IMP

Process View

Homo sapiens

2 genes annotated in human

negative regulation of b cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of b cell receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of b cell receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PTK2	PTK2 protein tyrosine kinase 2	0.986
TRIP6	thyroid hormone receptor interactor 6	0.868
TFF1	trefoil factor 1	0.809
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.799
BCAR1	breast cancer anti-estrogen resistance 1	0.680
LPXN	leupaxin	0.622
PILRA	paired immunoglobin-like type 2 receptor alpha	0.581
FHL2	four and a half LIM domains 2	0.540
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.530
PHC2	polyhomeotic homolog 2 (Drosophila)	0.502
HOXA1	homeobox A1	0.490
CD33	CD33 molecule	0.431
NCK2	NCK adaptor protein 2	0.316
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.281
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.225
PECAM1	platelet/endothelial cell adhesion molecule	0.187
LIMS1	LIM and senescent cell antigen-like domains 1	0.183	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.161
PXN	paxillin	0.152	Human
PHF21A	PHD finger protein 21A	0.152
ILK	integrin-linked kinase	0.149
BBS10	Bardet-Biedl syndrome 10	0.149
ITGA7	integrin, alpha 7	0.126
EPOR	erythropoietin receptor	0.123
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.109
FN1	fibronectin 1	0.099
SYK	spleen tyrosine kinase	0.098
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.089
VCL	vinculin	0.078
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.065
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.053
VAV1	vav 1 guanine nucleotide exchange factor	0.053
CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	0.048
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.042
SIGLEC7	sialic acid binding Ig-like lectin 7	0.041
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.040
SH3BP2	SH3-domain binding protein 2	0.039
POM121	POM121 membrane glycoprotein	0.038
SIGLEC10	sialic acid binding Ig-like lectin 10	0.037
PARVB	parvin, beta	0.037
ZNF426	zinc finger protein 426	0.032
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.032
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.031
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.031
PARVA	parvin, alpha	0.030
CD22	CD22 molecule	0.028
GRB2	growth factor receptor-bound protein 2	0.026
RNF5	ring finger protein 5	0.025
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.025
CNN1	calponin 1, basic, smooth muscle	0.024
ZNF331	zinc finger protein 331	0.024
SH2D2A	SH2 domain containing 2A	0.023
KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	0.023
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.023
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.022
CD72	CD72 molecule	0.022
DBNL	drebrin-like	0.020
FBP1	fructose-1,6-bisphosphatase 1	0.020
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.019
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.019
HK3	hexokinase 3 (white cell)	0.018
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.018
CSK	c-src tyrosine kinase	0.017
CYTH4	cytohesin 4	0.017
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.016
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.016
MYL9	myosin, light chain 9, regulatory	0.016
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.016
EHD2	EH-domain containing 2	0.016
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.015	Human
KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.015
DMBT1	deleted in malignant brain tumors 1	0.015
AR	androgen receptor	0.015
CAV2	caveolin 2	0.014
HES1	hairy and enhancer of split 1, (Drosophila)	0.014
SIRPA	signal-regulatory protein alpha	0.013
APOBR	apolipoprotein B receptor	0.013
DPEP2	dipeptidase 2	0.013
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.013
CD247	CD247 molecule	0.013
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.013
TLN1	talin 1	0.013
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.013
RHOU	ras homolog gene family, member U	0.012
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.012
GAB1	GRB2-associated binding protein 1	0.011
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.011
BTLA	B and T lymphocyte associated	0.011
ITGA6	integrin, alpha 6	0.011
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.011
ENG	endoglin	0.011
CATSPER1	cation channel, sperm associated 1	0.010
THAP2	THAP domain containing, apoptosis associated protein 2	0.010
CTGF	connective tissue growth factor	0.010