IMP

Process View

Homo sapiens

21 genes annotated in human

Multi-species View

positive regulation of interleukin 6 production

GO:0032755

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of interleukin 6 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of interleukin 6 production" (in gray)

Name	Description	Probability	Func Analog Organism
RIPK2	receptor-interacting serine-threonine kinase 2	0.782	Mouse
IL1R1	interleukin 1 receptor, type I	0.701
MAP2K4	mitogen-activated protein kinase kinase 4	0.646
TLR4	toll-like receptor 4	0.632
TICAM2	toll-like receptor adaptor molecule 2	0.534
MYD88	myeloid differentiation primary response gene (88)	0.494	Mouse
IRAK1	interleukin-1 receptor-associated kinase 1	0.474
NLRC4	NLR family, CARD domain containing 4	0.440
BIRC3	baculoviral IAP repeat containing 3	0.339
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.273
IRAK2	interleukin-1 receptor-associated kinase 2	0.204
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.167
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.157
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.153
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.110
TRAF2	TNF receptor-associated factor 2	0.108
TRAF3	TNF receptor-associated factor 3	0.088
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.083
ATF2	activating transcription factor 2	0.071
NOD2	nucleotide-binding oligomerization domain containing 2	0.068
IL6	interleukin 6 (interferon, beta 2)	0.064
SYK	spleen tyrosine kinase	0.063
MARK2	MAP/microtubule affinity-regulating kinase 2	0.062
TLR2	toll-like receptor 2	0.059
IL6R	interleukin 6 receptor	0.057
JUN	jun proto-oncogene	0.057
SETD8	SET domain containing (lysine methyltransferase) 8	0.057
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.044
MEFV	Mediterranean fever	0.044
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.043
SOCS3	suppressor of cytokine signaling 3	0.040
CPNE6	copine VI (neuronal)	0.039
TRAF1	TNF receptor-associated factor 1	0.039
PYDC2	pyrin domain containing 2	0.038
JAK1	Janus kinase 1	0.037
BIRC2	baculoviral IAP repeat containing 2	0.036
GATA2	GATA binding protein 2	0.035
TXN	thioredoxin	0.034
IL8	interleukin 8	0.033
HSPH1	heat shock 105kDa/110kDa protein 1	0.031
ARRB1	arrestin, beta 1	0.030
RUNX1	runt-related transcription factor 1	0.029
FZD1	frizzled homolog 1 (Drosophila)	0.029
MAPK14	mitogen-activated protein kinase 14	0.028	Human
SMAD3	SMAD family member 3	0.027
NOD1	nucleotide-binding oligomerization domain containing 1	0.027	Mouse
CCR1	chemokine (C-C motif) receptor 1	0.025
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.024
LY96	lymphocyte antigen 96	0.023
BTK	Bruton agammaglobulinemia tyrosine kinase	0.023
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.021
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.021
TLR1	toll-like receptor 1	0.021	Human Mouse
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.020
IRAK3	interleukin-1 receptor-associated kinase 3	0.019
IL1RAP	interleukin 1 receptor accessory protein	0.019
IRAK4	interleukin-1 receptor-associated kinase 4	0.019
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.019
VNN2	vanin 2	0.018
LY86	lymphocyte antigen 86	0.016
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.015
KIAA1712	KIAA1712	0.015
MAPK15	mitogen-activated protein kinase 15	0.014
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.013
SPOP	speckle-type POZ protein	0.013
FGF3	fibroblast growth factor 3	0.013
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.013
TLR7	toll-like receptor 7	0.013	Human Mouse
CCL20	chemokine (C-C motif) ligand 20	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
SAMHD1	SAM domain and HD domain 1	0.011
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.011
XPO7	exportin 7	0.011
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.011
GTF2I	general transcription factor IIi	0.011
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
ELF4	E74-like factor 4 (ets domain transcription factor)	0.011
IL1B	interleukin 1, beta	0.010	Mouse Rat
IRF7	interferon regulatory factor 7	0.010
PKN1	protein kinase N1	0.010
FOSL1	FOS-like antigen 1	0.010
ANG	angiogenin, ribonuclease, RNase A family, 5	0.010
STAP2	signal transducing adaptor family member 2	0.010