The network for 'peptidyl proline hydroxylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl proline hydroxylation

The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline.

Mus musculus
Name Description Probability Func Analog Organism
Leprel4 leprecan-like 4 0.766
P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide 0.745
Prnp prion protein 0.671
Fkbp9 FK506 binding protein 9 0.532
Epas1 endothelial PAS domain protein 1 0.518
P4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide 0.452
Txndc5 thioredoxin domain containing 5 0.303
Rpn2 ribophorin II 0.294
Surf4 surfeit gene 4 0.292
Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.265
Vegfa vascular endothelial growth factor A 0.253
Glt25d1 glycosyltransferase 25 domain containing 1 0.239
Lama4 laminin, alpha 4 0.229
Maged1 melanoma antigen, family D, 1 0.227
Sec31a Sec31 homolog A (S. cerevisiae) 0.220
Creb3l2 cAMP responsive element binding protein 3-like 2 0.214
Ppic peptidylprolyl isomerase C 0.209
Emilin1 elastin microfibril interfacer 1 0.181
Fkbp10 FK506 binding protein 10 0.168
Copz2 coatomer protein complex, subunit zeta 2 0.168
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.162
Vkorc1 vitamin K epoxide reductase complex, subunit 1 0.158
Rab34 RAB34, member of RAS oncogene family 0.157
Lepre1 leprecan 1 0.156
Hsph1 heat shock 105kDa/110kDa protein 1 0.156
Slc39a7 solute carrier family 39 (zinc transporter), member 7 0.133
Cul7 cullin 7 0.128
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.117
Rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.113
Prkcdbp protein kinase C, delta binding protein 0.104
Nucb1 nucleobindin 1 0.093
Pdia5 protein disulfide isomerase associated 5 0.087
Igfbp4 insulin-like growth factor binding protein 4 0.084
Pcolce procollagen C-endopeptidase enhancer protein 0.083
Sepn1 selenoprotein N, 1 0.081
Calu calumenin 0.076
Lamb2 laminin, beta 2 0.074
Egln1 EGL nine homolog 1 (C. elegans) 0.073
Col4a1 collagen, type IV, alpha 1 0.066
Hif1a hypoxia inducible factor 1, alpha subunit 0.062
Ckap4 cytoskeleton-associated protein 4 0.061
Aldoa aldolase A, fructose-bisphosphate 0.059
Maged2 melanoma antigen, family D, 2 0.057
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.057
Ikbip IKBKB interacting protein 0.056
Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.052
Gpx7 glutathione peroxidase 7 0.049
Crtap cartilage associated protein 0.047
Sparc secreted acidic cysteine rich glycoprotein 0.045
Slc25a28 solute carrier family 25, member 28 0.045
Pfkl phosphofructokinase, liver, B-type 0.044
Frmd6 FERM domain containing 6 0.039
Anxa5 annexin A5 0.038
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.038
Timp3 tissue inhibitor of metalloproteinase 3 0.037
Col4a2 collagen, type IV, alpha 2 0.036
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.036
Fbn1 fibrillin 1 0.036
Dpagt1 dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.035
Praf2 PRA1 domain family 2 0.035
Kdelr2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.035
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.034
Bnip3 BCL2/adenovirus E1B interacting protein 3 0.034
Angptl2 angiopoietin-like 2 0.033
Mxra8 matrix-remodelling associated 8 0.033
Aplp2 amyloid beta (A4) precursor-like protein 2 0.033
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.032
Bhlhe40 basic helix-loop-helix family, member e40 0.032
Itgb5 integrin beta 5 0.031
Hspa5 heat shock protein 5 0.031
Npr2 natriuretic peptide receptor 2 0.031
B3gnt9-ps UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9, pseudogene 0.031
Galnt2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 0.030
Sec24d Sec24 related gene family, member D (S. cerevisiae) 0.028
Dag1 dystroglycan 1 0.028
Smtn smoothelin 0.028
Lman1 lectin, mannose-binding, 1 0.028
Dctn1 dynactin 1 0.027
Ldha lactate dehydrogenase A 0.026
Pkm2 pyruvate kinase, muscle 0.025
Bmp1 bone morphogenetic protein 1 0.025
Olfml3 olfactomedin-like 3 0.024
Pgk1 phosphoglycerate kinase 1 0.024
Prkcsh protein kinase C substrate 80K-H 0.024
Lamc1 laminin, gamma 1 0.024
Atf6 activating transcription factor 6 0.023
Fam114a1 family with sequence similarity 114, member A1 0.023
Vhl von Hippel-Lindau tumor suppressor 0.023
Gusb glucuronidase, beta 0.023
Ero1l ERO1-like (S. cerevisiae) 0.022
Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 0.022
Cpxm1 carboxypeptidase X 1 (M14 family) 0.022
P4hb prolyl 4-hydroxylase, beta polypeptide 0.022
Gpr153 G protein-coupled receptor 153 0.021
Morc4 microrchidia 4 0.021
Csrp2 cysteine and glycine-rich protein 2 0.021
Ndn necdin 0.021
Tmem119 transmembrane protein 119 0.021
Dennd5a DENN/MADD domain containing 5A 0.019
Lix1l Lix1-like 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG14061 CG14061 gene product from transcript CG14061-RA 0.840
CG12558 CG12558 gene product from transcript CG12558-RA 0.572
BG642163 CG34102 gene product from transcript CG34102-RA 0.507
ERp60 CG8983 gene product from transcript CG8983-RA 0.306
TRAM CG11642 gene product from transcript CG11642-RB 0.274
CG31659 CG31659 gene product from transcript CG31659-RA 0.199
Gp93 Glycoprotein 93 0.196
CG9522 CG9522 gene product from transcript CG9522-RA 0.163
CG11664 CG11664 gene product from transcript CG11664-RA 0.138
Spn7 Serine protease inhibitor 7 0.128
CG11608 CG11608 gene product from transcript CG11608-RB 0.121
scf supercoiling factor 0.116
CG9168 CG9168 gene product from transcript CG9168-RA 0.097
CG18231 CG18231 gene product from transcript CG18231-RB 0.092
CG10586 CG10586 gene product from transcript CG10586-RA 0.090
lute CG5319 gene product from transcript CG5319-RA 0.090
Acp76A Accessory gland-specific peptide 76A 0.088
CG11727 CG11727 gene product from transcript CG11727-RD 0.073
CG18281 CG18281 gene product from transcript CG18281-RA 0.065
CG10041 CG10041 gene product from transcript CG10041-RA 0.065
bnk bottleneck 0.064
CG11977 CG11977 gene product from transcript CG11977-RB 0.056
Spn77Bc Serpin 77Bc 0.056
CG6149 CG6149 gene product from transcript CG6149-RB 0.054
Acp70A Accessory gland peptide 70A 0.054
CG33259 CG33259 gene product from transcript CG33259-RA 0.053
CG18672 CG18672 gene product from transcript CG18672-RA 0.053
CG18258 CG18258 gene product from transcript CG18258-RA 0.052
CG2111 CG2111 gene product from transcript CG2111-RA 0.051
nero CG2245 gene product from transcript CG2245-RA 0.051
CG6690 CG6690 gene product from transcript CG6690-RA 0.048
lectin-21Ca CG2826 gene product from transcript CG2826-RA 0.046
SA-2 Stromalin-2 0.046
CG13131 CG13131 gene product from transcript CG13131-RB 0.044
flower CG6151 gene product from transcript CG6151-RA 0.042
CG9525 CG9525 gene product from transcript CG9525-RA 0.041
CG7304 CG7304 gene product from transcript CG7304-RA 0.041
Ctr1B Copper transporter 1B 0.041
CG2983 CG2983 gene product from transcript CG2983-RA 0.040
CG31976 CG31976 gene product from transcript CG31976-RB 0.039
CG11828 CG11828 gene product from transcript CG11828-RC 0.039
CG11112 CG11112 gene product from transcript CG11112-RC 0.037
Acp29AB Accessory gland-specific peptide 29AB 0.037
CG32833 CG32833 gene product from transcript CG32833-RA 0.037
CaBP1 CG5809 gene product from transcript CG5809-RA 0.036
CG10472 CG10472 gene product from transcript CG10472-RA 0.035
nvd neverland 0.035
CG9194 CG9194 gene product from transcript CG9194-RA 0.035
CG6168 CG6168 gene product from transcript CG6168-RB 0.034
CG7998 CG7998 gene product from transcript CG7998-RA 0.034
CG18234 CG18234 gene product from transcript CG18234-RC 0.033
CG11637 CG11637 gene product from transcript CG11637-RA 0.033
Pdi Protein disulfide isomerase 0.033
lectin-30A CG17011 gene product from transcript CG17011-RA 0.033
CG9899 CG9899 gene product from transcript CG9899-RA 0.033
CG14357 CG14357 gene product from transcript CG14357-RB 0.032
Spp Signal peptide protease 0.032
Mst57Dc Male-specific RNA 57Dc 0.031
CG11598 CG11598 gene product from transcript CG11598-RB 0.031
onecut CG1922 gene product from transcript CG1922-RA 0.031
CG1701 CG1701 gene product from transcript CG1701-RB 0.030
CG15864 CG15864 gene product from transcript CG15864-RB 0.029
Mrtf Myocardin-related transcription factor 0.029
CG42481 CG42481 gene product from transcript CG42481-RA 0.029
CG18233 CG18233 gene product from transcript CG18233-RA 0.028
CG13557 CG13557 gene product from transcript CG13557-RA 0.028
Pdh Photoreceptor dehydrogenase 0.028
CG17732 CG17732 gene product from transcript CG17732-RB 0.028
pico CG11940 gene product from transcript CG11940-RA 0.028
Gsc Goosecoid 0.028
sima similar 0.027
Ir7a Ionotropic receptor 7a 0.027
Obp56f Odorant-binding protein 56f 0.027
CG32523 CG32523 gene product from transcript CG32523-RA 0.026
aay astray 0.026
CG14072 CG14072 gene product from transcript CG14072-RA 0.026
CG32379 CG32379 gene product from transcript CG32379-RB 0.026
Gr92a Gustatory receptor 92a 0.026
Eip75B Ecdysone-induced protein 75B 0.026
CG31524 CG31524 gene product from transcript CG31524-RB 0.026
lectin-46Cb CG1652 gene product from transcript CG1652-RA 0.025
CG18301 CG18301 gene product from transcript CG18301-RA 0.025
TwdlF TweedleF 0.025
CG18581 CG18581 gene product from transcript CG18581-RA 0.025
CG13622 CG13622 gene product from transcript CG13622-RB 0.025
CG17917 CG17917 gene product from transcript CG17917-RA 0.024
SKIP Shal K[+] channel interacting protein 0.024
CG15539 CG15539 gene product from transcript CG15539-RA 0.024
Ugt58Fa CG4414 gene product from transcript CG4414-RA 0.024
Spn2 Serine protease inhibitor 2 0.023
CG15635 CG15635 gene product from transcript CG15635-RB 0.022
CG31515 CG31515 gene product from transcript CG31515-RA 0.022
Rab2 Rab-protein 2 0.022
CG10651 CG10651 gene product from transcript CG10651-RA 0.022
CG17472 CG17472 gene product from transcript CG17472-RA 0.022
CG31202 CG31202 gene product from transcript CG31202-RA 0.022
CG10029 CG10029 gene product from transcript CG10029-RA 0.022
CG9698 CG9698 gene product from transcript CG9698-RA 0.022
CG7579 CG7579 gene product from transcript CG7579-RA 0.022
CG6071 CG6071 gene product from transcript CG6071-RA 0.022
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Homo sapiens
Name Description Probability Func Analog Organism
PDIA3 protein disulfide isomerase family A, member 3 0.537
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.349
ERO1L ERO1-like (S. cerevisiae) 0.151
EGLN3 egl nine homolog 3 (C. elegans) 0.021
PKM2 pyruvate kinase, muscle 0.018
EPAS1 endothelial PAS domain protein 1 0.013
VHL von Hippel-Lindau tumor suppressor 0.011
EGLN1 egl nine homolog 1 (C. elegans) 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Surf4 surfeit 4 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism