 homolog B (yeast) 0.037
Cdh5 cadherin 5 0.037
Cav1 caveolin 1, caveolae protein 0.037
Ifih1 interferon induced with helicase C domain 1 0.036
Ptrf polymerase I and transcript release factor 0.036
Ednrb endothelin receptor type B 0.036
Igbp1 immunoglobulin (CD79A) binding protein 1 0.036
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.036
Skil SKI-like 0.036
Hoxa3 homeobox A3 0.035
Apoe apolipoprotein E 0.035
Fzd8 frizzled homolog 8 (Drosophila) 0.035
Per2 period homolog 2 (Drosophila) 0.035
Marveld1 MARVEL (membrane-associating) domain containing 1 0.035
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism