The network for 'response to vitamin' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to vitamin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

Danio rerio
Name Description Probability Func Analog Organism
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.903
col1a1a collagen, type I, alpha 1a 0.689
col1a2 collagen, type I, alpha 2 0.663
ptgs2a prostaglandin-endoperoxide synthase 2a 0.585
fabp11a fatty acid binding protein 11a 0.518
itgb1b integrin, beta 1b 0.476
pparg peroxisome proliferator activated receptor gamma 0.428
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.417
fgfrl1a fibroblast growth factor receptor-like 1a 0.395
rbp4 retinol binding protein 4, plasma 0.388
lmna lamin A 0.369
id1 inhibitor of DNA binding 1 0.350
tgfbi transforming growth factor, beta-induced 0.344
sox9a SRY-box containing gene 9a 0.314
mstna myostatin a 0.307
prrx1a paired related homeobox 1a 0.295
col5a1 procollagen, type V, alpha 1 0.284
col5a2l collagen, type V, alpha 2-like 0.271
vim vimentin 0.257
itgb1a integrin, beta 1a 0.256
rarga retinoic acid receptor gamma a 0.238
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.236
tp53bp2 tumor protein p53 binding protein, 2 0.230
dcn decorin 0.225
crabp1b cellular retinoic acid binding protein 1b 0.217
crabp2a cellular retinoic acid binding protein 2, a 0.216
lpar1 lysophosphatidic acid receptor 1 0.210
dct dopachrome tautomerase 0.209
rbp7b retinol binding protein 7b, cellular 0.202
osr1 odd-skipped related 1 (Drosophila) 0.201
kiss1 KiSS-1 metastasis-suppressor 0.188
cyp51 cytochrome P450, family 51 0.182
il17rd interleukin 17 receptor D 0.176
insrb insulin receptor b 0.176
neo1 neogenin 1 0.174
fabp3 fatty acid binding protein 3, muscle and heart 0.168
zgc:172136 zgc:172136 0.163
postn periostin, osteoblast specific factor 0.160
inhbaa inhibin, beta Aa 0.160
vdra vitamin D receptor a 0.160
cx30.3 connexin 30.3 0.158
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.153
ptgs1 prostaglandin-endoperoxide synthase 1 0.150
dlx4a distal-less homeobox gene 4a 0.145
ca2 carbonic anhydrase II 0.144
wu:fb80a07 wu:fb80a07 0.142
nog3 noggin 3 0.140
sb:cb166 sb:cb166 0.138
bnc1 basonuclin 1 0.137
brd2b bromodomain containing 2b 0.132
mtp microsomal triglyceride transfer protein 0.129
apoeb apolipoprotein Eb 0.129
hsp47 heat shock protein 47 0.129
pmp22a peripheral myelin protein 22a 0.128
pck1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.125
npnt nephronectin 0.123
itgb1b.1 integrin, beta 1b.1 0.122
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.121
tmprss4a transmembrane protease, serine 4a 0.120
m17 IL-6 subfamily cytokine M17 0.119
twist1a twist1a 0.119
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.118
aqp12 aquaporin 12 0.118
mbnl1 muscleblind-like (Drosophila) 0.115
hnf4a hepatocyte nuclear factor 4, alpha 0.113
tgfbr2 transforming growth factor, beta receptor II 0.113
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.112
cbr1l carbonyl reductase 1-like 0.109
bmp2b bone morphogenetic protein 2b 0.108
duox dual oxidase 0.107
sult2st2 sulfotransferase family 2, cytosolic sulfotransferase 2 0.104
fabp10a fatty acid binding protein 10a, liver basic 0.102
lfng lunatic fringe homolog 0.102
col7a1l collagen type VII alpha 1-like 0.100
gdf11 growth differentiation factor 11 0.098
egfra epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 0.098
si:dkey-228g21.4 si:dkey-228g21.4 0.098
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.097
col1a1b collagen, type I, alpha 1b 0.097
fzd5 frizzled homolog 5 0.095
pdgfrl platelet-derived growth factor receptor-like 0.094
mdka midkine-related growth factor 0.093
rargb retinoic acid receptor, gamma b 0.093
ptgds prostaglandin D2 synthase 0.093
bmpr1bb bone morphogenetic protein receptor, type 1bb 0.093
casrl calcium-sensing receptor, like 0.093
ucp1 uncoupling protein 1 0.090
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.090
tyrp1b tyrosinase-related protein 1b 0.090
col6a3 collagen, type VI, alpha 3 0.089
hmgb1b high-mobility group box 1b 0.089
col10a1 collagen, type X, alpha 1 0.089
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.089
gsc goosecoid 0.088
mcoln1 mucolipin 1 0.088
gamt guanidinoacetate N-methyltransferase 0.088
bmp4 bone morphogenetic protein 4 0.087
agt angiotensinogen 0.085
bcl2l1 bcl2-like 1 0.085
slc26a3 solute carrier family 26, member 3 0.084
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDK6 cyclin-dependent kinase 6 0.571
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.161
THBS1 thrombospondin 1 0.157
NCOR2 nuclear receptor corepressor 2 0.157
RXRA retinoid X receptor, alpha 0.148
ENG endoglin 0.139
ACACB acetyl-CoA carboxylase beta 0.109
NRP1 neuropilin 1 0.094
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.094
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.089
RARA retinoic acid receptor, alpha 0.085
CCND3 cyclin D3 0.056
SETDB1 SET domain, bifurcated 1 0.040
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.033
MED25 mediator complex subunit 25 0.031
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.030
COL1A1 collagen, type I, alpha 1 0.030
TEK TEK tyrosine kinase, endothelial 0.030
MSN moesin 0.027
HNF4A hepatocyte nuclear factor 4, alpha 0.026
VAC14 Vac14 homolog (S. cerevisiae) 0.026
AXL AXL receptor tyrosine kinase 0.025
IL8 interleukin 8 0.024
CCR5 chemokine (C-C motif) receptor 5 0.024
IL1R1 interleukin 1 receptor, type I 0.024
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.023
WNT3A wingless-type MMTV integration site family, member 3A 0.022
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.021
IRS1 insulin receptor substrate 1 0.020
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.019
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.019
AGTR2 angiotensin II receptor, type 2 0.019
FADS2 fatty acid desaturase 2 0.018
DHCR7 7-dehydrocholesterol reductase 0.018
SMC1A structural maintenance of chromosomes 1A 0.017
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.017
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.016
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.016
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.016
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.016
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.016
NRIP1 nuclear receptor interacting protein 1 0.016
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.015
CCL20 chemokine (C-C motif) ligand 20 0.015
ICAM1 intercellular adhesion molecule 1 0.015
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.015
COL1A2 collagen, type I, alpha 2 0.015
HDAC1 histone deacetylase 1 0.015
CCND1 cyclin D1 0.014
COL4A1 collagen, type IV, alpha 1 0.014
COL5A1 collagen, type V, alpha 1 0.014
COL3A1 collagen, type III, alpha 1 0.014
ESR1 estrogen receptor 1 0.014
PLAUR plasminogen activator, urokinase receptor 0.013
CXCL11 chemokine (C-X-C motif) ligand 11 0.013
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.012
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.012
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.012
HR hairless homolog (mouse) 0.012
ANGPT2 angiopoietin 2 0.012
CCL2 chemokine (C-C motif) ligand 2 0.012
LRRK2 leucine-rich repeat kinase 2 0.011
STC1 stanniocalcin 1 0.011
IGFBP3 insulin-like growth factor binding protein 3 0.011
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.011
PPARA peroxisome proliferator-activated receptor alpha 0.011
CCNE1 cyclin E1 0.011
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.011
SRGN serglycin 0.011
IL6 interleukin 6 (interferon, beta 2) 0.011
JAK2 Janus kinase 2 0.010
ESR2 estrogen receptor 2 (ER beta) 0.010
FN1 fibronectin 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Vdr vitamin D receptor 0.881
Apoe apolipoprotein E 0.543
Nos3 nitric oxide synthase 3, endothelial cell 0.537
Wnt5a wingless-related MMTV integration site 5A 0.304
Lep leptin 0.224
Col1a1 collagen, type I, alpha 1 0.210
Cav1 caveolin 1, caveolae protein 0.202
Lepr leptin receptor 0.196
Ren1 renin 1 structural 0.165
Bglap bone gamma carboxyglutamate protein 0.152
Kl klotho 0.137
Esr1 estrogen receptor 1 (alpha) 0.133
Fgfr2 fibroblast growth factor receptor 2 0.129
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.127
Egfr epidermal growth factor receptor 0.101
Cdk2 cyclin-dependent kinase 2 0.092
Nos2 nitric oxide synthase 2, inducible 0.068
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.052
Pparg peroxisome proliferator activated receptor gamma 0.046
Slc12a1 solute carrier family 12, member 1 0.042
Apc adenomatosis polyposis coli 0.042
Ghr growth hormone receptor 0.041
Fgfr1 fibroblast growth factor receptor 1 0.040
Vegfa vascular endothelial growth factor A 0.029
Ccl2 chemokine (C-C motif) ligand 2 0.027
Bmp4 bone morphogenetic protein 4 0.026
Thra thyroid hormone receptor alpha 0.025
Notch2 Notch gene homolog 2 (Drosophila) 0.023
Ifng interferon gamma 0.023
Jag1 jagged 1 0.023
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.022
Ece1 endothelin converting enzyme 1 0.021
Fgf23 fibroblast growth factor 23 0.021
Nos1 nitric oxide synthase 1, neuronal 0.020
Ar androgen receptor 0.019
Sfrp2 secreted frizzled-related protein 2 0.019
Pkd1 polycystic kidney disease 1 homolog 0.019
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.019
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.019
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.018
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.018
Stat3 signal transducer and activator of transcription 3 0.018
Fam20c family with sequence similarity 20, member C 0.018
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.017
Tlr4 toll-like receptor 4 0.017
C3 complement component 3 0.017
Rbp1 retinol binding protein 1, cellular 0.017
Cdk4 cyclin-dependent kinase 4 0.017
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.016
Smad3 MAD homolog 3 (Drosophila) 0.016
Fstl1 follistatin-like 1 0.015
Csf1 colony stimulating factor 1 (macrophage) 0.015
Ccr2 chemokine (C-C motif) receptor 2 0.014
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.014
Mdk midkine 0.014
Insr insulin receptor 0.014
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.014
Ptgs2 prostaglandin-endoperoxide synthase 2 0.014
Klf15 Kruppel-like factor 15 0.013
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.012
Agtr1a angiotensin II receptor, type 1a 0.012
Spp1 secreted phosphoprotein 1 0.012
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.012
Grb10 growth factor receptor bound protein 10 0.012
Hif1a hypoxia inducible factor 1, alpha subunit 0.012
Mep1a meprin 1 alpha 0.011
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.011
Sox4 SRY-box containing gene 4 0.011
Il1r1 interleukin 1 receptor, type I 0.010
Ldlr low density lipoprotein receptor 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ephx1 epoxide hydrolase 1, microsomal 0.859
Col3a1 collagen, type III, alpha 1 0.460
Dnase1l3 deoxyribonuclease 1-like 3 0.393
Mgst1 microsomal glutathione S-transferase 1 0.392
Gstm2 glutathione S-transferase mu 2 0.380
Cd44 Cd44 molecule 0.376
Gja5 gap junction protein, alpha 5 0.343
Bgn biglycan 0.340
Col1a1 collagen, type I, alpha 1 0.320
Ptgs2 prostaglandin-endoperoxide synthase 2 0.320
Mgst2 microsomal glutathione S-transferase 2 0.308
Gsta3 glutathione S-transferase A3 0.303
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.301
Gstt1 glutathione S-transferase theta 1 0.297
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.296
