IMP

Process View

Homo sapiens

4 genes annotated in human

striated muscle adaptation

Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "striated muscle adaptation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "striated muscle adaptation" (in gray)

Name	Description	Probability	Func Analog Organism
MYOZ1	myozenin 1	0.961
TNNI1	troponin I type 1 (skeletal, slow)	0.932	Mouse
TNNC1	troponin C type 1 (slow)	0.888	Mouse
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.853
NEB	nebulin	0.730
TTN	titin	0.674
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.673
ACTA1	actin, alpha 1, skeletal muscle	0.649	Rat
ACTN2	actinin, alpha 2	0.638
TRIM63	tripartite motif containing 63	0.603	Rat
TNNI2	troponin I type 2 (skeletal, fast)	0.602
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.419
MRPL41	mitochondrial ribosomal protein L41	0.415
DES	desmin	0.334
FLNC	filamin C, gamma	0.217
TNNT2	troponin T type 2 (cardiac)	0.147
GFM1	G elongation factor, mitochondrial 1	0.136
TBX5	T-box 5	0.111
TNNT1	troponin T type 1 (skeletal, slow)	0.101	Mouse
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.091
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.090
ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	0.087
EP300	E1A binding protein p300	0.084
CALCA	calcitonin-related polypeptide alpha	0.084
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.083
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.081	Mouse
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.073
HDAC4	histone deacetylase 4	0.072
TNNI3	troponin I type 3 (cardiac)	0.064
HIST1H4F	histone cluster 1, H4f	0.060
MBNL1	muscleblind-like (Drosophila)	0.059
MYOZ2	myozenin 2	0.056
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.056
IRF2	interferon regulatory factor 2	0.056
HDAC9	histone deacetylase 9	0.053
TNNT3	troponin T type 3 (skeletal, fast)	0.052
NOMO1	NODAL modulator 1	0.051
KLF13	Kruppel-like factor 13	0.050
TRIM55	tripartite motif containing 55	0.044
CKM	creatine kinase, muscle	0.044
DLG2	discs, large homolog 2 (Drosophila)	0.043
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.043
TRIM54	tripartite motif containing 54	0.043
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.042
COASY	CoA synthase	0.042
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.040
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.040
DCAF6	DDB1 and CUL4 associated factor 6	0.040
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.038
RICTOR	RPTOR independent companion of MTOR, complex 2	0.037
HDAC5	histone deacetylase 5	0.036
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.035	Human
CCDC85B	coiled-coil domain containing 85B	0.035
TNNC2	troponin C type 2 (fast)	0.033
MKL1	megakaryoblastic leukemia (translocation) 1	0.033
HAND2	heart and neural crest derivatives expressed 2	0.033
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.032
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.031
TRIM43	tripartite motif containing 43	0.030
MAPK8	mitogen-activated protein kinase 8	0.030
HIST1H3B	histone cluster 1, H3b	0.030
LMCD1	LIM and cysteine-rich domains 1	0.029
MYOCD	myocardin	0.029
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.029
DLG1	discs, large homolog 1 (Drosophila)	0.028
TOM1L1	target of myb1 (chicken)-like 1	0.027
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.027
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.027
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.027	Human
SRL	sarcalumenin	0.026
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.026
LDB3	LIM domain binding 3	0.025
TCAP	titin-cap (telethonin)	0.025
MYF5	myogenic factor 5	0.025
C16orf74	chromosome 16 open reading frame 74	0.025
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.024
TRPC5	transient receptor potential cation channel, subfamily C, member 5	0.024	Human
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	0.023
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.023
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.022
ZEB2	zinc finger E-box binding homeobox 2	0.022
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.022
MYBPC2	myosin binding protein C, fast type	0.022
GMEB1	glucocorticoid modulatory element binding protein 1	0.021
PDPK1	3-phosphoinositide dependent protein kinase-1	0.021
OSM	oncostatin M	0.021
BTK	Bruton agammaglobulinemia tyrosine kinase	0.021
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.020
PTP4A3	protein tyrosine phosphatase type IVA, member 3	0.020
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.020
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.020
MYBPC3	myosin binding protein C, cardiac	0.020
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.020
ACTC1	actin, alpha, cardiac muscle 1	0.019
SYNPO2L	synaptopodin 2-like	0.019
TRRAP	transformation/transcription domain-associated protein	0.018
TOP1	topoisomerase (DNA) I	0.018
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.018
MYOG	myogenin (myogenic factor 4)	0.018	Mouse
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.018
OPTN	optineurin	0.018
PIM1	pim-1 oncogene	0.018
TPM1	tropomyosin 1 (alpha)	0.018
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.017
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.017
MYBPH	myosin binding protein H	0.017
SMPX	small muscle protein, X-linked	0.017
OBSL1	obscurin-like 1	0.017
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.017
TMEM98	transmembrane protein 98	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.017
SP1	Sp1 transcription factor	0.017
NCOR1	nuclear receptor corepressor 1	0.016
CELF2	CUGBP, Elav-like family member 2	0.016
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.016
FAS	Fas (TNF receptor superfamily, member 6)	0.016
ZKSCAN5	zinc finger with KRAB and SCAN domains 5	0.016
LMOD2	leiomodin 2 (cardiac)	0.016
SFRP5	secreted frizzled-related protein 5	0.016
PAX7	paired box 7	0.015
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.015
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.015
LRP12	low density lipoprotein receptor-related protein 12	0.015
SIRT1	sirtuin 1	0.015
SIX1	SIX homeobox 1	0.014
NCK2	NCK adaptor protein 2	0.014
OSBP2	oxysterol binding protein 2	0.014
STXBP5	syntaxin binding protein 5 (tomosyn)	0.014
CASQ1	calsequestrin 1 (fast-twitch, skeletal muscle)	0.014
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.014
TRPC7	transient receptor potential cation channel, subfamily C, member 7	0.014	Human
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.014
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.014
TBX1	T-box 1	0.013
MAPK12	mitogen-activated protein kinase 12	0.013
ZNF768	zinc finger protein 768	0.013
CD2AP	CD2-associated protein	0.013
ZNF250	zinc finger protein 250	0.013
MIB2	mindbomb homolog 2 (Drosophila)	0.013
CAV3	caveolin 3	0.013
NEBL	nebulette	0.013
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.013	Human
PGAM2	phosphoglycerate mutase 2 (muscle)	0.013
SPTBN1	spectrin, beta, non-erythrocytic 1	0.013
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.013
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.013
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.012
FBXW7	F-box and WD repeat domain containing 7	0.012
TPM2	tropomyosin 2 (beta)	0.012
DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.012
CRY1	cryptochrome 1 (photolyase-like)	0.012
PRKCB	protein kinase C, beta	0.012
CANX	calnexin	0.012
SPTB	spectrin, beta, erythrocytic	0.012
MYOM1	myomesin 1, 185kDa	0.012
ATF2	activating transcription factor 2	0.012
ATP13A3	ATPase type 13A3	0.012
BRAP	BRCA1 associated protein	0.012
MYOT	myotilin	0.012
MAPT	microtubule-associated protein tau	0.012
FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	0.012
AP4S1	adaptor-related protein complex 4, sigma 1 subunit	0.012
TCF4	transcription factor 4	0.012
GC	group-specific component (vitamin D binding protein)	0.012
PYGM	phosphorylase, glycogen, muscle	0.012
CASQ2	calsequestrin 2 (cardiac muscle)	0.012
ACHE	acetylcholinesterase	0.011
NXPH1	neurexophilin 1	0.011
CA3	carbonic anhydrase III, muscle specific	0.011
MYLK3	myosin light chain kinase 3	0.011
ENO3	enolase 3 (beta, muscle)	0.011
PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	0.011
OPRD1	opioid receptor, delta 1	0.011
SIRT2	sirtuin 2	0.011
MEF2C	myocyte enhancer factor 2C	0.011	Mouse
PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	0.011
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
MAX	MYC associated factor X	0.011
STIM1	stromal interaction molecule 1	0.011
ITGB1BP3	integrin beta 1 binding protein 3	0.011
ALPK3	alpha-kinase 3	0.011
GSN	gelsolin	0.011
ESR2	estrogen receptor 2 (ER beta)	0.011
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.011
RAPSN	receptor-associated protein of the synapse	0.011
EEF1G	eukaryotic translation elongation factor 1 gamma	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011	Mouse
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.011
HRC	histidine rich calcium binding protein	0.011
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.011
SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	0.011
SOCS5	suppressor of cytokine signaling 5	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.010
STMN4	stathmin-like 4	0.010
TAL1	T-cell acute lymphocytic leukemia 1	0.010
FANCD2	Fanconi anemia, complementation group D2	0.010
ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.010
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.010
ATP1B4	ATPase, Na+/K+ transporting, beta 4 polypeptide	0.010
PAM	peptidylglycine alpha-amidating monooxygenase	0.010
NRIP1	nuclear receptor interacting protein 1	0.010
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.010
MYH4	myosin, heavy chain 4, skeletal muscle	0.010
BIN1	bridging integrator 1	0.010
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.010
MYLK2	myosin light chain kinase 2	0.010
HFE2	hemochromatosis type 2 (juvenile)	0.010
EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2	0.010
EML4	echinoderm microtubule associated protein like 4	0.010
SMAD7	SMAD family member 7	0.010
GATA5	GATA binding protein 5	0.010