The network for 'negative regulation of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mitotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

Drosophila melanogaster
Name Description Probability Func Analog Organism
phl pole hole 0.985
Akt1 CG4006 gene product from transcript CG4006-RA 0.981
lok loki 0.981
CSN5 COP9 complex homolog subunit 5 0.964
Pp1-87B Protein phosphatase 1 at 87B 0.963
p53 CG33336 gene product from transcript CG33336-RB 0.959
Ras85D Ras oncogene at 85D 0.923
Bap55 Brahma associated protein 55kD 0.909
gro groucho 0.907
Egfr Epidermal growth factor receptor 0.873
ncd non-claret disjunctional 0.853
Snr1 Snf5-related 1 0.845
E2f2 E2F transcription factor 2 0.825
rl rolled 0.811
mus304 mutagen-sensitive 304 0.807
asp abnormal spindle 0.794
RecQ4 CG7487 gene product from transcript CG7487-RA 0.790
cnn centrosomin 0.780
smt3 CG4494 gene product from transcript CG4494-RA 0.775
Iswi Imitation SWI 0.775
Mad Mothers against dpp 0.769
CycB3 Cyclin B3 0.754
cdc2 CG5363 gene product from transcript CG5363-RA 0.749
Cdc37 CG12019 gene product from transcript CG12019-RA 0.671
alphaTub67C alpha-Tubulin at 67C 0.650
CSN3 COP9 complex homolog subunit 3 0.630
MED6 Mediator complex subunit 6 0.622
skpA CG16983 gene product from transcript CG16983-RD 0.616
mus301 mutagen-sensitive 301 0.549
MED17 Mediator complex subunit 17 0.524
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.515
mus205 mutagen-sensitive 205 0.511
RanGap Ran GTPase activating protein 0.505
Rpd3 CG7471 gene product from transcript CG7471-RA 0.493
CycE Cyclin E 0.491
hay haywire 0.488
ttv tout-velu 0.484
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.478
tefu telomere fusion 0.460
Dref DNA replication-related element factor 0.451
wee CG4488 gene product from transcript CG4488-RA 0.449
rux roughex 0.438
Brca2 Breast cancer 2, early onset homolog 0.432
thr three rows 0.431
pie pineapple eye 0.426
cdm cadmus 0.422
shn schnurri 0.420
CycA Cyclin A 0.411
Nup50 Nucleoporin 50 0.410
Spc105R Spc105-related 0.406
mus312 mutagen-sensitive 312 0.403
puc puckered 0.381
tld tolloid 0.367
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.361
gwl greatwall 0.359
CycB Cyclin B 0.358
scra scraps 0.352
Cp190 Centrosomal protein 190kD 0.349
slmb supernumerary limbs 0.349
CG6686 CG6686 gene product from transcript CG6686-RB 0.349
Top1 Topoisomerase 1 0.344
feo fascetto 0.335
fzy fizzy 0.330
gek genghis khan 0.330
dap dacapo 0.328
plu plutonium 0.323
CSN4 COP9 complex homolog subunit 4 0.313
mus308 mutagen-sensitive 308 0.311
fs(1)h female sterile (1) homeotic 0.310
Rbf Retinoblastoma-family protein 0.310
rho rhomboid 0.308
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.302
imd immune deficiency 0.298
dre4 CG1828 gene product from transcript CG1828-RB 0.293
Sse Separase 0.287
Mnn1 Menin 1 0.282
Krn Keren 0.282
Dsor1 Downstream of raf1 0.281
gbb glass bottom boat 0.280
Mcm7 Minichromosome maintenance 7 0.278
His2Av Histone H2A variant 0.277
CG9772 CG9772 gene product from transcript CG9772-RB 0.276
mask multiple ankyrin repeats single KH domain 0.276
Stat92E Signal-transducer and activator of transcription protein at 92E 0.263
mad2 CG17498 gene product from transcript CG17498-RA 0.257
DNApol-alpha60 DNA polymerase alpha 60kD 0.256
sina seven in absentia 0.255
CycC Cyclin C 0.254
Trf2 TATA box binding protein-related factor 2 0.254
Chc Clathrin heavy chain 0.251
Ada2b CG9638 gene product from transcript CG9638-RA 0.251
Hdac3 Histone deacetylase 3 0.248
spn-D spindle D 0.242
mus309 mutagen-sensitive 309 0.235
okr okra 0.229
BubR1 Bub1-related kinase 0.229
spn-E spindle E 0.228
brm brahma 0.225
mus201 mutagen-sensitive 201 0.219
hyd hyperplastic discs 0.212
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
mex-5 Protein MEX-5 0.221
mat-3 Protein MAT-3 0.150
oma-2 Protein OMA-2 0.112
dsh-2 Protein DSH-2 0.078
hcf-1 Protein HCF-1 0.070
hsp-70 Protein HSP-70 0.069
scc-1 Protein SCC-1 0.069
hsp-16.2 Protein HSP-16.2 0.069
cyk-4 Protein CYK-4 0.062
hsp-16.48 Protein HSP-16.48 0.060
egl-18 Protein EGL-18 0.056
toca-2 Protein TOCA-2 0.053
brc-1 Protein BRC-1 0.053
pgl-2 Protein PGL-2 0.050
lin-9 Protein LIN-9 0.050
hil-3 Protein HIL-3 0.048
asd-1 Protein ASD-1 0.047
gld-1 Protein GLD-1 0.046
arrd-13 Protein ARRD-13 0.046
mom-2 Protein MOM-2 0.046
fox-1 Protein FOX-1 0.046
vps-33.2 Protein VPS-33.2 0.043
hpo-10 Protein HPO-10 0.041
CELE_C38D4.4 Protein C38D4.4 0.039
rpl-4 Protein RPL-4 0.039
daf-1 Protein DAF-1 0.039
C27A12.7 Protein C27A12.7 0.039
his-6 Protein HIS-6 0.038
eya-1 Protein EYA-1 0.038
prg-1 Protein PRG-1 0.038
npp-3 Protein NPP-3 0.038
mek-2 Protein MEK-2 0.038
lag-1 Protein LAG-1 0.037
set-1 Protein SET-1 0.037
cec-9 Protein CEC-9 0.036
ceh-20 Protein CEH-20 0.036
pha-4 Protein PHA-4 0.036
T22D1.5 Protein T22D1.5 0.036
cyb-1 Protein CYB-1 0.036
F35C11.3 Protein F35C11.3 0.035
best-12 Protein BEST-12 0.035
rnr-1 Protein RNR-1 0.034
rps-15 Protein RPS-15 0.034
rla-0 Protein RLA-0 0.034
npp-16 Protein NPP-16 0.033
syp-4 Protein SYP-4 0.033
srgp-1 Protein SRGP-1 0.033
spe-26 Protein SPE-26 0.032
sos-1 Protein SOS-1 0.031
cpg-2 Protein CPG-2 0.031
T04D3.5 Protein T04D3.5 0.031
pri-2 Protein PRI-2 0.030
uaf-1 Protein UAF-1 0.030
T19H12.2 Protein T19H12.2 0.030
CELE_C24H12.5 Protein C24H12.5 0.030
bar-1 Protein BAR-1 0.030
eri-1 Protein ERI-1 0.029
cpb-1 Protein CPB-1 0.029
puf-6 Protein PUF-6 0.029
C14C11.2 Protein C14C11.2 0.029
sma-6 Protein SMA-6 0.029
tpxl-1 Protein TPXL-1 0.029
mel-28 Protein MEL-28 0.029
W05F2.6 Protein W05F2.6 0.029
pie-1 Protein PIE-1 0.029
let-60 Protein LET-60 0.028
T28D9.4 Protein T28D9.4 0.028
gpr-2 Protein GPR-2 0.028
F47D12.7 Protein F47D12.7 0.028
F20A1.9 Protein F20A1.9 0.028
Y55D9A.2 Protein Y55D9A.2 0.028
C02B10.5 Protein C02B10.5 0.028
B0205.9 Protein B0205.9 0.028
CELE_T19H5.4 Protein T19H5.4 0.028
gpr-1 Protein GPR-1 0.027
hcp-1 Protein HCP-1 0.027
him-3 Protein HIM-3 0.027
spdl-1 Protein SPDL-1 0.027
B0393.6 Protein B0393.6 0.027
hpo-9 Protein HPO-9 0.027
sel-12 Protein SEL-12 0.027
smc-3 Protein SMC-3 0.027
lin-45 Protein LIN-45 0.026
him-10 Protein HIM-10 0.026
cpg-1 Protein CPG-1 0.026
knl-1 Protein KNL-1 0.026
sur-2 Protein SUR-2 0.026
CELE_C56A3.8 Protein C56A3.8 0.026
K04B12.2 Protein K04B12.2 0.026
C31H1.1 Protein C31H1.1 0.026
dut-1 Protein DUT-1 0.026
CELE_B0238.9 Protein B0238.9 0.026
cnd-1 Protein CND-1 0.025
sas-4 Protein SAS-4 0.025
npp-19 Protein NPP-19 0.025
CELE_Y57A10A.5 Protein Y57A10A.5 0.025
ran-3 Protein RAN-3 0.025
T02G5.12 Protein T02G5.12 0.025
cul-2 Protein CUL-2 0.025
mes-4 Protein MES-4 0.025
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Danio rerio
Name Description Probability Func Analog Organism
wnt5b wingless-type MMTV integration site family, member 5b 0.768
mapk3 mitogen-activated protein kinase 3 0.729
ccnb1 cyclin B1 0.481
wnt11r wingless-type MMTV integration site family, member 11, related 0.404
ccna2 cyclin A2 0.255
cx30.3 connexin 30.3 0.226
ccnb2 cyclin B2 0.212
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.187
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.178
plk1 polo-like kinase 1 (Drosophila) 0.159
gro1 groucho 1 0.144
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.143
cdt1 chromatin licensing and DNA replication factor 1 0.141
stil TAL1 (SCL) interrupting locus 0.136
sass6 spindle assembly 6 homolog (C. elegans) 0.132
si:ch211-244o22.2 si:ch211-244o22.2 0.132
ptmaa prothymosin, alpha a 0.131
LOC566708 FL cytokine receptor-like 0.131
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.125
