IMP
Process View
The network for 'macrophage activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
macrophage activation involved in immune response
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.914 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.861 | |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.795 | |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.585 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.471 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.455 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.351 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.296 | |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.178 | |
| BCL3 | B-cell CLL/lymphoma 3 | 0.106 | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.099 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.089 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.080 | |
| BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 0.070 | |
| CD247 | CD247 molecule | 0.069 | |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.069 | |
| SYK | spleen tyrosine kinase | 0.068 | |
| SIRPB1 | signal-regulatory protein beta 1 | 0.067 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.064 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 0.059 | |
| LAT | linker for activation of T cells | 0.044 | |
| MYO9B | myosin IXB | 0.034 | |
| NCF4 | neutrophil cytosolic factor 4, 40kDa | 0.032 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.029 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.028 | |
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.025 | |
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.021 | |
| C4BPA | complement component 4 binding protein, alpha | 0.019 | |
| EGFR | epidermal growth factor receptor | 0.018 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.018 | |
| ARAF | v-raf murine sarcoma 3611 viral oncogene homolog | 0.018 | |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.017 | |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.016 | |
| CD14 | CD14 molecule | 0.015 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.015 | |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.015 | |
| C19orf6 | chromosome 19 open reading frame 6 | 0.014 | |
| EZR | ezrin | 0.014 | |
| LST1 | leukocyte specific transcript 1 | 0.013 | |
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.012 | |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.012 | |
| SPI1 | spleen focus forming virus (SFFV) proviral integration oncogene spi1 | 0.011 | |
| LAPTM5 | lysosomal protein transmembrane 5 | 0.011 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.011 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.011 | |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.010 | |
| SH2B2 | SH2B adaptor protein 2 | 0.010 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Tlr4 | toll-like receptor 4 | 0.465 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.161 | |
| Ldb3 | LIM domain binding 3 | 0.121 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.116 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.110 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.101 | |
| Cd44 | CD44 antigen | 0.101 | |
| Xcr1 | chemokine (C motif) receptor 1 | 0.061 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.060 | |
| Ifng | interferon gamma | 0.055 | |
| Cd22 | CD22 antigen | 0.051 | |
| Cd14 | CD14 antigen | 0.046 | |
| Lta | lymphotoxin A | 0.040 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.039 | |
| Tlr2 | toll-like receptor 2 | 0.036 | |
| Cd247 | CD247 antigen | 0.036 | |
| Mmp9 | matrix metallopeptidase 9 | 0.034 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.033 | |
| Cd7 | CD7 antigen | 0.030 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.030 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.029 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.025 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.024 | |
| Cd19 | CD19 antigen | 0.024 | |
| Il10 | interleukin 10 | 0.022 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.022 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.022 | |
| Il27ra | interleukin 27 receptor, alpha | 0.021 | |
| Lyz2 | lysozyme 2 | 0.020 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.019 | |
| Selp | selectin, platelet | 0.018 | |
| Cd4 | CD4 antigen | 0.018 | |
| Blk | B lymphoid kinase | 0.017 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.017 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.017 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.016 | |
| Actn2 | actinin alpha 2 | 0.015 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.015 | |
| Apoe | apolipoprotein E | 0.015 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.014 | |
| Fcrla | Fc receptor-like A | 0.014 | |
| Itk | IL2-inducible T-cell kinase | 0.014 | |
| Il1r1 | interleukin 1 receptor, type I | 0.013 | |
| Hcst | hematopoietic cell signal transducer | 0.013 | |
| Icos | inducible T-cell co-stimulator | 0.012 | |
| Tnf | tumor necrosis factor | 0.012 | |
| Cd180 | CD180 antigen | 0.012 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.012 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.012 | |
| Prkce | protein kinase C, epsilon | 0.012 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.012 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.012 | |
| Src | Rous sarcoma oncogene | 0.012 | |
| S1pr4 | sphingosine-1-phosphate receptor 4 | 0.011 | |
| Gzmb | granzyme B | 0.011 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.011 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.011 | |
| Gpr132 | G protein-coupled receptor 132 | 0.011 | |
| Itgax | integrin alpha X | 0.011 | |
| Il12rb2 | interleukin 12 receptor, beta 2 | 0.010 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.010 | |
| Ltb | lymphotoxin B | 0.010 | |
| Cd96 | CD96 antigen | 0.010 | |
| H2-Ob | histocompatibility 2, O region beta locus | 0.010 |