The network for 'ear morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ear morphogenesis

The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

Mus musculus
Name Description Probability Func Analog Organism
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pax2 paired box gene 2 1.000
Foxc1 forkhead box C1 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Foxc2 forkhead box C2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Pax3 paired box gene 3 1.000
Chd7 chromodomain helicase DNA binding protein 7 1.000
Sox2 SRY-box containing gene 2 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Prrx1 paired related homeobox 1 0.999
Bmp4 bone morphogenetic protein 4 0.999
Tbx3 T-box 3 0.999
Fgf10 fibroblast growth factor 10 0.999
Tbx1 T-box 1 0.999
Foxg1 forkhead box G1 0.998
Fgf8 fibroblast growth factor 8 0.998
Dlx5 distal-less homeobox 5 0.997
Tcfap2a transcription factor AP-2, alpha 0.997
Otx2 orthodenticle homolog 2 (Drosophila) 0.996
Pax6 paired box gene 6 0.996
Hoxa1 homeobox A1 0.996
Hoxd13 homeobox D13 0.994
Tgfb2 transforming growth factor, beta 2 0.993
Cdh23 cadherin 23 (otocadherin) 0.993
Msx1 homeobox, msh-like 1 0.993
Nog noggin 0.993
Hand1 heart and neural crest derivatives expressed transcript 1 0.993
Hand2 heart and neural crest derivatives expressed transcript 2 0.992
Pax9 paired box gene 9 0.992
Jag1 jagged 1 0.988
Ptk7 PTK7 protein tyrosine kinase 7 0.987
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.987
Rarg retinoic acid receptor, gamma 0.987
Ednra endothelin receptor type A 0.986
Sall4 sal-like 4 (Drosophila) 0.986
Rarb retinoic acid receptor, beta 0.984
Gsc goosecoid homeobox 0.984
Sox9 SRY-box containing gene 9 0.984
Pou4f3 POU domain, class 4, transcription factor 3 0.984
Fgf3 fibroblast growth factor 3 0.977
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.977
Gata3 GATA binding protein 3 0.975
Lmx1b LIM homeobox transcription factor 1 beta 0.975
Ush1g Usher syndrome 1G homolog (human) 0.975
Fgfr1 fibroblast growth factor receptor 1 0.973
Isl1 ISL1 transcription factor, LIM/homeodomain 0.973
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.972
Pou3f3 POU domain, class 3, transcription factor 3 0.968
Pax8 paired box gene 8 0.968
Neurod1 neurogenic differentiation 1 0.966
Hoxa2 homeobox A2 0.966
Hoxd3 homeobox D3 0.965
Chrd chordin 0.947
Pbx1 pre B-cell leukemia transcription factor 1 0.946
Msx2 homeobox, msh-like 2 0.945
Sox11 SRY-box containing gene 11 0.943
Ret ret proto-oncogene 0.936
Hoxa13 homeobox A13 0.929
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.920
Hoxd11 homeobox D11 0.920
Bmp7 bone morphogenetic protein 7 0.918
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.913
Acvr1 activin A receptor, type 1 0.910
Gbx2 gastrulation brain homeobox 2 0.909
Hoxb1 homeobox B1 0.909
Myo15 myosin XV 0.907
Lhx3 LIM homeobox protein 3 0.902
Twist2 twist homolog 2 (Drosophila) 0.902
Smo smoothened homolog (Drosophila) 0.901
Sall3 sal-like 3 (Drosophila) 0.900
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.898
Wnt5a wingless-related MMTV integration site 5A 0.894
Pitx1 paired-like homeodomain transcription factor 1 0.892
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.890
Efnb2 ephrin B2 0.882
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.881
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.881
Trp63 transformation related protein 63 0.879
Zeb1 zinc finger E-box binding homeobox 1 0.877
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.874
Neurog2 neurogenin 2 0.873
Tbx15 T-box 15 0.872
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.872
Col2a1 collagen, type II, alpha 1 0.869
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.865
Hmx3 H6 homeobox 3 0.864
Lhx1 LIM homeobox protein 1 0.863
Grb10 growth factor receptor bound protein 10 0.859
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.853
Wnt3a wingless-related MMTV integration site 3A 0.848
Lef1 lymphoid enhancer binding factor 1 0.836
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.823
Alx4 aristaless-like homeobox 4 0.821
Scn5a sodium channel, voltage-gated, type V, alpha 0.818
Tbx10 T-box 10 0.818
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
