IMP

Process View

Homo sapiens

1 genes annotated in human

establishment of monopolar cell polarity

The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of monopolar cell polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of monopolar cell polarity" (in gray)

Name	Description	Probability	Func Analog Organism
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.877	Fly
APC	adenomatous polyposis coli	0.860
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.849
LRRK2	leucine-rich repeat kinase 2	0.847
AXIN1	axin 1	0.529
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.514
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.261	Fly
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.222
CSNK1E	casein kinase 1, epsilon	0.214
ZNF512B	zinc finger protein 512B	0.211
JAM2	junctional adhesion molecule 2	0.177
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.173
SMAD3	SMAD family member 3	0.159
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.149	Fly
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.131
CEP164	centrosomal protein 164kDa	0.120
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.115
VCL	vinculin	0.105
PKP4	plakophilin 4	0.104
TJP2	tight junction protein 2 (zona occludens 2)	0.086
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.079
KIAA1377	KIAA1377	0.072
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.071
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.066
STRN3	striatin, calmodulin binding protein 3	0.060
PSEN1	presenilin 1	0.053
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.050
MCC	mutated in colorectal cancers	0.048
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.048
CSNK1D	casein kinase 1, delta	0.044
WT1	Wilms tumor 1	0.039
CDH5	cadherin 5, type 2 (vascular endothelium)	0.038
ZFYVE9	zinc finger, FYVE domain containing 9	0.037
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.036
PXN	paxillin	0.036
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.036
ENG	endoglin	0.033
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.032
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.031
C9orf100	chromosome 9 open reading frame 100	0.031
GAN	gigaxonin	0.031
CREBBP	CREB binding protein	0.031
HSPG2	heparan sulfate proteoglycan 2	0.030
JAM3	junctional adhesion molecule 3	0.028
CTGF	connective tissue growth factor	0.027
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.025
F11R	F11 receptor	0.025
SFN	stratifin	0.025
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.025
BAHD1	bromo adjacent homology domain containing 1	0.025
GLIS2	GLIS family zinc finger 2	0.023
MEX3C	mex-3 homolog C (C. elegans)	0.022
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.022
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.021
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.021
AHNAK	AHNAK nucleoprotein	0.021
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.020
ARHGAP5	Rho GTPase activating protein 5	0.019
ZMYND8	zinc finger, MYND-type containing 8	0.019
TSC22D1	TSC22 domain family, member 1	0.019
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.018
LRP6	low density lipoprotein receptor-related protein 6	0.018
TIFA	TRAF-interacting protein with forkhead-associated domain	0.018
BTRC	beta-transducin repeat containing	0.018
NKD2	naked cuticle homolog 2 (Drosophila)	0.018
MAP2K6	mitogen-activated protein kinase kinase 6	0.018
MYST2	MYST histone acetyltransferase 2	0.018
MYH10	myosin, heavy chain 10, non-muscle	0.017
TAOK1	TAO kinase 1	0.017
TJP1	tight junction protein 1 (zona occludens 1)	0.017
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.017
FLNA	filamin A, alpha	0.016
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.015
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.015
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.015
TRIP6	thyroid hormone receptor interactor 6	0.015
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.014	Zebrafish
RNF2	ring finger protein 2	0.014
PNMA2	paraneoplastic antigen MA2	0.014
TLN1	talin 1	0.014
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.014
SAC3D1	SAC3 domain containing 1	0.013
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.013
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.013
MARK2	MAP/microtubule affinity-regulating kinase 2	0.013
UBE3A	ubiquitin protein ligase E3A	0.013
C16orf48	chromosome 16 open reading frame 48	0.013
PCGF2	polycomb group ring finger 2	0.013
MYO6	myosin VI	0.013
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.013
RANBP2	RAN binding protein 2	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.012
PITX1	paired-like homeodomain 1	0.012
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.012
RAB5B	RAB5B, member RAS oncogene family	0.012
PNMA1	paraneoplastic antigen MA1	0.012
DBN1	drebrin 1	0.012
FERMT2	fermitin family member 2	0.012
FHOD3	formin homology 2 domain containing 3	0.012
TGFBR1	transforming growth factor, beta receptor 1	0.011
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.011
DST	dystonin	0.011
COL1A1	collagen, type I, alpha 1	0.011
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.011
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.011
SDC2	syndecan 2	0.011
CCDC92	coiled-coil domain containing 92	0.011
DPPA2	developmental pluripotency associated 2	0.011
YAP1	Yes-associated protein 1	0.011
DAAM1	dishevelled associated activator of morphogenesis 1	0.011
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.010
PDLIM5	PDZ and LIM domain 5	0.010
ZBTB8A	zinc finger and BTB domain containing 8A	0.010
FBXO30	F-box protein 30	0.010
FOXF2	forkhead box F2	0.010
EPAS1	endothelial PAS domain protein 1	0.010
FAM110C	family with sequence similarity 110, member C	0.010
OCLN	occludin	0.010
USP5	ubiquitin specific peptidase 5 (isopeptidase T)	0.010
FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.010
BBX	bobby sox homolog (Drosophila)	0.010
ZFP106	zinc finger protein 106 homolog (mouse)	0.010
MSN	moesin	0.010
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.010