The network for 'positive regulation of camp mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of camp mediated signaling

Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

Mus musculus
Name Description Probability Func Analog Organism
Kiss1 KiSS-1 metastasis-suppressor 0.889
Kiss1r KISS1 receptor 0.790
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.728
Ghr growth hormone receptor 0.674
Gnrhr gonadotropin releasing hormone receptor 0.671
Lep leptin 0.602
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.524
Amhr2 anti-Mullerian hormone type 2 receptor 0.494
Cga glycoprotein hormones, alpha subunit 0.454
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.451
Tshr thyroid stimulating hormone receptor 0.424
Esr2 estrogen receptor 2 (beta) 0.396
Foxf2 forkhead box F2 0.388
Kl klotho 0.386
Ar androgen receptor 0.375
Drd2 dopamine receptor D2 0.349
Esr1 estrogen receptor 1 (alpha) 0.311
Gnrh1 gonadotropin releasing hormone 1 0.307
Cd247 CD247 antigen 0.287
Lmx1b LIM homeobox transcription factor 1 beta 0.238
Pax8 paired box gene 8 0.237
Pnpla2 patatin-like phospholipase domain containing 2 0.233
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.221
Lhb luteinizing hormone beta 0.178
Cckbr cholecystokinin B receptor 0.173
Npy2r neuropeptide Y receptor Y2 0.166
Neurog3 neurogenin 3 0.152
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.146
Wnt2b wingless related MMTV integration site 2b 0.146
Mpl myeloproliferative leukemia virus oncogene 0.141
Fshr follicle stimulating hormone receptor 0.137
Sspo SCO-spondin 0.135
Rgs9 regulator of G-protein signaling 9 0.131
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.127
Mybpc3 myosin binding protein C, cardiac 0.125
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.121
Igf2 insulin-like growth factor 2 0.117
Cybb cytochrome b-245, beta polypeptide 0.115
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.109
Tacr1 tachykinin receptor 1 0.106
Adrb3 adrenergic receptor, beta 3 0.100
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.098
Htra3 HtrA serine peptidase 3 0.095
Cma1 chymase 1, mast cell 0.095
Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 0.095
Rhbdf1 rhomboid family 1 (Drosophila) 0.093
Ptgds prostaglandin D2 synthase (brain) 0.092
Pcdh12 protocadherin 12 0.088
Angpt1 angiopoietin 1 0.088
Pdcd1 programmed cell death 1 0.083
Bglap bone gamma carboxyglutamate protein 0.082
Bglap2 bone gamma-carboxyglutamate protein 2 0.081
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.081
Ppyr1 pancreatic polypeptide receptor 1 0.080
Lcn3 lipocalin 3 0.080
Duox2 dual oxidase 2 0.080
Adrb2 adrenergic receptor, beta 2 0.079
Foxd3 forkhead box D3 0.078
Star steroidogenic acute regulatory protein 0.077
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.076
Drd3 dopamine receptor D3 0.075
Thrb thyroid hormone receptor beta 0.074
Oprk1 opioid receptor, kappa 1 0.074
Ccl8 chemokine (C-C motif) ligand 8 0.074
Acan aggrecan 0.073
Amh anti-Mullerian hormone 0.073
Gja10 gap junction protein, alpha 10 0.071
Wnt10b wingless related MMTV integration site 10b 0.071
Tpsb2 tryptase beta 2 0.070
Nhlh2 nescient helix loop helix 2 0.070
Fndc7 fibronectin type III domain containing 7 0.070
Adm adrenomedullin 0.066
Tgfa transforming growth factor alpha 0.064
Mmp24 matrix metallopeptidase 24 0.064
Cd86 CD86 antigen 0.064
Inha inhibin alpha 0.064
Fgf10 fibroblast growth factor 10 0.063
Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 0.061
Tlr5 toll-like receptor 5 0.061
Eda ectodysplasin-A 0.061
Lhx3 LIM homeobox protein 3 0.060
Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric 0.060
Lepr leptin receptor 0.060
Col4a3 collagen, type IV, alpha 3 0.059
Rho rhodopsin 0.058
Ccbp2 chemokine binding protein 2 0.058
Kcnk3 potassium channel, subfamily K, member 3 0.057
Nppb natriuretic peptide type B 0.056
Cdh4 cadherin 4 0.056
Sfrp4 secreted frizzled-related protein 4 0.055
Prlr prolactin receptor 0.055
Opn4 opsin 4 (melanopsin) 0.054
Prop1 paired like homeodomain factor 1 0.054
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.054
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.054
Clec4d C-type lectin domain family 4, member d 0.053
Tspan10 tetraspanin 10 0.053
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.052
Avpr1a arginine vasopressin receptor 1A 0.052
Pgr progesterone receptor 0.051
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MPDZ multiple PDZ domain protein 1.000
IL8 interleukin 8 0.984
CXCL3 chemokine (C-X-C motif) ligand 3 0.981
CCL5 chemokine (C-C motif) ligand 5 0.976
CCR5 chemokine (C-C motif) receptor 5 0.973
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.962
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.955
ARRB1 arrestin, beta 1 0.945
CXCL2 chemokine (C-X-C motif) ligand 2 0.889
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.782
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.780
CXCL11 chemokine (C-X-C motif) ligand 11 0.749
CCL20 chemokine (C-C motif) ligand 20 0.739
TBXA2R thromboxane A2 receptor 0.696
IFNG interferon, gamma 0.543
IL6 interleukin 6 (interferon, beta 2) 0.479
IL1B interleukin 1, beta 0.470
CXCL5 chemokine (C-X-C motif) ligand 5 0.355
CCR2 chemokine (C-C motif) receptor 2 0.348
CCL22 chemokine (C-C motif) ligand 22 0.340
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.338
CXCL10 chemokine (C-X-C motif) ligand 10 0.324
DPP4 dipeptidyl-peptidase 4 0.290
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.267
CXCR3 chemokine (C-X-C motif) receptor 3 0.199
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.196
NCF2 neutrophil cytosolic factor 2 0.148
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.145
CCL8 chemokine (C-C motif) ligand 8 0.130
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.127
CCL4 chemokine (C-C motif) ligand 4 0.119
CCL11 chemokine (C-C motif) ligand 11 0.115
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.107
CCR7 chemokine (C-C motif) receptor 7 0.097
IL10 interleukin 10 0.084
CXCR5 chemokine (C-X-C motif) receptor 5 0.078
CCL2 chemokine (C-C motif) ligand 2 0.077
CCL19 chemokine (C-C motif) ligand 19 0.074
CXCL13 chemokine (C-X-C motif) ligand 13 0.073
UBD ubiquitin D 0.072
CXCR2 chemokine (C-X-C motif) receptor 2 0.070
CCL7 chemokine (C-C motif) ligand 7 0.068
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.068
IL2RB interleukin 2 receptor, beta 0.062
CXCL9 chemokine (C-X-C motif) ligand 9 0.061
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.049
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.047
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.044
RAP1A RAP1A, member of RAS oncogene family 0.043
CD40LG CD40 ligand 0.042
ARRDC3 arrestin domain containing 3 0.040
GPR6 G protein-coupled receptor 6 0.038
CCR4 chemokine (C-C motif) receptor 4 0.037
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.036
SSTR2 somatostatin receptor 2 0.033
PTEN phosphatase and tensin homolog 0.032
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.032
PF4 platelet factor 4 0.032
TLR2 toll-like receptor 2 0.030
PF4V1 platelet factor 4 variant 1 0.030
SSTR3 somatostatin receptor 3 0.030
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.027
IL1R2 interleukin 1 receptor, type II 0.026
GHRHR growth hormone releasing hormone receptor 0.026
CCL3 chemokine (C-C motif) ligand 3 0.026
IL6R interleukin 6 receptor 0.024
HTR4 5-hydroxytryptamine (serotonin) receptor 4 0.022
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.021
BCL2A1 BCL2-related protein A1 0.021
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.021
CXCR1 chemokine (C-X-C motif) receptor 1 0.021
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.020
CCR9 chemokine (C-C motif) receptor 9 0.019
NCF1 neutrophil cytosolic factor 1 0.019
CLEC7A C-type lectin domain family 7, member A 0.019
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.019
OPRD1 opioid receptor, delta 1 0.019
PKN2 protein kinase N2 0.018
NUCB1 nucleobindin 1 0.017
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.017
TNF tumor necrosis factor 0.017
OPRM1 opioid receptor, mu 1 0.017
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.016
IRF4 interferon regulatory factor 4 0.015
SOD2 superoxide dismutase 2, mitochondrial 0.015
GPSM2 G-protein signaling modulator 2 0.015
ADRB1 adrenergic, beta-1-, receptor 0.015
IL4 interleukin 4 0.015
SELL selectin L 0.014
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.014
CCL13 chemokine (C-C motif) ligand 13 0.013
AQP9 aquaporin 9 0.013
IL1F5 interleukin 1 family, member 5 (delta) 0.013
IL1A interleukin 1, alpha 0.013
MAPK10 mitogen-activated protein kinase 10 0.013
CCR6 chemokine (C-C motif) receptor 6 0.013
SELE selectin E 0.013
KCNF1 potassium voltage-gated channel, subfamily F, member 1 0.013
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.012
CCL1 chemokine (C-C motif) ligand 1 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.041
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.034
Csf1 colony stimulating factor 1 (macrophage) 0.031
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.031
C1qbp complement component 1, q subcomponent binding protein 0.031
Il1a interleukin 1 alpha 0.028
Cxcl10 chemokine (C-X-C motif) ligand 10 0.027
Ccl5 chemokine (C-C motif) ligand 5 0.024
Cd247 Cd247 molecule 0.024
Mx1 myxovirus (influenza virus) resistance 1 0.024
Slc25a11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.022
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.022
Serpinb3 serine protease inhibitor B3 0.021
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.020
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.020
Atp5d ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.019
Uqcrc1 ubiquinol-cytochrome c reductase core protein I 0.019
Foxj3 forkhead box J3 0.018
Cxcl13 chemokine (C-X-C motif) ligand 13 0.017
Xcl1 chemokine (C motif) ligand 1 0.017
Pyy peptide YY (mapped) 0.016
Timm10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.016
Tecr trans-2,3-enoyl-CoA reductase 0.016
Tyrobp Tyro protein tyrosine kinase binding protein 0.016
Ccl2 chemokine (C-C motif) ligand 2 0.015
Il6 interleukin 6 0.015
LOC100360169 rCG21044-like 0.015
Cxcl11 chemokine (C-X-C motif) ligand 11 0.014
LOC56764 dnaj-like protein 0.014
Ubd ubiquitin D 0.013
Gpx4 glutathione peroxidase 4 0.013
Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 0.013
Oasl 2'-5'-oligoadenylate synthetase-like 0.013
Thbd thrombomodulin 0.013
Ccl20 chemokine (C-C motif) ligand 20 0.013
Oas1a 2'-5' oligoadenylate synthetase 1A 0.013
Pdyn prodynorphin 0.013
Il2rg interleukin 2 receptor, gamma 0.012
Rbp3 retinol binding protein 3, interstitial 0.012
Mrgprf MAS-related GPR, member F 0.012
Ccl4 chemokine (C-C motif) ligand 4 0.012
RGD1565168 similar to RAP2A, member of RAS oncogene family 0.012
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.012
Il1b interleukin 1 beta 0.012
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.012
Irf7 interferon regulatory factor 7 0.011
Aldoa aldolase A, fructose-bisphosphate 0.011
Trhr2 thyrotropin releasing hormone receptor 2 0.011
Nxph4 neurexophilin 4 0.011
Dnase1l3 deoxyribonuclease 1-like 3 0.011
Dspp dentin sialophosphoprotein 0.011
Glra1 glycine receptor, alpha 1 0.011
Cd14 CD14 molecule 0.011
Lhb luteinizing hormone beta 0.011
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.011
Igh-6 immunoglobulin heavy chain 6 0.011
Dock8 dedicator of cytokinesis 8 0.010
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.010
Grk4 G protein-coupled receptor kinase 4 0.010
Capn8 calpain 8 0.010
Nmnat2 nicotinamide nucleotide adenylyltransferase 2 0.010
Arhgap23 Rho GTPase activating protein 23 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism