IMP

Process View

Homo sapiens

2 genes annotated in human

desensitization of g protein coupled receptor protein signaling pathway by arrestin

GO:0002032

The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "desensitization of g protein coupled receptor protein signaling pathway by arrestin"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "desensitization of g protein coupled receptor protein signaling pathway by arrestin" (in gray)

Name	Description	Probability	Func Analog Organism
ARRB1	arrestin, beta 1	1.000	Human
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.999
MPDZ	multiple PDZ domain protein	0.998
MAPK10	mitogen-activated protein kinase 10	0.989
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.819
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.787
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.778
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.772
MAP2K4	mitogen-activated protein kinase kinase 4	0.725
RAB5C	RAB5C, member RAS oncogene family	0.703
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.701
ACTG1	actin, gamma 1	0.444
CFL1	cofilin 1 (non-muscle)	0.383
HIST2H2AB	histone cluster 2, H2ab	0.373
GNMT	glycine N-methyltransferase	0.355
ARRDC3	arrestin domain containing 3	0.354
DGKZ	diacylglycerol kinase, zeta	0.208
EZR	ezrin	0.131
GNAS	GNAS complex locus	0.129
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.114
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.112
PDE4D	phosphodiesterase 4D, cAMP-specific	0.107
ARRB2	arrestin, beta 2	0.103
PTAFR	platelet-activating factor receptor	0.090
ADRB2	adrenergic, beta-2-, receptor, surface	0.085
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.083
MAPK9	mitogen-activated protein kinase 9	0.081
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.079
AGTR1	angiotensin II receptor, type 1	0.070
TBC1D10A	TBC1 domain family, member 10A	0.068
SSTR3	somatostatin receptor 3	0.068
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.067
UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	0.060
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.054
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.053	Human
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.045	Human
SDC3	syndecan 3	0.043
H1FX	H1 histone family, member X	0.043
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.042
CORO1A	coronin, actin binding protein, 1A	0.041
GPR6	G protein-coupled receptor 6	0.040
FASN	fatty acid synthase	0.034
PTPRA	protein tyrosine phosphatase, receptor type, A	0.031
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.031	Human
LNX1	ligand of numb-protein X 1	0.030
SRCIN1	SRC kinase signaling inhibitor 1	0.030
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.030	Human
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.030
LIMK1	LIM domain kinase 1	0.030
ENG	endoglin	0.028
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.027
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.027
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.027	Human
PDX1	pancreatic and duodenal homeobox 1	0.026
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.026
RIMS4	regulating synaptic membrane exocytosis 4	0.026
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.026
PTPRR	protein tyrosine phosphatase, receptor type, R	0.025
GHRHR	growth hormone releasing hormone receptor	0.025
MED8	mediator complex subunit 8	0.024
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.024
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.024
AFF2	AF4/FMR2 family, member 2	0.023
MAPK3	mitogen-activated protein kinase 3	0.022
OR2H1	olfactory receptor, family 2, subfamily H, member 1	0.022
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.021
YY1	YY1 transcription factor	0.021
KRT33B	keratin 33B	0.021
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.020	Human
CCR3	chemokine (C-C motif) receptor 3	0.020
GRM5	glutamate receptor, metabotropic 5	0.020
SLC14A2	solute carrier family 14 (urea transporter), member 2	0.020
DNM1	dynamin 1	0.020
CCK	cholecystokinin	0.019
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.019
MYH9	myosin, heavy chain 9, non-muscle	0.019
ADAM15	ADAM metallopeptidase domain 15	0.019
SPRR2A	small proline-rich protein 2A	0.019
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.019
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.019	Human
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.018
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.018
PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	0.018
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.017
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.017
SMCP	sperm mitochondria-associated cysteine-rich protein	0.017
DRD1	dopamine receptor D1	0.017	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.017
PSG7	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)	0.017
CDH8	cadherin 8, type 2	0.016
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.016
COPG2	coatomer protein complex, subunit gamma 2	0.016
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.016
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.016
GCM1	glial cells missing homolog 1 (Drosophila)	0.016
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.016
FGF18	fibroblast growth factor 18	0.016
AQP7	aquaporin 7	0.016
NXPH3	neurexophilin 3	0.016
CALM3	calmodulin 3 (phosphorylase kinase, delta)	0.016
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.015
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.015
