The network for 'cell differentiation in spinal cord' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell differentiation in spinal cord

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.

Homo sapiens
Name Description Probability Func Analog Organism
NOTCH3 notch 3 1.000
NOTCH1 notch 1 1.000
JAG1 jagged 1 0.998
MEOX2 mesenchyme homeobox 2 0.993
SUFU suppressor of fused homolog (Drosophila) 0.990
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.986
SOX10 SRY (sex determining region Y)-box 10 0.955
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.953
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.916
POU3F2 POU class 3 homeobox 2 0.914
JAG2 jagged 2 0.889
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.865
RUNX1 runt-related transcription factor 1 0.830
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.814
PTCH1 patched 1 0.798
LBX1 ladybird homeobox 1 0.793
PDX1 pancreatic and duodenal homeobox 1 0.789
STK36 serine/threonine kinase 36 0.789
TNRC6A trinucleotide repeat containing 6A 0.773
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.768
RAX retina and anterior neural fold homeobox 0.761
FGF3 fibroblast growth factor 3 0.750
PEX26 peroxisomal biogenesis factor 26 0.708
GLI1 GLI family zinc finger 1 0.671
MYOD1 myogenic differentiation 1 0.655
GRB10 growth factor receptor-bound protein 10 0.649
MAML1 mastermind-like 1 (Drosophila) 0.648
LDB1 LIM domain binding 1 0.601
XIAP X-linked inhibitor of apoptosis 0.587
HOXD12 homeobox D12 0.571
LTBP4 latent transforming growth factor beta binding protein 4 0.567
LHX5 LIM homeobox 5 0.556
ZNF764 zinc finger protein 764 0.553
BHLHE23 basic helix-loop-helix family, member e23 0.541
TNRC6B trinucleotide repeat containing 6B 0.513
NOTCH2 notch 2 0.506
FEV FEV (ETS oncogene family) 0.503
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.490
GFI1B growth factor independent 1B transcription repressor 0.477
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.444
C1QL1 complement component 1, q subcomponent-like 1 0.439
TP73 tumor protein p73 0.432
LMX1A LIM homeobox transcription factor 1, alpha 0.428
TCF12 transcription factor 12 0.419
FOXD3 forkhead box D3 0.416
IRS1 insulin receptor substrate 1 0.409
SOX1 SRY (sex determining region Y)-box 1 0.406
HOXD9 homeobox D9 0.403
VHL von Hippel-Lindau tumor suppressor 0.387
TCF4 transcription factor 4 0.353
HOXD11 homeobox D11 0.351
GBX2 gastrulation brain homeobox 2 0.341
PAX7 paired box 7 0.340
LRP6 low density lipoprotein receptor-related protein 6 0.336
NPAS1 neuronal PAS domain protein 1 0.329
TNRC6C trinucleotide repeat containing 6C 0.320
HES2 hairy and enhancer of split 2 (Drosophila) 0.315
PYY peptide YY 0.312
HIPK2 homeodomain interacting protein kinase 2 0.311
LMO1 LIM domain only 1 (rhombotin 1) 0.310
FOXL1 forkhead box L1 0.306
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.306
HOXB9 homeobox B9 0.306
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.290
WNT10A wingless-type MMTV integration site family, member 10A 0.287
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.285
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.283
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.280
QPRT quinolinate phosphoribosyltransferase 0.277
TUBB2B tubulin, beta 2B 0.275
POU3F1 POU class 3 homeobox 1 0.274
FGF8 fibroblast growth factor 8 (androgen-induced) 0.268
HOXC8 homeobox C8 0.259
OTP orthopedia homeobox 0.259
FZD8 frizzled homolog 8 (Drosophila) 0.254
MARCKSL1 MARCKS-like 1 0.250
ECEL1 endothelin converting enzyme-like 1 0.239
INSR insulin receptor 0.229
LPHN1 latrophilin 1 0.229
TAL1 T-cell acute lymphocytic leukemia 1 0.225
HOXC12 homeobox C12 0.222
ZNF263 zinc finger protein 263 0.215
NEUROG3 neurogenin 3 0.207
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.205
GLIS3 GLIS family zinc finger 3 0.203
BARX1 BARX homeobox 1 0.201
ALX3 ALX homeobox 3 0.196
KLHL35 kelch-like 35 (Drosophila) 0.196
PAX2 paired box 2 0.194
CDX2 caudal type homeobox 2 0.194
HAND2 heart and neural crest derivatives expressed 2 0.193
FOXB1 forkhead box B1 0.181
HOXC6 homeobox C6 0.175
HOXC11 homeobox C11 0.174
POU3F3 POU class 3 homeobox 3 0.173
GATA5 GATA binding protein 5 0.173
ARHGAP22 Rho GTPase activating protein 22 0.173
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.166
MNX1 motor neuron and pancreas homeobox 1 0.163
NKX2-2 NK2 homeobox 2 0.163
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 1.000
notch1a notch homolog 1a 0.988
eng2a engrailed 2a 0.972
nkx2.2a NK2 transcription factor related 2a 0.971
gli2a GLI-Kruppel family member GLI2a 0.963
foxa1 forkhead box A1 0.961
tbx16 T-box gene 16 0.960
foxa2 forkhead box A2 0.959
flh floating head 0.946
ndr2 nodal-related 2 0.937
dld deltaD 0.934
tbx2b T-box 2b 0.911
olig2 oligodendrocyte lineage transcription factor 2 0.889
dla deltaA 0.883
ntla no tail a 0.875
shha sonic hedgehog a 0.844
lhx5 LIM homeobox 5 0.830
chd chordin 0.819
ascl1a achaete-scute complex-like 1a (Drosophila) 0.815
pitx2 paired-like homeodomain transcription factor 2 0.811
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.795
prl prolactin 0.794
hnf1ba HNF1 homeobox Ba 0.752
dlb deltaB 0.679
ihha Indian hedgehog homolog a 0.639
otpb orthopedia homolog b 0.618
hlxb9la homeo box HB9 like a 0.611
fzd8a frizzled homolog 8a 0.609
nkx2.1a NK2 homeobox 1a 0.599
dcc deleted in colorectal carcinoma 0.594
isl1 islet1 0.589
tbx20 T-box 20 0.584
hhex hematopoietically expressed homeobox 0.543
otx2 orthodenticle homolog 2 0.537
hoxd11a homeo box D11a 0.512
nkx2.2b NK2 transcription factor related 2b 0.511
lft1 lefty1 0.501
tal1 T-cell acute lymphocytic leukemia 1 0.497
dbx1a developing brain homeobox 1a 0.491
wnt8b wingless-type MMTV integration site family, member 8b 0.490
nkx2.1b NK2 homeobox 1b 0.486
sox10 SRY-box containing gene 10 0.463
cdx4 caudal type homeo box transcription factor 4 0.461
fezf2 FEZ family zinc finger 2 0.456
fn1 fibronectin 1 0.456
runx1 runt-related transcription factor 1 0.444
phox2a paired-like homeobox 2a 0.444
eve1 even-skipped-like1 0.436
pdx1 pancreatic and duodenal homeobox 1 0.426
hoxd12a homeo box D12a 0.416
mib mind bomb 0.410
dkk1b dickkopf 1b 0.408
gata2a GATA-binding protein 2a 0.407
sox32 SRY-box containing gene 32 0.399
lhx2b LIM homeobox 2b 0.395
gbx2 gastrulation brain homeo box 2 0.379
meis3 myeloid ecotropic viral integration site 3 0.366
foxd3 forkhead box D3 0.366
ptch1 patched 1 0.365
pcdh18a protocadherin 18a 0.364
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.362
tal2 T-cell acute lymphocytic leukemia 2 0.355
fgf3 fibroblast growth factor 3 0.353
barhl2 BarH-like 2 0.339
lhx3 LIM homeobox 3 0.337
ascl1b achaete-scute complex-like 1b (Drosophila) 0.334
sox17 SRY-box containing gene 17 0.334
hlxb9lb homeo box HB9 like b 0.327
gata3 GATA-binding protein 3 0.311
nkx2.9 NK2 transcription factor related, locus 9 (Drosophila) 0.303
gli1 GLI-Kruppel family member 1 0.303
pax2a paired box gene 2a 0.299
myf5 myogenic factor 5 0.278
reln reelin 0.274
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.270
olig3 oligodendrocyte transcription factor 3 0.269
arx aristaless related homeobox 0.254
sox2 SRY-box containing gene 2 0.251
otpa orthopedia homolog a 0.251
eng2b engrailed 2b 0.228
slc45a2 solute carrier family 45, member 2 0.225
six3a sine oculis homeobox homolog 3a 0.220
pax8 paired box gene 8 0.218
chrna2a cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) 0.213
lmo4a LIM domain only 4a 0.205
gbx1 gastrulation brain homeobox 1 0.201
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.200
her5 hairy-related 5 0.199
atoh7 atonal homolog 7 0.194
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.193
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.193
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.190
gata6 GATA-binding protein 6 0.188
apc adenomatosis polyposis coli 0.186
six3b sine oculis homeobox homolog 3b 0.186
lhx1a LIM homeobox 1a 0.184
dbh dopamine beta hydroxylase 0.182
ptf1a pancreas specific transcription factor, 1a 0.180
wnt5b wingless-type MMTV integration site family, member 5b 0.177
sox1a SRY-box containing gene 1a 0.174
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Shh sonic hedgehog 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Pax2 paired box gene 2 0.999
Msx1 homeobox, msh-like 1 0.995
Hand1 heart and neural crest derivatives expressed transcript 1 0.995
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.995
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.994
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.990
Gli2 GLI-Kruppel family member GLI2 0.987
Fgfr2 fibroblast growth factor receptor 2 0.983
Foxg1 forkhead box G1 0.982
Tbx1 T-box 1 0.981
Foxc2 forkhead box C2 0.980
Lhx1 LIM homeobox protein 1 0.978
T brachyury 0.967
Sox2 SRY-box containing gene 2 0.965
Fgf10 fibroblast growth factor 10 0.963
Dlx5 distal-less homeobox 5 0.962
Sox9 SRY-box containing gene 9 0.961
Ptf1a pancreas specific transcription factor, 1a 0.958
Gli3 GLI-Kruppel family member GLI3 0.957
Neurog2 neurogenin 2 0.956
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.955
Pax3 paired box gene 3 0.953
Wt1 Wilms tumor 1 homolog 0.940
Isl1 ISL1 transcription factor, LIM/homeodomain 0.939
Hoxd9 homeobox D9 0.932
Pax8 paired box gene 8 0.926
Bmp7 bone morphogenetic protein 7 0.924
Hoxa1 homeobox A1 0.923
Hoxd3 homeobox D3 0.920
Hand2 heart and neural crest derivatives expressed transcript 2 0.917
Sox3 SRY-box containing gene 3 0.917
Tal1 T-cell acute lymphocytic leukemia 1 0.916
Gdnf glial cell line derived neurotrophic factor 0.914
Hoxa10 homeobox A10 0.914
Eya1 eyes absent 1 homolog (Drosophila) 0.908
Fgf8 fibroblast growth factor 8 0.902
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.899
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.895
Nog noggin 0.888
Lmx1a LIM homeobox transcription factor 1 alpha 0.883
Alx4 aristaless-like homeobox 4 0.870
Nodal nodal 0.866
Tcfap2a transcription factor AP-2, alpha 0.864
Pitx1 paired-like homeodomain transcription factor 1 0.855
Prrx1 paired related homeobox 1 0.851
Phox2b paired-like homeobox 2b 0.850
Pax6 paired box gene 6 0.842
Wnt6 wingless-related MMTV integration site 6 0.839
Ret ret proto-oncogene 0.827
Hoxb6 homeobox B6 0.826
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.820
Tcf21 transcription factor 21 0.815
Twist2 twist homolog 2 (Drosophila) 0.811
Gli1 GLI-Kruppel family member GLI1 0.802
Tbx3 T-box 3 0.793
Hoxc4 homeobox C4 0.792
Emx2 empty spiracles homolog 2 (Drosophila) 0.790
Hoxd10 homeobox D10 0.783
Hoxd11 homeobox D11 0.781
Gata4 GATA binding protein 4 0.778
Hoxa2 homeobox A2 0.774
Wnt3a wingless-related MMTV integration site 3A 0.769
Uncx UNC homeobox 0.769
Fgf15 fibroblast growth factor 15 0.758
Hoxc6 homeobox C6 0.746
Hoxd13 homeobox D13 0.743
Sox7 SRY-box containing gene 7 0.740
Lhx9 LIM homeobox protein 9 0.739
Fgf3 fibroblast growth factor 3 0.733
Emx1 empty spiracles homolog 1 (Drosophila) 0.733
Hes5 hairy and enhancer of split 5 (Drosophila) 0.722
Hoxa11 homeobox A11 0.719
Hoxd1 homeobox D1 0.715
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.714
Neurod1 neurogenic differentiation 1 0.707
Gbx2 gastrulation brain homeobox 2 0.694
Pbx1 pre B-cell leukemia transcription factor 1 0.687
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.684
Msx2 homeobox, msh-like 2 0.675
Neurog3 neurogenin 3 0.652
Hes1 hairy and enhancer of split 1 (Drosophila) 0.649
Bmp4 bone morphogenetic protein 4 0.637
Insm1 insulinoma-associated 1 0.635
Alx3 aristaless-like homeobox 3 0.635
Pax9 paired box gene 9 0.619
Pdx1 pancreatic and duodenal homeobox 1 0.617
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.610
Lhx3 LIM homeobox protein 3 0.608
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.593
Hoxb3 homeobox B3 0.593
En1 engrailed 1 0.593
Pou3f3 POU domain, class 3, transcription factor 3 0.589
Fgfr1 fibroblast growth factor receptor 1 0.586
Lhx5 LIM homeobox protein 5 0.577
Adra2b adrenergic receptor, alpha 2b 0.577
Wnt1 wingless-related MMTV integration site 1 0.577
Atoh1 atonal homolog 1 (Drosophila) 0.568
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism