The network for 'neuroblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuroblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.

Danio rerio
Name Description Probability Func Analog Organism
eng2a engrailed 2a 0.930
ascl1a achaete-scute complex-like 1a (Drosophila) 0.917
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.841
nkx2.2a NK2 transcription factor related 2a 0.711
alcama activated leukocyte cell adhesion molecule a 0.661
gata3 GATA-binding protein 3 0.656
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.619
barhl2 BarH-like 2 0.606
foxn4 forkhead box N4 0.514
lhx3 LIM homeobox 3 0.494
notch3 notch homolog 3 0.469
olig2 oligodendrocyte lineage transcription factor 2 0.467
evx1 even-skipped homeobox 1 0.465
pitx3 paired-like homeodomain transcription factor 3 0.461
sox2 SRY-box containing gene 2 0.451
dab1a disabled homolog 1a (Drosophila) 0.441
pax6a paired box gene 6a 0.429
neurod4 neurogenic differentiation 4 0.411
cdh2 cadherin 2, neuronal 0.403
ascl1b achaete-scute complex-like 1b (Drosophila) 0.402
sim1a single-minded homolog 1a (Drosophila) 0.394
met met proto-oncogene (hepatocyte growth factor receptor) 0.383
otpb orthopedia homolog b 0.377
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.353
pou3f3a POU class 3 homeobox 3a 0.351
dlb deltaB 0.340
irf6 interferon regulatory factor 6 0.334
nkx2.1a NK2 homeobox 1a 0.323
prox1 prospero-related homeobox gene 1 0.316
jag1b jagged 1b 0.296
neurog1 neurogenin 1 0.294
midn midnolin 0.291
pax8 paired box gene 8 0.284
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.282
dla deltaA 0.275
wnt8b wingless-type MMTV integration site family, member 8b 0.272
sox21a SRY-box containing gene 21a 0.263
pax6b paired box gene 6b 0.262
yap1 Yes-associated protein 1 0.244
eya1 eyes absent homolog 1 0.239
fgf8b fibroblast growth factor 8 b 0.232
jag2 jagged 2 0.219
gbx2 gastrulation brain homeo box 2 0.216
dcc deleted in colorectal carcinoma 0.210
krt4 keratin 4 0.200
ptf1a pancreas specific transcription factor, 1a 0.197
her9 hairy-related 9 0.194
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.194
brd2a bromodomain-containing 2a 0.190
emx3 empty spiracles homeobox 3 0.190
cdh1 cadherin 1, epithelial 0.189
nkx1.2la NK1 transcription factor related 2-like,a 0.180
rx3 retinal homeobox gene 3 0.178
otx2 orthodenticle homolog 2 0.175
neo1 neogenin 1 0.171
tp73 tumor protein p73 0.170
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.162
her8a hairy-related 8a 0.162
eng2b engrailed 2b 0.161
lhx5 LIM homeobox 5 0.155
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.155
hnf1ba HNF1 homeobox Ba 0.154
ntn1b netrin 1b 0.151
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.151
foxa1 forkhead box A1 0.142
inab internexin neuronal intermediate filament protein, alpha b 0.139
hgfa hepatocyte growth factor a 0.136
ntn1a netrin 1a 0.135
phox2a paired-like homeobox 2a 0.133
myod1 myogenic differentiation 1 0.130
vsx2 visual system homeobox 2 0.127
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.125
plp1a proteolipid protein 1a 0.125
unc5b unc-5 homolog B (C. elegans) 0.123
fzd8a frizzled homolog 8a 0.121
lamc1 laminin, gamma 1 0.121
gro1 groucho 1 0.120
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.119
arx aristaless related homeobox 0.119
fgfr1a fibroblast growth factor receptor 1a 0.118
otx1b orthodenticle homolog 1b 0.114
alcamb activated leukocyte cell adhesion molecule b 0.112
tfe3b transcription factor binding to IGHM enhancer 3b 0.110
fgfr2 fibroblast growth factor receptor 2 0.110
irx7 iroquois homeobox protein 7 0.110
efnb2a ephrin B2a 0.108
dlx3b distal-less homeobox gene 3b 0.107
pea3 ETS-domain transcription factor pea3 0.107
wnt9a wingless-type MMTV integration site family, member 9A 0.106
atoh1a atonal homolog 1a 0.105
chd7 chromodomain helicase DNA binding protein 7 0.103
mef2d myocyte enhancer factor 2d 0.103
notch1b notch homolog 1b 0.103
notch1a notch homolog 1a 0.102
srf serum response factor 0.101
nova2 neuro-oncological ventral antigen 2 0.100
ccnd1 cyclin D1 0.099
grhl2b grainyhead-like 2b (Drosophila) 0.098
gro2 groucho 2 0.095
btg1 B-cell translocation gene 1 0.094
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mam mastermind 0.946
SoxN SoxNeuro 0.940
wg wingless 0.928
gcm glial cells missing 0.906
pros prospero 0.900
numb CG3779 gene product from transcript CG3779-RB 0.890
gsb gooseberry 0.772
N Notch 0.764
Antp Antennapedia 0.749
hkb huckebein 0.711
Ubx Ultrabithorax 0.691
robo roundabout 0.673
gt giant 0.606
Pc Polycomb 0.602
en engrailed 0.591
kni knirps 0.564
ss spineless 0.556
spdo sanpodo 0.546
sca scabrous 0.523
Abd-B Abdominal B 0.520
comm commissureless 0.517
abd-A abdominal A 0.499
SAK Sak kinase 0.497
ph-p polyhomeotic proximal 0.482
slmb supernumerary limbs 0.470
grn grain 0.469
stan starry night 0.458
slp1 sloppy paired 1 0.454
sli slit 0.444
amos absent MD neurons and olfactory sensilla 0.426
sens senseless 0.423
E(spl) Enhancer of split 0.406
pdm2 POU domain protein 2 0.383
CycE Cyclin E 0.372
oc ocelliless 0.367
Pcl Polycomblike 0.323
stg string 0.321
ems empty spiracles 0.259
al aristaless 0.248
prd paired 0.246
aPKC atypical protein kinase C 0.231
Dll Distal-less 0.228
mira miranda 0.201
lea leak 0.193
nub nubbin 0.192
cas castor 0.191
Abl Abl tyrosine kinase 0.183
HLHm5 E(spl) region transcript m5 0.183
fz2 frizzled 2 0.173
ptc patched 0.166
rho rhomboid 0.158
mid midline 0.152
ro rough 0.151
salm spalt major 0.148
HLHmbeta E(spl) region transcript mbeta 0.146
rn rotund 0.144
pan pangolin 0.143
eyg eyegone 0.141
HLHmgamma E(spl) region transcript mgamma 0.139
nkd naked cuticle 0.135
gsb-n gooseberry-neuro 0.128
brat brain tumor 0.124
Ser Serrate 0.123
D Dichaete 0.123
lbe ladybird early 0.122
Caps Calcium activated protein for secretion 0.121
klu klumpfuss 0.120
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.117
hh hedgehog 0.117
slp2 sloppy paired 2 0.117
HGTX CG13475 gene product from transcript CG13475-RB 0.116
bab2 CG9102 gene product from transcript CG9102-RA 0.109
Traf4 TNF-receptor-associated factor 4 0.109
hth homothorax 0.106
Su(H) Suppressor of Hairless 0.103
fzy fizzy 0.102
ase asense 0.102
ovo CG6824 gene product from transcript CG6824-RE 0.097
sd scalloped 0.096
hb hunchback 0.096
HLHm7 E(spl) region transcript m7 0.095
slou slouch 0.093
da daughterless 0.091
dpn deadpan 0.090
ft fat 0.088
ds dachsous 0.088
Dfd Deformed 0.086
run runt 0.085
Dip1 Dorsal interacting protein 1 0.083
elav embryonic lethal abnormal vision 0.082
mi minus 0.082
Trim9 CG31721 gene product from transcript CG31721-RB 0.080
CycA Cyclin A 0.075
nerfin-1 nervous fingers 1 0.072
dy dusky 0.071
toy twin of eyeless 0.071
Hcf Host cell factor 0.070
ara araucan 0.069
trx trithorax 0.068
mirr mirror 0.064
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Sox2 SRY-box containing gene 2 1.000
Pax6 paired box gene 6 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Sall4 sal-like 4 (Drosophila) 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Fgf8 fibroblast growth factor 8 0.998
Pax2 paired box gene 2 0.998
Eya1 eyes absent 1 homolog (Drosophila) 0.996
Otx1 orthodenticle homolog 1 (Drosophila) 0.994
Emx1 empty spiracles homolog 1 (Drosophila) 0.993
Ctnnb1 catenin (cadherin associated protein), beta 1 0.993
Notch1 Notch gene homolog 1 (Drosophila) 0.992
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.991
Pou5f1 POU domain, class 5, transcription factor 1 0.989
Fgfr1 fibroblast growth factor receptor 1 0.988
Fgf10 fibroblast growth factor 10 0.987
Chd7 chromodomain helicase DNA binding protein 7 0.985
Foxc1 forkhead box C1 0.982
Pax3 paired box gene 3 0.981
Tcfap2a transcription factor AP-2, alpha 0.976
Psen1 presenilin 1 0.974
Msx2 homeobox, msh-like 2 0.972
Rxra retinoid X receptor alpha 0.967
Hes1 hairy and enhancer of split 1 (Drosophila) 0.966
Pitx2 paired-like homeodomain transcription factor 2 0.965
Gbx2 gastrulation brain homeobox 2 0.959
Msx1 homeobox, msh-like 1 0.958
Smo smoothened homolog (Drosophila) 0.953
Foxc2 forkhead box C2 0.947
Neurod1 neurogenic differentiation 1 0.946
Lmx1b LIM homeobox transcription factor 1 beta 0.946
Rarg retinoic acid receptor, gamma 0.944
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.918
Jag1 jagged 1 0.908
