IMP
Process View
The network for 'positive regulation of nitric oxide synthase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of nitric oxide synthase activity
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.348 | |
| PARD6A | par-6 partitioning defective 6 homolog alpha (C. elegans) | 0.219 | |
| MPDZ | multiple PDZ domain protein | 0.212 | |
| ESR1 | estrogen receptor 1 | 0.184 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.140 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.129 | |
| HP | haptoglobin | 0.077 | |
| NOXA1 | NADPH oxidase activator 1 | 0.061 | |
| PPP5C | protein phosphatase 5, catalytic subunit | 0.056 | |
| MAPT | microtubule-associated protein tau | 0.045 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.039 | |
| CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.036 | |
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.036 | |
| APOC1 | apolipoprotein C-I | 0.024 | |
| APOA1 | apolipoprotein A-I | 0.022 | |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.022 | |
| CDCP1 | CUB domain containing protein 1 | 0.019 | |
| MYLK2 | myosin light chain kinase 2 | 0.018 | |
| A2M | alpha-2-macroglobulin | 0.017 | |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.016 | |
| SPRR2A | small proline-rich protein 2A | 0.016 | |
| ADAM15 | ADAM metallopeptidase domain 15 | 0.016 | |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.013 | |
| APOC3 | apolipoprotein C-III | 0.013 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.012 | |
| PRKCZ | protein kinase C, zeta | 0.012 | |
| MUC1 | mucin 1, cell surface associated | 0.011 | |
| ARRDC3 | arrestin domain containing 3 | 0.010 | |
| LCAT | lecithin-cholesterol acyltransferase | 0.010 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Pten | phosphatase and tensin homolog | 0.997 | |
| Lepr | leptin receptor | 0.907 | |
| Trp53 | transformation related protein 53 | 0.815 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.811 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.650 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.564 | |
| Agtr1a | angiotensin II receptor, type 1a | 0.545 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.468 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.464 | |
| Ldlr | low density lipoprotein receptor | 0.374 | |
| Fshr | follicle stimulating hormone receptor | 0.371 | |
| Apoe | apolipoprotein E | 0.358 | |
| Apc | adenomatosis polyposis coli | 0.323 | |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.306 | |
| Fbn1 | fibrillin 1 | 0.274 | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.257 | |
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.254 | |
| Col1a1 | collagen, type I, alpha 1 | 0.224 | |
| Ghr | growth hormone receptor | 0.198 | |
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.187 | |
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.171 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.168 | |
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.148 | |
| Lox | lysyl oxidase | 0.148 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.129 | |
| Tgfb1 | transforming growth factor, beta 1 | 0.122 | |
| Braf | Braf transforming gene | 0.111 | |
| Ren1 | renin 1 structural | 0.108 | |
| Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.100 | |
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.097 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.088 | |
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.086 | |
| Egfr | epidermal growth factor receptor | 0.085 | |
| Nf1 | neurofibromatosis 1 | 0.084 | |
| Lmna | lamin A | 0.084 | |
| Rxra | retinoid X receptor alpha | 0.074 | |
| Wt1 | Wilms tumor 1 homolog | 0.073 | |
| Eln | elastin | 0.072 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.071 | |
| Tgfbr1 | transforming growth factor, beta receptor I | 0.068 | |
| Asap1 | ArfGAP with SH# domain, ankyrin repeat and PH domain1 | 0.065 | |
| Lep | leptin | 0.061 | |
| Vegfa | vascular endothelial growth factor A | 0.061 | |
| Actr3 | ARP3 actin-related protein 3 homolog (yeast) | 0.059 | |
| Vdr | vitamin D receptor | 0.055 | |
| Kit | kit oncogene | 0.054 | |
| Fyn | Fyn proto-oncogene | 0.053 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.053 | |
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.051 | |
| Mt2 | metallothionein 2 | 0.050 | |
| Npy1r | neuropeptide Y receptor Y1 | 0.049 | |
| Ar | androgen receptor | 0.048 | |
| Angptl4 | angiopoietin-like 4 | 0.047 | |
| Lrp1 | low density lipoprotein receptor-related protein 1 | 0.045 | |
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.043 | |
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.041 | |
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.041 | |
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.040 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.040 | |
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.038 | |
| Akt2 | thymoma viral proto-oncogene 2 | 0.037 | |
| Nos1 | nitric oxide synthase 1, neuronal | 0.036 | |
| Shh | sonic hedgehog | 0.036 | |
| Klf15 | Kruppel-like factor 15 | 0.036 | |
| Git1 | G protein-coupled receptor kinase-interactor 1 | 0.035 | |
| Pcdh12 | protocadherin 12 | 0.035 | |
| Inhba | inhibin beta-A | 0.035 | |
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.034 | |
| Smad4 | MAD homolog 4 (Drosophila) | 0.034 | |
| Egr1 | early growth response 1 | 0.033 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.032 | |
| Gnb2 | guanine nucleotide binding protein (G protein), beta 2 | 0.031 | |
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.028 | |
| Arhgdia | Rho GDP dissociation inhibitor (GDI) alpha | 0.028 | |
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.028 | |
| Prkar1a | protein kinase, cAMP dependent regulatory, type I, alpha | 0.027 | |
| Adrbk1 | adrenergic receptor kinase, beta 1 | 0.027 | |
| Gja1 | gap junction protein, alpha 1 | 0.026 | |
| Npc1 | Niemann Pick type C1 | 0.026 | |
| Cdc42 | cell division cycle 42 homolog (S. cerevisiae) | 0.025 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.025 | |
| Wdr1 | WD repeat domain 1 | 0.025 | |
| Pdgfb | platelet derived growth factor, B polypeptide | 0.024 | |
| Pltp | phospholipid transfer protein | 0.023 | |
| Cav1 | caveolin 1, caveolae protein | 0.022 | |
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.021 | |
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.021 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.021 | |
| Nf2 | neurofibromatosis 2 | 0.021 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.021 | |
| Ilk | integrin linked kinase | 0.020 | |
| Arntl | aryl hydrocarbon receptor nuclear translocator-like | 0.020 | |
| Cx3cr1 | chemokine (C-X3-C) receptor 1 | 0.020 | |
| Fkbp1a | FK506 binding protein 1a | 0.020 | |
| Smad2 | MAD homolog 2 (Drosophila) | 0.019 | |
| Tlr2 | toll-like receptor 2 | 0.019 | |
| Lpl | lipoprotein lipase | 0.019 | |
| Sept7 | septin 7 | 0.019 | |
| Src | Rous sarcoma oncogene | 0.019 | |
| Actg1 | actin, gamma, cytoplasmic 1 | 0.019 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Sub1 | SUB1 homolog (S. cerevisiae) | 0.480 | |
| Ptp4a2 | protein tyrosine phosphatase 4a2 | 0.261 | |
| Cdc34 | cell division cycle 34 homolog (S. cerevisiae) | 0.079 | |
| Dynll1 | dynein light chain LC8-type 1 | 0.078 | |
| Calm1 | calmodulin 1 | 0.072 | |
| Atp6v1d | ATPase, H+ transporting, lysosomal V1 subunit D | 0.069 | |
| Ywhah | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.056 | |
| Ppia | peptidylprolyl isomerase A (cyclophilin A) | 0.047 | |
| Gnb2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 0.042 | |
| Arf5 | ADP-ribosylation factor 5 | 0.042 | |
| Tuba1c | tubulin, alpha 1C | 0.037 | |
| Ccnd2 | cyclin D2 | 0.036 | |
| Mlf2 | myeloid leukemia factor 2 | 0.035 | |
| Fkbp1a | FK506 binding protein 1a | 0.033 | |
| Actr2 | ARP2 actin-related protein 2 homolog (yeast) | 0.032 | |
| Sirpa | signal-regulatory protein alpha | 0.028 | |
| Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.025 | |
| Clcn3 | chloride channel 3 | 0.021 | |
| Mapk3 | mitogen activated protein kinase 3 | 0.019 | |
| Rasa1 | RAS p21 protein activator (GTPase activating protein) 1 | 0.019 | |
| Wsb2 | WD repeat and SOCS box-containing 2 | 0.019 | |
| Zfp91 | zinc finger protein 91 | 0.017 | |
| Actn4 | actinin alpha 4 | 0.014 | |
| Efhd2 | EF-hand domain family, member D2 | 0.014 | |
| Htr2b | 5-hydroxytryptamine (serotonin) receptor 2B | 0.013 | |
| Gsk3b | glycogen synthase kinase 3 beta | 0.013 | |
| Fkbp4 | FK506 binding protein 4 | 0.013 | |
| Kitlg | KIT ligand | 0.013 | |
| Mapk6 | mitogen-activated protein kinase 6 | 0.012 | |
| Entpd1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.012 | |
| Ptms | parathymosin | 0.012 | |
| Fam108a1 | family with sequence similarity 108, member A1 | 0.012 | |
| Calm2 | calmodulin 2 | 0.011 | |
| Pgam1 | phosphoglycerate mutase 1 (brain) | 0.010 |