IMP

Process View

Homo sapiens

19 genes annotated in human

positive regulation of ligase activity

Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of ligase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of ligase activity" (in gray)

Name	Description	Probability	Func Analog Organism
RING1	ring finger protein 1	0.958
RNF2	ring finger protein 2	0.910
CBX8	chromobox homolog 8	0.875
BMI1	BMI1 polycomb ring finger oncogene	0.828
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.729
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.673
CBX7	chromobox homolog 7	0.589
SIRT2	sirtuin 2	0.448
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.390
ARIH2	ariadne homolog 2 (Drosophila)	0.341
CTAG1B	cancer/testis antigen 1B	0.259
NAP1L5	nucleosome assembly protein 1-like 5	0.205
TEKT4	tektin 4	0.180
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.178
CBX6	chromobox homolog 6	0.163
RNF144B	ring finger protein 144B	0.159
PJA1	praja ring finger 1	0.140
EID2	EP300 interacting inhibitor of differentiation 2	0.139
PLK1	polo-like kinase 1	0.124
FHL1	four and a half LIM domains 1	0.123
UBE3A	ubiquitin protein ligase E3A	0.119
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.101
CBX4	chromobox homolog 4	0.097
USP11	ubiquitin specific peptidase 11	0.091
GSK3B	glycogen synthase kinase 3 beta	0.083
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.082
EID2B	EP300 interacting inhibitor of differentiation 2B	0.079
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.071	Human
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.061
RYBP	RING1 and YY1 binding protein	0.061
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.060
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.060
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.059
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.058
MAGEA12	melanoma antigen family A, 12	0.058	Human
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.056
ATF5	activating transcription factor 5	0.048
ADRB2	adrenergic, beta-2-, receptor, surface	0.048
RNF11	ring finger protein 11	0.046
MAGEA3	melanoma antigen family A, 3	0.045
LNX1	ligand of numb-protein X 1	0.044
MAGEA6	melanoma antigen family A, 6	0.044	Human
BCOR	BCL6 corepressor	0.043
GCLC	glutamate-cysteine ligase, catalytic subunit	0.042
BIRC3	baculoviral IAP repeat containing 3	0.039
MYST1	MYST histone acetyltransferase 1	0.037
PRNP	prion protein	0.037
APLF	aprataxin and PNKP like factor	0.037
CCDC6	coiled-coil domain containing 6	0.036
MAGEA5	melanoma antigen family A, 5	0.036
BAX	BCL2-associated X protein	0.035
EID3	EP300 interacting inhibitor of differentiation 3	0.035
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.033
LIG4	ligase IV, DNA, ATP-dependent	0.031
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.031
PCGF1	polycomb group ring finger 1	0.030	Human
CLSPN	claspin	0.030
DAXX	death-domain associated protein	0.030
TRIM69	tripartite motif containing 69	0.029
KAT5	K(lysine) acetyltransferase 5	0.029
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.028
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.026
PCGF5	polycomb group ring finger 5	0.025	Human
NRIP1	nuclear receptor interacting protein 1	0.025
TUBB2C	tubulin, beta 2C	0.025
SUFU	suppressor of fused homolog (Drosophila)	0.024
PML	promyelocytic leukemia	0.022
PHC2	polyhomeotic homolog 2 (Drosophila)	0.022
TNIP1	TNFAIP3 interacting protein 1	0.022
TRIM28	tripartite motif containing 28	0.022
MOAP1	modulator of apoptosis 1	0.020
MAGEA2	melanoma antigen family A, 2	0.020
MAK	male germ cell-associated kinase	0.020
MAGEC1	melanoma antigen family C, 1	0.020	Human
EID1	EP300 interacting inhibitor of differentiation 1	0.019
PCGF3	polycomb group ring finger 3	0.019	Human
PCGF2	polycomb group ring finger 2	0.018	Human
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	0.018
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.017
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.017
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.017
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.016
YAF2	YY1 associated factor 2	0.016
DDIT4	DNA-damage-inducible transcript 4	0.016
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.015
BIRC2	baculoviral IAP repeat containing 2	0.015
ERH	enhancer of rudimentary homolog (Drosophila)	0.015
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.015
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.015
CSNK2B	casein kinase 2, beta polypeptide	0.015
RANGAP1	Ran GTPase activating protein 1	0.014
EIF4E	eukaryotic translation initiation factor 4E	0.014
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.014
NHEJ1	nonhomologous end-joining factor 1	0.014
HSPA1L	heat shock 70kDa protein 1-like	0.014
TUBG1	tubulin, gamma 1	0.014
MAGEA4	melanoma antigen family A, 4	0.013	Human
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.013
PTTG1	pituitary tumor-transforming 1	0.013
MAGEB2	melanoma antigen family B, 2	0.012	Human
RNF31	ring finger protein 31	0.012
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.012
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.012
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.012
TADA3	transcriptional adaptor 3	0.012
ANAPC11	anaphase promoting complex subunit 11	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
MAGEC2	melanoma antigen family C, 2	0.011
CTAG2	cancer/testis antigen 2	0.011
CUL4A	cullin 4A	0.011
CDKN2AIP	CDKN2A interacting protein	0.011
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.010
KRT15	keratin 15	0.010
RFWD2	ring finger and WD repeat domain 2	0.010