The network for 'ruffle organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.777
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.776
MPDZ multiple PDZ domain protein 0.440
TPM4 tropomyosin 4 0.320
ARFIP2 ADP-ribosylation factor interacting protein 2 0.314
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.281
ACTB actin, beta 0.279
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.203
ZYX zyxin 0.133
EMP3 epithelial membrane protein 3 0.127
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.118
RAB1A RAB1A, member RAS oncogene family 0.110
NCOA1 nuclear receptor coactivator 1 0.110
MSN moesin 0.102
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.099
PFN1 profilin 1 0.092
CFL1 cofilin 1 (non-muscle) 0.085
NCF4 neutrophil cytosolic factor 4, 40kDa 0.082
RHOG ras homolog gene family, member G (rho G) 0.076
SOS1 son of sevenless homolog 1 (Drosophila) 0.068
FKBP1A FK506 binding protein 1A, 12kDa 0.063
NCF1 neutrophil cytosolic factor 1 0.057
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.056
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.055
RHOA ras homolog gene family, member A 0.053
SPAG9 sperm associated antigen 9 0.048
RAB6A RAB6A, member RAS oncogene family 0.046
RAB1B RAB1B, member RAS oncogene family 0.045
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.045
COTL1 coactosin-like 1 (Dictyostelium) 0.044
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.044
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.039
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.039
RALBP1 ralA binding protein 1 0.038
CAPNS1 calpain, small subunit 1 0.038
BAIAP2 BAI1-associated protein 2 0.034
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.030
LST1 leukocyte specific transcript 1 0.030
PNPLA6 patatin-like phospholipase domain containing 6 0.029
WASF2 WAS protein family, member 2 0.029
PTK2 PTK2 protein tyrosine kinase 2 0.028
ACTG1 actin, gamma 1 0.028
VASP vasodilator-stimulated phosphoprotein 0.028
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.028
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.027
CD44 CD44 molecule (Indian blood group) 0.026
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.025
PEBP4 phosphatidylethanolamine-binding protein 4 0.025
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.025
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.024
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.024
HTT huntingtin 0.023
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.023
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.023
ARF6 ADP-ribosylation factor 6 0.023
LASP1 LIM and SH3 protein 1 0.022
CDC34 cell division cycle 34 homolog (S. cerevisiae) 0.022
NCF2 neutrophil cytosolic factor 2 0.022
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.021
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.021
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.021
TSC22D1 TSC22 domain family, member 1 0.021
RHEB Ras homolog enriched in brain 0.021
CLTB clathrin, light chain B 0.020
RAB8A RAB8A, member RAS oncogene family 0.020
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.020
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.020
FYN FYN oncogene related to SRC, FGR, YES 0.019
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.019
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.018
RALGDS ral guanine nucleotide dissociation stimulator 0.018
DEF6 differentially expressed in FDCP 6 homolog (mouse) 0.017
PICALM phosphatidylinositol binding clathrin assembly protein 0.017
RARA retinoic acid receptor, alpha 0.017
WASF1 WAS protein family, member 1 0.017
TMOD3 tropomodulin 3 (ubiquitous) 0.017
DLG5 discs, large homolog 5 (Drosophila) 0.016
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.016
RGS19 regulator of G-protein signaling 19 0.016
CDV3 CDV3 homolog (mouse) 0.016
PLAUR plasminogen activator, urokinase receptor 0.016
CAPZB capping protein (actin filament) muscle Z-line, beta 0.016
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.016
RIN1 Ras and Rab interactor 1 0.016
FMNL1 formin-like 1 0.016
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.015
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.015
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.015
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.015
FAM89B family with sequence similarity 89, member B 0.015
SFN stratifin 0.014
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.014
DLG4 discs, large homolog 4 (Drosophila) 0.014
XIRP1 xin actin-binding repeat containing 1 0.014
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.014
MAP2K1 mitogen-activated protein kinase kinase 1 0.014
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.013
RHOC ras homolog gene family, member C 0.013
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.013
HIP1 huntingtin interacting protein 1 0.013
