The network for 'autophagic cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

autophagic cell death

A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells.

Homo sapiens
Name Description Probability Func Analog Organism
SMN1 survival of motor neuron 1, telomeric 0.998
CCND3 cyclin D3 0.981
CCND1 cyclin D1 0.972
CDK6 cyclin-dependent kinase 6 0.949
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.945
CDK2 cyclin-dependent kinase 2 0.878
NLRC4 NLR family, CARD domain containing 4 0.870
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.588
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.472
DBF4 DBF4 homolog (S. cerevisiae) 0.465
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.358
CCNE1 cyclin E1 0.337
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.305
ANXA7 annexin A7 0.280
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.277
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.262
EIF1B eukaryotic translation initiation factor 1B 0.253
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.233
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.178
LRDD leucine-rich repeats and death domain containing 0.151
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.135
CCND2 cyclin D2 0.125
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.118
ELF4 E74-like factor 4 (ets domain transcription factor) 0.108
SKP1 S-phase kinase-associated protein 1 0.103
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.102
RBL1 retinoblastoma-like 1 (p107) 0.100
SOX4 SRY (sex determining region Y)-box 4 0.098
RB1 retinoblastoma 1 0.098
IFI16 interferon, gamma-inducible protein 16 0.094
CCNE2 cyclin E2 0.084
RIPK2 receptor-interacting serine-threonine kinase 2 0.083
SKP2 S-phase kinase-associated protein 2 (p45) 0.070
EIF3H eukaryotic translation initiation factor 3, subunit H 0.068
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.066
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.066
GBP2 guanylate binding protein 2, interferon-inducible 0.066
EIF4A2 eukaryotic translation initiation factor 4A2 0.056
TK1 thymidine kinase 1, soluble 0.056
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.053
CCNB2 cyclin B2 0.051
TNS1 tensin 1 0.049
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.047
SH3KBP1 SH3-domain kinase binding protein 1 0.047
TBC1D17 TBC1 domain family, member 17 0.046
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.046
EIF3M eukaryotic translation initiation factor 3, subunit M 0.045
CDK4 cyclin-dependent kinase 4 0.043
NMI N-myc (and STAT) interactor 0.043
CARD16 caspase recruitment domain family, member 16 0.043
CTSS cathepsin S 0.041
DNM2 dynamin 2 0.036
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 0.036
RBL2 retinoblastoma-like 2 (p130) 0.035
SIAH1 seven in absentia homolog 1 (Drosophila) 0.035
SP100 SP100 nuclear antigen 0.034
EIF3L eukaryotic translation initiation factor 3, subunit L 0.034
CLEC2B C-type lectin domain family 2, member B 0.034
SMC1A structural maintenance of chromosomes 1A 0.034
CDT1 chromatin licensing and DNA replication factor 1 0.034
GBP1 guanylate binding protein 1, interferon-inducible 0.033
ATG10 ATG10 autophagy related 10 homolog (S. cerevisiae) 0.032
CDK11B cyclin-dependent kinase 11B 0.032
CCNG2 cyclin G2 0.031
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.031
PLSCR1 phospholipid scramblase 1 0.031
NFE2L1 nuclear factor (erythroid-derived 2)-like 1 0.030
ZNF655 zinc finger protein 655 0.029
IL18 interleukin 18 (interferon-gamma-inducing factor) 0.029
MTA2 metastasis associated 1 family, member 2 0.026
KCTD15 potassium channel tetramerisation domain containing 15 0.026
BASP1 brain abundant, membrane attached signal protein 1 0.025
ZEB2 zinc finger E-box binding homeobox 2 0.024
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.024
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.024
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.024
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.023
PCDHA4 protocadherin alpha 4 0.023
WDFY3 WD repeat and FYVE domain containing 3 0.023
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.023
ATF2 activating transcription factor 2 0.023
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.023
CKS1B CDC28 protein kinase regulatory subunit 1B 0.022
CDK14 cyclin-dependent kinase 14 0.022
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.022
TRIM22 tripartite motif containing 22 0.021
LY96 lymphocyte antigen 96 0.021
S100A8 S100 calcium binding protein A8 0.021
VTA1 Vps20-associated 1 homolog (S. cerevisiae) 0.021
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.021
FAM118B family with sequence similarity 118, member B 0.021
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 0.021
BTN3A2 butyrophilin, subfamily 3, member A2 0.020
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.019
FOXM1 forkhead box M1 0.019
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.019
TECPR1 tectonin beta-propeller repeat containing 1 0.019
EIF3A eukaryotic translation initiation factor 3, subunit A 0.019
EIF3D eukaryotic translation initiation factor 3, subunit D 0.018
TSC22D1 TSC22 domain family, member 1 0.018
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Nc Nedd2-like caspase 0.282
LysE Lysozyme E 0.231
Atg2 Autophagy-specific gene 2 0.226
LysD Lysozyme D 0.223
CecA1 Cecropin A1 0.192
th thread 0.183
Cad99C CG31009 gene product from transcript CG31009-RB 0.163
jar jaguar 0.161
Src42A Src oncogene at 42A 0.160
Atg7 Autophagy-specific gene 7 0.157
CecA2 Cecropin A2 0.154
slp1 sloppy paired 1 0.150
Tor Target of rapamycin 0.150
puc puckered 0.139
Psn Presenilin 0.139
MED4 Mediator complex subunit 4 0.135
LysB Lysozyme B 0.133
loco locomotion defects 0.129
BRWD3 CG31132 gene product from transcript CG31132-RA 0.126
LysC Lysozyme C 0.126
ctp cut up 0.122
Atg18 Autophagy-specific gene 18 0.121
ush u-shaped 0.108
Hsc70-4 Heat shock protein cognate 4 0.105
Or22a Odorant receptor 22a 0.103
Rel Relish 0.102
Eip93F CG18389 gene product from transcript CG18389-RB 0.101
Sas Sialic acid phosphate synthase 0.101
Sox14 Sox box protein 14 0.101
Atg8a Autophagy-specific gene 8a 0.097
CG2852 CG2852 gene product from transcript CG2852-RA 0.095
Eig71Ea Ecdysone-induced gene 71Ea 0.092
bif bifocal 0.091
hep hemipterous 0.087
Gld2 CG5732 gene product from transcript CG5732-RA 0.087
Atg9 Autophagy-specific gene 9 0.084
regucalcin CG1803 gene product from transcript CG1803-RA 0.084
eIF-4a Eukaryotic initiation factor 4a 0.084
MED10 Mediator complex subunit 10 0.084
CG3305 CG3305 gene product from transcript CG3305-RA 0.083
ash1 absent, small, or homeotic discs 1 0.079
Ice CG7788 gene product from transcript CG7788-RA 0.078
CG17244 CG17244 gene product from transcript CG17244-RA 0.078
Act42A Actin 42A 0.078
step steppke 0.075
bond james bond 0.075
Unc-76 CG3981 gene product from transcript CG3981-RB 0.075
cib ciboulot 0.074
CG14526 CG14526 gene product from transcript CG14526-RB 0.073
fd68A forkhead domain 68A 0.069
Eig71Ed Ecdysone-induced gene 71Ed 0.069
Myo10A unconventional myosin class XV 0.068
jumu jumeau 0.068
yata CG1973 gene product from transcript CG1973-RA 0.067
cnc cap-n-collar 0.066
CG5958 CG5958 gene product from transcript CG5958-RA 0.066
Hsp60C CG7235 gene product from transcript CG7235-RA 0.064
B52 CG10851 gene product from transcript CG10851-RB 0.063
Klp68D Kinesin-like protein at 68D 0.063
CG7379 CG7379 gene product from transcript CG7379-RA 0.063
CG4306 CG4306 gene product from transcript CG4306-RA 0.063
nbs CG6754 gene product from transcript CG6754-RC 0.063
CG10630 CG10630 gene product from transcript CG10630-RA 0.062
Rap2l Ras-associated protein 2-like 0.062
key kenny 0.061
His3.3B Histone H3.3B 0.061
Mmp1 Matrix metalloproteinase 1 0.061
LanB1 CG7123 gene product from transcript CG7123-RA 0.060
CSN8 COP9 complex homolog subunit 8 0.059
ssp5 short spindle 5 0.059
lmg lemming 0.055
Eig71Eb Ecdysone-induced gene 71Eb 0.055
CG2233 CG2233 gene product from transcript CG2233-RA 0.055
CecC Cecropin C 0.055
CG14062 CG14062 gene product from transcript CG14062-RB 0.054
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.054
Rala Ras-related protein 0.054
CG15828 CG15828 gene product from transcript CG15828-RC 0.053
Cys Cystatin-like 0.052
L Lobe 0.052
Lsd-2 Lipid storage droplet-2 0.052
CG11380 CG11380 gene product from transcript CG11380-RA 0.051
imd immune deficiency 0.051
btsz bitesize 0.050
Npc2g Niemann-Pick type C-2g 0.050
zen zerknullt 0.049
CG6569 CG6569 gene product from transcript CG6569-RA 0.049
Eig71Ei CG7327 gene product from transcript CG7327-RA 0.049
EcR Ecdysone receptor 0.048
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.048
byn brachyenteron 0.048
pyr pyramus 0.047
l(2)05510 lethal (2) 05510 0.047
CG13060 CG13060 gene product from transcript CG13060-RA 0.047
CG13040 CG13040 gene product from transcript CG13040-RA 0.046
chm chameau 0.046
IP3K2 Inositol 1,4,5-triphosphate kinase 2 0.046
eIF4E-5 CG8277 gene product from transcript CG8277-RA 0.046
CG2950 CG2950 gene product from transcript CG2950-RD 0.046
Obp56d Odorant-binding protein 56d 0.046
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psap prosaposin 0.286
Ctsb cathepsin B 0.256
Tmbim6 transmembrane BAX inhibitor motif containing 6 0.119
Ctsa cathepsin A 0.108
Ftl ferritin, light polypeptide 0.056
Lgals3 lectin, galactoside-binding, soluble, 3 0.045
Ypel5 yippee-like 5 (Drosophila) 0.035
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.032
LOC100360986 mCG1035404-like 0.031
Txnrd1 thioredoxin reductase 1 0.030
Arf1 ADP-ribosylation factor 1 0.030
Cltc clathrin, heavy chain (Hc) 0.030
Ifrd1 interferon-related developmental regulator 1 0.030
Ctss cathepsin S 0.029
Ctsl1 cathepsin L1 0.028
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.028
Dcn decorin 0.027
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.025
Morf4l2 mortality factor 4 like 2 0.025
Pnliprp1 pancreatic lipase-related protein 1 0.023
Hmox1 heme oxygenase (decycling) 1 0.021
Cryba1 crystallin, beta A1 0.021
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.021
Cd63 Cd63 molecule 0.019
Ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.019
Tmem49 transmembrane protein 49 0.019
Gns glucosamine (N-acetyl)-6-sulfatase 0.018
Chrm4 cholinergic receptor, muscarinic 4 0.018
Sqstm1 sequestosome 1 0.018
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.018
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.018
Lrrc7 leucine rich repeat containing 7 0.018
Fuca1 fucosidase, alpha-L- 1, tissue 0.018
Cpa4 carboxypeptidase A4 0.017
Rab11a RAB11a, member RAS oncogene family 0.017
Vom1r105 vomeronasal 1 receptor 105 0.017
Ier5 immediate early response 5 0.016
Hexa hexosaminidase A 0.016
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.016
Gnl3 guanine nucleotide binding protein-like 3 (nucleolar) 0.016
Csrnp1 cysteine-serine-rich nuclear protein 1 0.016
Cnr2 cannabinoid receptor 2 (macrophage) 0.016
Snrpe small nuclear ribonucleoprotein polypeptide E 0.016
Gadd45b growth arrest and DNA-damage-inducible, beta 0.016
Vom1r100 vomeronasal 1 receptor 100 0.015
Arf4 ADP-ribosylation factor 4 0.015
Gabarapl2 GABA(A) receptor-associated protein like 2 0.015
Lgmn legumain 0.015
Adcy5 adenylate cyclase 5 0.015
Shank3 SH3 and multiple ankyrin repeat domains 3 0.014
Prf1 perforin 1 (pore forming protein) 0.014
Sdcbp syndecan binding protein 0.014
Ppt1 palmitoyl-protein thioesterase 1 0.014
Adk adenosine kinase 0.014
Cd52 CD52 antigen 0.014
Car1 carbonic anhydrase 1 0.014
Psbpc1 prostatic steroid binding protein C1 0.014
Napsa napsin A aspartic peptidase 0.014
Odf1 outer dense fiber of sperm tails 1 0.014
Amelx amelogenin X chromosome 0.014
Sycp1 synaptonemal complex protein 1 0.014
Grifin galectin-related inter-fiber protein 0.014
Dnase2b deoxyribonuclease II beta 0.013
Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) 0.013
Cpa3 carboxypeptidase A3, mast cell 0.013
Pate4 prostate and testis expressed 4 0.013
Mt2A metallothionein 2A 0.013
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.013
Clec7a C-type lectin domain family 7, member a 0.013
Vegp2 von Ebners gland protein 2 0.013
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.013
Lad1 ladinin 1 0.013
Hes1 hairy and enhancer of split 1 (Drosophila) 0.013
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.013
Hoxd10 homeo box D10 0.013
Glul glutamate-ammonia ligase (glutamine synthetase) 0.013
Abcg8 ATP-binding cassette, subfamily G (WHITE), member 8 0.013
Nucb1 nucleobindin 1 0.013
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.013
Prl4a1 prolactin family 4, subfamily a, member 1 0.013
Vax1 ventral anterior homeobox 1 0.013
RT1-Da RT1 class II, locus Da 0.012
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.012
RGD1559588 similar to cell surface receptor FDFACT 0.012
Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 0.012
Ifngr1 interferon gamma receptor 1 0.012
Nupr1 nuclear protein, transcriptional regulator, 1 0.012
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.012
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.012
Rraga Ras-related GTP binding A 0.012
Maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.012
Mgp matrix Gla protein 0.012
B2m beta-2 microglobulin 0.012
LOC494538 ABP beta 0.012
Mink1 misshapen-like kinase 1 (zebrafish) 0.012
Slc48a1 solute carrier family 48 (heme transporter), member 1 0.012
Loxl1 lysyl oxidase-like 1 0.012
Il4ra interleukin 4 receptor, alpha 0.012
LOC100362817 rCG33447-like 0.012
Twf1 twinfilin, actin-binding protein, homolog 1 (Drosophila) 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism