The network for 'morphogenesis of an epithelial sheet' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of an epithelial sheet

The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.

Danio rerio
Name Description Probability Func Analog Organism
tbx16 T-box gene 16 0.938
pitx2 paired-like homeodomain transcription factor 2 0.937
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.916
hnf1ba HNF1 homeobox Ba 0.848
lhx2b LIM homeobox 2b 0.715
six4b sine oculis homeobox homolog 4b 0.704
itgav integrin, alpha V 0.675
ndr2 nodal-related 2 0.659
cdh1 cadherin 1, epithelial 0.636
gata3 GATA-binding protein 3 0.634
pitx3 paired-like homeodomain transcription factor 3 0.630
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.552
cldnb claudin b 0.514
itgb1b.2 integrin, beta 1b.2 0.493
eomesa eomesodermin homolog a 0.458
tp63 tumor protein p63 0.432
plcg1 phospholipase C, gamma 1 0.409
anxa2b annexin A2b 0.398
dla deltaA 0.373
npy8ar neuropeptide Y receptor Y8a 0.367
runx2b runt-related transcription factor 2b 0.358
dlb deltaB 0.341
ptgs1 prostaglandin-endoperoxide synthase 1 0.330
vax2 ventral anterior homeobox 2 0.322
cdh5 cadherin 5 0.302
notch3 notch homolog 3 0.301
lft1 lefty1 0.294
mib mind bomb 0.294
tll1 tolloid-like 1 0.289
notch2 notch homolog 2 0.288
dbx1b developing brain homeobox 1b 0.284
tbx2a T-box gene 2a 0.269
sox19b SRY-box containing gene 19b 0.266
bmp4 bone morphogenetic protein 4 0.266
nrarpa notch-regulated ankyrin repeat protein a 0.259
rx3 retinal homeobox gene 3 0.251
plxna4 plexin A4 0.247
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.245
cldn11b claudin 11b 0.245
tbx6 T-box gene 6 0.241
snai1a snail homolog 1a (Drosophila) 0.239
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.236
fzd3a frizzled homolog 3a 0.229
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.228
opn1lw1 opsin 1 (cone pigments), long-wave-sensitive, 1 0.223
otx2 orthodenticle homolog 2 0.221
vent ventral expressed homeobox 0.218
cldnh claudin h 0.215
hhex hematopoietically expressed homeobox 0.212
bmper BMP binding endothelial regulator 0.210
meis2.1 myeloid ecotropic viral integration site 2.1 0.205
foxa3 forkhead box A3 0.205
traf4a tnf receptor-associated factor 4a 0.205
foxc1a forkhead box C1a 0.203
wnt11 wingless-type MMTV integration site family, member 11 0.201
itgb1b.1 integrin, beta 1b.1 0.199
otpb orthopedia homolog b 0.198
lpar1 lysophosphatidic acid receptor 1 0.197
wu:fb36d12 wu:fb36d12 0.191
lhx9 LIM homeobox 9 0.190
fgfr4 fibroblast growth factor receptor 4 0.190
cldni claudin i 0.187
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.184
nkx2.1a NK2 homeobox 1a 0.183
scrib scribbled homolog (Drosophila) 0.183
tac1 tachykinin 1 0.181
hand2 heart and neural crest derivatives expressed transcript 2 0.177
has2 hyaluronan synthase 2 0.174
gli2a GLI-Kruppel family member GLI2a 0.172
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.171
fbln1 fibulin 1 0.170
efnb3b ephrin B3b 0.168
pou3f3b POU class 3 homeobox 3b 0.167
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.167
fgfr2 fibroblast growth factor receptor 2 0.166
runx3 runt-related transcription factor 3 0.165
six4a sine oculis homeobox homolog 4a 0.160
mych myelocytomatosis oncogene homolog 0.153
sox19a SRY-box containing gene 19a 0.153
fgfrl1b fibroblast growth factor receptor-like 1b 0.145
hoxb3a homeo box B3a 0.140
boc brother of CDO 0.139
oclna occludin a 0.134
tbx5a T-box 5a 0.132
jag2 jagged 2 0.128
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.128
six3a sine oculis homeobox homolog 3a 0.128
dbx1a developing brain homeobox 1a 0.127
sox32 SRY-box containing gene 32 0.124
pomca proopiomelanocortin a 0.123
her7 hairy and enhancer of split related-7 0.122
spry2 sprouty homolog 2 0.120
cldn1 claudin 1 0.120
inha inhibin, alpha 0.117
loxl3b lysyl oxidase-like 3b 0.117
wnt9a wingless-type MMTV integration site family, member 9A 0.116
itgb1a integrin, beta 1a 0.114
dspa desmoplakin a 0.114
wnt8b wingless-type MMTV integration site family, member 8b 0.114
sim1a single-minded homolog 1a (Drosophila) 0.113
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.043
mys myospheroid 0.037
Mad Mothers against dpp 0.027
Nmdar2 NMDA receptor 2 0.025
if inflated 0.023
Egfr Epidermal growth factor receptor 0.022
wg wingless 0.014
Rel Relish 0.012
Ca-beta Ca2+-channel-protein-beta-subunit 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FN1 fibronectin 1 0.994
FHL2 four and a half LIM domains 2 0.989
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.967
JAG1 jagged 1 0.909
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.748
DDR2 discoidin domain receptor tyrosine kinase 2 0.719
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.681
ENG endoglin 0.644
COL1A1 collagen, type I, alpha 1 0.633
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.553
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 0.553
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.543
NOTCH3 notch 3 0.511
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.495
ITGA6 integrin, alpha 6 0.481
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.457
COL1A2 collagen, type I, alpha 2 0.383
DLG1 discs, large homolog 1 (Drosophila) 0.374
ABI2 abl-interactor 2 0.367
CTGF connective tissue growth factor 0.362
PXN paxillin 0.327
FKBP1A FK506 binding protein 1A, 12kDa 0.318
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.307
EPS8 epidermal growth factor receptor pathway substrate 8 0.290
FLNA filamin A, alpha 0.246
PTPRC protein tyrosine phosphatase, receptor type, C 0.223
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.202
COL3A1 collagen, type III, alpha 1 0.191
THBS1 thrombospondin 1 0.190
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.190
SFN stratifin 0.188
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.185
TGFB3 transforming growth factor, beta 3 0.179
BMP2 bone morphogenetic protein 2 0.171
COL5A2 collagen, type V, alpha 2 0.149
HSF1 heat shock transcription factor 1 0.145
NOTCH1 notch 1 0.145
TP63 tumor protein p63 0.134
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.126
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.120
AMOTL2 angiomotin like 2 0.119
LRRK2 leucine-rich repeat kinase 2 0.117
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.111
F11R F11 receptor 0.108
COL4A1 collagen, type IV, alpha 1 0.096
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.096
SDC2 syndecan 2 0.095
MAP2K4 mitogen-activated protein kinase kinase 4 0.092
TM4SF1 transmembrane 4 L six family member 1 0.088
INADL InaD-like (Drosophila) 0.087
RANBP9 RAN binding protein 9 0.080
BMPR1A bone morphogenetic protein receptor, type IA 0.077
IGFBP3 insulin-like growth factor binding protein 3 0.074
LAMB1 laminin, beta 1 0.074
TLN1 talin 1 0.069
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.068
JAG2 jagged 2 0.068
CYR61 cysteine-rich, angiogenic inducer, 61 0.067
DSG2 desmoglein 2 0.058
ACVR1 activin A receptor, type I 0.057
ITGB5 integrin, beta 5 0.057
GDF5 growth differentiation factor 5 0.056
PLEC plectin 0.054
CTNND1 catenin (cadherin-associated protein), delta 1 0.054
DMD dystrophin 0.052
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.051
CD63 CD63 molecule 0.047
PDIA3 protein disulfide isomerase family A, member 3 0.045
SH3D19 SH3 domain containing 19 0.043
CYTH1 cytohesin 1 0.043
FBLN1 fibulin 1 0.041
JUN jun proto-oncogene 0.040
COL6A1 collagen, type VI, alpha 1 0.040
MKL1 megakaryoblastic leukemia (translocation) 1 0.040
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.039
MAPK14 mitogen-activated protein kinase 14 0.039
ITGB4 integrin, beta 4 0.038
CD9 CD9 molecule 0.036
SNX33 sorting nexin 33 0.035
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.034
FHL3 four and a half LIM domains 3 0.033
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.033
ADAM12 ADAM metallopeptidase domain 12 0.031
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.031
ATF2 activating transcription factor 2 0.031
DLL1 delta-like 1 (Drosophila) 0.031
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.030
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.030
JUP junction plakoglobin 0.030
HAP1 huntingtin-associated protein 1 0.029
VCAM1 vascular cell adhesion molecule 1 0.029
CDH5 cadherin 5, type 2 (vascular endothelium) 0.028
PDGFC platelet derived growth factor C 0.028
SELPLG selectin P ligand 0.027
PRKG1 protein kinase, cGMP-dependent, type I 0.027
YAP1 Yes-associated protein 1 0.026
VCL vinculin 0.025
CSNK1E casein kinase 1, epsilon 0.025
ELN elastin 0.025
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.998
Jag1 jagged 1 0.990
Hoxa1 homeobox A1 0.990
Vangl2 vang-like 2 (van gogh, Drosophila) 0.989
Tbx3 T-box 3 0.975
Shh sonic hedgehog 0.974
Fgfr1 fibroblast growth factor receptor 1 0.965
Gli3 GLI-Kruppel family member GLI3 0.962
Hoxa10 homeobox A10 0.955
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.947
Hoxa2 homeobox A2 0.945
Bmp4 bone morphogenetic protein 4 0.933
Pitx1 paired-like homeodomain transcription factor 1 0.907
Wnt3a wingless-related MMTV integration site 3A 0.905
Meox2 mesenchyme homeobox 2 0.885
Hoxb6 homeobox B6 0.878
Hoxd3 homeobox D3 0.876
Pitx2 paired-like homeodomain transcription factor 2 0.859
Fgf8 fibroblast growth factor 8 0.855
Smad6 MAD homolog 6 (Drosophila) 0.854
Zic3 zinc finger protein of the cerebellum 3 0.825
Gdnf glial cell line derived neurotrophic factor 0.809
Pax2 paired box gene 2 0.777
Hoxb5 homeobox B5 0.774
Hoxd9 homeobox D9 0.767
Tbx2 T-box 2 0.764
Notch1 Notch gene homolog 1 (Drosophila) 0.757
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.726
Hoxd4 homeobox D4 0.723
Pax8 paired box gene 8 0.720
Hoxa9 homeobox A9 0.709
Ctnnb1 catenin (cadherin associated protein), beta 1 0.699
Ptk7 PTK7 protein tyrosine kinase 7 0.681
Wt1 Wilms tumor 1 homolog 0.680
Vegfa vascular endothelial growth factor A 0.678
Hoxb3 homeobox B3 0.676
Vangl1 vang-like 1 (van gogh, Drosophila) 0.650
Hoxa11 homeobox A11 0.644
Hoxa5 homeobox A5 0.638
Fgf10 fibroblast growth factor 10 0.628
Hoxd11 homeobox D11 0.619
Hand1 heart and neural crest derivatives expressed transcript 1 0.604
Lhx1 LIM homeobox protein 1 0.602
Pax3 paired box gene 3 0.595
Hoxc6 homeobox C6 0.584
Eng endoglin 0.579
Notch2 Notch gene homolog 2 (Drosophila) 0.578
Tbx1 T-box 1 0.567
Foxc1 forkhead box C1 0.544
Col4a3 collagen, type IV, alpha 3 0.538
Hoxc4 homeobox C4 0.510
Rarb retinoic acid receptor, beta 0.495
Yap1 yes-associated protein 1 0.494
Otx2 orthodenticle homolog 2 (Drosophila) 0.490
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.487
Psen1 presenilin 1 0.484
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.471
Hoxa3 homeobox A3 0.458
Foxc2 forkhead box C2 0.457
Hoxd10 homeobox D10 0.451
Tcfap2a transcription factor AP-2, alpha 0.444
Rarg retinoic acid receptor, gamma 0.440
Tcfcp2l1 transcription factor CP2-like 1 0.411
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.405
Prrx1 paired related homeobox 1 0.405
Pou3f3 POU domain, class 3, transcription factor 3 0.399
Hoxb2 homeobox B2 0.390
Hes1 hairy and enhancer of split 1 (Drosophila) 0.373
Wnt6 wingless-related MMTV integration site 6 0.370
Trp63 transformation related protein 63 0.367
Sall4 sal-like 4 (Drosophila) 0.357
Itga3 integrin alpha 3 0.354
Gas1 growth arrest specific 1 0.348
Hoxb4 homeobox B4 0.347
Pbx1 pre B-cell leukemia transcription factor 1 0.346
Hoxa13 homeobox A13 0.338
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.335
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.330
Lrp6 low density lipoprotein receptor-related protein 6 0.314
Alx1 ALX homeobox 1 0.313
Mapk14 mitogen-activated protein kinase 14 0.306
Gata3 GATA binding protein 3 0.296
Lama5 laminin, alpha 5 0.289
Hoxa4 homeobox A4 0.288
Meox1 mesenchyme homeobox 1 0.287
Tcfap2c transcription factor AP-2, gamma 0.287
Hoxb9 homeobox B9 0.274
Hoxd8 homeobox D8 0.271
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.269
She src homology 2 domain-containing transforming protein E 0.266
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.262
Nog noggin 0.256
Sox7 SRY-box containing gene 7 0.253
Hic1 hypermethylated in cancer 1 0.246
Foxh1 forkhead box H1 0.238
Dll4 delta-like 4 (Drosophila) 0.237
Efnb2 ephrin B2 0.237
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.235
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.233
Tcf21 transcription factor 21 0.229
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Rattus norvegicus
Name Description Probability Func Analog Organism
Syt4 synaptotagmin IV 0.018
Irs3 insulin receptor substrate 3 0.015
Col12a1 collagen, type XII, alpha 1 0.014
Col1a2 collagen, type I, alpha 2 0.014
Lamc1 laminin, gamma 1 0.013
Foxq1 forkhead box Q1 0.013
Lig3 ligase III, DNA, ATP-dependent 0.013
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.012
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.012
Itpr3 inositol 1,4,5-triphosphate receptor, type 3 0.012
Lamb2 laminin, beta 2 0.012
Jun Jun oncogene 0.012
Fblim1 filamin binding LIM protein 1 0.012
Mos Moloney sarcoma oncogene 0.011
Sox13 SRY (sex determining region Y)-box 13 0.011
Ltbp3 latent transforming growth factor beta binding protein 3 0.011
Dock6 dedicator of cytokinesis 6 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism