The network for 'morphogenesis of a branching structure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of a branching structure

The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.

Danio rerio
Name Description Probability Func Analog Organism
notch3 notch homolog 3 0.829
tbx1 T-box 1 0.808
shha sonic hedgehog a 0.766
pitx3 paired-like homeodomain transcription factor 3 0.716
bmp2b bone morphogenetic protein 2b 0.618
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.605
etv2 ets variant gene 2 0.556
nrp1a neuropilin 1a 0.556
jag2 jagged 2 0.543
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.479
kdrl kinase insert domain receptor like 0.459
dlc deltaC 0.450
traf4a tnf receptor-associated factor 4a 0.426
dlx5a distal-less homeobox gene 5a 0.423
wt1b wilms tumor 1b 0.409
slit3 slit (Drosophila) homolog 3 0.406
notch1a notch homolog 1a 0.404
alcamb activated leukocyte cell adhesion molecule b 0.362
ptgs1 prostaglandin-endoperoxide synthase 1 0.308
bmp4 bone morphogenetic protein 4 0.300
bmp2a bone morphogenetic protein 2a 0.273
met met proto-oncogene (hepatocyte growth factor receptor) 0.271
osr2 odd-skipped related 2 (Drosophila) 0.262
six4b sine oculis homeobox homolog 4b 0.261
cdh2 cadherin 2, neuronal 0.255
wnt11 wingless-type MMTV integration site family, member 11 0.248
jag1b jagged 1b 0.232
sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.226
mmp2 matrix metalloproteinase 2 0.221
ntn1a netrin 1a 0.212
plce1 phospholipase C, epsilon 1 0.210
hoxb2a homeo box B2a 0.209
sema3aa semaphorin 3aa 0.209
edn1 endothelin 1 0.204
foxd3 forkhead box D3 0.199
unc45a unc-45 homolog A (C. elegans) 0.193
nrarpa notch-regulated ankyrin repeat protein a 0.190
tbx20 T-box 20 0.182
wnt3a wingless-type MMTV integration site family, member 3A 0.169
foxa1 forkhead box A1 0.166
wnt3 wingless-type MMTV integration site family, member 3 0.165
mecom MDS1 and EVI1 complex locus 0.152
plcg1 phospholipase C, gamma 1 0.139
foxa3 forkhead box A3 0.138
aplnra apelin receptor a 0.131
boc brother of CDO 0.130
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.129
wu:fv91b12 wu:fv91b12 0.128
nkx2.3 NK2 transcription factor related 3 0.116
hmx1 H6 homeo box 1 0.116
grem2 gremlin 2, cysteine knot superfamily 0.111
hnf1ba HNF1 homeobox Ba 0.110
frem3 Fras1 related extracellular matrix 3 0.110
ntn1b netrin 1b 0.107
cxcr4b chemokine (C-X-C motif), receptor 4b 0.104
pax6b paired box gene 6b 0.104
fbn2b fibrillin 2b 0.103
fgf3 fibroblast growth factor 3 0.100
eng1a engrailed 1a 0.097
foxj1b forkhead box J1b 0.097
igfbp3 insulin-like growth factor binding protein 3 0.096
hoxa13b homeo box A13b 0.095
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.093
rhoub ras homolog gene family, member Ub 0.093
pea3 ETS-domain transcription factor pea3 0.090
efnb2a ephrin B2a 0.085
eya1 eyes absent homolog 1 0.085
osr1 odd-skipped related 1 (Drosophila) 0.081
dusp6 dual specificity phosphatase 6 0.078
runx2a runt-related transcription factor 2a 0.078
cxcr4a chemokine (C-X-C motif) receptor 4a 0.076
hoxa2b homeo box A2b 0.075
angpt1 angiopoietin 1 0.075
prrx1a paired related homeobox 1a 0.075
nrp2a neuropilin 2a 0.074
wnt5b wingless-type MMTV integration site family, member 5b 0.073
aplnrb apelin receptor b 0.073
insm1a insulinoma-associated 1a 0.072
hoxd10a homeo box D10a 0.072
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.072
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.070
myog myogenin 0.069
si:ch73-60e21.1 si:ch73-60e21.1 0.066
wnt10a wingless-type MMTV integration site family, member 10a 0.065
col14a1 collagen, type XIV, alpha 1 0.065
hoxb3a homeo box B3a 0.062
hhex hematopoietically expressed homeobox 0.062
flncb filamin C, gamma b (actin binding protein 280) 0.061
hlxb9lb homeo box HB9 like b 0.061
ache acetylcholinesterase 0.060
pax2a paired box gene 2a 0.060
pld1a phospholipase D1a 0.060
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.060
hoxb8a homeo box B8a 0.060
sox1a SRY-box containing gene 1a 0.059
nkx2.5 NK2 transcription factor related 5 0.059
fgf8a fibroblast growth factor 8 a 0.058
runx3 runt-related transcription factor 3 0.058
hoxd12a homeo box D12a 0.056
fibin fin bud initiation factor 0.056
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tkv thickveins 0.940
mew multiple edematous wings 0.921
Mad Mothers against dpp 0.886
N Notch 0.809
crb crumbs 0.792
btl breathless 0.787
pyd polychaetoid 0.761
salm spalt major 0.739
pnt pointed 0.731
dpp decapentaplegic 0.683
smo smoothened 0.676
stumps CG31317 gene product from transcript CG31317-RC 0.621
Dad Daughters against dpp 0.603
noc no ocelli 0.593
rhea CG6831 gene product from transcript CG6831-RA 0.579
ap apterous 0.578
vvl ventral veins lacking 0.573
put punt 0.571
aop anterior open 0.570
arm armadillo 0.541
Egfr Epidermal growth factor receptor 0.537
lola longitudinals lacking 0.495
tgo tango 0.481
wg wingless 0.444
msn misshapen 0.430
Rab5 Rab-protein 5 0.411
luna CG33473 gene product from transcript CG33473-RB 0.352
elB elbow B 0.346
argos CG4531 gene product from transcript CG4531-RA 0.337
sax saxophone 0.337
Pten CG5671 gene product from transcript CG5671-RB 0.321
bsk basket 0.318
pio piopio 0.308
slou slouch 0.278
so sine oculis 0.267
stai stathmin 0.262
Nrx-IV Neurexin IV 0.258
bnl branchless 0.253
sgg shaggy 0.252
vari varicose 0.239
shn schnurri 0.233
eya eyes absent 0.232
LanB2 Laminin B2 0.226
Nsf2 NEM-sensitive fusion protein 2 0.221
ptc patched 0.219
os outstretched 0.217
Sema-1a CG18405 gene product from transcript CG18405-RD 0.215
fu fused 0.213
H Hairless 0.210
stan starry night 0.210
nej nejire 0.210
CkIIalpha Casein kinase II alpha subunit 0.195
wkd whacked 0.190
BicD Bicaudal D 0.188
spi spitz 0.172
GckIII Germinal centre kinase III 0.169
Mrtf Myocardin-related transcription factor 0.168
shg shotgun 0.166
gcm glial cells missing 0.160
jing CG9397 gene product from transcript CG9397-RI 0.159
eyg eyegone 0.153
rst roughest 0.152
ci cubitus interruptus 0.148
babo baboon 0.147
shot short stop 0.146
sr stripe 0.145
Gyc76C Guanylyl cyclase at 76C 0.137
Traf4 TNF-receptor-associated factor 4 0.133
Adar Adenosine deaminase acting on RNA 0.133
LanA Laminin A 0.129
Cip4 CG15015 gene product from transcript CG15015-RA 0.128
Hph HIF prolyl hydroxylase 0.126
tutl turtle 0.121
Sema-2a CG4700 gene product from transcript CG4700-RC 0.118
cora coracle 0.115
ara araucan 0.114
conv convoluted 0.107
sd scalloped 0.105
DAAM Dishevelled Associated Activator of Morphogenesis 0.104
sty sprouty 0.102
shi shibire 0.100
kni knirps 0.100
Sra-1 specifically Rac1-associated protein 1 0.100
Rala Ras-related protein 0.099
otk off-track 0.096
wb wing blister 0.095
ft fat 0.095
trx trithorax 0.094
Ptp69D Protein tyrosine phosphatase 69D 0.089
CadN Cadherin-N 0.088
knk knickkopf 0.087
Ppn Papilin 0.084
Mef2 Myocyte enhancer factor 2 0.083
nkd naked cuticle 0.083
fs(1)M3 female sterile (1) M3 0.083
dsh dishevelled 0.082
Ephrin CG1862 gene product from transcript CG1862-RA 0.081
Grasp65 CG7809 gene product from transcript CG7809-RA 0.081
beta-Spec beta Spectrin 0.079
Fak56D Focal Adhesion Kinase 0.076
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
VEGFA vascular endothelial growth factor A 0.989
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.986
NRP1 neuropilin 1 0.975
EGFR epidermal growth factor receptor 0.964
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.962
RARA retinoic acid receptor, alpha 0.944
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.943
THBS1 thrombospondin 1 0.941
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.940
CREBBP CREB binding protein 0.936
FN1 fibronectin 1 0.932
EGR1 early growth response 1 0.907
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.893
COL4A1 collagen, type IV, alpha 1 0.888
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.873
FGFR1 fibroblast growth factor receptor 1 0.858
FGF1 fibroblast growth factor 1 (acidic) 0.845
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.815
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.809
JAG1 jagged 1 0.793
ENG endoglin 0.771
NCOR2 nuclear receptor corepressor 2 0.760
HOXA10 homeobox A10 0.686
BMPR1A bone morphogenetic protein receptor, type IA 0.675
PML promyelocytic leukemia 0.659
GAS6 growth arrest-specific 6 0.639
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.639
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.637
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.618
TIMP3 TIMP metallopeptidase inhibitor 3 0.617
COL4A2 collagen, type IV, alpha 2 0.608
IL1R1 interleukin 1 receptor, type I 0.602
LRRK2 leucine-rich repeat kinase 2 0.595
ESR1 estrogen receptor 1 0.582
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.527
LUM lumican 0.503
COL2A1 collagen, type II, alpha 1 0.495
PLAT plasminogen activator, tissue 0.492
CAV1 caveolin 1, caveolae protein, 22kDa 0.487
MET met proto-oncogene (hepatocyte growth factor receptor) 0.486
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.443
FGF10 fibroblast growth factor 10 0.437
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.411
TGFB1 transforming growth factor, beta 1 0.387
COL6A1 collagen, type VI, alpha 1 0.379
COL5A1 collagen, type V, alpha 1 0.376
CTGF connective tissue growth factor 0.374
RUNX1 runt-related transcription factor 1 0.374
PLCG1 phospholipase C, gamma 1 0.352
PGF placental growth factor 0.340
NCOA6 nuclear receptor coactivator 6 0.319
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.308
COL1A1 collagen, type I, alpha 1 0.302
COL4A4 collagen, type IV, alpha 4 0.300
DAXX death-domain associated protein 0.299
MEIS1 Meis homeobox 1 0.293
TM4SF1 transmembrane 4 L six family member 1 0.279
COL4A6 collagen, type IV, alpha 6 0.272
CTNND1 catenin (cadherin-associated protein), delta 1 0.268
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.255
IQGAP1 IQ motif containing GTPase activating protein 1 0.247
TGFB2 transforming growth factor, beta 2 0.239
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.224
TGFB3 transforming growth factor, beta 3 0.207
EGR3 early growth response 3 0.197
SIRT1 sirtuin 1 0.196
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.190
POU5F1 POU class 5 homeobox 1 0.188
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.188
SFN stratifin 0.188
NOTCH3 notch 3 0.186
EP300 E1A binding protein p300 0.185
MEIS2 Meis homeobox 2 0.181
FGF2 fibroblast growth factor 2 (basic) 0.173
HSPG2 heparan sulfate proteoglycan 2 0.163
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.160
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.159
FOXF1 forkhead box F1 0.158
TP53 tumor protein p53 0.152
RB1 retinoblastoma 1 0.151
PARVA parvin, alpha 0.151
EFNA1 ephrin-A1 0.148
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.148
S100A2 S100 calcium binding protein A2 0.148
BMP7 bone morphogenetic protein 7 0.147
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.146
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.143
SORBS3 sorbin and SH3 domain containing 3 0.139
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.135
MSN moesin 0.134
IGFBP5 insulin-like growth factor binding protein 5 0.130
PTGIS prostaglandin I2 (prostacyclin) synthase 0.129
COL4A5 collagen, type IV, alpha 5 0.128
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.128
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.126
TNC tenascin C 0.124
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.116
COL1A2 collagen, type I, alpha 2 0.112
EGR2 early growth response 2 0.111
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Pax2 paired box gene 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Shh sonic hedgehog 0.999
Rarg retinoic acid receptor, gamma 0.998
Bcl2 B-cell leukemia/lymphoma 2 0.998
Hoxd11 homeobox D11 0.998
Pax8 paired box gene 8 0.998
Pten phosphatase and tensin homolog 0.998
Lhx1 LIM homeobox protein 1 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.997
Esr1 estrogen receptor 1 (alpha) 0.995
Ret ret proto-oncogene 0.995
Pax3 paired box gene 3 0.994
Prrx1 paired related homeobox 1 0.994
Vegfa vascular endothelial growth factor A 0.993
Fgfr1 fibroblast growth factor receptor 1 0.993
Meox2 mesenchyme homeobox 2 0.992
Vdr vitamin D receptor 0.992
Fgf8 fibroblast growth factor 8 0.990
Nos1 nitric oxide synthase 1, neuronal 0.990
Drd2 dopamine receptor D2 0.989
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.989
Ar androgen receptor 0.986
Foxc1 forkhead box C1 0.986
Fgfr3 fibroblast growth factor receptor 3 0.985
Tbx2 T-box 2 0.984
Lepr leptin receptor 0.981
Wnt5a wingless-related MMTV integration site 5A 0.980
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.976
Gdnf glial cell line derived neurotrophic factor 0.974
Tbx3 T-box 3 0.974
Acvr1 activin A receptor, type 1 0.973
Egfr epidermal growth factor receptor 0.971
Gli2 GLI-Kruppel family member GLI2 0.971
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.970
Ptgs2 prostaglandin-endoperoxide synthase 2 0.965
Rara retinoic acid receptor, alpha 0.965
Bmp4 bone morphogenetic protein 4 0.965
Nodal nodal 0.965
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.961
Pbx1 pre B-cell leukemia transcription factor 1 0.958
Epha4 Eph receptor A4 0.955
Eya1 eyes absent 1 homolog (Drosophila) 0.955
Rarb retinoic acid receptor, beta 0.951
Apc adenomatosis polyposis coli 0.951
Emx2 empty spiracles homolog 2 (Drosophila) 0.949
Efnb2 ephrin B2 0.935
Lef1 lymphoid enhancer binding factor 1 0.933
Sox7 SRY-box containing gene 7 0.932
Emx1 empty spiracles homolog 1 (Drosophila) 0.931
Snai1 snail homolog 1 (Drosophila) 0.926
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.920
Tcfap2c transcription factor AP-2, gamma 0.917
Nog noggin 0.916
Dlx1 distal-less homeobox 1 0.914
Wt1 Wilms tumor 1 homolog 0.913
Ptch1 patched homolog 1 0.912
Bmp5 bone morphogenetic protein 5 0.898
Cbl Casitas B-lineage lymphoma 0.895
Sox9 SRY-box containing gene 9 0.893
Nos2 nitric oxide synthase 2, inducible 0.893
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.893
Wnt3a wingless-related MMTV integration site 3A 0.892
Hoxa11 homeobox A11 0.892
Fzd1 frizzled homolog 1 (Drosophila) 0.887
Csf1 colony stimulating factor 1 (macrophage) 0.884
Acvrl1 activin A receptor, type II-like 1 0.882
Tcf21 transcription factor 21 0.881
Ccr2 chemokine (C-C motif) receptor 2 0.877
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.875
Bmp7 bone morphogenetic protein 7 0.872
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.872
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.871
Wnt4 wingless-related MMTV integration site 4 0.867
Lep leptin 0.865
Insr insulin receptor 0.864
Smad3 MAD homolog 3 (Drosophila) 0.858
Plau plasminogen activator, urokinase 0.855
Ccl2 chemokine (C-C motif) ligand 2 0.853
Fgf10 fibroblast growth factor 10 0.850
Il6st interleukin 6 signal transducer 0.850
Lamc1 laminin, gamma 1 0.847
Msx2 homeobox, msh-like 2 0.845
Il10 interleukin 10 0.845
Hoxb4 homeobox B4 0.841
Hoxb3 homeobox B3 0.839
Nos3 nitric oxide synthase 3, endothelial cell 0.839
Cd44 CD44 antigen 0.838
Gata6 GATA binding protein 6 0.836
Notch3 Notch gene homolog 3 (Drosophila) 0.832
Ptk7 PTK7 protein tyrosine kinase 7 0.832
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.827
Zic3 zinc finger protein of the cerebellum 3 0.824
Hoxa9 homeobox A9 0.823
Inpp5d inositol polyphosphate-5-phosphatase D 0.822
Tbx1 T-box 1 0.821
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism