IMP

Process View

Homo sapiens

4 genes annotated in human

response to low density lipoprotein particle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to low density lipoprotein particle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to low density lipoprotein particle" (in gray)

Name	Description	Probability	Func Analog Organism
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.992
HNF4A	hepatocyte nuclear factor 4, alpha	0.976
RXRA	retinoid X receptor, alpha	0.960
PLAU	plasminogen activator, urokinase	0.951
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.905
CTNND1	catenin (cadherin-associated protein), delta 1	0.832
DSG2	desmoglein 2	0.731
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.594
MED15	mediator complex subunit 15	0.423
JUP	junction plakoglobin	0.421
CREBBP	CREB binding protein	0.396
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.318	Human
AR	androgen receptor	0.258
HR	hairless homolog (mouse)	0.175
RUNX1	runt-related transcription factor 1	0.169
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.145	Human
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.142
STX12	syntaxin 12	0.137
PLAT	plasminogen activator, tissue	0.128
NCOR2	nuclear receptor corepressor 2	0.117
SREBF2	sterol regulatory element binding transcription factor 2	0.097
PPARA	peroxisome proliferator-activated receptor alpha	0.093	Human
NCOR1	nuclear receptor corepressor 1	0.092
CHD9	chromodomain helicase DNA binding protein 9	0.089
HIPK2	homeodomain interacting protein kinase 2	0.088
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.083
DSP	desmoplakin	0.075
GLIS2	GLIS family zinc finger 2	0.058
NCOA6	nuclear receptor coactivator 6	0.054
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.053
ESRRG	estrogen-related receptor gamma	0.052
LDLR	low density lipoprotein receptor	0.051
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.046
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.045
BTRC	beta-transducin repeat containing	0.044
PLAUR	plasminogen activator, urokinase receptor	0.043
INSIG1	insulin induced gene 1	0.041
CTNNBIP1	catenin, beta interacting protein 1	0.041
PPARG	peroxisome proliferator-activated receptor gamma	0.040
ORM1	orosomucoid 1	0.040
RARA	retinoic acid receptor, alpha	0.038
NCOA1	nuclear receptor coactivator 1	0.038
SP1	Sp1 transcription factor	0.037
SMAD3	SMAD family member 3	0.035
TRIM11	tripartite motif containing 11	0.033
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.030
PKP3	plakophilin 3	0.030
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.029
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.029
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.029
PROX1	prospero homeobox 1	0.028
FOXO3	forkhead box O3	0.027
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.027	Human
TCF4	transcription factor 4	0.026
EPAS1	endothelial PAS domain protein 1	0.025
PVR	poliovirus receptor	0.025
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.025	Human
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.025
SREBF1	sterol regulatory element binding transcription factor 1	0.024	Human
MEP1B	meprin A, beta	0.024
PGR	progesterone receptor	0.023
EMD	emerin	0.023
APC	adenomatous polyposis coli	0.023
EGF	epidermal growth factor	0.022
VTN	vitronectin	0.022
PLEKHA7	pleckstrin homology domain containing, family A member 7	0.022
FRMD5	FERM domain containing 5	0.022
G6PC	glucose-6-phosphatase, catalytic subunit	0.022
PTAFR	platelet-activating factor receptor	0.021
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.021
VCAN	versican	0.021
TGFA	transforming growth factor, alpha	0.020
NDRG1	N-myc downstream regulated 1	0.020
HDAC3	histone deacetylase 3	0.019
ITGB4	integrin, beta 4	0.019
SPHK1	sphingosine kinase 1	0.019
ACTN1	actinin, alpha 1	0.018
ESR1	estrogen receptor 1	0.017
HTT	huntingtin	0.017
PTK7	PTK7 protein tyrosine kinase 7	0.017
MUC1	mucin 1, cell surface associated	0.017
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.016
DSG3	desmoglein 3	0.016
CDH5	cadherin 5, type 2 (vascular endothelium)	0.016
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.016
DSG1	desmoglein 1	0.016
FOXO1	forkhead box O1	0.016
MVK	mevalonate kinase	0.016
MVD	mevalonate (diphospho) decarboxylase	0.016
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.016
PKP2	plakophilin 2	0.016
CLCA2	chloride channel accessory 2	0.015
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.015
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.015
TAL1	T-cell acute lymphocytic leukemia 1	0.015
THBS1	thrombospondin 1	0.015
HNF1A	HNF1 homeobox A	0.015
ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome	0.014
MED26	mediator complex subunit 26	0.014
GPR87	G protein-coupled receptor 87	0.014
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.014
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.014	Human
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.014
KRT14	keratin 14	0.014
SKIL	SKI-like oncogene	0.014
CDK6	cyclin-dependent kinase 6	0.014
PDK4	pyruvate dehydrogenase kinase, isozyme 4	0.014
DHCR7	7-dehydrocholesterol reductase	0.014
CCND3	cyclin D3	0.014
INHBA	inhibin, beta A	0.013
KNG1	kininogen 1	0.013
EMP1	epithelial membrane protein 1	0.013
DSC3	desmocollin 3	0.013	Human
VAV2	vav 2 guanine nucleotide exchange factor	0.013
SPP1	secreted phosphoprotein 1	0.012
ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12	0.012	Human
HDAC10	histone deacetylase 10	0.012
NFYC	nuclear transcription factor Y, gamma	0.012
MPZL2	myelin protein zero-like 2	0.012
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.012
KLF13	Kruppel-like factor 13	0.012
TGFB1	transforming growth factor, beta 1	0.012
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
SRCAP	Snf2-related CREBBP activator protein	0.012
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.012
NCOA2	nuclear receptor coactivator 2	0.012
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.012	Human
ADH6	alcohol dehydrogenase 6 (class V)	0.012
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.012
SQLE	squalene epoxidase	0.012
HDAC4	histone deacetylase 4	0.011
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.011
CXADR	coxsackie virus and adenovirus receptor	0.011
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.011
PERP	PERP, TP53 apoptosis effector	0.011
MED14	mediator complex subunit 14	0.011
PTK6	PTK6 protein tyrosine kinase 6	0.011
CLDN1	claudin 1	0.011
C18orf8	chromosome 18 open reading frame 8	0.011
HBEGF	heparin-binding EGF-like growth factor	0.011
BNC1	basonuclin 1	0.011
CDK3	cyclin-dependent kinase 3	0.011
MED25	mediator complex subunit 25	0.011
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.011
ACTN4	actinin, alpha 4	0.011
ITGB6	integrin, beta 6	0.011
CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	0.011
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.011
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.011
ANGPTL4	angiopoietin-like 4	0.011
GJB2	gap junction protein, beta 2, 26kDa	0.011
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.011
PSEN1	presenilin 1	0.011
SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.011
SNAI1	snail homolog 1 (Drosophila)	0.010
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.010
FERMT1	fermitin family member 1	0.010
BCL6	B-cell CLL/lymphoma 6	0.010
RAB11B	RAB11B, member RAS oncogene family	0.010
FASN	fatty acid synthase	0.010
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.010
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.010
TM4SF4	transmembrane 4 L six family member 4	0.010
FABP4	fatty acid binding protein 4, adipocyte	0.010
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.010
NKD2	naked cuticle homolog 2 (Drosophila)	0.010
FHL3	four and a half LIM domains 3	0.010
SLC26A3	solute carrier family 26, member 3	0.010
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.010
LEF1	lymphoid enhancer-binding factor 1	0.010