IMP

Process View

Mus musculus

2 genes annotated in mouse

positive regulation of activation of membrane attack complex

GO:0001970

Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of activation of membrane attack complex"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of activation of membrane attack complex" (in gray)

Name	Description	Probability	Func Analog Organism
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.826
Lyz2	lysozyme 2	0.791
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.757
C9	complement component 9	0.706	Mouse
Hc	hemolytic complement	0.517	Mouse
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.444
Il10	interleukin 10	0.432
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.428
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.418
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.406
Proc	protein C	0.390
Apcs	serum amyloid P-component	0.375
Apoe	apolipoprotein E	0.372
Ifng	interferon gamma	0.367
Plg	plasminogen	0.331
Fas	Fas (TNF receptor superfamily member 6)	0.300
Tnf	tumor necrosis factor	0.296
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.270
Fgg	fibrinogen gamma chain	0.247
Cd28	CD28 antigen	0.244
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.240
Saa4	serum amyloid A 4	0.234
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.230
Pzp	pregnancy zone protein	0.225	Mouse
C1ra	complement component 1, r subcomponent A	0.222
Gc	group specific component	0.209
Ahsg	alpha-2-HS-glycoprotein	0.205
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.195
Creb3l3	cAMP responsive element binding protein 3-like 3	0.194
Hpx	hemopexin	0.181
Hp	haptoglobin	0.180
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.168
Ikbkg	inhibitor of kappaB kinase gamma	0.166
Rag2	recombination activating gene 2	0.164
Kng1	kininogen 1	0.159
F7	coagulation factor VII	0.153
Mug2	murinoglobulin 2	0.152
Apof	apolipoprotein F	0.151
Lipc	lipase, hepatic	0.150
Ces3a	carboxylesterase 3A	0.142
Foxp3	forkhead box P3	0.142
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.141
C8a	complement component 8, alpha polypeptide	0.137	Mouse
F9	coagulation factor IX	0.125
C3	complement component 3	0.123
Rab27a	RAB27A, member RAS oncogene family	0.121
F12	coagulation factor XII (Hageman factor)	0.117
Hrg	histidine-rich glycoprotein	0.113
Stat3	signal transducer and activator of transcription 3	0.111
Cp	ceruloplasmin	0.109
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.107
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.100
Alb	albumin	0.098
Gfi1	growth factor independent 1	0.094
Il2	interleukin 2	0.093
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.091
F2	coagulation factor II	0.089
Cfb	complement factor B	0.086
F11	coagulation factor XI	0.082
Il27ra	interleukin 27 receptor, alpha	0.082
Rag1	recombination activating gene 1	0.079
Tlr2	toll-like receptor 2	0.075
Fga	fibrinogen alpha chain	0.075
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.074
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.072
C2	complement component 2 (within H-2S)	0.072
Mbl1	mannose-binding lectin (protein A) 1	0.071
Saa2	serum amyloid A 2	0.071
Cd19	CD19 antigen	0.070
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.069
C8b	complement component 8, beta polypeptide	0.069	Mouse
F10	coagulation factor X	0.069
Lyst	lysosomal trafficking regulator	0.066
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.066
Ambp	alpha 1 microglobulin/bikunin	0.065
Dpys	dihydropyrimidinase	0.064
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.063
Cfi	complement component factor i	0.062
Mup3	major urinary protein 3	0.061
Azgp1	alpha-2-glycoprotein 1, zinc	0.058
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.058
Nlrp3	NLR family, pyrin domain containing 3	0.058
Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.057
Aadac	arylacetamide deacetylase (esterase)	0.055
Lcn2	lipocalin 2	0.053
Hao1	hydroxyacid oxidase 1, liver	0.052
Stx11	syntaxin 11	0.052
Fgb	fibrinogen beta chain	0.052
Akr1c6	aldo-keto reductase family 1, member C6	0.052
Lbp	lipopolysaccharide binding protein	0.050
Cfh	complement component factor h	0.049
Gckr	glucokinase regulatory protein	0.048
Rdh7	retinol dehydrogenase 7	0.046
Cps1	carbamoyl-phosphate synthetase 1	0.046
Ces1c	carboxylesterase 1C	0.046
Cpn2	carboxypeptidase N, polypeptide 2	0.045
Hal	histidine ammonia lyase	0.045
Apoa1	apolipoprotein A-I	0.044
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.043
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.043
Klkb1	kallikrein B, plasma 1	0.042
Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2	0.041
Afm	afamin	0.041
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.038
Folr2	folate receptor 2 (fetal)	0.038
Tat	tyrosine aminotransferase	0.037
Apoc4	apolipoprotein C-IV	0.037
Cxcl13	chemokine (C-X-C motif) ligand 13	0.036
Otc	ornithine transcarbamylase	0.035
Clec4f	C-type lectin domain family 4, member f	0.035
C4b	complement component 4B (Childo blood group)	0.034	Mouse
Fcna	ficolin A	0.034
Mbl2	mannose-binding lectin (protein C) 2	0.033
Flt3	FMS-like tyrosine kinase 3	0.033
Apoa5	apolipoprotein A-V	0.032
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.032
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.032
Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5	0.030
Spp1	secreted phosphoprotein 1	0.030
Slc17a3	solute carrier family 17 (sodium phosphate), member 3	0.030
Glyat	glycine-N-acyltransferase	0.030
C1qc	complement component 1, q subcomponent, C chain	0.029
Orm2	orosomucoid 2	0.029
Saa3	serum amyloid A 3	0.029
Inhbc	inhibin beta-C	0.028
Apon	apolipoprotein N	0.028
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.027
C1s	complement component 1, s subcomponent	0.027
Mug1	murinoglobulin 1	0.027	Mouse
Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	0.027
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.026
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.026
Hgd	homogentisate 1, 2-dioxygenase	0.026
Cml2	camello-like 2	0.025
C4bp	complement component 4 binding protein	0.025
Fabp1	fatty acid binding protein 1, liver	0.024
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.024
Itk	IL2-inducible T-cell kinase	0.024
Il6	interleukin 6	0.024
Xdh	xanthine dehydrogenase	0.023
Ftcd	formiminotransferase cyclodeaminase	0.023
Cyp2c44	cytochrome P450, family 2, subfamily c, polypeptide 44	0.023
Sycn	syncollin	0.023
C6	complement component 6	0.023
Mat1a	methionine adenosyltransferase I, alpha	0.023
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.023
Orm1	orosomucoid 1	0.022
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.022
Fasl	Fas ligand (TNF superfamily, member 6)	0.020
F13b	coagulation factor XIII, beta subunit	0.020
Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	0.020
Accn5	amiloride-sensitive cation channel 5, intestinal	0.020
G6pc	glucose-6-phosphatase, catalytic	0.020
Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	0.018
Ang	angiogenin, ribonuclease, RNase A family, 5	0.018
C1qb	complement component 1, q subcomponent, beta polypeptide	0.018
Prss2	protease, serine, 2	0.018
Apom	apolipoprotein M	0.018
Mup5	major urinary protein 5	0.018
Ghrl	ghrelin	0.018
Prodh2	proline dehydrogenase (oxidase) 2	0.017
Tlr4	toll-like receptor 4	0.017
Cd5l	CD5 antigen-like	0.017
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.017
1700015E13Rik	RIKEN cDNA 1700015E13 gene	0.017
Bhmt	betaine-homocysteine methyltransferase	0.017
Acsm1	acyl-CoA synthetase medium-chain family member 1	0.017
Cyp2c37	cytochrome P450, family 2. subfamily c, polypeptide 37	0.017
Cox8c	cytochrome c oxidase, subunit VIIIc	0.017
Pon1	paraoxonase 1	0.016
Cyp2d9	cytochrome P450, family 2, subfamily d, polypeptide 9	0.016
Selp	selectin, platelet	0.016
Lect2	leukocyte cell-derived chemotaxin 2	0.016
Crp	C-reactive protein, pentraxin-related	0.016
Ccl9	chemokine (C-C motif) ligand 9	0.016
Ttc36	tetratricopeptide repeat domain 36	0.016
Pla1a	phospholipase A1 member A	0.016
Sftpb	surfactant associated protein B	0.016
Nnmt	nicotinamide N-methyltransferase	0.015
Uox	urate oxidase	0.015
Trf	transferrin	0.015
H2-Q10	histocompatibility 2, Q region locus 10	0.015
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.015
Tssk1	testis-specific serine kinase 1	0.015
Fgl1	fibrinogen-like protein 1	0.015
Aldh8a1	aldehyde dehydrogenase 8 family, member A1	0.014
Spp2	secreted phosphoprotein 2	0.014
Keg1	kidney expressed gene 1	0.014
Pabpc2	poly(A) binding protein, cytoplasmic 2	0.014
Slco1a1	solute carrier organic anion transporter family, member 1a1	0.014
Aox3	aldehyde oxidase 3	0.014
Oc90	otoconin 90	0.014
Il6st	interleukin 6 signal transducer	0.014
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.014
Proz	protein Z, vitamin K-dependent plasma glycoprotein	0.014
Gsg1	germ cell-specific gene 1	0.013
Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	0.013
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.013
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.013
Sds	serine dehydratase	0.013
Rhox6	reproductive homeobox 6	0.013
Tdo2	tryptophan 2,3-dioxygenase	0.013
Wap	whey acidic protein	0.013
Apoh	apolipoprotein H	0.013
Soat2	sterol O-acyltransferase 2	0.013
Esr2	estrogen receptor 2 (beta)	0.013
Myd88	myeloid differentiation primary response gene 88	0.013
BC051019	cDNA sequence BC051019	0.013
Gnmt	glycine N-methyltransferase	0.013
Slc17a2	solute carrier family 17 (sodium phosphate), member 2	0.012
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.012
Slco1b2	solute carrier organic anion transporter family, member 1b2	0.012
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.012
Fetub	fetuin beta	0.012
Apoc3	apolipoprotein C-III	0.012
Mup19	major urinary protein 19	0.012
Tmprss6	transmembrane serine protease 6	0.012
H2-K1	histocompatibility 2, K1, K region	0.012
Cyp2c54	cytochrome P450, family 2, subfamily c, polypeptide 54	0.012
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.011
Fbp1	fructose bisphosphatase 1	0.011
Tsnaxip1	translin-associated factor X (Tsnax) interacting protein 1	0.011
Bex6	brain expressed gene 6	0.011
Pparg	peroxisome proliferator activated receptor gamma	0.011
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.011
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.011
C1rb	complement component 1, r subcomponent B	0.011
Aspdh	aspartate dehydrogenase domain containing	0.011
Nags	N-acetylglutamate synthase	0.010
Tcra	T-cell receptor alpha chain	0.010
Marco	macrophage receptor with collagenous structure	0.010
Hamp	hepcidin antimicrobial peptide	0.010
Itgb2	integrin beta 2	0.010
Fmo3	flavin containing monooxygenase 3	0.010
Orm3	orosomucoid 3	0.010
Mrc1	mannose receptor, C type 1	0.010
Pah	phenylalanine hydroxylase	0.010