Foxg1 forkhead box G1 0.899
Lef1 lymphoid enhancer binding factor 1 0.897
Pten phosphatase and tensin homolog 0.893
Bmp4 bone morphogenetic protein 4 0.892
Pbx1 pre B-cell leukemia transcription factor 1 0.874
Emx2 empty spiracles homolog 2 (Drosophila) 0.872
En2 engrailed 2 0.859
Tbx1 T-box 1 0.850
Trp63 transformation related protein 63 0.841
Nanog Nanog homeobox 0.831
En1 engrailed 1 0.826
Isl1 ISL1 transcription factor, LIM/homeodomain 0.825
Hand2 heart and neural crest derivatives expressed transcript 2 0.820
Hand1 heart and neural crest derivatives expressed transcript 1 0.819
Nog noggin 0.801
Wnt1 wingless-related MMTV integration site 1 0.798
Trp53 transformation related protein 53 0.797
Gli2 GLI-Kruppel family member GLI2 0.785
Arid1a AT rich interactive domain 1A (SWI-like) 0.759
Wnt3a wingless-related MMTV integration site 3A 0.734
Efnb2 ephrin B2 0.725
Chd4 chromodomain helicase DNA binding protein 4 0.698
Rb1 retinoblastoma 1 0.694
Hoxa1 homeobox A1 0.681
Rara retinoic acid receptor, alpha 0.680
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.667
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.667
Dlx5 distal-less homeobox 5 0.647
Ptf1a pancreas specific transcription factor, 1a 0.638
Sox9 SRY-box containing gene 9 0.636
Neurog1 neurogenin 1 0.636
Sall1 sal-like 1 (Drosophila) 0.632
Neurog2 neurogenin 2 0.614
Fgf3 fibroblast growth factor 3 0.604
Lmx1a LIM homeobox transcription factor 1 alpha 0.601
Esrrb estrogen related receptor, beta 0.559
Dll1 delta-like 1 (Drosophila) 0.557
Hes5 hairy and enhancer of split 5 (Drosophila) 0.554
T brachyury 0.540
Prrx1 paired related homeobox 1 0.531
Insm1 insulinoma-associated 1 0.512
Lhx1 LIM homeobox protein 1 0.501
Id1 inhibitor of DNA binding 1 0.480
Bdnf brain derived neurotrophic factor 0.475
Hoxa13 homeobox A13 0.461
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.461
Vangl2 vang-like 2 (van gogh, Drosophila) 0.456
Rarb retinoic acid receptor, beta 0.430
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.429
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.426
Cdk2 cyclin-dependent kinase 2 0.422
Hoxa2 homeobox A2 0.412
Notch2 Notch gene homolog 2 (Drosophila) 0.406
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.405
Bmp7 bone morphogenetic protein 7 0.405
Sox11 SRY-box containing gene 11 0.371
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.364
Ikzf1 IKAROS family zinc finger 1 0.352
Zeb1 zinc finger E-box binding homeobox 1 0.350
Sox3 SRY-box containing gene 3 0.344
Tcfap2c transcription factor AP-2, gamma 0.334
Lrp6 low density lipoprotein receptor-related protein 6 0.332
Id2 inhibitor of DNA binding 2 0.329
Gsc goosecoid homeobox 0.319
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gsk3a glycogen synthase kinase 3 alpha 0.035
Sox13 SRY (sex determining region Y)-box 13 0.028
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.025
Top2a topoisomerase (DNA) II alpha 0.023
Atp2c1 ATPase, Ca++ transporting, type 2C, member 1 0.019
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.019
Dock6 dedicator of cytokinesis 6 0.018
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.018
Fgfr4 fibroblast growth factor receptor 4 0.018
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.017
Calcr calcitonin receptor 0.014
Timp3 TIMP metallopeptidase inhibitor 3 0.013
Foxj1 forkhead box J1 0.012
Cd4 Cd4 molecule 0.012
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.012
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.011
Mcm5 minichromosome maintenance complex component 5 0.011
Acan aggrecan 0.011
Pacs1 phosphofurin acidic cluster sorting protein 1 0.011
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.011
Gucy2c guanylate cyclase 2C 0.011
Wipf1 WAS/WASL interacting protein family, member 1 0.011
Syt11 synaptotagmin XI 0.011
Gjb4 gap junction protein, beta 4 0.011
Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.011
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.011
Hoxa2 homeo box A2 0.010
Ccbp2 chemokine binding protein 2 0.010
Unc5b unc-5 homolog B (C. elegans) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism