IMP
Process View
The network for 'desensitization of g protein coupled receptor protein signaling pathway by arrestin' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
desensitization of g protein coupled receptor protein signaling pathway by arrestin
The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| ARRB1 | arrestin, beta 1 | 1.000 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.999 | |
| MPDZ | multiple PDZ domain protein | 0.998 | |
| MAPK10 | mitogen-activated protein kinase 10 | 0.989 | |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.819 | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.787 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.778 | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.772 | |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.725 | |
| RAB5C | RAB5C, member RAS oncogene family | 0.703 | |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.701 | |
| ACTG1 | actin, gamma 1 | 0.444 | |
| CFL1 | cofilin 1 (non-muscle) | 0.383 | |
| HIST2H2AB | histone cluster 2, H2ab | 0.373 | |
| GNMT | glycine N-methyltransferase | 0.355 | |
| ARRDC3 | arrestin domain containing 3 | 0.354 | |
| DGKZ | diacylglycerol kinase, zeta | 0.208 | |
| EZR | ezrin | 0.131 | |
| GNAS | GNAS complex locus | 0.129 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.114 | |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1 | 0.112 | |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.107 | |
| ARRB2 | arrestin, beta 2 | 0.103 | |
| PTAFR | platelet-activating factor receptor | 0.090 | |
| ADRB2 | adrenergic, beta-2-, receptor, surface | 0.085 | |
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.083 | |
| MAPK9 | mitogen-activated protein kinase 9 | 0.081 | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.079 | |
| AGTR1 | angiotensin II receptor, type 1 | 0.070 | |
| TBC1D10A | TBC1 domain family, member 10A | 0.068 | |
| SSTR3 | somatostatin receptor 3 | 0.068 | |
| OR2AG1 | olfactory receptor, family 2, subfamily AG, member 1 | 0.067 | |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.060 | |
| AP2A1 | adaptor-related protein complex 2, alpha 1 subunit | 0.054 | |
| HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | 0.053 | |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.045 | |
| SDC3 | syndecan 3 | 0.043 | |
| H1FX | H1 histone family, member X | 0.043 | |
| GABRA1 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 0.042 | |
| CORO1A | coronin, actin binding protein, 1A | 0.041 | |
| GPR6 | G protein-coupled receptor 6 | 0.040 | |
| FASN | fatty acid synthase | 0.034 | |
| PTPRA | protein tyrosine phosphatase, receptor type, A | 0.031 | |
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A | 0.031 | |
| LNX1 | ligand of numb-protein X 1 | 0.030 | |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.030 | |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A | 0.030 | |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.030 | |
| LIMK1 | LIM domain kinase 1 | 0.030 | |
| ENG | endoglin | 0.028 | |
| GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 0.027 | |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.027 | |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4 | 0.027 | |
| PDX1 | pancreatic and duodenal homeobox 1 | 0.026 | |
| NEK6 | NIMA (never in mitosis gene a)-related kinase 6 | 0.026 | |
| RIMS4 | regulating synaptic membrane exocytosis 4 | 0.026 | |
| SNCG | synuclein, gamma (breast cancer-specific protein 1) | 0.026 | |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.025 | |
| GHRHR | growth hormone releasing hormone receptor | 0.025 | |
| MED8 | mediator complex subunit 8 | 0.024 | |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.024 | |
| RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1 | 0.024 | |
| AFF2 | AF4/FMR2 family, member 2 | 0.023 | |
| MAPK3 | mitogen-activated protein kinase 3 | 0.022 | |
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 | 0.022 | |
| CYP4A11 | cytochrome P450, family 4, subfamily A, polypeptide 11 | 0.021 | |
| YY1 | YY1 transcription factor | 0.021 | |
| KRT33B | keratin 33B | 0.021 | |
| HTR1D | 5-hydroxytryptamine (serotonin) receptor 1D | 0.020 | |
| CCR3 | chemokine (C-C motif) receptor 3 | 0.020 | |
| GRM5 | glutamate receptor, metabotropic 5 | 0.020 | |
| SLC14A2 | solute carrier family 14 (urea transporter), member 2 | 0.020 | |
| DNM1 | dynamin 1 | 0.020 | |
| CCK | cholecystokinin | 0.019 | |
| CEACAM4 | carcinoembryonic antigen-related cell adhesion molecule 4 | 0.019 | |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.019 | |
| ADAM15 | ADAM metallopeptidase domain 15 | 0.019 | |
| SPRR2A | small proline-rich protein 2A | 0.019 | |
| GABRG2 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 0.019 | |
| HTR1E | 5-hydroxytryptamine (serotonin) receptor 1E | 0.019 | |
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 | 0.018 | |
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.018 | |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.018 | |
| CHRNB4 | cholinergic receptor, nicotinic, beta 4 | 0.017 | |
| ZP2 | zona pellucida glycoprotein 2 (sperm receptor) | 0.017 | |
| SMCP | sperm mitochondria-associated cysteine-rich protein | 0.017 | |
| DRD1 | dopamine receptor D1 | 0.017 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.017 | |
| PSG7 | pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) | 0.017 | |
| CDH8 | cadherin 8, type 2 | 0.016 | |
| SLC6A7 | solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 | 0.016 | |
| COPG2 | coatomer protein complex, subunit gamma 2 | 0.016 | |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.016 | |
| HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A | 0.016 | |
| GCM1 | glial cells missing homolog 1 (Drosophila) | 0.016 | |
| DLGAP2 | discs, large (Drosophila) homolog-associated protein 2 | 0.016 | |
| FGF18 | fibroblast growth factor 18 | 0.016 | |
| AQP7 | aquaporin 7 | 0.016 | |
| NXPH3 | neurexophilin 3 | 0.016 | |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | 0.016 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Syngap1 | synaptic Ras GTPase activating protein 1 homolog (rat) | 0.084 | |
| Hoxc4 | homeo box C4 | 0.043 | |
| Hist1h2aa | histone cluster 1, H2aa | 0.038 | |
| Pomc | proopiomelanocortin | 0.027 | |
| Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.027 | |
| Zfp382 | zinc finger protein 382 | 0.024 | |
| Foxc2 | forkhead box C2 | 0.021 | |
| Hoxd3 | homeo box D3 | 0.018 | |
| Aipl1 | aryl hydrocarbon receptor-interacting protein-like 1 | 0.014 | |
| Pip4k2b | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.013 | |
| Ptger4 | prostaglandin E receptor 4 (subtype EP4) | 0.011 | |
| Itgam | integrin, alpha M | 0.010 |