IMP
Process View
i kappab phosphorylation
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "i kappab phosphorylation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| NOTCH1 | notch 1 | 1.000 | Fly | |
| JAG1 | jagged 1 | 1.000 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 1.000 | ||
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.999 | Zebrafish | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.999 | ||
| NOTCH3 | notch 3 | 0.994 | Fly | |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.994 | Fly | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.992 | Mouse | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.940 | ||
| LY96 | lymphocyte antigen 96 | 0.758 | ||
| MAML1 | mastermind-like 1 (Drosophila) | 0.673 | ||
| TLR4 | toll-like receptor 4 | 0.524 | ||
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.472 | ||
| CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.460 | ||
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.436 | ||
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.319 | ||
| DLL1 | delta-like 1 (Drosophila) | 0.242 | ||
| SPEN | spen homolog, transcriptional regulator (Drosophila) | 0.221 | ||
| TBK1 | TANK-binding kinase 1 | 0.220 | ||
| TLR2 | toll-like receptor 2 | 0.213 | ||
| XIAP | X-linked inhibitor of apoptosis | 0.193 | ||
| TRAF6 | TNF receptor-associated factor 6 | 0.187 | ||
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.178 | ||
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.178 | ||
| NOTCH2NL | notch 2 N-terminal like | 0.172 | ||
| CHUK | conserved helix-loop-helix ubiquitous kinase | 0.149 | ||
| CLTC | clathrin, heavy chain (Hc) | 0.125 | ||
| BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 0.106 | ||
| FKBP5 | FK506 binding protein 5 | 0.106 | ||
| ATXN1L | ataxin 1-like | 0.102 | ||
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.100 | ||
| JAG2 | jagged 2 | 0.086 | ||
| CARD11 | caspase recruitment domain family, member 11 | 0.071 | ||
| NOTCH2 | notch 2 | 0.068 | Fly | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.064 | ||
| TLR1 | toll-like receptor 1 | 0.064 | Human | |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.057 | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.055 | ||
| TRADD | TNFRSF1A-associated via death domain | 0.053 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.048 | ||
| MAVS | mitochondrial antiviral signaling protein | 0.040 | ||
| CCR1 | chemokine (C-C motif) receptor 1 | 0.036 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.035 | ||
| SYK | spleen tyrosine kinase | 0.030 | ||
| PRKCA | protein kinase C, alpha | 0.029 | ||
| P2RY13 | purinergic receptor P2Y, G-protein coupled, 13 | 0.027 | ||
| STAP2 | signal transducing adaptor family member 2 | 0.025 | ||
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.024 | Mouse | |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.024 | ||
| CIR1 | corepressor interacting with RBPJ, 1 | 0.024 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.023 | ||
| CLEC7A | C-type lectin domain family 7, member A | 0.023 | ||
| CREBBP | CREB binding protein | 0.021 | ||
| VNN2 | vanin 2 | 0.021 | ||
| ARAF | v-raf murine sarcoma 3611 viral oncogene homolog | 0.021 | ||
| IRAK4 | interleukin-1 receptor-associated kinase 4 | 0.020 | ||
| NCOR2 | nuclear receptor corepressor 2 | 0.020 | ||
| SMAD3 | SMAD family member 3 | 0.020 | ||
| ARRB1 | arrestin, beta 1 | 0.019 | ||
| BCL10 | B-cell CLL/lymphoma 10 | 0.019 | ||
| NLRC5 | NLR family, CARD domain containing 5 | 0.017 | ||
| IGSF6 | immunoglobulin superfamily, member 6 | 0.017 | ||
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | 0.016 | ||
| SPOP | speckle-type POZ protein | 0.016 | ||
| TFEC | transcription factor EC | 0.016 | ||
| LY86 | lymphocyte antigen 86 | 0.016 | ||
| TLR7 | toll-like receptor 7 | 0.015 | ||
| DOCK8 | dedicator of cytokinesis 8 | 0.014 | ||
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1 | 0.013 | ||
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 0.013 | ||
| CYLD | cylindromatosis (turban tumor syndrome) | 0.013 | ||
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.012 | ||
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.012 | ||
| SQSTM1 | sequestosome 1 | 0.012 | ||
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.011 | ||
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.011 | ||
| ATXN1 | ataxin 1 | 0.011 | ||
| CDK9 | cyclin-dependent kinase 9 | 0.010 |