zgc:56200 zgc:56200 0.121
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.120
ccne cyclin E 0.110
csnk1da casein kinase 1, delta a 0.108
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.106
si:ch211-69g19.2 si:ch211-69g19.2 0.105
mcl1b myeloid cell leukemia sequence 1b 0.104
orc1 origin recognition complex, subunit 1 0.101
tp53 tumor protein p53 0.100
gmnn geminin, DNA replication inhibitor 0.099
smad9 MAD homolog 9 (Drosophila) 0.092
ahctf1 AT hook containing transcription factor 1 0.092
sox2 SRY-box containing gene 2 0.089
zgc:65861 zgc:65861 0.088
caprin1a cell cycle associated protein 1a 0.086
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.086
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.085
dtl denticleless homolog (Drosophila) 0.081
mmp2 matrix metalloproteinase 2 0.079
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.079
kif23 kinesin family member 23 0.077
map2k4a mitogen-activated protein kinase kinase 4a 0.076
ccnd1 cyclin D1 0.075
bmp2b bone morphogenetic protein 2b 0.073
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.072
rhoab ras homolog gene family, member Ab 0.071
twist1a twist1a 0.071
tgfb3 transforming growth factor, beta 3 0.071
fabp7a fatty acid binding protein 7, brain, a 0.070
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.069
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.067
zgc:153910 zgc:153910 0.065
rpa1 replication protein A1 0.063
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.062
zff9 zinc finger protein 9 0.061
si:ch211-173o4.2 si:ch211-173o4.2 0.059
rest RE1-silencing transcription factor 0.059
h1fx H1 histone family, member X 0.059
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.058
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.058
spock3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.055
orc6 origin recognition complex, subunit 6 0.055
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.054
adipor2 adiponectin receptor 2 0.053
alcamb activated leukocyte cell adhesion molecule b 0.052
cand1 cullin-associated and neddylation-dissociated 1 0.052
dharma dharma 0.051
rrm1 ribonucleotide reductase M1 polypeptide 0.050
snrpc small nuclear ribonucleoprotein polypeptide C 0.049
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.049
pbx4 pre-B-cell leukemia transcription factor 4 0.049
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.048
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.047
tbx5a T-box 5a 0.045
mcl1a myeloid cell leukemia sequence 1a 0.045
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.044
vcana versican a 0.044
bcl2l1 bcl2-like 1 0.043
atoh7 atonal homolog 7 0.043
zgc:174506 zgc:174506 0.042
rpa3 replication protein A3 0.042
wnt4a wingless-type MMTV integration site family, member 4a 0.042
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.042
nusap1 nucleolar and spindle associated protein 1 0.041
map2k6 mitogen-activated protein kinase kinase 6 0.040
acvr1l activin A receptor, type I like 0.039
fgf17 fibroblast growth factor 17 0.039
zgc:101598 zgc:101598 0.039
large like-glycosyltransferase 0.038
rpl7a ribosomal protein L7a 0.038
rbpms2 RNA binding protein with multiple splicing 2 0.038
si:ch211-215h6.2 si:ch211-215h6.2 0.037
smc4 structural maintenance of chromosomes 4 0.037
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.037
spry4 sprouty (Drosophila) homolog 4 0.037
smc1al structural maintenance of chromosomes 1A, like 0.037
lpp LIM domain containing preferred translocation partner in lipoma 0.036
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.036
tgfbr2 transforming growth factor, beta receptor II 0.036
emx2 empty spiracles homeobox 2 0.034
arl4ab ADP-ribosylation factor-like 4ab 0.033
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 1.000
CDK2 cyclin-dependent kinase 2 1.000
TP53 tumor protein p53 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
BRCA1 breast cancer 1, early onset 1.000
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.998
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.990
MCM7 minichromosome maintenance complex component 7 0.977
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.973
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.957
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.955
CUL1 cullin 1 0.937
E2F1 E2F transcription factor 1 0.932
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.921
CDC25A cell division cycle 25 homolog A (S. pombe) 0.921
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.918
PLK1 polo-like kinase 1 0.891
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.868
RAD50 RAD50 homolog (S. cerevisiae) 0.866
FBXW11 F-box and WD repeat domain containing 11 0.846
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.843
MSH6 mutS homolog 6 (E. coli) 0.830
SMAD1 SMAD family member 1 0.802
CCNA2 cyclin A2 0.790
CREBBP CREB binding protein 0.753
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.750
CCNE1 cyclin E1 0.747
CCND1 cyclin D1 0.741
RBBP8 retinoblastoma binding protein 8 0.725
CDK4 cyclin-dependent kinase 4 0.723
RBL1 retinoblastoma-like 1 (p107) 0.722
HSPA1B heat shock 70kDa protein 1B 0.712
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.693
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.689
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.684
CBX5 chromobox homolog 5 0.680
EP300 E1A binding protein p300 0.679
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.679
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.669
BCL2 B-cell CLL/lymphoma 2 0.647
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.619
ANAPC4 anaphase promoting complex subunit 4 0.605
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.602
MAPK14 mitogen-activated protein kinase 14 0.591
TOLLIP toll interacting protein 0.585
TOPBP1 topoisomerase (DNA) II binding protein 1 0.585
NBN nibrin 0.580
CUL2 cullin 2 0.575
MCM2 minichromosome maintenance complex component 2 0.572
MAPK1 mitogen-activated protein kinase 1 0.561
SKP2 S-phase kinase-associated protein 2 (p45) 0.554
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.544
HDAC1 histone deacetylase 1 0.542
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.542
FOS FBJ murine osteosarcoma viral oncogene homolog 0.541
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.541
SMAD7 SMAD family member 7 0.538
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.536
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.525
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.516
IER3 immediate early response 3 0.512
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.504
BTRC beta-transducin repeat containing 0.501
SRPK2 SRSF protein kinase 2 0.501
XIAP X-linked inhibitor of apoptosis 0.499
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.488
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.487
FADD Fas (TNFRSF6)-associated via death domain 0.484
MDC1 mediator of DNA-damage checkpoint 1 0.477
CNOT6 CCR4-NOT transcription complex, subunit 6 0.469
ARID1A AT rich interactive domain 1A (SWI-like) 0.466
AR androgen receptor 0.461
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.459
BAD BCL2-associated agonist of cell death 0.455
UBE3A ubiquitin protein ligase E3A 0.450
CDK8 cyclin-dependent kinase 8 0.447
YAP1 Yes-associated protein 1 0.439
RBL2 retinoblastoma-like 2 (p130) 0.437
CCND3 cyclin D3 0.430
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.422
BLM Bloom syndrome, RecQ helicase-like 0.417
POU5F1 POU class 5 homeobox 1 0.411
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.410
CDK6 cyclin-dependent kinase 6 0.410
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.406
CUX1 cut-like homeobox 1 0.404
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.403
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.391
H2AFX H2A histone family, member X 0.379
PBK PDZ binding kinase 0.377
RAD9A RAD9 homolog A (S. pombe) 0.372
COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 0.372
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.369
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.360
CUL3 cullin 3 0.358
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.357
TFDP1 transcription factor Dp-1 0.355
SMAD3 SMAD family member 3 0.346
IRAK2 interleukin-1 receptor-associated kinase 2 0.341
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.328
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Rb1 retinoblastoma 1 0.998
Smad4 MAD homolog 4 (Drosophila) 0.985
Pten phosphatase and tensin homolog 0.982
Brca1 breast cancer 1 0.964
Apc adenomatosis polyposis coli 0.954
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.907
E2f1 E2F transcription factor 1 0.901
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.889
Mdm4 transformed mouse 3T3 cell double minute 4 0.861
Brca2 breast cancer 2 0.854
Fgfr2 fibroblast growth factor receptor 2 0.819
Nbn nibrin 0.819
Msh2 mutS homolog 2 (E. coli) 0.750
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.745
Ptch1 patched homolog 1 0.741
Cdk1 cyclin-dependent kinase 1 0.725
Nf1 neurofibromatosis 1 0.714
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.689
Bmp4 bone morphogenetic protein 4 0.684
Cdk4 cyclin-dependent kinase 4 0.668
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.659
Gli3 GLI-Kruppel family member GLI3 0.644
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.626
Dtl denticleless homolog (Drosophila) 0.615
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.581
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.556
Ret ret proto-oncogene 0.547
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.514
Prc1 protein regulator of cytokinesis 1 0.514
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.509
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.501
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.497
Atm ataxia telangiectasia mutated homolog (human) 0.495
Fgfr1 fibroblast growth factor receptor 1 0.477
Shh sonic hedgehog 0.476
Cdk2 cyclin-dependent kinase 2 0.443
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.422
Bmpr1a bone morphogenetic protein receptor, type 1A 0.422
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.411
Rpgrip1l Rpgrip1-like 0.350
Skil SKI-like 0.344
Rnf2 ring finger protein 2 0.340
Plk1 polo-like kinase 1 (Drosophila) 0.330
Kif23 kinesin family member 23 0.328
Tgfb2 transforming growth factor, beta 2 0.323
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.322
Foxo3 forkhead box O3 0.310
Braf Braf transforming gene 0.309
Ccna2 cyclin A2 0.309
Foxc1 forkhead box C1 0.290
Sox9 SRY-box containing gene 9 0.287
Top2a topoisomerase (DNA) II alpha 0.277
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.274
Meox2 mesenchyme homeobox 2 0.268
Mybl2 myeloblastosis oncogene-like 2 0.257
Tcf19 transcription factor 19 0.255
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.251
Cenpk centromere protein K 0.250
Sox4 SRY-box containing gene 4 0.249
Ccnf cyclin F 0.249
Rbl1 retinoblastoma-like 1 (p107) 0.248
Notch1 Notch gene homolog 1 (Drosophila) 0.247
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.236
Gtse1 G two S phase expressed protein 1 0.236
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.234
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.234
Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.229
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.228
Rad51ap1 RAD51 associated protein 1 0.227
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.221
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.219
Dna2 DNA replication helicase 2 homolog (yeast) 0.217
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.216
Lig1 ligase I, DNA, ATP-dependent 0.216
Cbl Casitas B-lineage lymphoma 0.213
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.211
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.207
Smad1 MAD homolog 1 (Drosophila) 0.207
Gli2 GLI-Kruppel family member GLI2 0.207
Ube3a ubiquitin protein ligase E3A 0.202
Ctnnb1 catenin (cadherin associated protein), beta 1 0.199
Cenpf centromere protein F 0.197
Timeless timeless homolog (Drosophila) 0.195
Tcf3 transcription factor 3 0.194
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.192
Gja1 gap junction protein, alpha 1 0.192
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.188
Smad3 MAD homolog 3 (Drosophila) 0.182
Raf1 v-raf-leukemia viral oncogene 1 0.181
Trp63 transformation related protein 63 0.179
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.178
Mdm2 transformed mouse 3T3 cell double minute 2 0.176
Bmi1 Bmi1 polycomb ring finger oncogene 0.173
Cd80 CD80 antigen 0.167
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.162
Cdt1 chromatin licensing and DNA replication factor 1 0.160
Rbl2 retinoblastoma-like 2 0.155
Xpa xeroderma pigmentosum, complementation group A 0.154
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.153
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Rattus norvegicus
Name Description Probability Func Analog Organism
Top2a topoisomerase (DNA) II alpha 0.032
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.023
Pkm2 pyruvate kinase, muscle 0.017
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.016
Cdk2 cyclin dependent kinase 2 0.014
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GLC7 Glc7p 0.999
KEL1 Kel1p 0.965
CDC28 Cdc28p 0.949
CDC55 Cdc55p 0.941
RAD53 Rad53p 0.920
BUB3 Bub3p 0.822
PPH22 Pph22p 0.720
PPH21 Pph21p 0.609
HHT1 Hht1p 0.603
CCR4 Ccr4p 0.544
SLK19 Slk19p 0.533
RAD9 Rad9p 0.503
RTS1 Rts1p 0.456
SPT16 Spt16p 0.445
CDC14 Cdc14p 0.441
CDC12 Cdc12p 0.437
REG1 Reg1p 0.411
BFA1 Bfa1p 0.403
CLB3 Clb3p 0.392
GIC1 Gic1p 0.387
CDC25 Cdc25p 0.379
MCM2 Mcm2p 0.365
BUB1 Bub1p 0.342
CDC6 Cdc6p 0.333
CDC20 Cdc20p 0.331
BUD14 Bud14p 0.310
LTE1 Lte1p 0.299
BMH1 Bmh1p 0.293
SET1 Set1p 0.287
MRC1 Mrc1p 0.275
PSR2 Psr2p 0.274
CHL4 Chl4p 0.272
BEM3 Bem3p 0.271
MAD2 Mad2p 0.267
KIN1 Kin1p 0.261
PIK1 Pik1p 0.258
CLB4 Clb4p 0.253
SIC1 Sic1p 0.252
SKP1 Skp1p 0.242
CLB5 Clb5p 0.236
MSA1 Msa1p 0.231
ELM1 Elm1p 0.229
DBF4 Dbf4p 0.227
CTF18 Ctf18p 0.223
TOF1 Tof1p 0.214
ZDS1 Zds1p 0.202
MCM10 Mcm10p 0.201
MCD1 Mcd1p 0.194
SDS22 Sds22p 0.194
HFI1 Hfi1p 0.183
KCS1 Kcs1p 0.180
SLD2 Sld2p 0.175
BCK1 Bck1p 0.163
RPO26 Rpo26p 0.159
IML3 Iml3p 0.156
KIN4 Kin4p 0.152
RAD52 Rad52p 0.152
RAD17 Rad17p 0.151
MPT5 Mpt5p 0.151
BCK2 Bck2p 0.147
CKA1 Cka1p 0.142
YNG1 Yng1p 0.142
PPZ1 Ppz1p 0.135
RCO1 Rco1p 0.134
CLU1 Clu1p 0.131
ZDS2 Zds2p 0.131
SMC4 Smc4p 0.130
UBP8 Ubp8p 0.129
SLX4 Slx4p 0.125
FAR1 Far1p 0.123
PDS5 Pds5p 0.121
SKO1 Sko1p 0.120
CDC34 Cdc34p 0.119
MEC1 Mec1p 0.118
RSC1 Rsc1p 0.117
SPC110 Spc110p 0.114
SNF5 Snf5p 0.114
DPB2 Dpb2p 0.113
STI1 Sti1p 0.112
ASK10 Ask10p 0.112
PSR1 Psr1p 0.111
POL30 Pol30p 0.110
TIP41 Tip41p 0.110
MCM4 Mcm4p 0.109
CLB6 Clb6p 0.108
KIC1 Kic1p 0.107
HTA1 Hta1p 0.106
SPT5 Spt5p 0.106
RRM3 Rrm3p 0.106
SWE1 Swe1p 0.106
HRR25 Hrr25p 0.103
DSN1 Dsn1p 0.102
NUD1 Nud1p 0.102
YPI1 Ypi1p 0.101
CBF2 Cbf2p 0.100
RAD27 Rad27p 0.098
KIN3 Kin3p 0.098
NIS1 Nis1p 0.098
SKM1 Skm1p 0.097
UBC4 Ubc4p 0.096