eya1 eyes absent homolog 1 0.999
bmp4 bone morphogenetic protein 4 0.999
pax2a paired box gene 2a 0.995
sox2 SRY-box containing gene 2 0.988
hnf1ba HNF1 homeobox Ba 0.985
fgf8a fibroblast growth factor 8 a 0.970
fgf10a fibroblast growth factor 10a 0.964
fgf3 fibroblast growth factor 3 0.962
gli2a GLI-Kruppel family member GLI2a 0.960
fgfr1a fibroblast growth factor receptor 1a 0.944
dla deltaA 0.939
osr1 odd-skipped related 1 (Drosophila) 0.939
dlx2a distal-less homeobox gene 2a 0.937
chd chordin 0.933
gpr126 G protein-coupled receptor 126 0.930
fgfr4 fibroblast growth factor receptor 4 0.928
atoh1b atonal homolog 1b 0.918
gbx2 gastrulation brain homeo box 2 0.912
foxi1 forkhead box I1 0.911
bmp2b bone morphogenetic protein 2b 0.911
gata3 GATA-binding protein 3 0.902
msxc muscle segment homeobox C 0.895
tbx1 T-box 1 0.895
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.855
flh floating head 0.852
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.846
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.834
dlx3b distal-less homeobox gene 3b 0.824
atoh1a atonal homolog 1a 0.813
lft1 lefty1 0.799
six4b sine oculis homeobox homolog 4b 0.785
hoxb3a homeo box B3a 0.776
tfap2a transcription factor AP-2 alpha 0.762
foxc1a forkhead box C1a 0.750
hand2 heart and neural crest derivatives expressed transcript 2 0.746
bmp2a bone morphogenetic protein 2a 0.728
shha sonic hedgehog a 0.716
dlx4a distal-less homeobox gene 4a 0.713
lef1 lymphocyte enhancer binding factor 1 0.676
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.665
neurog1 neurogenin 1 0.663
fzd7a frizzled homolog 7a 0.659
dlx4b distal-less homeobox gene 4b 0.634
dlc deltaC 0.631
gata2a GATA-binding protein 2a 0.628
jag1b jagged 1b 0.614
wnt1 wingless-type MMTV integration site family, member 1 0.611
shhb sonic hedgehog b 0.608
sfrp1a secreted frizzled-related protein 1a 0.598
ncs1a neuronal calcium sensor 1a 0.595
fgf8b fibroblast growth factor 8 b 0.594
gbx1 gastrulation brain homeobox 1 0.588
myo7aa myosin VIIAa 0.584
hmx3 homeo box (H6 family) 3 0.574
foxg1a forkhead box G1a 0.562
pcdh8 protocadherin 8 0.559
dkk1b dickkopf 1b 0.559
twist3 twist3 0.558
emx3 empty spiracles homeobox 3 0.556
irx1b iroquois homeobox protein 1, b 0.555
igfbp3 insulin-like growth factor binding protein 3 0.533
sox3 SRY-box containing gene 3 0.528
snai1b snail homolog 1b (Drosophila) 0.525
jag2 jagged 2 0.525
prdm1a PR domain containing 1a, with ZNF domain 0.515
mib mind bomb 0.501
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.495
dacha dachshund a 0.495
fgf17 fibroblast growth factor 17 0.476
dlx2b distal-less homeobox gene 2b 0.472
lhx1a LIM homeobox 1a 0.466
foxa2 forkhead box A2 0.459
pcdh10b protocadherin 10b 0.452
dlx6a distal-less homeobox gene 6a 0.439
fzd8a frizzled homolog 8a 0.436
msxe muscle segment homeobox E 0.430
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.417
six4a sine oculis homeobox homolog 4a 0.405
dlx5a distal-less homeobox gene 5a 0.393
sox19a SRY-box containing gene 19a 0.387
sox9a SRY-box containing gene 9a 0.386
wif1 wnt inhibitory factor 1 0.383
neurod4 neurogenic differentiation 4 0.377
raraa retinoic acid receptor, alpha a 0.371
smad1 MAD homolog 1 (Drosophila) 0.369
rxrbb retinoid x receptor, beta b 0.366
has2 hyaluronan synthase 2 0.357
tp63 tumor protein p63 0.350
wnt5b wingless-type MMTV integration site family, member 5b 0.333
vax1 ventral anterior homeobox 1 0.332
aplnrb apelin receptor b 0.330
tgfb2 transforming growth factor, beta 2 0.330
notch2 notch homolog 2 0.327
ncam1b neural cell adhesion molecule 1b 0.322
pax9 paired box gene 9 0.305
hapln1a hyaluronan and proteoglycan link protein 1a 0.304
mmp2 matrix metalloproteinase 2 0.302
fzd10 frizzled homolog 10 0.301
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.300
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.300
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.597
TAL1 T-cell acute lymphocytic leukemia 1 0.369
COL1A1 collagen, type I, alpha 1 0.305
NOTCH1 notch 1 0.261
CHD7 chromodomain helicase DNA binding protein 7 0.201
SMAD1 SMAD family member 1 0.171
FSTL1 follistatin-like 1 0.168
VEGFA vascular endothelial growth factor A 0.152
