IMP
Process View
negative regulation of platelet derived growth factor receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of platelet derived growth factor receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| C1QA | complement component 1, q subcomponent, A chain | 1.000 | Human | |
| GHR | growth hormone receptor | 0.998 | ||
| C1QC | complement component 1, q subcomponent, C chain | 0.985 | Human | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.952 | ||
| TBC1D10A | TBC1 domain family, member 10A | 0.908 | ||
| C1QB | complement component 1, q subcomponent, B chain | 0.894 | Human | |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.816 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.766 | ||
| EZR | ezrin | 0.654 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.613 | ||
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.546 | ||
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.504 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.448 | ||
| APP | amyloid beta (A4) precursor protein | 0.427 | ||
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.386 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.286 | ||
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.266 | ||
| DPYSL4 | dihydropyrimidinase-like 4 | 0.265 | ||
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.219 | ||
| C17orf28 | chromosome 17 open reading frame 28 | 0.153 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.150 | ||
| TBXA2R | thromboxane A2 receptor | 0.150 | ||
| MARCO | macrophage receptor with collagenous structure | 0.149 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.148 | ||
| APOE | apolipoprotein E | 0.119 | ||
| SNCAIP | synuclein, alpha interacting protein | 0.098 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.097 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.096 | ||
| ADRB2 | adrenergic, beta-2-, receptor, surface | 0.093 | ||
| SORBS1 | sorbin and SH3 domain containing 1 | 0.087 | ||
| MAPT | microtubule-associated protein tau | 0.087 | ||
| DCN | decorin | 0.081 | ||
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | 0.078 | ||
| SOCS2 | suppressor of cytokine signaling 2 | 0.061 | ||
| FABP4 | fatty acid binding protein 4, adipocyte | 0.061 | ||
| FCN2 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) | 0.058 | ||
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 | 0.051 | ||
| PTEN | phosphatase and tensin homolog | 0.051 | ||
| DUSP7 | dual specificity phosphatase 7 | 0.046 | ||
| FRMD5 | FERM domain containing 5 | 0.046 | ||
| STAB1 | stabilin 1 | 0.041 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.039 | ||
| ITGA1 | integrin, alpha 1 | 0.039 | ||
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 0.037 | ||
| PGF | placental growth factor | 0.034 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.029 | ||
| AVPR2 | arginine vasopressin receptor 2 | 0.029 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.029 | ||
| DUSP3 | dual specificity phosphatase 3 | 0.029 | ||
| TPPP | tubulin polymerization promoting protein | 0.029 | ||
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.028 | ||
| DOCK7 | dedicator of cytokinesis 7 | 0.027 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.026 | ||
| NF2 | neurofibromin 2 (merlin) | 0.024 | ||
| SEPT4 | septin 4 | 0.023 | ||
| VEGFA | vascular endothelial growth factor A | 0.023 | ||
| MAPK3 | mitogen-activated protein kinase 3 | 0.023 | ||
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.023 | ||
| MSN | moesin | 0.021 | ||
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.021 | ||
| WASL | Wiskott-Aldrich syndrome-like | 0.021 | ||
| DPPA4 | developmental pluripotency associated 4 | 0.021 | ||
| PDZD3 | PDZ domain containing 3 | 0.021 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.020 | ||
| SLAMF8 | SLAM family member 8 | 0.020 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.020 | ||
| TREM2 | triggering receptor expressed on myeloid cells 2 | 0.019 | ||
| C4B | complement component 4B (Chido blood group) | 0.019 | ||
| TEK | TEK tyrosine kinase, endothelial | 0.019 | ||
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.019 | ||
| LDLR | low density lipoprotein receptor | 0.019 | ||
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.018 | ||
| GGT5 | gamma-glutamyltransferase 5 | 0.018 | ||
| MS4A7 | membrane-spanning 4-domains, subfamily A, member 7 | 0.018 | ||
| PID1 | phosphotyrosine interaction domain containing 1 | 0.017 | ||
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.017 | ||
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.016 | ||
| MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.016 | ||
| SPARCL1 | SPARC-like 1 (hevin) | 0.016 | ||
| TLR7 | toll-like receptor 7 | 0.015 | ||
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.015 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.015 | ||
| CD163 | CD163 molecule | 0.015 | ||
| SLCO2B1 | solute carrier organic anion transporter family, member 2B1 | 0.015 | ||
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.015 | ||
| TMEM176A | transmembrane protein 176A | 0.015 | ||
| FXYD1 | FXYD domain containing ion transport regulator 1 | 0.014 | ||
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.014 | ||
| CSK | c-src tyrosine kinase | 0.014 | ||
| C3 | complement component 3 | 0.014 | ||
| DARC | Duffy blood group, chemokine receptor | 0.014 | ||
| MSR1 | macrophage scavenger receptor 1 | 0.014 | ||
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.014 | ||
| APBA1 | amyloid beta (A4) precursor protein-binding, family A, member 1 | 0.014 | ||
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.014 | ||
| SYN1 | synapsin I | 0.014 | ||
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.013 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.013 | ||
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.013 | ||
| C1R | complement component 1, r subcomponent | 0.013 | ||
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.013 | ||
| MPEG1 | macrophage expressed 1 | 0.013 | ||
| CD68 | CD68 molecule | 0.013 | ||
| WISP2 | WNT1 inducible signaling pathway protein 2 | 0.013 | ||
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.013 | ||
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.013 | ||
| TCN2 | transcobalamin II | 0.013 | ||
| A2M | alpha-2-macroglobulin | 0.013 | ||
| PLTP | phospholipid transfer protein | 0.013 | ||
| PSEN1 | presenilin 1 | 0.013 | ||
| CLDN5 | claudin 5 | 0.012 | ||
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.012 | ||
| APOD | apolipoprotein D | 0.012 | ||
| LEP | leptin | 0.012 | ||
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.012 | ||
| SCN1B | sodium channel, voltage-gated, type I, beta | 0.012 | ||
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 0.012 | ||
| GPX3 | glutathione peroxidase 3 (plasma) | 0.012 | ||
| HCST | hematopoietic cell signal transducer | 0.012 | ||
| CRYAB | crystallin, alpha B | 0.012 | ||
| MARK1 | MAP/microtubule affinity-regulating kinase 1 | 0.012 | ||
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.012 | ||
| LAMA2 | laminin, alpha 2 | 0.012 | ||
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.011 | ||
| PRELP | proline/arginine-rich end leucine-rich repeat protein | 0.011 | ||
| CTSD | cathepsin D | 0.011 | ||
| SLC25A47 | solute carrier family 25, member 47 | 0.011 | ||
| SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 0.011 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.011 | Human | |
| HSPA1B | heat shock 70kDa protein 1B | 0.011 | ||
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.011 | ||
| ROBO4 | roundabout homolog 4, magic roundabout (Drosophila) | 0.011 | ||
| OLFML2B | olfactomedin-like 2B | 0.011 | ||
| SOX18 | SRY (sex determining region Y)-box 18 | 0.011 | ||
| MMRN2 | multimerin 2 | 0.010 | ||
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.010 | ||
| CADM3 | cell adhesion molecule 3 | 0.010 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.010 | ||
| HSPA1A | heat shock 70kDa protein 1A | 0.010 | ||
| APOC1 | apolipoprotein C-I | 0.010 | ||
| SOD3 | superoxide dismutase 3, extracellular | 0.010 | ||
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.010 | ||
| ARHGAP31 | Rho GTPase activating protein 31 | 0.010 |