The network for 'nucleobase biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.

Mus musculus
Name Description Probability Func Analog Organism
Ren1 renin 1 structural 0.088
Hif1a hypoxia inducible factor 1, alpha subunit 0.064
Gja1 gap junction protein, alpha 1 0.041
Rcc1 regulator of chromosome condensation 1 0.037
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.035
Rb1 retinoblastoma 1 0.035
Srm spermidine synthase 0.032
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.030
Atad3a ATPase family, AAA domain containing 3A 0.028
Rrp9 RRP9, small subunit (SSU) processome component, homolog (yeast) 0.024
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.024
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.024
Rrp1b ribosomal RNA processing 1 homolog B (S. cerevisiae) 0.023
Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.020
Mettl1 methyltransferase like 1 0.020
Agtr1a angiotensin II receptor, type 1a 0.019
Vars valyl-tRNA synthetase 0.018
Cdt1 chromatin licensing and DNA replication factor 1 0.018
Ints5 integrator complex subunit 5 0.018
E2f1 E2F transcription factor 1 0.017
Lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.017
Spp1 secreted phosphoprotein 1 0.017
Smyd5 SET and MYND domain containing 5 0.016
Vegfa vascular endothelial growth factor A 0.015
Grwd1 glutamate-rich WD repeat containing 1 0.015
Ung uracil DNA glycosylase 0.014
Mybbp1a MYB binding protein (P160) 1a 0.014
Tcof1 Treacher Collins Franceschetti syndrome 1, homolog 0.014
Timeless timeless homolog (Drosophila) 0.013
Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.013
Mybl2 myeloblastosis oncogene-like 2 0.012
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.012
Fpgs folylpolyglutamyl synthetase 0.012
Pdcd6 programmed cell death 6 0.012
BC048355 cDNA sequence BC048355 0.011
Phgdh 3-phosphoglycerate dehydrogenase 0.011
Ccnf cyclin F 0.011
Snrpa small nuclear ribonucleoprotein polypeptide A 0.011
Pgls 6-phosphogluconolactonase 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG7322 CG7322 gene product from transcript CG7322-RA 0.013
CG11089 CG11089 gene product from transcript CG11089-RD 0.013
Oat Ornithine aminotransferase precursor 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PRTFDC1 phosphoribosyl transferase domain containing 1 0.231
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 0.228
WDYHV1 WDYHV motif containing 1 0.218
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 0.182
LONP1 lon peptidase 1, mitochondrial 0.168
YARS tyrosyl-tRNA synthetase 0.122
GMPS guanine monphosphate synthetase 0.121
MARS methionyl-tRNA synthetase 0.097
PRPS2 phosphoribosyl pyrophosphate synthetase 2 0.091
IARS isoleucyl-tRNA synthetase 0.085
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.079
ODC1 ornithine decarboxylase 1 0.059
AARS alanyl-tRNA synthetase 0.052
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.045
MCM6 minichromosome maintenance complex component 6 0.044
VARS valyl-tRNA synthetase 0.044
GARS glycyl-tRNA synthetase 0.042
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.041
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.039
RFC2 replication factor C (activator 1) 2, 40kDa 0.039
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.038
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.038
PCNA proliferating cell nuclear antigen 0.035
UCK2 uridine-cytidine kinase 2 0.033
PUS1 pseudouridylate synthase 1 0.029
PHGDH phosphoglycerate dehydrogenase 0.029
TMEM97 transmembrane protein 97 0.029
SARS seryl-tRNA synthetase 0.028
PFAS phosphoribosylformylglycinamidine synthase 0.026
FTSJ1 FtsJ homolog 1 (E. coli) 0.026
USP50 ubiquitin specific peptidase 50 0.025
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.024
NUP93 nucleoporin 93kDa 0.022
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.022
RPIA ribose 5-phosphate isomerase A 0.022
SLBP stem-loop binding protein 0.021
BLMH bleomycin hydrolase 0.018
CYCS cytochrome c, somatic 0.018
KIAA0020 KIAA0020 0.018
TRIB3 tribbles homolog 3 (Drosophila) 0.017
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.017
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.016
RRP1B ribosomal RNA processing 1 homolog B (S. cerevisiae) 0.015
BYSL bystin-like 0.015
PTDSS1 phosphatidylserine synthase 1 0.014
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.014
IPO4 importin 4 0.013
SSRP1 structure specific recognition protein 1 0.013
CTBP2 C-terminal binding protein 2 0.012
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.012
NME1 non-metastatic cells 1, protein (NM23A) expressed in 0.012
CARS cysteinyl-tRNA synthetase 0.012
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.012
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.012
SMS spermine synthase 0.011
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.011
JUP junction plakoglobin 0.011
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.011
EIF1B eukaryotic translation initiation factor 1B 0.011
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.011
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.011
ACTL6A actin-like 6A 0.011
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.010
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.010
PSAT1 phosphoserine aminotransferase 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cfl2 cofilin 2, muscle 0.082
Rcn2 reticulocalbin 2, EF-hand calcium binding domain 0.081
Ola1 Obg-like ATPase 1 0.075
Fam92a1 family with sequence similarity 92, member A1 0.073
Pgrmc1 progesterone receptor membrane component 1 0.053
Rraga Ras-related GTP binding A 0.051
Prim1 DNA primase, p49 subunit 0.046
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.039
Ndn necdin homolog (mouse) 0.034
Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.031
Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 0.030
Chmp5 chromatin modifying protein 5 0.026
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.025
Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked 0.022
Dhfr dihydrofolate reductase 0.021
Txnl1 thioredoxin-like 1 0.020
Strap serine/threonine kinase receptor associated protein 0.019
Trappc6b trafficking protein particle complex 6B 0.019
Rnmt RNA (guanine-7-) methyltransferase 0.018
Brp16 brain protein 16 0.018
Wdr77 WD repeat domain 77 0.018
Cpsf2 cleavage and polyadenylation specific factor 2 0.017
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.017
Ypel5 yippee-like 5 (Drosophila) 0.017
Becn1 beclin 1, autophagy related 0.016
Gars glycyl-tRNA synthetase 0.016
Rabggtb Rab geranylgeranyltransferase, beta subunit 0.015
Scoc short coiled-coil protein 0.015
Zwint ZW10 interactor 0.015
Dld dihydrolipoamide dehydrogenase 0.015
Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.015
Pgam2 phosphoglycerate mutase 2 (muscle) 0.015
Ttn titin 0.015
Eif4e eukaryotic translation initiation factor 4E 0.014
Prpf3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.014
Bcat1 branched chain aminotransferase 1, cytosolic 0.014
Tnni2 troponin I type 2 (skeletal, fast) 0.013
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.013
Ndfip1 Nedd4 family interacting protein 1 0.013
Pdcd10 programmed cell death 10 0.013
Tsr2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.013
Prkar2b protein kinase, cAMP dependent regulatory, type II beta 0.013
Usp14 ubiquitin specific peptidase 14 0.013
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.012
Mybpc2 myosin binding protein C, fast-type 0.011
Pfn2 profilin 2 0.011
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.011
Aldh18a1 aldehyde dehydrogenase 18 family, member A1 0.011
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.011
Lmbrd1 LMBR1 domain containing 1 0.011
Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 0.010
Polr1a polymerase (RNA) I polypeptide A 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ADE13 Ade13p 0.038
APT2 Apt2p 0.031
ADE1 Ade1p 0.028
URA1 Ura1p 0.026
URA4 Ura4p 0.026
CLN1 Cln1p 0.025
UBA1 Uba1p 0.024
APT1 Apt1p 0.022
GUA1 Gua1p 0.021
URA2 Ura2p 0.021
DLD3 Dld3p 0.020
FUR1 Fur1p 0.020
ADE6 Ade6p 0.019
FSH1 Fsh1p 0.019
ZRC1 Zrc1p 0.018
UBX6 Ubx6p 0.018
MDS3 Mds3p 0.018
AAP1 Aap1p 0.017
NRM1 Nrm1p 0.017
CYS3 Cys3p 0.017
ADE2 Ade2p 0.016
TAE1 Tae1p 0.016
YJL070C hypothetical protein 0.016
ADE17 Ade17p 0.015
ADE12 Ade12p 0.015
YNL010W hypothetical protein 0.015
ECM30 Ecm30p 0.015
DCS2 Dcs2p 0.015
MNE1 Mne1p 0.014
HLR1 Hlr1p 0.014
PLB2 Plb2p 0.014
YDL121C hypothetical protein 0.014
PCL1 Pcl1p 0.014
HTS1 Hts1p 0.014
URA6 Ura6p 0.014
YJL144W hypothetical protein 0.013
PRT1 Prt1p 0.013
YLR264C-A hypothetical protein 0.013
SRD1 Srd1p 0.013
GLN1 Gln1p 0.013
LEU2 Leu2p 0.013
GUK1 Guk1p 0.013
URA3 Ura3p 0.013
ADE4 Ade4p 0.013
NUT2 Nut2p 0.013
MF(ALPHA)2 Mf(alpha)2p 0.013
PHM6 Phm6p 0.013
IMD2 Imd2p 0.013
BIO2 Bio2p 0.013
SPE3 Spe3p 0.013
SPL2 Spl2p 0.012
YAH1 Yah1p 0.012
DPH5 Dph5p 0.012
HXT3 Hxt3p 0.012
YLR162W hypothetical protein 0.012
MER1 Mer1p 0.012
YOL038C-A hypothetical protein 0.012
NMT1 Nmt1p 0.012
ARP10 Arp10p 0.012
YIR035C hypothetical protein 0.012
HAL5 Hal5p 0.012
UBP11 Ubp11p 0.011
LYS12 Lys12p 0.011
MF(ALPHA)1 Mf(alpha)1p 0.011
MET8 Met8p 0.011
GCV1 Gcv1p 0.011
CCS1 Ccs1p 0.011
MET17 Met17p 0.011
YEL073C hypothetical protein 0.011
TOS2 Tos2p 0.011
CLB1 Clb1p 0.011
SWC7 Swc7p 0.011
MSA2 Msa2p 0.011
SNF3 Snf3p 0.011
MDE1 Mde1p 0.011
PMU1 Pmu1p 0.011
WSC4 Wsc4p 0.011
KIN3 Kin3p 0.011
YBR013C hypothetical protein 0.011
YLR042C hypothetical protein 0.011
ATP6 Atp6p 0.011
CUP1-1 Cup1-1p 0.011
YPR157W hypothetical protein 0.011
FMT1 Fmt1p 0.011
CTP1 Ctp1p 0.011
SVS1 Svs1p 0.011
YAR068W hypothetical protein 0.011
YOL014W hypothetical protein 0.011
PHO3 Pho3p 0.010
YPR091C hypothetical protein 0.010
AUA1 Aua1p 0.010
FAA2 Faa2p 0.010
RKI1 Rki1p 0.010
YLR063W hypothetical protein 0.010
YOL013W-A hypothetical protein 0.010
SNU13 Snu13p 0.010
TMA108 Tma108p 0.010
MDN1 Mdn1p 0.010
ARE2 Are2p 0.010
UPS3 Ups3p 0.010