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.149
CSNK1E casein kinase 1, epsilon 0.138
EGFR epidermal growth factor receptor 0.136
NOTCH3 notch 3 0.136
CHD8 chromodomain helicase DNA binding protein 8 0.129
PTCH1 patched 1 0.122
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.120
SMAD3 SMAD family member 3 0.118
TRIP6 thyroid hormone receptor interactor 6 0.095
INSR insulin receptor 0.090
SEC23A Sec23 homolog A (S. cerevisiae) 0.088
BMPR1A bone morphogenetic protein receptor, type IA 0.084
NKX2-1 NK2 homeobox 1 0.080
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.074
PPARA peroxisome proliferator-activated receptor alpha 0.065
MDFI MyoD family inhibitor 0.062
SOX2 SRY (sex determining region Y)-box 2 0.061
LAT linker for activation of T cells 0.060
CALCA calcitonin-related polypeptide alpha 0.053
COL2A1 collagen, type II, alpha 1 0.052
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.052
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.050
FGF10 fibroblast growth factor 10 0.050
BMP7 bone morphogenetic protein 7 0.049
BMP2 bone morphogenetic protein 2 0.049
BBS10 Bardet-Biedl syndrome 10 0.048
FOXA2 forkhead box A2 0.046
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.046
WT1 Wilms tumor 1 0.043
POU5F1 POU class 5 homeobox 1 0.042
USHBP1 Usher syndrome 1C binding protein 1 0.042
ZFYVE9 zinc finger, FYVE domain containing 9 0.040
MSX2 msh homeobox 2 0.040
BMP1 bone morphogenetic protein 1 0.039
TTN titin 0.038
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.033
FGF2 fibroblast growth factor 2 (basic) 0.032
SH3BP4 SH3-domain binding protein 4 0.031
AXIN1 axin 1 0.028
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.027
DHCR7 7-dehydrocholesterol reductase 0.024
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.024
IRS1 insulin receptor substrate 1 0.024
SNIP1 Smad nuclear interacting protein 1 0.020
SIX3 SIX homeobox 3 0.019
HOXC8 homeobox C8 0.019
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.019
KRTAP4-12 keratin associated protein 4-12 0.019
ELF5 E74-like factor 5 (ets domain transcription factor) 0.018
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.017
IDI1 isopentenyl-diphosphate delta isomerase 1 0.017
RSBN1 round spermatid basic protein 1 0.016
FZD1 frizzled homolog 1 (Drosophila) 0.016
HOXA11 homeobox A11 0.016
LRRK2 leucine-rich repeat kinase 2 0.016
PAX2 paired box 2 0.016
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.015
FGFR2 fibroblast growth factor receptor 2 0.015
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.015
LRP6 low density lipoprotein receptor-related protein 6 0.015
CEP164 centrosomal protein 164kDa 0.015
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.014
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.014
RET ret proto-oncogene 0.014
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.014
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.014
TBC1D10A TBC1 domain family, member 10A 0.014
HOXA9 homeobox A9 0.014
KCTD1 potassium channel tetramerisation domain containing 1 0.013
DLX2 distal-less homeobox 2 0.013
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.013
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.013
NGFR nerve growth factor receptor 0.013
SIM2 single-minded homolog 2 (Drosophila) 0.013
ZFP28 zinc finger protein 28 homolog (mouse) 0.013
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.013
RUNX1 runt-related transcription factor 1 0.013
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.013
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.013
CAV1 caveolin 1, caveolae protein, 22kDa 0.012
COL1A2 collagen, type I, alpha 2 0.012
SIX1 SIX homeobox 1 0.012
HMGA2 high mobility group AT-hook 2 0.012
PHF3 PHD finger protein 3 0.012
FRS2 fibroblast growth factor receptor substrate 2 0.012
YY1 YY1 transcription factor 0.012
SALL2 sal-like 2 (Drosophila) 0.012
FBLN1 fibulin 1 0.011
SC4MOL sterol-C4-methyl oxidase-like 0.011
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.011
GRB10 growth factor receptor-bound protein 10 0.011
ZADH2 zinc binding alcohol dehydrogenase domain containing 2 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism