IMP

Process View

Homo sapiens

14 genes annotated in human

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to heat"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to heat" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.964	Yeast
FGFR2	fibroblast growth factor receptor 2	0.959
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.795	Yeast
FGF1	fibroblast growth factor 1 (acidic)	0.716
HSPA1B	heat shock 70kDa protein 1B	0.626
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.577
HSPA1A	heat shock 70kDa protein 1A	0.498
NOSTRIN	nitric oxide synthase trafficker	0.440
RBBP4	retinoblastoma binding protein 4	0.404	Human
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.378	Yeast
MAPK14	mitogen-activated protein kinase 14	0.372	Yeast
FGFR1	fibroblast growth factor receptor 1	0.344
FKBP4	FK506 binding protein 4, 59kDa	0.298
HDAC1	histone deacetylase 1	0.296
HSPH1	heat shock 105kDa/110kDa protein 1	0.279
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.258	Yeast
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.252
MAP2K4	mitogen-activated protein kinase kinase 4	0.238
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.237
HSPA8	heat shock 70kDa protein 8	0.226	Human Yeast
ARRB2	arrestin, beta 2	0.208
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.182
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.166	Yeast
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.163
IL1R1	interleukin 1 receptor, type I	0.157
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.157	Yeast
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.151	Yeast
BAG3	BCL2-associated athanogene 3	0.132
PPP5C	protein phosphatase 5, catalytic subunit	0.129
JUN	jun proto-oncogene	0.107
HSPB1	heat shock 27kDa protein 1	0.106
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.096
NUP98	nucleoporin 98kDa	0.095
IRAK2	interleukin-1 receptor-associated kinase 2	0.094
FGF10	fibroblast growth factor 10	0.091	Human
RBBP7	retinoblastoma binding protein 7	0.089
STIP1	stress-induced-phosphoprotein 1	0.089
CACYBP	calcyclin binding protein	0.072
VCP	valosin containing protein	0.066
DAPK1	death-associated protein kinase 1	0.064
NXF1	nuclear RNA export factor 1	0.057
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.053
TRAF6	TNF receptor-associated factor 6	0.052
HDAC2	histone deacetylase 2	0.049
NCOR1	nuclear receptor corepressor 1	0.048
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.047
CREBBP	CREB binding protein	0.043
SQSTM1	sequestosome 1	0.042
SAP30	Sin3A-associated protein, 30kDa	0.041
XIAP	X-linked inhibitor of apoptosis	0.039
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.039
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.037
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.037
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.033
PDCD6IP	programmed cell death 6 interacting protein	0.031
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.031
CPNE6	copine VI (neuronal)	0.030
TOP1	topoisomerase (DNA) I	0.028
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.028
PELI3	pellino homolog 3 (Drosophila)	0.027
ATF2	activating transcription factor 2	0.024
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.023
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.023	Yeast
CXCL11	chemokine (C-X-C motif) ligand 11	0.023
IL1RAP	interleukin 1 receptor accessory protein	0.022
MAPK1	mitogen-activated protein kinase 1	0.021
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.021
TP53	tumor protein p53	0.020	Rat
SH3RF3	SH3 domain containing ring finger 3	0.020
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.020
FHL2	four and a half LIM domains 2	0.020
BAG1	BCL2-associated athanogene	0.019
PKN1	protein kinase N1	0.019
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.019
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.019
PPID	peptidylprolyl isomerase D	0.018	Yeast
FGF7	fibroblast growth factor 7	0.017	Human
IL1RN	interleukin 1 receptor antagonist	0.016
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.016
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.015
HSPB8	heat shock 22kDa protein 8	0.015
DUSP1	dual specificity phosphatase 1	0.014
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.014	Yeast
EED	embryonic ectoderm development	0.014
ARRB1	arrestin, beta 1	0.014
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.013
C16orf70	chromosome 16 open reading frame 70	0.013
NQO1	NAD(P)H dehydrogenase, quinone 1	0.013
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.013
MYD88	myeloid differentiation primary response gene (88)	0.013
TRIM39	tripartite motif containing 39	0.012
SH3KBP1	SH3-domain kinase binding protein 1	0.012
EP300	E1A binding protein p300	0.012
IRAK3	interleukin-1 receptor-associated kinase 3	0.012
NCF2	neutrophil cytosolic factor 2	0.011
MTA3	metastasis associated 1 family, member 3	0.011
FLNB	filamin B, beta	0.011
XPO7	exportin 7	0.011
SART3	squamous cell carcinoma antigen recognized by T cells 3	0.011
TOMM34	translocase of outer mitochondrial membrane 34	0.011
KIAA1967	KIAA1967	0.011
CRYAB	crystallin, alpha B	0.011
GTF2I	general transcription factor IIi	0.011
FRS2	fibroblast growth factor receptor substrate 2	0.011
HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	0.011