IMP

Process View

Mus musculus

15 genes annotated in mouse

positive regulation of membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of membrane potential"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of membrane potential" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	1.000	Rat
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	1.000
Dlg4	discs, large homolog 4 (Drosophila)	0.994	Rat
Nrxn1	neurexin I	0.990
Nrxn3	neurexin III	0.985	Mouse
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.906
Arc	activity regulated cytoskeletal-associated protein	0.699
Dab1	disabled homolog 1 (Drosophila)	0.653
Emx1	empty spiracles homolog 1 (Drosophila)	0.479
Nrxn2	neurexin II	0.440	Mouse
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.402
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.372
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.319
Dlg2	discs, large homolog 2 (Drosophila)	0.290
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.273
Rims1	regulating synaptic membrane exocytosis 1	0.271
Grm1	glutamate receptor, metabotropic 1	0.243
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.206	Rat
Rims2	regulating synaptic membrane exocytosis 2	0.192
Fbxl20	F-box and leucine-rich repeat protein 20	0.173
Cit	citron	0.173
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.170
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.132
Shank2	SH3/ankyrin domain gene 2	0.132	Mouse
Dnm1	dynamin 1	0.121
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.107
Ina	internexin neuronal intermediate filament protein, alpha	0.100
Stxbp1	syntaxin binding protein 1	0.095
Snap25	synaptosomal-associated protein 25	0.095
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.091
Parl	presenilin associated, rhomboid-like	0.077
Prkce	protein kinase C, epsilon	0.075
Stxbp5	syntaxin binding protein 5 (tomosyn)	0.074
Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	0.071
Dsg1a	desmoglein 1 alpha	0.070
Cbln1	cerebellin 1 precursor protein	0.068
Adcy1	adenylate cyclase 1	0.063
Bsn	bassoon	0.059
Accn2	amiloride-sensitive cation channel 2, neuronal	0.058
Gak	cyclin G associated kinase	0.053
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.053
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.053
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.053
Lrp1	low density lipoprotein receptor-related protein 1	0.051
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.051
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.050
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.048
Rab3a	RAB3A, member RAS oncogene family	0.047
Shank3	SH3/ankyrin domain gene 3	0.045
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.043
Src	Rous sarcoma oncogene	0.042
Rora	RAR-related orphan receptor alpha	0.041
Syt2	synaptotagmin II	0.039
Dlg3	discs, large homolog 3 (Drosophila)	0.039
Kalrn	kalirin, RhoGEF kinase	0.039
Drd1a	dopamine receptor D1A	0.039
Mapk3	mitogen-activated protein kinase 3	0.038
Dcx	doublecortin	0.038
Grik4	glutamate receptor, ionotropic, kainate 4	0.038
Dsg4	desmoglein 4	0.038
Myh10	myosin, heavy polypeptide 10, non-muscle	0.037
Fam50a	family with sequence similarity 50, member A	0.036
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.035
Pcdh10	protocadherin 10	0.035
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.034
Max	Max protein	0.032
Mtap2	microtubule-associated protein 2	0.032
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.031
Syt1	synaptotagmin I	0.030
Prkcb	protein kinase C, beta	0.029
Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	0.028
Homer1	homer homolog 1 (Drosophila)	0.028
Pkd1	polycystic kidney disease 1 homolog	0.027
Grid2	glutamate receptor, ionotropic, delta 2	0.027
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.027
Mgat3	mannoside acetylglucosaminyltransferase 3	0.026
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.025
Cys1	cystin 1	0.024
Kcnt1	potassium channel, subfamily T, member 1	0.024
Nsf	N-ethylmaleimide sensitive fusion protein	0.023
Htt	huntingtin	0.023
Shc3	src homology 2 domain-containing transforming protein C3	0.022
Wnk2	WNK lysine deficient protein kinase 2	0.022
Sox18	SRY-box containing gene 18	0.022
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.021
Adam11	a disintegrin and metallopeptidase domain 11	0.021
Lrfn2	leucine rich repeat and fibronectin type III domain containing 2	0.021
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.021
Klc2	kinesin light chain 2	0.020
Dnase1l1	deoxyribonuclease 1-like 1	0.020
Lamb2	laminin, beta 2	0.020
Grm5	glutamate receptor, metabotropic 5	0.020
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.019
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.019
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.019
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.018
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.018
Dnaja3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.018
Rusc1	RUN and SH3 domain containing 1	0.018
Nlgn3	neuroligin 3	0.018
Inadl	InaD-like (Drosophila)	0.017
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.017
Plcb1	phospholipase C, beta 1	0.017
Syt3	synaptotagmin III	0.016
Mdm2	transformed mouse 3T3 cell double minute 2	0.015
Prrt3	proline-rich transmembrane protein 3	0.015
Ap2s1	adaptor-related protein complex 2, sigma 1 subunit	0.015
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.015
Arhgef5	Rho guanine nucleotide exchange factor (GEF) 5	0.015
Dusp4	dual specificity phosphatase 4	0.015
Plcg1	phospholipase C, gamma 1	0.015
Cldn5	claudin 5	0.014
Eng	endoglin	0.014
Ptprb	protein tyrosine phosphatase, receptor type, B	0.014
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.013
Ptprt	protein tyrosine phosphatase, receptor type, T	0.013
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.013
Actn2	actinin alpha 2	0.013
Tbx2	T-box 2	0.013
Tenc1	tensin like C1 domain-containing phosphatase	0.013
Nos1	nitric oxide synthase 1, neuronal	0.013
Stk11	serine/threonine kinase 11	0.013
Sstr4	somatostatin receptor 4	0.013
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.012
Pdx1	pancreatic and duodenal homeobox 1	0.012
Shc2	SHC (Src homology 2 domain containing) transforming protein 2	0.012
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.012
Shisa9	shisa homolog 9 (Xenopus laevis)	0.012
Mdga1	MAM domain containing glycosylphosphatidylinositol anchor 1	0.011
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.011
Bai1	brain-specific angiogenesis inhibitor 1	0.011
Esam	endothelial cell-specific adhesion molecule	0.011
Cdh8	cadherin 8	0.011
Nrg3	neuregulin 3	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.011
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.011
Pdzd4	PDZ domain containing 4	0.011
Syt5	synaptotagmin V	0.011
Mapk4	mitogen-activated protein kinase 4	0.011
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.011
Cxxc4	CXXC finger 4	0.011
Jup	junction plakoglobin	0.011
Sorcs1	VPS10 domain receptor protein SORCS 1	0.011
Adamts18	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18	0.011
Kifc2	kinesin family member C2	0.011
Pnma2	paraneoplastic antigen MA2	0.011
Arx	aristaless related homeobox	0.011
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.010	Rat
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.010
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.010
Gpr173	G-protein coupled receptor 173	0.010
Dpf1	D4, zinc and double PHD fingers family 1	0.010
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.010
Rhpn1	rhophilin, Rho GTPase binding protein 1	0.010