IMP

Process View

Danio rerio

1 genes annotated in zebrafish

cellular response to drug

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to drug"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to drug" (in gray)

Name	Description	Probability	Func Analog Organism
esr1	estrogen receptor 1	0.468
mib	mind bomb	0.430
adipoql	adiponectin, C1Q and collagen domain containing, like	0.251	Mouse
isl1	islet1	0.242
prox1	prospero-related homeobox gene 1	0.137
pdlim7	PDZ and LIM domain 7	0.136
pax6b	paired box gene 6b	0.127	Rat
cdh2	cadherin 2, neuronal	0.127
egr2b	early growth response 2b	0.088
ins	preproinsulin	0.079
fabp11a	fatty acid binding protein 11a	0.075
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.066
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.062
foxe3	forkhead box E3	0.057
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.051
adipor2	adiponectin receptor 2	0.047
piwil2	piwi-like 2 (Drosophila)	0.047
notch1a	notch homolog 1a	0.046
rnasel1	ribonuclease like 1	0.046
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.045
gpia	glucose phosphate isomerase a	0.044
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.043	Mouse
sox9a	SRY-box containing gene 9a	0.041
tm4sf4	transmembrane 4 L six family member 4	0.040
zgc:123180	zgc:123180	0.040
adipor1a	adiponectin receptor 1a	0.039
mstnb	myostatin b	0.037
sod1	superoxide dismutase 1, soluble	0.037
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.036
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.035
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.035
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.032
mif	macrophage migration inhibitory factor	0.032
mef2a	myocyte enhancer factor 2a	0.031
rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.031
tkt	transketolase	0.031
pck1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.031
midn	midnolin	0.030
mych	myelocytomatosis oncogene homolog	0.029
ctsba	cathepsin B, a	0.028
ccng1	cyclin G1	0.028
hnf1ba	HNF1 homeobox Ba	0.027
cp	ceruloplasmin	0.027
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.027
cpa5	carboxypeptidase A5	0.027
spata2	spermatogenesis associated 2	0.026
f2r	coagulation factor II (thrombin) receptor	0.025
im:7164961	im:7164961	0.025
edn1	endothelin 1	0.024
il8	interleukin 8	0.024
vwf	von Willebrand factor	0.024
opn1sw1	opsin 1 (cone pigments), short-wave-sensitive 1	0.024
tmem88a	transmembrane protein 88 a	0.023
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.023
nr0b1	nuclear receptor subfamily 0, group B, member 1	0.022
spns2	spinster homolog 2 (Drosophila)	0.022
pbx4	pre-B-cell leukemia transcription factor 4	0.022
mycl1b	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b	0.022
sat1a	spermidine/spermine N1-acetyltransferase 1a	0.022
tfeb	transcription factor EB	0.021
junb	jun B proto-oncogene	0.021
atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.021
sub1	SUB1 homolog (S. cerevisiae)	0.021
tfa	transferrin-a	0.021
sfrp5	secreted frizzled-related protein 5	0.021
smyd1a	SET and MYND domain containing 1a	0.020
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.020
pdx1	pancreatic and duodenal homeobox 1	0.020
pax2a	paired box gene 2a	0.019
asl	argininosuccinate lyase	0.019
th2	tyrosine hydroxylase 2	0.019
sh3bp4a	SH3-domain binding protein 4a	0.019
wu:fc31g04	wu:fc31g04	0.019
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.019
adrb1	adrenergic receptor, beta 1	0.019
adra2a	adrenergic, alpha-2A-, receptor	0.018
slc12a10.2	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2	0.018
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.018
npc1	Niemann-Pick disease, type C1	0.018
rc3	rabconnectin 3	0.018
znf536	zinc finger protein 536	0.018
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.018
fshb	follicle stimulating hormone, beta polypeptide	0.018
si:dkey-13i19.8	si:dkey-13i19.8	0.017
hcrt	hypocretin (orexin) neuropeptide precursor	0.017
tfap2a	transcription factor AP-2 alpha	0.017
park7	parkinson disease (autosomal recessive, early onset) 7	0.017
tyrp1b	tyrosinase-related protein 1b	0.017
zgc:110010	zgc:110010	0.017
dclk2	doublecortin-like kinase 2	0.017
cbr1l	carbonyl reductase 1-like	0.016
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.016
fgf20b	fibroblast growth factor 20b	0.016
s1pr3	sphingosine-1-phosphate receptor 3	0.016
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.016
ucn3l	urocortin 3, like	0.016
btg1	B-cell translocation gene 1	0.016
zgc:112084	zgc:112084	0.016
zgc:100919	zgc:100919	0.016
nkx2.2a	NK2 transcription factor related 2a	0.016
sf3b1	splicing factor 3b, subunit 1	0.016
hand2	heart and neural crest derivatives expressed transcript 2	0.016
selt1b	selenoprotein T, 1b	0.016
esr2b	estrogen receptor 2b	0.015	Rat
slc3a2	solute carrier family 3, member 2	0.015
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.015
lnx2b	ligand of numb-protein X 2b	0.015
psen1	presenilin 1	0.015
aldh2a	aldehyde dehydrogenase 2 family (mitochondrial)a	0.015
adh8a	alcohol dehydrogenase 8a	0.015
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.015
pbx1a	pre-B-cell leukemia transcription factor 1a	0.015
wt1b	wilms tumor 1b	0.014
ptgesl	prostaglandin E synthase 2-like	0.014
zgc:112056	zgc:112056	0.014
crb2a	crumbs homolog 2a	0.014
atoh7	atonal homolog 7	0.014
chrm2a	cholinergic receptor, muscarinic 2a	0.014
tbx5b	T-box 5b	0.014
sbf1	SET binding factor 1	0.014
valopb	vertebrate ancient long opsin b	0.014
otc	ornithine carbamoyltransferase	0.014
LOC405768	protein kinase Npk	0.014
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.014
mt2	metallothionein 2	0.014
srsf5b	serine/arginine-rich splicing factor 5b	0.014
socs3b	suppressor of cytokine signaling 3b	0.014
tbx1	T-box 1	0.014
elk4	ELK4, ETS-domain protein	0.014
jag1a	jagged 1a	0.014
spon1b	spondin 1b	0.014
si:rp71-39b20.7	si:rp71-39b20.7	0.013
napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.013
foxp2	forkhead box P2	0.013
gata5	GATA-binding protein 5	0.013
sdcbp	syndecan binding protein (syntenin)	0.013
nucb2b	nucleobindin 2b	0.013
mef2cb	myocyte enhancer factor 2cb	0.013	Mouse
zgc:172136	zgc:172136	0.013
pdlim1	PDZ and LIM domain 1 (elfin)	0.013
kiss1rb	KISS1 receptor b	0.013
dpf3	D4, zinc and double PHD fingers, family 3	0.013
hnf1a	HNF1 homeobox a	0.013
jag1b	jagged 1b	0.013
pcsk7	proprotein convertase subtilisin/kexin type 7	0.013
elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	0.013
sec24c	SEC24 family, member C (S. cerevisiae)	0.013
runx2a	runt-related transcription factor 2a	0.013
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.013
prdm4	PR domain containing 4	0.013
thraa	thyroid hormone receptor alpha a	0.013
fgf8a	fibroblast growth factor 8 a	0.012
wu:fv91b12	wu:fv91b12	0.012
limk2	LIM domain kinase 2	0.012
zgc:56530	zgc:56530	0.012
sh2b1	SH2B adaptor protein 1	0.012
hspb12	heat shock protein, alpha-crystallin-related, b12	0.012
ctnna	catenin (cadherin-associated protein), alpha	0.012
si:dkey-228g21.4	si:dkey-228g21.4	0.012
kiss1	KiSS-1 metastasis-suppressor	0.012
pth2	parathyroid hormone 2	0.012
LOC569642	hypothetical protein LOC569642	0.012
rras	related RAS viral (r-ras) oncogene homolog	0.012
irf9	interferon regulatory factor 9	0.012
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.012
col4a3	collagen, type IV, alpha 3	0.012
junbl	jun B proto-oncogene, like	0.012
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.012
tbx5a	T-box 5a	0.012
wu:fb12e11	wu:fb12e11	0.012
ggps1	geranylgeranyl diphosphate synthase 1	0.012
tmem2	transmembrane protein 2	0.012
ifrd2	interferon-related developmental regulator 2	0.012
hpx	hemopexin	0.012
ddt	D-dopachrome tautomerase	0.012
kiss1ra	KISS1 receptor a	0.012
fign	fidgetin	0.012
smyd2a	SET and MYND domain containing 2a	0.012
fgf1	fibroblast growth factor 1	0.012
hs6st1a	heparan sulfate 6-O-sulfotransferase 1a	0.012
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.012
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
igfbp1a	insulin-like growth factor binding protein 1a	0.011
zgc:110343	zgc:110343	0.011
sars	seryl-tRNA synthetase	0.011
per2	period homolog 2 (Drosophila)	0.011
ppp3cb	protein phosphatase 3, catalytic subunit, beta isozyme	0.011
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.011
ifi30	interferon gamma inducible protein 30	0.011
zgc:103499	zgc:103499	0.011
adrb2a	adrenergic receptor, beta 2a	0.011
zgc:110239	zgc:110239	0.011
LOC568691	opsin-3-like	0.011
hat1	histone acetyltransferase 1	0.011
zgc:101724	zgc:101724	0.011
spra	sepiapterin reductase a	0.011
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.011
bdnf	brain-derived neurotrophic factor	0.011
hspa5	heat shock protein 5	0.011
tk2	thymidine kinase 2, mitochondrial	0.011
olig2	oligodendrocyte lineage transcription factor 2	0.011
gc	group-specific component (vitamin D binding protein)	0.011
cygb1	cytoglobin 1	0.011
zgc:77396	zgc:77396	0.011
lmo4a	LIM domain only 4a	0.011
il6st	interleukin 6 signal transducer	0.011
im:7138016	im:7138016	0.011
sart3	squamous cell carcinoma antigen recognised by T cells 3	0.011
fabp11b	fatty acid binding protein 11b	0.011
fam20b	family with sequence similarity 20, member B (H. sapiens)	0.011
ctsl1a	cathepsin L, 1 a	0.011
LOC559201	similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)	0.011
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.011
plxna3	plexin A3	0.011
vtg1	vitellogenin 1	0.011
met	met proto-oncogene (hepatocyte growth factor receptor)	0.011
fabp10a	fatty acid binding protein 10a, liver basic	0.011
bactin1	bactin1	0.010
tgfb3	transforming growth factor, beta 3	0.010
ambra1	autophagy/beclin-1 regulator 1	0.010
rhag	Rhesus blood group-associated glycoprotein	0.010
etv1	ets variant gene 1	0.010
pparg	peroxisome proliferator activated receptor gamma	0.010
abca1a	ATP-binding cassette, sub-family A (ABC1), member 1A	0.010
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.010
hhex	hematopoietically expressed homeobox	0.010
im:7155681	im:7155681	0.010
srd5a2a	steroid-5-alpha-reductase, alpha polypeptide 2a	0.010
tmem177	transmembrane protein 177	0.010
zgc:174888	zgc:174888	0.010
zgc:110348	zgc:110348	0.010
sst1.1	somatostatin 1, tandem duplicate 1	0.010