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Vasp vasodilator-stimulated phosphoprotein 0.592
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.511
Arpc4 actin related protein 2/3 complex, subunit 4 0.329
Sgpl1 sphingosine phosphate lyase 1 0.251
Kdr kinase insert domain protein receptor 0.247
Actb actin, beta 0.229
Csf1 colony stimulating factor 1 (macrophage) 0.200
Tgfb1 transforming growth factor, beta 1 0.147
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.147
C1qa complement component 1, q subcomponent, alpha polypeptide 0.146
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.144
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.120
Flt4 FMS-like tyrosine kinase 4 0.116
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.112
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.109
Shc1 src homology 2 domain-containing transforming protein C1 0.108
Cdh5 cadherin 5 0.091
Necap2 NECAP endocytosis associated 2 0.087
Rac1 RAS-related C3 botulinum substrate 1 0.082
Enah enabled homolog (Drosophila) 0.074
Vegfa vascular endothelial growth factor A 0.068
Mapkap1 mitogen-activated protein kinase associated protein 1 0.066
Inpp5d inositol polyphosphate-5-phosphatase D 0.066
Wdr1 WD repeat domain 1 0.061
Stat3 signal transducer and activator of transcription 3 0.061
Bmp2 bone morphogenetic protein 2 0.059
Cbl Casitas B-lineage lymphoma 0.058
Pecam1 platelet/endothelial cell adhesion molecule 1 0.050
5430411K18Rik RIKEN cDNA 5430411K18 gene 0.048
Msn moesin 0.047
Ctnnb1 catenin (cadherin associated protein), beta 1 0.046
Dnm1 dynamin 1 0.045
Rptor regulatory associated protein of MTOR, complex 1 0.044
Emcn endomucin 0.043
Grb2 growth factor receptor bound protein 2 0.043
Tgfbr2 transforming growth factor, beta receptor II 0.043
Pld4 phospholipase D family, member 4 0.042
Tyrobp TYRO protein tyrosine kinase binding protein 0.041
Rhoa ras homolog gene family, member A 0.041
Plcg1 phospholipase C, gamma 1 0.038
Ldlr low density lipoprotein receptor 0.038
Gja1 gap junction protein, alpha 1 0.038
Cd68 CD68 antigen 0.037
Unc93b1 unc-93 homolog B1 (C. elegans) 0.037
Vegfc vascular endothelial growth factor C 0.037
Rhog ras homolog gene family, member G 0.036
Schip1 schwannomin interacting protein 1 0.036
Hspa1b heat shock protein 1B 0.034
Laptm5 lysosomal-associated protein transmembrane 5 0.034
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.031
Psen1 presenilin 1 0.031
Rictor RPTOR independent companion of MTOR, complex 2 0.031
Cav1 caveolin 1, caveolae protein 0.030
Foxc2 forkhead box C2 0.030
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.030
Notch2 Notch gene homolog 2 (Drosophila) 0.030
Csnk2b casein kinase 2, beta polypeptide 0.029
Cyba cytochrome b-245, alpha polypeptide 0.028
Cd44 CD44 antigen 0.028
Tjap1 tight junction associated protein 1 0.028
Lcp1 lymphocyte cytosolic protein 1 0.026
Itgb2 integrin beta 2 0.026
Esam endothelial cell-specific adhesion molecule 0.026
Wasf1 WASP family 1 0.026
Fxyd5 FXYD domain-containing ion transport regulator 5 0.026
Capzb capping protein (actin filament) muscle Z-line, beta 0.026
Csf1r colony stimulating factor 1 receptor 0.026
Mmp9 matrix metallopeptidase 9 0.025
Sox18 SRY-box containing gene 18 0.025
Nos3 nitric oxide synthase 3, endothelial cell 0.025
Stat6 signal transducer and activator of transcription 6 0.025
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.025
Arf1 ADP-ribosylation factor 1 0.024
Lmf1 lipase maturation factor 1 0.024
Abhd5 abhydrolase domain containing 5 0.024
Ctsd cathepsin D 0.023
Cfl1 cofilin 1, non-muscle 0.023
Parvg parvin, gamma 0.022
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.022
Il6st interleukin 6 signal transducer 0.022
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.021
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.021
Pdgfb platelet derived growth factor, B polypeptide 0.021
Ptprc protein tyrosine phosphatase, receptor type, C 0.021
Shisa5 shisa homolog 5 (Xenopus laevis) 0.021
Wwox WW domain-containing oxidoreductase 0.021
Rnd3 Rho family GTPase 3 0.021
Plvap plasmalemma vesicle associated protein 0.021
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.021
Plxnd1 plexin D1 0.020
Fuz fuzzy homolog (Drosophila) 0.020
Ednrb endothelin receptor type B 0.020
Cd97 CD97 antigen 0.020
Litaf LPS-induced TN factor 0.019
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.019
Tek endothelial-specific receptor tyrosine kinase 0.019
Cnn2 calponin 2 0.019
Cd300a CD300A antigen 0.019
Dab2 disabled homolog 2 (Drosophila) 0.019
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tagln transgelin 0.038
Acta2 smooth muscle alpha-actin 0.017
Ptbp1 polypyrimidine tract binding protein 1 0.014
Coro1a coronin, actin binding protein 1A 0.011
Emp1 epithelial membrane protein 1 0.011
Pfn1 profilin 1 0.011
Hck hemopoietic cell kinase 0.011
Cald1 caldesmon 1 0.010
Tpm3 tropomyosin 3, gamma 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism