IMP

Process View

Mus musculus

6 genes annotated in mouse

secondary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "secondary heart field specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "secondary heart field specification" (in gray)

Name	Description	Probability	Func Analog Organism
Pitx2	paired-like homeodomain transcription factor 2	0.999
Shh	sonic hedgehog	0.999
Foxc1	forkhead box C1	0.997
Fgfr2	fibroblast growth factor receptor 2	0.995
Pax3	paired box gene 3	0.991
Ctnnb1	catenin (cadherin associated protein), beta 1	0.985
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.978
Fgf8	fibroblast growth factor 8	0.976
Tgfb2	transforming growth factor, beta 2	0.972
Tbx1	T-box 1	0.970
Gata4	GATA binding protein 4	0.961
Hand2	heart and neural crest derivatives expressed transcript 2	0.939
Nodal	nodal	0.927
Bmp4	bone morphogenetic protein 4	0.924	Human
Vegfa	vascular endothelial growth factor A	0.923
Notch1	Notch gene homolog 1 (Drosophila)	0.896
Rarg	retinoic acid receptor, gamma	0.894
Isl1	ISL1 transcription factor, LIM/homeodomain	0.818	Human
Foxc2	forkhead box C2	0.812
Pax6	paired box gene 6	0.794
Sox9	SRY-box containing gene 9	0.763
Fgfr1	fibroblast growth factor receptor 1	0.753
Acvr1	activin A receptor, type 1	0.723
Ednra	endothelin receptor type A	0.705
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.682
Rxra	retinoid X receptor alpha	0.680
Rarb	retinoic acid receptor, beta	0.625
Tcfap2a	transcription factor AP-2, alpha	0.623
Chrd	chordin	0.564
Smo	smoothened homolog (Drosophila)	0.495
Jag1	jagged 1	0.477
Otx2	orthodenticle homolog 2 (Drosophila)	0.451
Notch2	Notch gene homolog 2 (Drosophila)	0.446
Meox2	mesenchyme homeobox 2	0.427
Psen1	presenilin 1	0.418
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.390
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.380
Rara	retinoic acid receptor, alpha	0.355
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.344
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.338
Gsk3b	glycogen synthase kinase 3 beta	0.314
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.307
Ece1	endothelin converting enzyme 1	0.301
Chd7	chromodomain helicase DNA binding protein 7	0.275
Gsc	goosecoid homeobox	0.259
Gli3	GLI-Kruppel family member GLI3	0.251
Sox4	SRY-box containing gene 4	0.235
Sall4	sal-like 4 (Drosophila)	0.216
Smad3	MAD homolog 3 (Drosophila)	0.213
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.211
Eya1	eyes absent 1 homolog (Drosophila)	0.210
Tgfbr2	transforming growth factor, beta receptor II	0.192
Hand1	heart and neural crest derivatives expressed transcript 1	0.186
Mesp1	mesoderm posterior 1	0.186
Hdac4	histone deacetylase 4	0.180
Mef2c	myocyte enhancer factor 2C	0.177
Hoxa3	homeobox A3	0.161
Ntf3	neurotrophin 3	0.145
Hdac5	histone deacetylase 5	0.143
Gbx2	gastrulation brain homeobox 2	0.136
Apc	adenomatosis polyposis coli	0.133
Gata6	GATA binding protein 6	0.130
Smad7	MAD homolog 7 (Drosophila)	0.114
Trp53	transformation related protein 53	0.113
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.107
Rnf111	ring finger 111	0.104
Dnahc11	dynein, axonemal, heavy chain 11	0.099
Zfpm2	zinc finger protein, multitype 2	0.090
Msx1	homeobox, msh-like 1	0.088
Smad6	MAD homolog 6 (Drosophila)	0.083
Cfc1	cripto, FRL-1, cryptic family 1	0.067
Bmp7	bone morphogenetic protein 7	0.065
Pkd1	polycystic kidney disease 1 homolog	0.065
Arid1a	AT rich interactive domain 1A (SWI-like)	0.063
Hoxa1	homeobox A1	0.059
Zic3	zinc finger protein of the cerebellum 3	0.056
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.052
Lrp6	low density lipoprotein receptor-related protein 6	0.052
Efnb2	ephrin B2	0.044
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.043
Foxa2	forkhead box A2	0.043
Vangl2	vang-like 2 (van gogh, Drosophila)	0.042
Lef1	lymphoid enhancer binding factor 1	0.042
Hes1	hairy and enhancer of split 1 (Drosophila)	0.041
Tbx3	T-box 3	0.040
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.036
Tcfcp2l1	transcription factor CP2-like 1	0.031
Pou5f1	POU domain, class 5, transcription factor 1	0.031
Dnahc5	dynein, axonemal, heavy chain 5	0.031
Hdac7	histone deacetylase 7	0.028
Msx2	homeobox, msh-like 2	0.028
Adam17	a disintegrin and metallopeptidase domain 17	0.028
Wnt3a	wingless-related MMTV integration site 3A	0.027
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.026
Fgf10	fibroblast growth factor 10	0.026
Gli2	GLI-Kruppel family member GLI2	0.026
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.026
Lefty1	left right determination factor 1	0.024
Lrp5	low density lipoprotein receptor-related protein 5	0.024
Smad2	MAD homolog 2 (Drosophila)	0.023
Dlx5	distal-less homeobox 5	0.023
Dll1	delta-like 1 (Drosophila)	0.023
Smad4	MAD homolog 4 (Drosophila)	0.021
Prrx1	paired related homeobox 1	0.021
Foxg1	forkhead box G1	0.020
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.019
Foxh1	forkhead box H1	0.017
Egfr	epidermal growth factor receptor	0.017
Zeb1	zinc finger E-box binding homeobox 1	0.017
Pitx1	paired-like homeodomain transcription factor 1	0.017
Nog	noggin	0.016
Pcdh12	protocadherin 12	0.016
Fuz	fuzzy homolog (Drosophila)	0.015
Thra	thyroid hormone receptor alpha	0.015
Lhx1	LIM homeobox protein 1	0.014
Znrf4	zinc and ring finger 4	0.014
Lhx3	LIM homeobox protein 3	0.014
Gata5	GATA binding protein 5	0.013
Nf1	neurofibromatosis 1	0.013
Tcf4	transcription factor 4	0.013
Npr2	natriuretic peptide receptor 2	0.013
Zeb2	zinc finger E-box binding homeobox 2	0.013
Hipk3	homeodomain interacting protein kinase 3	0.013
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.013
Plxnd1	plexin D1	0.013
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.012
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.012
Arid1b	AT rich interactive domain 1B (SWI-like)	0.012
Megf8	multiple EGF-like-domains 8	0.011
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.011
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.011
Cdx2	caudal type homeobox 2	0.011
Tcf21	transcription factor 21	0.010
Lrrk2	leucine-rich repeat kinase 2	0.010
Bmper	BMP-binding endothelial regulator	0.010
Utf1	undifferentiated embryonic cell transcription factor 1	0.010
Lmx1b	LIM homeobox transcription factor 1 beta	0.010