Fn1 fibronectin 1 0.282
Ccl2 chemokine (C-C motif) ligand 2 0.278
Serpina4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.263
Apcs amyloid P component, serum 0.254
Ces1c carboxylesterase 1C 0.253
Igfals insulin-like growth factor binding protein, acid labile subunit 0.248
Cd14 CD14 molecule 0.243
Neurl3 neuralized homolog 3 (Drosophila) 0.241
Fabp1 fatty acid binding protein 1, liver 0.239
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.235
C5ar1 complement component 5a receptor 1 0.219
LOC305103 cell surface glycoprotein gp42 0.219
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.201
Ptprh protein tyrosine phosphatase, receptor type, H 0.197
Foxd3 forkhead box D3 0.193
Stc1 stanniocalcin 1 0.192
Dab2 disabled homolog 2 (Drosophila) 0.188
Vcan versican 0.185
Ccl4 chemokine (C-C motif) ligand 4 0.178
Selp selectin P 0.177
Dmgdh dimethylglycine dehydrogenase 0.175
Clcn5 chloride channel 5 0.171
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.171
Cybb cytochrome b-245, beta polypeptide 0.170
Sycn syncollin 0.169
Cps1 carbamoyl-phosphate synthetase 1 0.167
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.163
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.162
Fap fibroblast activation protein, alpha 0.159
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.159
Sftpd surfactant protein D 0.157
Lgals1 lectin, galactoside-binding, soluble, 1 0.157
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.156
Pzp pregnancy-zone protein 0.155
Kcne1 potassium voltage-gated channel, Isk-related family, member 1 0.154
Gpx2 glutathione peroxidase 2 0.153
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.153
Ppard peroxisome proliferator-activated receptor delta 0.152
Dmbt1 deleted in malignant brain tumors 1 0.150
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.149
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.145
Arl11 ADP-ribosylation factor-like 11 0.144
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.143
Bcl2 B-cell CLL/lymphoma 2 0.140
A1i3 alpha-1-inhibitor III 0.139
Ccl20 chemokine (C-C motif) ligand 20 0.139
Il1b interleukin 1 beta 0.139
Anxa5 annexin A5 0.138
Mmp3 matrix metallopeptidase 3 0.137
Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.137
Mmp12 matrix metallopeptidase 12 0.137
Lox lysyl oxidase 0.137
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.136
Rara retinoic acid receptor, alpha 0.136
Thbd thrombomodulin 0.135
Nlrp6 NLR family, pyrin domain containing 6 0.135
Mosc2 MOCO sulphurase C-terminal domain containing 2 0.135
Ccnd3 cyclin D3 0.133
Igfbp5 insulin-like growth factor binding protein 5 0.132
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.132
Hspb1 heat shock protein 1 0.131
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.129
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.129
Znf503 zinc finger protein 503 0.128
Cltc clathrin, heavy chain (Hc) 0.126
Ripk3 receptor-interacting serine-threonine kinase 3 0.125
Foxd1 forkhead box D1 0.125
Mef2d myocyte enhancer factor 2D 0.124
Smad7 SMAD family member 7 0.122
Rbp2 retinol binding protein 2, cellular 0.121
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.121
Tat tyrosine aminotransferase 0.120
Mmp2 matrix metallopeptidase 2 0.120
Gulo gulonolactone (L-) oxidase 0.120
Spp1 secreted phosphoprotein 1 0.119
Apoa5 apolipoprotein A-V 0.119
Col8a1 collagen, type VIII, alpha 1 0.119
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.118
Ddt D-dopachrome tautomerase 0.118
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.117
Il1r2 interleukin 1 receptor, type II 0.115
Stat6 signal transducer and activator of transcription 6 0.114
Il6 interleukin 6 0.113
Postn periostin, osteoblast specific factor 0.112
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.112
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism