IMP

Process View

Mus musculus

2 genes annotated in mouse

rhombomere 2 development

The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rhombomere 2 development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "rhombomere 2 development" (in gray)

Name	Description	Probability	Func Analog Organism
Hoxa1	homeobox A1	1.000	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	1.000
Hoxa2	homeobox A2	1.000
Tbx1	T-box 1	1.000
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	1.000
Pax2	paired box gene 2	0.999
Foxc2	forkhead box C2	0.996
Otx2	orthodenticle homolog 2 (Drosophila)	0.995
Pax3	paired box gene 3	0.995
Tcfap2a	transcription factor AP-2, alpha	0.994
Fgf8	fibroblast growth factor 8	0.994
Shh	sonic hedgehog	0.994
Gbx2	gastrulation brain homeobox 2	0.989
Foxc1	forkhead box C1	0.982
Hoxa3	homeobox A3	0.982
Foxg1	forkhead box G1	0.980
Dlx5	distal-less homeobox 5	0.975
Prrx1	paired related homeobox 1	0.965
Gli3	GLI-Kruppel family member GLI3	0.953
Msx1	homeobox, msh-like 1	0.953
Ednra	endothelin receptor type A	0.946
Hand2	heart and neural crest derivatives expressed transcript 2	0.913
Bmp4	bone morphogenetic protein 4	0.881
Isl1	ISL1 transcription factor, LIM/homeodomain	0.875
Pitx2	paired-like homeodomain transcription factor 2	0.866
Smo	smoothened homolog (Drosophila)	0.847
Fgfr2	fibroblast growth factor receptor 2	0.844
Lmx1a	LIM homeobox transcription factor 1 alpha	0.811
Hoxd3	homeobox D3	0.807
Jag1	jagged 1	0.787
Chd7	chromodomain helicase DNA binding protein 7	0.775
Hoxb1	homeobox B1	0.758	Mouse
Fgf10	fibroblast growth factor 10	0.743
Hoxb2	homeobox B2	0.737	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.719
Gsc	goosecoid homeobox	0.667
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.624
Hmx3	H6 homeobox 3	0.618
Chrd	chordin	0.590
Rarb	retinoic acid receptor, beta	0.577
Sox9	SRY-box containing gene 9	0.563
Hand1	heart and neural crest derivatives expressed transcript 1	0.542
Hoxb3	homeobox B3	0.474
Wnt1	wingless-related MMTV integration site 1	0.472
Rarg	retinoic acid receptor, gamma	0.454
En1	engrailed 1	0.435
Fgf3	fibroblast growth factor 3	0.422
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.418
Fgfr1	fibroblast growth factor receptor 1	0.416
Zeb1	zinc finger E-box binding homeobox 1	0.373
Sox2	SRY-box containing gene 2	0.347
Msx2	homeobox, msh-like 2	0.339
Tgfb2	transforming growth factor, beta 2	0.328
Gata3	GATA binding protein 3	0.320
Vangl2	vang-like 2 (van gogh, Drosophila)	0.292
Prrx2	paired related homeobox 2	0.290
Pax9	paired box gene 9	0.224
Pax6	paired box gene 6	0.220
Rara	retinoic acid receptor, alpha	0.208
Phox2b	paired-like homeobox 2b	0.198
Dlx2	distal-less homeobox 2	0.197
Tbx10	T-box 10	0.195
Gli2	GLI-Kruppel family member GLI2	0.190
Ntf3	neurotrophin 3	0.165
Efnb2	ephrin B2	0.149
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.148
Nog	noggin	0.138
Bmp7	bone morphogenetic protein 7	0.101
Zic3	zinc finger protein of the cerebellum 3	0.093
T	brachyury	0.092
Hoxc4	homeobox C4	0.091
Sox11	SRY-box containing gene 11	0.090
Vegfa	vascular endothelial growth factor A	0.087
Hoxc8	homeobox C8	0.086
Pbx1	pre B-cell leukemia transcription factor 1	0.086
En2	engrailed 2	0.083
Hoxb5	homeobox B5	0.083
Emx2	empty spiracles homolog 2 (Drosophila)	0.081
Hoxa5	homeobox A5	0.074
Hmx2	H6 homeobox 2	0.074
Hoxd11	homeobox D11	0.066
Hoxb6	homeobox B6	0.066
Bdnf	brain derived neurotrophic factor	0.066
Pax8	paired box gene 8	0.065
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.062
Zic2	zinc finger protein of the cerebellum 2	0.062
Ece1	endothelin converting enzyme 1	0.061
Tgfbr2	transforming growth factor, beta receptor II	0.060
Lmx1b	LIM homeobox transcription factor 1 beta	0.060
Lhx1	LIM homeobox protein 1	0.059
Hoxd1	homeobox D1	0.059	Mouse
Dlx6	distal-less homeobox 6	0.058
Sall4	sal-like 4 (Drosophila)	0.056
Hoxa4	homeobox A4	0.053
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.052
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.051
Foxi1	forkhead box I1	0.050
Mesp1	mesoderm posterior 1	0.050
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.049
Mecom	MDS1 and EVI1 complex locus	0.048
Pitx1	paired-like homeodomain transcription factor 1	0.046
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.045
Gdnf	glial cell line derived neurotrophic factor	0.042
Pou4f3	POU domain, class 4, transcription factor 3	0.042
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.042
Twist2	twist homolog 2 (Drosophila)	0.042
Neurog1	neurogenin 1	0.041
Bnc1	basonuclin 1	0.038
Dlx1	distal-less homeobox 1	0.037
Hoxa10	homeobox A10	0.036
Hoxb4	homeobox B4	0.036
Neurog2	neurogenin 2	0.034
Wnt3a	wingless-related MMTV integration site 3A	0.033
Fgf15	fibroblast growth factor 15	0.032
Acvr1	activin A receptor, type 1	0.031
Nkx3-2	NK3 homeobox 2	0.030
Hoxa9	homeobox A9	0.029
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.029
Hoxb8	homeobox B8	0.029
Hoxd9	homeobox D9	0.028
Hoxd13	homeobox D13	0.025
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.025
Wt1	Wilms tumor 1 homolog	0.024
Sall3	sal-like 3 (Drosophila)	0.023
Myf5	myogenic factor 5	0.023
Hmga2	high mobility group AT-hook 2	0.023
Lhx5	LIM homeobox protein 5	0.023
Uncx	UNC homeobox	0.022
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.022
Hoxa11	homeobox A11	0.021
Hoxc6	homeobox C6	0.021
Fbln1	fibulin 1	0.020
Hmx1	H6 homeobox 1	0.020
Shox2	short stature homeobox 2	0.019
Pou4f2	POU domain, class 4, transcription factor 2	0.019
Alx4	aristaless-like homeobox 4	0.017
Hoxb9	homeobox B9	0.016
Pax1	paired box gene 1	0.016
Ebf3	early B-cell factor 3	0.016
Foxd1	forkhead box D1	0.016
Hes5	hairy and enhancer of split 5 (Drosophila)	0.016
Lef1	lymphoid enhancer binding factor 1	0.015
Hoxc5	homeobox C5	0.015
Bmp2	bone morphogenetic protein 2	0.015
Hoxd4	homeobox D4	0.014
Pax7	paired box gene 7	0.014
Foxi3	forkhead box I3	0.014
Mab21l2	mab-21-like 2 (C. elegans)	0.014
Neurod1	neurogenic differentiation 1	0.014
Matn3	matrilin 3	0.013
Nrg1	neuregulin 1	0.013
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.013
Lrp2	low density lipoprotein receptor-related protein 2	0.013
Gata4	GATA binding protein 4	0.013
Nhlh1	nescient helix loop helix 1	0.013
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.012
Efna2	ephrin A2	0.012
Fev	FEV (ETS oncogene family)	0.012
Hoxa7	homeobox A7	0.012
Fgfr3	fibroblast growth factor receptor 3	0.012
Hes1	hairy and enhancer of split 1 (Drosophila)	0.012
Hoxd8	homeobox D8	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Alx1	ALX homeobox 1	0.012
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.012
Hesx1	homeobox gene expressed in ES cells	0.011
Ptf1a	pancreas specific transcription factor, 1a	0.011
Gpr50	G-protein-coupled receptor 50	0.011
Emid2	EMI domain containing 2	0.011
Cntnap2	contactin associated protein-like 2	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Foxa2	forkhead box A2	0.010
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.010
Tshz1	teashirt zinc finger family member 1	0.010
Egr2	early growth response 2	0.010
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010