IMP

Process View

Homo sapiens

4 genes annotated in human

Multi-species View

positive regulation of rig i signaling pathway

GO:1900246

Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of rig i signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of rig i signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.998
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.997
SP100	SP100 nuclear antigen	0.981
IFI44	interferon-induced protein 44	0.970
XAF1	XIAP associated factor 1	0.895
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.823
SAMD9	sterile alpha motif domain containing 9	0.816
IFIH1	interferon induced with helicase C domain 1	0.709
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.693
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.676
IFI44L	interferon-induced protein 44-like	0.658
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.613
TRIM5	tripartite motif containing 5	0.590	Human
SP110	SP110 nuclear body protein	0.585
SAMD9L	sterile alpha motif domain containing 9-like	0.540
TRIM39	tripartite motif containing 39	0.489	Human
RTP4	receptor (chemosensory) transporter protein 4	0.465
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.442
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.435
MED15	mediator complex subunit 15	0.424
PARP9	poly (ADP-ribose) polymerase family, member 9	0.423
HERC5	hect domain and RLD 5	0.316
EPSTI1	epithelial stromal interaction 1 (breast)	0.310
RSAD2	radical S-adenosyl methionine domain containing 2	0.284
TDRD7	tudor domain containing 7	0.283
STAT1	signal transducer and activator of transcription 1, 91kDa	0.259
ZNF263	zinc finger protein 263	0.252
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.232
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.217
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.207
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.192
IRF9	interferon regulatory factor 9	0.155
DTX3L	deltex 3-like (Drosophila)	0.144
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.129
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.112
IFI16	interferon, gamma-inducible protein 16	0.108
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.098
ISG15	ISG15 ubiquitin-like modifier	0.093
OASL	2'-5'-oligoadenylate synthetase-like	0.092
TRIM25	tripartite motif containing 25	0.092
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.084
TRIM22	tripartite motif containing 22	0.075	Human
TRIM21	tripartite motif containing 21	0.073	Human
GBP1	guanylate binding protein 1, interferon-inducible	0.073
IFI6	interferon, alpha-inducible protein 6	0.063
PHF11	PHD finger protein 11	0.061
DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	0.061	Human
PLSCR1	phospholipid scramblase 1	0.061
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.054
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.048
TRIM17	tripartite motif containing 17	0.045	Human
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.042
TRIM26	tripartite motif containing 26	0.042
APOL6	apolipoprotein L, 6	0.040
XIAP	X-linked inhibitor of apoptosis	0.036
TRIM32	tripartite motif containing 32	0.033
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.032
GBP3	guanylate binding protein 3	0.031
USP18	ubiquitin specific peptidase 18	0.031
MCOLN1	mucolipin 1	0.027
IFI27	interferon, alpha-inducible protein 27	0.026
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.026
TRIM6-TRIM34	TRIM6-TRIM34 readthrough	0.026
TRIM8	tripartite motif containing 8	0.025
LAP3	leucine aminopeptidase 3	0.024
TRIM43	tripartite motif containing 43	0.024
ADAR	adenosine deaminase, RNA-specific	0.022
RNF126	ring finger protein 126	0.022
TLR3	toll-like receptor 3	0.022
TRIM41	tripartite motif containing 41	0.021	Human
ARIH2	ariadne homolog 2 (Drosophila)	0.021
NMI	N-myc (and STAT) interactor	0.020
TRIM34	tripartite motif containing 34	0.020
CYLD	cylindromatosis (turban tumor syndrome)	0.020
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.019
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.018
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.017
TMEM140	transmembrane protein 140	0.017
ZNF473	zinc finger protein 473	0.017
HERC6	hect domain and RLD 6	0.017
BTN3A3	butyrophilin, subfamily 3, member A3	0.015
ZNRF1	zinc and ring finger 1	0.015
TRIM35	tripartite motif containing 35	0.014
TRIM52	tripartite motif containing 52	0.014
STAT2	signal transducer and activator of transcription 2, 113kDa	0.014
RNF11	ring finger protein 11	0.014
ZNFX1	zinc finger, NFX1-type containing 1	0.013
FADD	Fas (TNFRSF6)-associated via death domain	0.012
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.012
CTSO	cathepsin O	0.012
TRIM4	tripartite motif containing 4	0.012	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.012
TRIM14	tripartite motif containing 14	0.012
C19orf66	chromosome 19 open reading frame 66	0.012
IRF2	interferon regulatory factor 2	0.012
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.012
RNF5	ring finger protein 5	0.011
IL15	interleukin 15	0.011
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.011
MR1	major histocompatibility complex, class I-related	0.011
RNF114	ring finger protein 114	0.011
TRAF6	TNF receptor-associated factor 6	0.011
MKRN3	makorin ring finger protein 3	0.011
PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide	0.011
MYD88	myeloid differentiation primary response gene (88)	0.010
MEX3B	mex-3 homolog B (C. elegans)	0.010
RNF166	ring finger protein 166	0.010
FAS	Fas (TNF receptor superfamily, member 6)	0.010
PML	promyelocytic leukemia	0.010