The network for 'positive regulation of biomineral tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of biomineral tissue development

Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.

Homo sapiens
Name Description Probability Func Analog Organism
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.999
BMPR1A bone morphogenetic protein receptor, type IA 0.999
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.997
TGFB1 transforming growth factor, beta 1 0.981
FKBP1A FK506 binding protein 1A, 12kDa 0.976
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.943
BMPR1B bone morphogenetic protein receptor, type IB 0.916
ENG endoglin 0.892
BMP2 bone morphogenetic protein 2 0.890
FSTL1 follistatin-like 1 0.874
SMAD7 SMAD family member 7 0.788
GDF5 growth differentiation factor 5 0.704
SMAD2 SMAD family member 2 0.594
TGFB3 transforming growth factor, beta 3 0.581
ARRDC3 arrestin domain containing 3 0.572
TGFBR1 transforming growth factor, beta receptor 1 0.514
EP300 E1A binding protein p300 0.509
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.463
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.300
NOG noggin 0.245
FGF21 fibroblast growth factor 21 0.237
ACVR1 activin A receptor, type I 0.235
SH3BP4 SH3-domain binding protein 4 0.231
GFI1B growth factor independent 1B transcription repressor 0.186
HDAC9 histone deacetylase 9 0.125
PRKG1 protein kinase, cGMP-dependent, type I 0.123
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.123
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.104
BMP4 bone morphogenetic protein 4 0.083
KCTD1 potassium channel tetramerisation domain containing 1 0.080
FGF18 fibroblast growth factor 18 0.065
NRP1 neuropilin 1 0.054
ACVR1B activin A receptor, type IB 0.049
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.048
TBC1D10A TBC1 domain family, member 10A 0.045
HDAC4 histone deacetylase 4 0.034
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.033
FGF4 fibroblast growth factor 4 0.033
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.033
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.030
WIF1 WNT inhibitory factor 1 0.028
ACVR2B activin A receptor, type IIB 0.028
ZFYVE9 zinc finger, FYVE domain containing 9 0.027
WNT1 wingless-type MMTV integration site family, member 1 0.027
TGFBR3 transforming growth factor, beta receptor III 0.024
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.023
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 0.022
RXRA retinoid X receptor, alpha 0.021
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.020
COL2A1 collagen, type II, alpha 1 0.019
SFRP1 secreted frizzled-related protein 1 0.019
C8orf40 chromosome 8 open reading frame 40 0.017
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.017
SNX9 sorting nexin 9 0.016
TGFB2 transforming growth factor, beta 2 0.016
IHH Indian hedgehog 0.016
KCNC3 potassium voltage-gated channel, Shaw-related subfamily, member 3 0.016
MEF2A myocyte enhancer factor 2A 0.015
NELL1 NEL-like 1 (chicken) 0.015
FGF8 fibroblast growth factor 8 (androgen-induced) 0.015
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.015
EFNB3 ephrin-B3 0.015
EIF2D eukaryotic translation initiation factor 2D 0.014
FOXF2 forkhead box F2 0.014
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.014
INHBB inhibin, beta B 0.014
BMP7 bone morphogenetic protein 7 0.014
DLX4 distal-less homeobox 4 0.014
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.014
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 0.013
USP15 ubiquitin specific peptidase 15 0.013
AQP5 aquaporin 5 0.013
ACVR2A activin A receptor, type IIA 0.013
GDNF glial cell derived neurotrophic factor 0.013
JAG2 jagged 2 0.013
HOXC8 homeobox C8 0.013
BMP6 bone morphogenetic protein 6 0.012
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.012
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.012
FOXF1 forkhead box F1 0.011
SMAD6 SMAD family member 6 0.011
PITX2 paired-like homeodomain 2 0.011
ACAN aggrecan 0.011
SOX21 SRY (sex determining region Y)-box 21 0.010
FZD10 frizzled homolog 10 (Drosophila) 0.010
LBX1 ladybird homeobox 1 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Kl klotho 0.476
Acvr1 activin A receptor, type 1 0.453
Bmp7 bone morphogenetic protein 7 0.415
Tgfbr2 transforming growth factor, beta receptor II 0.339
Fgf8 fibroblast growth factor 8 0.324
Tgfb2 transforming growth factor, beta 2 0.275
Fgfr2 fibroblast growth factor receptor 2 0.263
Prrx2 paired related homeobox 2 0.243
Shh sonic hedgehog 0.202
Smo smoothened homolog (Drosophila) 0.190
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.175
Hdac4 histone deacetylase 4 0.164
Lhx1 LIM homeobox protein 1 0.120
Bmp2 bone morphogenetic protein 2 0.112
Wnt3a wingless-related MMTV integration site 3A 0.110
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.107
Gli3 GLI-Kruppel family member GLI3 0.102
Cd80 CD80 antigen 0.099
Msx1 homeobox, msh-like 1 0.089
Tbx2 T-box 2 0.086
Foxc1 forkhead box C1 0.075
Gata6 GATA binding protein 6 0.069
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.066
Adrb1 adrenergic receptor, beta 1 0.064
Prrx1 paired related homeobox 1 0.063
Tgfbr1 transforming growth factor, beta receptor I 0.062
Tbx1 T-box 1 0.057
T brachyury 0.055
Fgf5 fibroblast growth factor 5 0.053
Alx4 aristaless-like homeobox 4 0.053
Smad6 MAD homolog 6 (Drosophila) 0.051
Pnpla2 patatin-like phospholipase domain containing 2 0.050
Vdr vitamin D receptor 0.049
Maf avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog 0.048
Sox9 SRY-box containing gene 9 0.048
Wnt4 wingless-related MMTV integration site 4 0.045
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.044
Wnt7a wingless-related MMTV integration site 7A 0.040
Pou3f3 POU domain, class 3, transcription factor 3 0.035
Fgfr1 fibroblast growth factor receptor 1 0.035
Pax2 paired box gene 2 0.035
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.034
Runx2 runt related transcription factor 2 0.034
Rarb retinoic acid receptor, beta 0.034
Fzd1 frizzled homolog 1 (Drosophila) 0.033
Foxd2 forkhead box D2 0.033
Pax3 paired box gene 3 0.033
Pdcd1 programmed cell death 1 0.031
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.030
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.030
Wt1 Wilms tumor 1 homolog 0.028
Wnt10b wingless related MMTV integration site 10b 0.027
Nodal nodal 0.027
Lhx6 LIM homeobox protein 6 0.027
Mef2c myocyte enhancer factor 2C 0.026
Csf1 colony stimulating factor 1 (macrophage) 0.026
Rarg retinoic acid receptor, gamma 0.025
Pou3f1 POU domain, class 3, transcription factor 1 0.025
Grm2 glutamate receptor, metabotropic 2 0.023
Gpc3 glypican 3 0.023
Fzd7 frizzled homolog 7 (Drosophila) 0.023
Hand1 heart and neural crest derivatives expressed transcript 1 0.023
Gdnf glial cell line derived neurotrophic factor 0.023
Eln elastin 0.022
Fzd8 frizzled homolog 8 (Drosophila) 0.022
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.021
Fgf3 fibroblast growth factor 3 0.021
Bmpr1a bone morphogenetic protein receptor, type 1A 0.021
Hand2 heart and neural crest derivatives expressed transcript 2 0.021
Pparg peroxisome proliferator activated receptor gamma 0.020
Pax8 paired box gene 8 0.020
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.020
Grid1 glutamate receptor, ionotropic, delta 1 0.020
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.020
Acan aggrecan 0.020
Hoxd11 homeobox D11 0.020
Adrb3 adrenergic receptor, beta 3 0.019
Acvr2a activin receptor IIA 0.019
Cdh6 cadherin 6 0.019
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.019
Fgfr3 fibroblast growth factor receptor 3 0.019
Hoxa11 homeobox A11 0.018
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.018
Twist1 twist homolog 1 (Drosophila) 0.018
C1qtnf1 C1q and tumor necrosis factor related protein 1 0.017
Sstr4 somatostatin receptor 4 0.017
Foxc2 forkhead box C2 0.017
Hoxc5 homeobox C5 0.016
Tgfbr3 transforming growth factor, beta receptor III 0.016
Bmper BMP-binding endothelial regulator 0.016
Pax1 paired box gene 1 0.016
ND6 NADH dehydrogenase subunit 6 0.016
Lmx1a LIM homeobox transcription factor 1 alpha 0.015
Rara retinoic acid receptor, alpha 0.015
Pthlh parathyroid hormone-like peptide 0.015
Wnt5b wingless-related MMTV integration site 5B 0.015
Sh3pxd2a SH3 and PX domains 2A 0.015
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.015
Emid2 EMI domain containing 2 0.014
Pax9 paired box gene 9 0.014
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.365
Znf503 zinc finger protein 503 0.138
Fgfr1 Fibroblast growth factor receptor 1 0.129
Cd44 Cd44 molecule 0.122
Stat6 signal transducer and activator of transcription 6 0.113
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.094
Jak2 Janus kinase 2 0.091
Tgfbr2 transforming growth factor, beta receptor II 0.090
Ntn1 netrin 1 0.074
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.066
Myh9 myosin, heavy chain 9, non-muscle 0.063
Irs1 insulin receptor substrate 1 0.063
Smad7 SMAD family member 7 0.062
Edn1 endothelin 1 0.059
Socs3 suppressor of cytokine signaling 3 0.048
Padi1 peptidyl arginine deiminase, type I 0.047
Rara retinoic acid receptor, alpha 0.046
Cd14 CD14 molecule 0.046
Efnb1 ephrin B1 0.044
Clcn1 chloride channel 1 0.044
Smad4 SMAD family member 4 0.041
Jdp2 Jun dimerization protein 2 0.040
Tgfb2 transforming growth factor, beta 2 0.040
Sod3 superoxide dismutase 3, extracellular 0.039
Mmp23 matrix metallopeptidase 23 0.038
Vcan versican 0.035
Crtap cartilage associated protein 0.035
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.034
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.032
Smad1 SMAD family member 1 0.032
Pdlim5 PDZ and LIM domain 5 0.032
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.031
Cbfb core-binding factor, beta subunit 0.030
Emp1 epithelial membrane protein 1 0.030
Ddr2 discoidin domain receptor tyrosine kinase 2 0.030
Tgfbr1 transforming growth factor, beta receptor 1 0.028
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.028
Gata6 GATA binding protein 6 0.028
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.027
Ptgs1 prostaglandin-endoperoxide synthase 1 0.027
Pqcp polyglutamine-containing protein 0.027
Rcvrn recoverin 0.027
Casp1 caspase 1 0.026
Mpeg1 macrophage expressed 1 0.026
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.026
Fgb fibrinogen beta chain 0.026
Casp3 caspase 3 0.026
Ece1 endothelin converting enzyme 1 0.025
Prkch protein kinase C, eta 0.024
Il1rap interleukin 1 receptor accessory protein 0.024
Lamc1 laminin, gamma 1 0.024
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.024
Klf2 Kruppel-like factor 2 (lung) 0.024
Cish cytokine inducible SH2-containing protein 0.023
Catsper2 cation channel, sperm associated 2 0.023
Rest RE1-silencing transcription factor 0.022
A4galt alpha 1,4-galactosyltransferase 0.022
Wdr26 WD repeat domain 26 0.022
Gpnmb glycoprotein (transmembrane) nmb 0.022
Usp25 ubiquitin specific peptidase 25 0.022
Calcrl calcitonin receptor-like 0.022
Il17re interleukin 17 receptor E 0.022
Pdpn podoplanin 0.022
Ubtf upstream binding transcription factor, RNA polymerase I 0.022
Pias2 protein inhibitor of activated STAT, 2 0.021
Arhgap42 Rho GTPase activating protein 42 0.021
Vipr1 vasoactive intestinal peptide receptor 1 0.021
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.021
Socs2 suppressor of cytokine signaling 2 0.021
S1pr2 sphingosine-1-phosphate receptor 2 0.021
Ugdh UDP-glucose dehydrogenase 0.021
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.021
Pawr PRKC, apoptosis, WT1, regulator 0.020
LOC313672 kazrin 0.020
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.020
Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 0.020
Nradd neurotrophin receptor associated death domain 0.020
Nrg1 neuregulin 1 0.020
Fut9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.019
Gjb3 gap junction protein, beta 3 0.019
Zfp423 zinc finger protein 423 0.019
Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 0.019
Bmp7 bone morphogenetic protein 7 0.019
Clcnkb chloride channel Kb 0.019
Lox lysyl oxidase 0.019
Fusip1 FUS interacting protein (serine-arginine rich) 1 0.019
Psen1 presenilin 1 0.019
Capn5 calpain 5 0.018
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.018
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.018
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.018
Chm choroideremia (Rab escort protein 1) 0.018
Fkbp10 FK506 binding protein 10 0.017
Kremen1 kringle containing transmembrane protein 1 0.017
Fam198b family with sequence similarity 198, member B 0.017
Stat3 signal transducer and activator of transcription 3 0.017
Soat1 sterol O-acyltransferase 1 0.017
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.017
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.017
Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 0.017
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism