IMP

Process View

Homo sapiens

20 genes annotated in human

positive regulation of biomineral tissue development

Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of biomineral tissue development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of biomineral tissue development" (in gray)

Name	Description	Probability	Func Analog Organism
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.999	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.999
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.997
TGFB1	transforming growth factor, beta 1	0.981
FKBP1A	FK506 binding protein 1A, 12kDa	0.976
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.943
BMPR1B	bone morphogenetic protein receptor, type IB	0.916
ENG	endoglin	0.892
BMP2	bone morphogenetic protein 2	0.890
FSTL1	follistatin-like 1	0.874
SMAD7	SMAD family member 7	0.788
GDF5	growth differentiation factor 5	0.704	Human
SMAD2	SMAD family member 2	0.594
TGFB3	transforming growth factor, beta 3	0.581
ARRDC3	arrestin domain containing 3	0.572
TGFBR1	transforming growth factor, beta receptor 1	0.514	Human
EP300	E1A binding protein p300	0.509
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.463
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.300
NOG	noggin	0.245
FGF21	fibroblast growth factor 21	0.237
ACVR1	activin A receptor, type I	0.235
SH3BP4	SH3-domain binding protein 4	0.231
GFI1B	growth factor independent 1B transcription repressor	0.186
HDAC9	histone deacetylase 9	0.125
PRKG1	protein kinase, cGMP-dependent, type I	0.123
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.123
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.104
BMP4	bone morphogenetic protein 4	0.083
KCTD1	potassium channel tetramerisation domain containing 1	0.080
FGF18	fibroblast growth factor 18	0.065
NRP1	neuropilin 1	0.054
ACVR1B	activin A receptor, type IB	0.049	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.048
TBC1D10A	TBC1 domain family, member 10A	0.045
HDAC4	histone deacetylase 4	0.034
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.033
FGF4	fibroblast growth factor 4	0.033
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.033
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.030
WIF1	WNT inhibitory factor 1	0.028
ACVR2B	activin A receptor, type IIB	0.028
ZFYVE9	zinc finger, FYVE domain containing 9	0.027
WNT1	wingless-type MMTV integration site family, member 1	0.027	Human
TGFBR3	transforming growth factor, beta receptor III	0.024
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.023
PIGP	phosphatidylinositol glycan anchor biosynthesis, class P	0.022
RXRA	retinoid X receptor, alpha	0.021
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.020
COL2A1	collagen, type II, alpha 1	0.019
SFRP1	secreted frizzled-related protein 1	0.019
C8orf40	chromosome 8 open reading frame 40	0.017
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.017
SNX9	sorting nexin 9	0.016
TGFB2	transforming growth factor, beta 2	0.016	Human
IHH	Indian hedgehog	0.016
KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0.016
MEF2A	myocyte enhancer factor 2A	0.015
NELL1	NEL-like 1 (chicken)	0.015
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.015
EFNB3	ephrin-B3	0.015
EIF2D	eukaryotic translation initiation factor 2D	0.014
FOXF2	forkhead box F2	0.014
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.014
INHBB	inhibin, beta B	0.014
BMP7	bone morphogenetic protein 7	0.014
DLX4	distal-less homeobox 4	0.014
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.014
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.013
USP15	ubiquitin specific peptidase 15	0.013
AQP5	aquaporin 5	0.013
ACVR2A	activin A receptor, type IIA	0.013
GDNF	glial cell derived neurotrophic factor	0.013
JAG2	jagged 2	0.013
HOXC8	homeobox C8	0.013
BMP6	bone morphogenetic protein 6	0.012
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.012
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.012
FOXF1	forkhead box F1	0.011
SMAD6	SMAD family member 6	0.011
PITX2	paired-like homeodomain 2	0.011
ACAN	aggrecan	0.011
SOX21	SRY (sex determining region Y)-box 21	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
LBX1	ladybird homeobox 1	0.010