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.015
GRIK1	glutamate receptor, ionotropic, kainate 1	0.015
NELL1	NEL-like 1 (chicken)	0.015
DSCAML1	Down syndrome cell adhesion molecule like 1	0.015
CCKBR	cholecystokinin B receptor	0.015
MMP20	matrix metallopeptidase 20	0.015
ODF1	outer dense fiber of sperm tails 1	0.015
POLR1A	polymerase (RNA) I polypeptide A, 194kDa	0.015
SLC18A1	solute carrier family 18 (vesicular monoamine), member 1	0.015
S100B	S100 calcium binding protein B	0.014
OPRM1	opioid receptor, mu 1	0.014
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.014
AQP2	aquaporin 2 (collecting duct)	0.014
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.014
REG3A	regenerating islet-derived 3 alpha	0.014
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.014
PNOC	prepronociceptin	0.014
TGM4	transglutaminase 4 (prostate)	0.014
PLA2G1B	phospholipase A2, group IB (pancreas)	0.013
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.013
C3orf27	chromosome 3 open reading frame 27	0.013
SLC17A2	solute carrier family 17 (sodium phosphate), member 2	0.013
FEZF2	FEZ family zinc finger 2	0.013
CNGA3	cyclic nucleotide gated channel alpha 3	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
AMOTL2	angiomotin like 2	0.013
GSN	gelsolin	0.013
GIF	gastric intrinsic factor (vitamin B synthesis)	0.013
ADRA1A	adrenergic, alpha-1A-, receptor	0.013
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.013
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.013
BFSP1	beaded filament structural protein 1, filensin	0.013
CRH	corticotropin releasing hormone	0.013
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.013
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.013
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.013
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.012
FKBP1A	FK506 binding protein 1A, 12kDa	0.012
MAS1	MAS1 oncogene	0.012
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.012
CALCR	calcitonin receptor	0.012
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.012
RELN	reelin	0.012
CLTA	clathrin, light chain A	0.012
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.012
TNNI3	troponin I type 3 (cardiac)	0.012
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.012
HAND1	heart and neural crest derivatives expressed 1	0.012
NPY1R	neuropeptide Y receptor Y1	0.012
WNT8B	wingless-type MMTV integration site family, member 8B	0.012
TBR1	T-box, brain, 1	0.012
S100A2	S100 calcium binding protein A2	0.012
MTMR7	myotubularin related protein 7	0.012
CTTN	cortactin	0.011
SPACA1	sperm acrosome associated 1	0.011
CNR2	cannabinoid receptor 2 (macrophage)	0.011
CPNE1	copine I	0.011
AVPR1B	arginine vasopressin receptor 1B	0.011
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.011
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.011
ACRV1	acrosomal vesicle protein 1	0.011
IL6R	interleukin 6 receptor	0.011
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.011
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.011
ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	0.011
LGI1	leucine-rich, glioma inactivated 1	0.011
SPTB	spectrin, beta, erythrocytic	0.011
IL17RA	interleukin 17 receptor A	0.011
DLGAP3	discs, large (Drosophila) homolog-associated protein 3	0.011
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.011
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.011
DUSP3	dual specificity phosphatase 3	0.011
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.011
CAPNS1	calpain, small subunit 1	0.011
GPC5	glypican 5	0.011
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.011
MYF6	myogenic factor 6 (herculin)	0.011
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.011
OPRK1	opioid receptor, kappa 1	0.011
GYPE	glycophorin E (MNS blood group)	0.011
SCN2A	sodium channel, voltage-gated, type II, alpha subunit	0.011
NPY5R	neuropeptide Y receptor Y5	0.011
SCTR	secretin receptor	0.011
MUSK	muscle, skeletal, receptor tyrosine kinase	0.011
CRP	C-reactive protein, pentraxin-related	0.011
DUSP1	dual specificity phosphatase 1	0.011
KRT9	keratin 9	0.011
CHIA	chitinase, acidic	0.011
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.011
SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	0.011
GP5	glycoprotein V (platelet)	0.011
PADI4	peptidyl arginine deiminase, type IV	0.011
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.011
OCA2	oculocutaneous albinism II	0.011
RHO	rhodopsin	0.010
PAX6	paired box 6	0.010
SMR3B	submaxillary gland androgen regulated protein 3B	0.010
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.010
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.010
PHKA2	phosphorylase kinase, alpha 2 (liver)	0.010
TBX5	T-box 5	0.010
PRL	prolactin	0.010
ZNRF4	zinc and ring finger 4	0.010
PHOX2B	paired-like homeobox 2b	0.010
UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	0.010
CHRNB3	cholinergic receptor, nicotinic, beta 3	0.010
SMR3A	submaxillary gland androgen regulated protein 3A	0.010
FAM163A	family with sequence similarity 163, member A	0.010
TSHR	thyroid stimulating hormone receptor	0.010
CTNNA2	catenin (cadherin-associated protein), alpha 2	0.010
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.010
ADRBK1	adrenergic, beta, receptor kinase 1	0.010
KIF26A	kinesin family member 26A	0.010
KL	klotho	0.010
CRISP3	cysteine-rich secretory protein 3	0.010
CRHR2	corticotropin releasing hormone receptor 2	0.010
FAM5B	family with sequence similarity 5, member B	0.010
CXCR1	chemokine (C-X-C motif) receptor 1	0.010