IMP

Process View

Mus musculus

14 genes annotated in mouse

Multi-species View

negative regulation of insulin secretion

GO:0046676

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of insulin secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Nos3	nitric oxide synthase 3, endothelial cell	0.962
Esr1	estrogen receptor 1 (alpha)	0.808
LOC100048884	novel member of the major urinary protein (Mup) gene family	0.785	Mouse
Lep	leptin	0.726
Fst	follistatin	0.687
Amhr2	anti-Mullerian hormone type 2 receptor	0.642	Mouse
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.546
Mup19	major urinary protein 19	0.500	Mouse
Mup10	major urinary protein 10	0.462	Mouse
Fshr	follicle stimulating hormone receptor	0.398
Esr2	estrogen receptor 2 (beta)	0.395
Ghr	growth hormone receptor	0.380
Pim3	proviral integration site 3	0.325
Vegfa	vascular endothelial growth factor A	0.322
Nodal	nodal	0.315
Acvr1	activin A receptor, type 1	0.297	Mouse
Lepr	leptin receptor	0.295
Apc	adenomatosis polyposis coli	0.268
Irs2	insulin receptor substrate 2	0.264
Mup12	major urinary protein 12	0.250	Mouse
Mup1	major urinary protein 1	0.247
Fbn1	fibrillin 1	0.236
Prlr	prolactin receptor	0.234
Ar	androgen receptor	0.231
Pim1	proviral integration site 1	0.229	Mouse
Mup9	major urinary protein 9	0.222	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.221
Pim2	proviral integration site 2	0.217	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.212
Mup7	major urinary protein 7	0.206	Mouse
Mup14	major urinary protein 14	0.186	Mouse
Eng	endoglin	0.185
Mup8	major urinary protein 8	0.183	Mouse
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.183
Kiss1	KiSS-1 metastasis-suppressor	0.161
Ece1	endothelin converting enzyme 1	0.160
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.137
Mup13	major urinary protein 13	0.136
Mup17	major urinary protein 17	0.136
LOC100048885	major urinary protein LOC100048885	0.133	Mouse
Nf1	neurofibromatosis 1	0.121
Mup4	major urinary protein 4	0.119	Mouse
Gata4	GATA binding protein 4	0.114
Sfrp2	secreted frizzled-related protein 2	0.112
Cbl	Casitas B-lineage lymphoma	0.108
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.102
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.100	Mouse
Ldlr	low density lipoprotein receptor	0.099
Insr	insulin receptor	0.098
Cav1	caveolin 1, caveolae protein	0.096
Htt	huntingtin	0.089
Prkg1	protein kinase, cGMP-dependent, type I	0.087
Smad3	MAD homolog 3 (Drosophila)	0.083
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.079
Mup3	major urinary protein 3	0.079	Mouse
Mup11	major urinary protein 11	0.077	Mouse
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.076
Smad4	MAD homolog 4 (Drosophila)	0.074
Mup2	major urinary protein 2	0.071	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.070
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.067
Jag1	jagged 1	0.064
Mup15	major urinary protein 15	0.063	Mouse
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.061
Mup5	major urinary protein 5	0.060	Mouse
Svs5	seminal vesicle secretory protein 5	0.057
Bglap	bone gamma carboxyglutamate protein	0.055
Tgfb2	transforming growth factor, beta 2	0.055
Pnpla2	patatin-like phospholipase domain containing 2	0.054
Lox	lysyl oxidase	0.051
Tgfbr2	transforming growth factor, beta receptor II	0.050	Mouse
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.050
Ush1g	Usher syndrome 1G homolog (human)	0.045
Pten	phosphatase and tensin homolog	0.043
Cd70	CD70 antigen	0.043
Nos1	nitric oxide synthase 1, neuronal	0.043	Rat
Shc1	src homology 2 domain-containing transforming protein C1	0.042
Tgfbr3	transforming growth factor, beta receptor III	0.042
Egfr	epidermal growth factor receptor	0.041
Igf1	insulin-like growth factor 1	0.039
U46068	cDNA sequence U46068	0.039
Tgfb1	transforming growth factor, beta 1	0.039
Inha	inhibin alpha	0.038
Gnrhr	gonadotropin releasing hormone receptor	0.037
Foxc1	forkhead box C1	0.037
Klk1b8	kallikrein 1-related peptidase b8	0.036
Nos2	nitric oxide synthase 2, inducible	0.036
Kl	klotho	0.036
Rab27a	RAB27A, member RAS oncogene family	0.035
Gnrh1	gonadotropin releasing hormone 1	0.033
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.033
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.033
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.031
Agtr2	angiotensin II receptor, type 2	0.031
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.029
Socs1	suppressor of cytokine signaling 1	0.029
Col1a1	collagen, type I, alpha 1	0.029
Ros1	Ros1 proto-oncogene	0.028
Gpc3	glypican 3	0.028
Apoe	apolipoprotein E	0.028
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.026
Pomc	pro-opiomelanocortin-alpha	0.026
Irs3	insulin receptor substrate 3	0.026
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.026
Mta2	metastasis-associated gene family, member 2	0.026
Klk1b4	kallikrein 1-related pepidase b4	0.025
Thra	thyroid hormone receptor alpha	0.024
Vdr	vitamin D receptor	0.024
Pkm2	pyruvate kinase, muscle	0.024
Srf	serum response factor	0.023
Ifnb1	interferon beta 1, fibroblast	0.023
Klk1b26	kallikrein 1-related petidase b26	0.023
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.023
Csf1	colony stimulating factor 1 (macrophage)	0.022
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.022
Fgf8	fibroblast growth factor 8	0.022
Adipoq	adiponectin, C1Q and collagen domain containing	0.021
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.021
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.021
Nsf	N-ethylmaleimide sensitive fusion protein	0.021
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.020
Ctnnd1	catenin (cadherin associated protein), delta 1	0.020
Kiss1r	KISS1 receptor	0.019
Klf3	Kruppel-like factor 3 (basic)	0.019
Agtr1a	angiotensin II receptor, type 1a	0.019
Klk1b1	kallikrein 1-related peptidase b1	0.019
Hif1a	hypoxia inducible factor 1, alpha subunit	0.019
Skil	SKI-like	0.019
Pgr	progesterone receptor	0.019
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.019
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.018
Plcg1	phospholipase C, gamma 1	0.018
Pdx1	pancreatic and duodenal homeobox 1	0.017
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.017
Timp4	tissue inhibitor of metalloproteinase 4	0.017
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.016
Snai3	snail homolog 3 (Drosophila)	0.016
Obp1a	odorant binding protein Ia	0.016	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.016
Pparg	peroxisome proliferator activated receptor gamma	0.016
Btg4	B-cell translocation gene 4	0.016
Zbtb7a	zinc finger and BTB domain containing 7a	0.015
Myh10	myosin, heavy polypeptide 10, non-muscle	0.015
Crh	corticotropin releasing hormone	0.015
Sox9	SRY-box containing gene 9	0.015
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.015
Hipk3	homeodomain interacting protein kinase 3	0.015
Drd1a	dopamine receptor D1A	0.015
Adam17	a disintegrin and metallopeptidase domain 17	0.015
Homer1	homer homolog 1 (Drosophila)	0.014
Nanog	Nanog homeobox	0.014
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.014
Fzd1	frizzled homolog 1 (Drosophila)	0.014
Cdh5	cadherin 5	0.014
Grm1	glutamate receptor, metabotropic 1	0.014
Cfd	complement factor D (adipsin)	0.014
Kit	kit oncogene	0.014
Gja1	gap junction protein, alpha 1	0.013
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.013
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.013
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.013
Rab3a	RAB3A, member RAS oncogene family	0.013
Bmp4	bone morphogenetic protein 4	0.012
En1	engrailed 1	0.012
Gab1	growth factor receptor bound protein 2-associated protein 1	0.012
Shank2	SH3/ankyrin domain gene 2	0.012
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.012
Tnni2	troponin I, skeletal, fast 2	0.012
Gm5506	predicted gene 5506	0.012
Rgs11	regulator of G-protein signaling 11	0.012
Stx4a	syntaxin 4A (placental)	0.012
Hmgb4	high-mobility group box 4	0.011
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.011
Mfn2	mitofusin 2	0.011
Bmp2	bone morphogenetic protein 2	0.011
Oit1	oncoprotein induced transcript 1	0.011	Human
Mup6	major urinary protein 6	0.011	Mouse
Pramel7	preferentially expressed antigen in melanoma like 7	0.011
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.011
Grpr	gastrin releasing peptide receptor	0.011
Prl2b1	prolactin family 2, subfamily b, member 1	0.011
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.011
Ces3a	carboxylesterase 3A	0.011
Tgfbr1	transforming growth factor, beta receptor I	0.011	Mouse
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.011
Scarb1	scavenger receptor class B, member 1	0.010
Klk1b11	kallikrein 1-related peptidase b11	0.010
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.010
Smcp	sperm mitochondria-associated cysteine-rich protein	0.010