IMP

Process View

Homo sapiens

17 genes annotated in human

secondary metabolic process

GO:0019748

The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "secondary metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "secondary metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PGK1	phosphoglycerate kinase 1	0.836
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.806
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.737	Human
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.707
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.701
AKR7A3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.598	Human
AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.537
RHOA	ras homolog gene family, member A	0.442	Fly
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.399
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.358
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.356
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.355
ARHGAP1	Rho GTPase activating protein 1	0.305
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.292
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.273	Fly
XIAP	X-linked inhibitor of apoptosis	0.241
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.201
LMO2	LIM domain only 2 (rhombotin-like 1)	0.157
MAP2K4	mitogen-activated protein kinase kinase 4	0.141
JUN	jun proto-oncogene	0.106
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.095
MAPK8	mitogen-activated protein kinase 8	0.080	Fly
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.077
EFNA1	ephrin-A1	0.072
NLRC4	NLR family, CARD domain containing 4	0.066
ATP8	ATP synthase F0 subunit 8	0.063
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.060
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.059	Fly
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.059
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.057	Fly
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.056
PRMT2	protein arginine methyltransferase 2	0.054
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.052
ARRB1	arrestin, beta 1	0.051
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.051	Fly
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.050
EGFR	epidermal growth factor receptor	0.047
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.047	Human
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.046
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.046	Human
ENO1	enolase 1, (alpha)	0.043
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.043	Fly
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.041
JUP	junction plakoglobin	0.041
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.039	Fly
EFNA5	ephrin-A5	0.038
DSG2	desmoglein 2	0.037
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.036
NCF4	neutrophil cytosolic factor 4, 40kDa	0.035
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.035
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.032	Fly
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.029	Human
ANAPC4	anaphase promoting complex subunit 4	0.028
C6	complement component 6	0.027
EZR	ezrin	0.027
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.027	Fly
DSP	desmoplakin	0.024
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.024
ZNF746	zinc finger protein 746	0.023
CTNND1	catenin (cadherin-associated protein), delta 1	0.023
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.023	Fly
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.022
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.022
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.022
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.020
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.020
EPHA7	EPH receptor A7	0.020	Fly
GLYAT	glycine-N-acyltransferase	0.019
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.019	Fly
IL1RAP	interleukin 1 receptor accessory protein	0.018
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.018
CFLAR	CASP8 and FADD-like apoptosis regulator	0.018
CDH5	cadherin 5, type 2 (vascular endothelium)	0.018
RAI1	retinoic acid induced 1	0.018
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.016
ADH6	alcohol dehydrogenase 6 (class V)	0.016
SH3BP2	SH3-domain binding protein 2	0.015
ELF4	E74-like factor 4 (ets domain transcription factor)	0.015
AADAC	arylacetamide deacetylase (esterase)	0.015
IFI16	interferon, gamma-inducible protein 16	0.015
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.015
RAB27A	RAB27A, member RAS oncogene family	0.014
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.014
F9	coagulation factor IX	0.014
GSK3B	glycogen synthase kinase 3 beta	0.013
GJB3	gap junction protein, beta 3, 31kDa	0.013
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.013	Human Rat
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.013
IQGAP1	IQ motif containing GTPase activating protein 1	0.012
HRG	histidine-rich glycoprotein	0.012
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.012	Human
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.012
FMO4	flavin containing monooxygenase 4	0.012	Human
C8A	complement component 8, alpha polypeptide	0.012
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.012
PVRL3	poliovirus receptor-related 3	0.011
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.011
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.011
PTN	pleiotrophin	0.011
AMBRA1	autophagy/beclin-1 regulator 1	0.011
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.011
NCKIPSD	NCK interacting protein with SH3 domain	0.011
ADAM15	ADAM metallopeptidase domain 15	0.011
TGFA	transforming growth factor, alpha	0.011
TNK2	tyrosine kinase, non-receptor, 2	0.011
COL7A1	collagen, type VII, alpha 1	0.011
DAO	D-amino-acid oxidase	0.011
GAS7	growth arrest-specific 7	0.010
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.010
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.010
TALDO1	transaldolase 1	0.010
GRB10	growth factor receptor-bound protein 10	0.010