The network for 'megakaryocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

megakaryocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

Homo sapiens
Name Description Probability Func Analog Organism
HIST1H3D histone cluster 1, H3d 0.998
TAL1 T-cell acute lymphocytic leukemia 1 0.983
HIST1H2BD histone cluster 1, H2bd 0.982
HIST1H2AE histone cluster 1, H2ae 0.968
HIST1H2BG histone cluster 1, H2bg 0.938
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.860
HIST2H2BE histone cluster 2, H2be 0.845
HIST1H2AC histone cluster 1, H2ac 0.833
HIST1H2AM histone cluster 1, H2am 0.829
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.779
HIST1H1C histone cluster 1, H1c 0.774
HIST1H4B histone cluster 1, H4b 0.754
HIST1H2AI histone cluster 1, H2ai 0.742
CXCL2 chemokine (C-X-C motif) ligand 2 0.725
SP1 Sp1 transcription factor 0.685
PBX1 pre-B-cell leukemia homeobox 1 0.640
HIST1H3A histone cluster 1, H3a 0.639
HIST1H2AJ histone cluster 1, H2aj 0.637
HIST1H3B histone cluster 1, H3b 0.626
HIST1H4D histone cluster 1, H4d 0.589
HIST1H2BI histone cluster 1, H2bi 0.547
HIST1H2AB histone cluster 1, H2ab 0.523
HDAC3 histone deacetylase 3 0.518
HIST1H4A histone cluster 1, H4a 0.501
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.498
HIST1H1E histone cluster 1, H1e 0.497
HIST1H2BJ histone cluster 1, H2bj 0.416
HIST1H4E histone cluster 1, H4e 0.415
HIST1H4F histone cluster 1, H4f 0.405
SETD8 SET domain containing (lysine methyltransferase) 8 0.356
HIST1H4H histone cluster 1, H4h 0.354
EP300 E1A binding protein p300 0.338
HIST1H2BC histone cluster 1, H2bc 0.312
GATA2 GATA binding protein 2 0.308
HIST1H2AL histone cluster 1, H2al 0.281
HIST1H2BE histone cluster 1, H2be 0.277
HIST1H4J histone cluster 1, H4j 0.275
HIST1H3G histone cluster 1, H3g 0.269
IL8 interleukin 8 0.263
HIST1H2BF histone cluster 1, H2bf 0.235
HIST1H2BM histone cluster 1, H2bm 0.211
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.205
DPP4 dipeptidyl-peptidase 4 0.202
HIST1H2BB histone cluster 1, H2bb 0.185
CXCL5 chemokine (C-X-C motif) ligand 5 0.174
PSEN2 presenilin 2 (Alzheimer disease 4) 0.166
HIST2H4A histone cluster 2, H4a 0.156
HIST1H2AG histone cluster 1, H2ag 0.149
SP3 Sp3 transcription factor 0.147
CXCL10 chemokine (C-X-C motif) ligand 10 0.131
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.129
CXCL11 chemokine (C-X-C motif) ligand 11 0.123
HIST1H4I histone cluster 1, H4i 0.095
MKL1 megakaryoblastic leukemia (translocation) 1 0.090
KDM1A lysine (K)-specific demethylase 1A 0.087
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.084
MYOD1 myogenic differentiation 1 0.084
HIST1H2AK histone cluster 1, H2ak 0.077
HIST1H2BH histone cluster 1, H2bh 0.075
PTMA prothymosin, alpha 0.072
HIST1H2BO histone cluster 1, H2bo 0.070
RUNX1 runt-related transcription factor 1 0.064
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.064
HIST1H4L histone cluster 1, H4l 0.062
CCL20 chemokine (C-C motif) ligand 20 0.061
HMG20A high mobility group 20A 0.059
TP53BP1 tumor protein p53 binding protein 1 0.057
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.056
HIST1H1D histone cluster 1, H1d 0.056
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.056
HIST1H2BN histone cluster 1, H2bn 0.053
GAB1 GRB2-associated binding protein 1 0.052
HIST1H3H histone cluster 1, H3h 0.051
HIST1H4C histone cluster 1, H4c 0.050
KITLG KIT ligand 0.047
HMGA1 high mobility group AT-hook 1 0.047
HIST2H2AC histone cluster 2, H2ac 0.044
GATA4 GATA binding protein 4 0.044
HIST1H3F histone cluster 1, H3f 0.042
CXCL3 chemokine (C-X-C motif) ligand 3 0.041
MYOCD myocardin 0.040
SOS1 son of sevenless homolog 1 (Drosophila) 0.039
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.039
HIST2H4B histone cluster 2, H4b 0.036
HIST1H3I histone cluster 1, H3i 0.035
DAXX death-domain associated protein 0.035
CCL2 chemokine (C-C motif) ligand 2 0.035
MYOG myogenin (myogenic factor 4) 0.034
PHF10 PHD finger protein 10 0.034
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.033
HIST2H2AA4 histone cluster 2, H2aa4 0.033
HIST2H2AA3 histone cluster 2, H2aa3 0.033
HIST1H3C histone cluster 1, H3c 0.032
HAND2 heart and neural crest derivatives expressed 2 0.031
UBD ubiquitin D 0.031
LMO2 LIM domain only 2 (rhombotin-like 1) 0.030
H3F3A H3 histone, family 3A 0.027
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.027
NCOR2 nuclear receptor corepressor 2 0.026
POU2F1 POU class 2 homeobox 1 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tal1 T-cell acute lymphocytic leukemia 1 0.697
drl draculin 0.314
runx1 runt-related transcription factor 1 0.289
gata1a GATA binding protein 1a 0.243
lmo2 LIM domain only 2 (rhombotin-like 1) 0.149
pdlim7 PDZ and LIM domain 7 0.137
mef2ca myocyte enhancer factor 2ca 0.121
cmyb transcription factor cmyb 0.096
gfi1.1 growth factor independent 1.1 0.096
hand2 heart and neural crest derivatives expressed transcript 2 0.073
LOC566708 FL cytokine receptor-like 0.057
sox7 SRY-box containing gene 7 0.057
kdrl kinase insert domain receptor like 0.056
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.053
hmgb3a high-mobility group box 3a 0.043
per3 period homolog 3 (Drosophila) 0.041
prdm1a PR domain containing 1a, with ZNF domain 0.039
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.037
crip2 cysteine-rich protein 2 0.036
etv2 ets variant gene 2 0.035
gata3 GATA-binding protein 3 0.034
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.029
tyr tyrosinase 0.028
xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.028
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.027
tnni1b troponin I, skeletal, slow b 0.027
flt4 fms-related tyrosine kinase 4 0.026
hmgb1b high-mobility group box 1b 0.025
h3f3a H3 histone, family 3A 0.024
ids iduronate 2-sulfatase 0.023
tmem88a transmembrane protein 88 a 0.023
hhex hematopoietically expressed homeobox 0.023
mef2cb myocyte enhancer factor 2cb 0.022
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.022
h2afvl H2A histone family, member V, like 0.021
rbm24a RNA binding motif protein 24a 0.021
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.020
hbae1 hemoglobin alpha embryonic-1 0.020
ppox protoporphyrinogen oxidase 0.019
gata2a GATA-binding protein 2a 0.019
jag1b jagged 1b 0.019
dusp5 dual specificity phosphatase 5 0.018
lnx2b ligand of numb-protein X 2b 0.018
fli1a friend leukemia integration 1a 0.017
zgc:103697 zgc:103697 0.017
sox3 SRY-box containing gene 3 0.016
si:ch211-57k11.10 si:ch211-57k11.10 0.016
tbx2b T-box 2b 0.015
faf1 Fas associated factor 1 0.015
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.015
zfpm1 zinc finger protein, multitype 1 0.015
tie1 endothelium-specific receptor tyrosine kinase 1 0.015
cpox coproporphyrinogen oxidase 0.015
clcn7 chloride channel 7 0.015
unc45b unc-45 homolog B (C. elegans) 0.014
LOC100151531 zinc finger protein Gfi-1b-like 0.014
foxo3b forkhead box O3b 0.014
epor erythropoietin receptor 0.014
foxj1a forkhead box J1a 0.014
prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 0.014
ndrg4 N-myc downstream regulated gene 4 0.014
ror2 receptor tyrosine kinase-like orphan receptor 2 0.014
cahz carbonic anhydrase 0.014
LOC554173 abnormal spindles 0.013
mecom MDS1 and EVI1 complex locus 0.013
tbx5b T-box 5b 0.013
csf1ra colony stimulating factor 1 receptor, a 0.013
tcf21 transcription factor 21 0.013
sox11a SRY-box containing gene 11a 0.013
stat1b signal transducer and activator of transcription 1b 0.013
pitx2 paired-like homeodomain transcription factor 2 0.013
vamp2 vesicle-associated membrane protein 2 0.013
ets2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.013
eif3hb eukaryotic translation initiation factor 3, subunit H, b 0.012
rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.012
tpm4 tropomyosin 4 0.012
tbx2a T-box gene 2a 0.012
pdcd2 programmed cell death 2 0.012
tfpi2 tissue factor pathway inhibitor 2 0.012
foxp1b forkhead box P1b 0.012
im:7151449 im:7151449 0.012
zbtb4 zinc finger and BTB domain containing 4 0.012
mitfa microphthalmia-associated transcription factor a 0.012
htatsf1 HIV TAT specific factor 1 0.012
setd5 SET domain containing 5 0.011
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.011
polr2j polymerase (RNA) II (DNA directed) polypeptide J 0.011
ptprb protein tyrosine phosphatase, receptor type, b 0.011
fli1b friend leukemia integration 1b 0.011
hmga1a high mobility group AT-hook 1a 0.011
cetn2 centrin, EF-hand protein, 2 0.011
fev FEV (ETS oncogene family) 0.011
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.011
dll4 delta-like 4 (Drosophila) 0.011
gtf2f2a general transcription factor IIF, polypeptide 2a 0.011
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.011
mpp1 membrane protein, palmitoylated 1 0.011
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.011
ap1g1 adaptor-related protein complex 1, gamma 1 subunit 0.011
lmo4a LIM domain only 4a 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 1.000
Shh sonic hedgehog 0.998
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.994
Pitx2 paired-like homeodomain transcription factor 2 0.981
Vegfa vascular endothelial growth factor A 0.967
Hand2 heart and neural crest derivatives expressed transcript 2 0.962
Kdr kinase insert domain protein receptor 0.940
Neurod1 neurogenic differentiation 1 0.936
Zfpm2 zinc finger protein, multitype 2 0.931
Isl1 ISL1 transcription factor, LIM/homeodomain 0.929
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.926
Pax3 paired box gene 3 0.924
Gfi1b growth factor independent 1B 0.923
Pax6 paired box gene 6 0.915
Rxra retinoid X receptor alpha 0.906
Pbx1 pre B-cell leukemia transcription factor 1 0.906
Gata6 GATA binding protein 6 0.896
Otx2 orthodenticle homolog 2 (Drosophila) 0.890
Cbl Casitas B-lineage lymphoma 0.881
Ptf1a pancreas specific transcription factor, 1a 0.866
Foxc1 forkhead box C1 0.832
Trp53 transformation related protein 53 0.805
Foxc2 forkhead box C2 0.789
Meox2 mesenchyme homeobox 2 0.727
Gata1 GATA binding protein 1 0.709
Tgfbr2 transforming growth factor, beta receptor II 0.693
Gli3 GLI-Kruppel family member GLI3 0.679
Tgfb2 transforming growth factor, beta 2 0.671
Klf3 Kruppel-like factor 3 (basic) 0.648
Fgf8 fibroblast growth factor 8 0.634
Ikzf1 IKAROS family zinc finger 1 0.598
Tal1 T-cell acute lymphocytic leukemia 1 0.591
Msx1 homeobox, msh-like 1 0.586
Pten phosphatase and tensin homolog 0.541
Sox4 SRY-box containing gene 4 0.534
Jag1 jagged 1 0.521
Neurod4 neurogenic differentiation 4 0.519
Hoxa1 homeobox A1 0.518
Runx1 runt related transcription factor 1 0.515
Neurog2 neurogenin 2 0.447
Tbx3 T-box 3 0.440
Gli2 GLI-Kruppel family member GLI2 0.434
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.415
Tcfap2a transcription factor AP-2, alpha 0.411
Hand1 heart and neural crest derivatives expressed transcript 1 0.406
Epor erythropoietin receptor 0.388
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.386
Hdac4 histone deacetylase 4 0.380
Zeb1 zinc finger E-box binding homeobox 1 0.376
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.364
Sox2 SRY-box containing gene 2 0.354
Sox11 SRY-box containing gene 11 0.343
Vegfc vascular endothelial growth factor C 0.341
Tgfb1 transforming growth factor, beta 1 0.341
Fgfr2 fibroblast growth factor receptor 2 0.339
Hoxa9 homeobox A9 0.333
Rb1 retinoblastoma 1 0.327
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.326
Sp3 trans-acting transcription factor 3 0.321
Kiss1 KiSS-1 metastasis-suppressor 0.320
Tbx1 T-box 1 0.312
Smad4 MAD homolog 4 (Drosophila) 0.309
Sox9 SRY-box containing gene 9 0.308
Notch1 Notch gene homolog 1 (Drosophila) 0.305
Sp1 trans-acting transcription factor 1 0.301
Hoxd13 homeobox D13 0.301
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.298
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.297
Gja1 gap junction protein, alpha 1 0.296
Kdm2b lysine (K)-specific demethylase 2B 0.295
Ncoa6 nuclear receptor coactivator 6 0.294
Nos3 nitric oxide synthase 3, endothelial cell 0.292
Efna2 ephrin A2 0.285
Ets1 E26 avian leukemia oncogene 1, 5' domain 0.245
Pbx3 pre B-cell leukemia transcription factor 3 0.234
Hoxa5 homeobox A5 0.232
Crlf3 cytokine receptor-like factor 3 0.221
Foxg1 forkhead box G1 0.219
Foxf2 forkhead box F2 0.193
Ptch1 patched homolog 1 0.185
Nf1 neurofibromatosis 1 0.185
Cdh5 cadherin 5 0.183
Lhx3 LIM homeobox protein 3 0.181
Tcf21 transcription factor 21 0.180
Kitl kit ligand 0.180
Gata5 GATA binding protein 5 0.179
Hoxa13 homeobox A13 0.179
Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.177
Emx1 empty spiracles homolog 1 (Drosophila) 0.177
Smo smoothened homolog (Drosophila) 0.175
Smad3 MAD homolog 3 (Drosophila) 0.172
Hhex hematopoietically expressed homeobox 0.168
Notch2 Notch gene homolog 2 (Drosophila) 0.167
Mitf microphthalmia-associated transcription factor 0.166
Apc adenomatosis polyposis coli 0.166
Bmp4 bone morphogenetic protein 4 0.164
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.164
Wasf2 WAS protein family, member 2 0.153
Wipf1 WAS/WASL interacting protein family, member 1 0.144
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.143
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism