The network for 'regulation of cardiac muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardiac muscle tissue development

Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.941
kdrl kinase insert domain receptor like 0.882
mef2cb myocyte enhancer factor 2cb 0.801
fgf8a fibroblast growth factor 8 a 0.799
bmp4 bone morphogenetic protein 4 0.754
has2 hyaluronan synthase 2 0.691
gli1 GLI-Kruppel family member 1 0.620
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.530
tbx5a T-box 5a 0.515
nkx2.5 NK2 transcription factor related 5 0.501
meis2.2 myeloid ecotropic viral integration site 2.2 0.416
lft1 lefty1 0.406
spry4 sprouty (Drosophila) homolog 4 0.403
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.370
wnt1 wingless-type MMTV integration site family, member 1 0.341
wls wntless homolog (Drosophila) 0.332
pcdh8 protocadherin 8 0.322
hspb1 heat shock protein, alpha-crystallin-related, 1 0.321
wnt4a wingless-type MMTV integration site family, member 4a 0.317
dlc deltaC 0.303
wnt5b wingless-type MMTV integration site family, member 5b 0.299
fli1a friend leukemia integration 1a 0.279
fgfr1a fibroblast growth factor receptor 1a 0.268
gata5 GATA-binding protein 5 0.264
tbx2b T-box 2b 0.261
gata6 GATA-binding protein 6 0.259
fgf3 fibroblast growth factor 3 0.248
met met proto-oncogene (hepatocyte growth factor receptor) 0.247
fn1 fibronectin 1 0.241
gro1 groucho 1 0.238
mtp microsomal triglyceride transfer protein 0.235
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.230
tbx20 T-box 20 0.229
gpia glucose phosphate isomerase a 0.220
drl draculin 0.213
klf4 Kruppel-like factor 4 0.210
twist1a twist1a 0.208
alcamb activated leukocyte cell adhesion molecule b 0.202
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.201
wnt11r wingless-type MMTV integration site family, member 11, related 0.199
klf4a Kruppel-like transcription factor 4a 0.191
boc brother of CDO 0.183
esr2a estrogen receptor 2a 0.178
etv2 ets variant gene 2 0.178
gro2 groucho 2 0.171
vasa vasa homolog 0.171
vcana versican a 0.160
hand2 heart and neural crest derivatives expressed transcript 2 0.158
crip2 cysteine-rich protein 2 0.157
oep one-eyed pinhead 0.153
tbx2a T-box gene 2a 0.153
wnt8a wingless-type MMTV integration site family, member 8a 0.152
pdlim7 PDZ and LIM domain 7 0.150
sema3aa semaphorin 3aa 0.142
smad9 MAD homolog 9 (Drosophila) 0.138
rasgef1ba RasGEF domain family, member 1Ba 0.135
wu:fv91b12 wu:fv91b12 0.134
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.131
myf5 myogenic factor 5 0.129
gbx2 gastrulation brain homeo box 2 0.129
fzd7b frizzled homolog 7b 0.125
igf1rb insulin-like growth factor 1b receptor 0.125
lft2 lefty2 0.120
myl7 myosin, light polypeptide 7, regulatory 0.119
mef2ca myocyte enhancer factor 2ca 0.119
wnt3 wingless-type MMTV integration site family, member 3 0.116
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.114
dld deltaD 0.113
chd chordin 0.112
pld1a phospholipase D1a 0.111
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.109
scube2 signal peptide, CUB domain, EGF-like 2 0.109
pax2a paired box gene 2a 0.105
rbpms2 RNA binding protein with multiple splicing 2 0.101
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.099
esrra estrogen-related receptor alpha 0.097
sox21a SRY-box containing gene 21a 0.097
aplnrb apelin receptor b 0.097
wnt8b wingless-type MMTV integration site family, member 8b 0.097
sfrp1a secreted frizzled-related protein 1a 0.096
efnb3b ephrin B3b 0.095
fyna FYN oncogene related to SRC, FGR, YES a 0.094
fgf17 fibroblast growth factor 17 0.094
tbx18 T-box 18 0.092
foxj1a forkhead box J1a 0.092
ttna titin a 0.092
kif23 kinesin family member 23 0.088
hspb12 heat shock protein, alpha-crystallin-related, b12 0.087
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.086
her7 hairy and enhancer of split related-7 0.084
lats1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.084
hnf1ba HNF1 homeobox Ba 0.084
zbtb4 zinc finger and BTB domain containing 4 0.083
prickle1a prickle-like 1 (Drosophila) a 0.083
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.083
smyd1b SET and MYND domain containing 1b 0.083
sulf1 sulfatase 1 0.082
fstl1b follistatin-like 1b 0.081
rxrab retinoid x receptor, alpha b 0.081
tead3a TEA domain family member 3 a 0.081
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
TBX5 T-box 5 0.999
FGF10 fibroblast growth factor 10 0.991
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.991
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.988
FGFR1 fibroblast growth factor receptor 1 0.937
JAG1 jagged 1 0.895
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.888
BMPR1A bone morphogenetic protein receptor, type IA 0.864
LRP6 low density lipoprotein receptor-related protein 6 0.839
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.797
FGF2 fibroblast growth factor 2 (basic) 0.741
EP300 E1A binding protein p300 0.709
NOTCH1 notch 1 0.553
HDAC4 histone deacetylase 4 0.416
FSTL1 follistatin-like 1 0.402
MAML1 mastermind-like 1 (Drosophila) 0.301
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.266
TGFB1 transforming growth factor, beta 1 0.250
FGF7 fibroblast growth factor 7 0.242
FZD1 frizzled homolog 1 (Drosophila) 0.235
MEF2A myocyte enhancer factor 2A 0.221
KAT2B K(lysine) acetyltransferase 2B 0.215
BMP2 bone morphogenetic protein 2 0.197
HDAC1 histone deacetylase 1 0.176
GATA4 GATA binding protein 4 0.169
FRS2 fibroblast growth factor receptor substrate 2 0.161
WWOX WW domain containing oxidoreductase 0.152
NCK2 NCK adaptor protein 2 0.141
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.140
LRRK2 leucine-rich repeat kinase 2 0.133
PLCG1 phospholipase C, gamma 1 0.128
RUNX1 runt-related transcription factor 1 0.124
TGFB3 transforming growth factor, beta 3 0.120
KRT5 keratin 5 0.114
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.112
NOTCH3 notch 3 0.109
CABLES1 Cdk5 and Abl enzyme substrate 1 0.096
FGF8 fibroblast growth factor 8 (androgen-induced) 0.095
HDAC9 histone deacetylase 9 0.091
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.086
ESR1 estrogen receptor 1 0.085
TP73 tumor protein p73 0.082
SATB2 SATB homeobox 2 0.082
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.079
TTR transthyretin 0.076
SMAD7 SMAD family member 7 0.072
DLG2 discs, large homolog 2 (Drosophila) 0.072
BMP7 bone morphogenetic protein 7 0.068
FGF4 fibroblast growth factor 4 0.063
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.063
AXIN1 axin 1 0.060
KLF13 Kruppel-like factor 13 0.059
MYOD1 myogenic differentiation 1 0.058
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.058
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.057
NRP1 neuropilin 1 0.053
FZD8 frizzled homolog 8 (Drosophila) 0.049
ATXN1L ataxin 1-like 0.045
KRT6C keratin 6C 0.044
TGFB2 transforming growth factor, beta 2 0.044
WNT3A wingless-type MMTV integration site family, member 3A 0.040
SIRT1 sirtuin 1 0.039
NCOA1 nuclear receptor coactivator 1 0.038
NCOA3 nuclear receptor coactivator 3 0.037
MKL1 megakaryoblastic leukemia (translocation) 1 0.034
HIPK2 homeodomain interacting protein kinase 2 0.032
TRO trophinin 0.030
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.029
LBX1 ladybird homeobox 1 0.028
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.025
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.025
FGFR3 fibroblast growth factor receptor 3 0.024
PTGIS prostaglandin I2 (prostacyclin) synthase 0.024
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.023
WNT3 wingless-type MMTV integration site family, member 3 0.022
AR androgen receptor 0.022
NCOR2 nuclear receptor corepressor 2 0.021
SNAI1 snail homolog 1 (Drosophila) 0.021
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.020
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.019
NOG noggin 0.019
FOXF1 forkhead box F1 0.018
AHR aryl hydrocarbon receptor 0.018
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.018
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.017
SPEN spen homolog, transcriptional regulator (Drosophila) 0.017
FST follistatin 0.017
FOXA2 forkhead box A2 0.017
GAB2 GRB2-associated binding protein 2 0.017
GATAD2B GATA zinc finger domain containing 2B 0.016
NOSTRIN nitric oxide synthase trafficker 0.016
PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B 0.016
VEGFA vascular endothelial growth factor A 0.016
RAX retina and anterior neural fold homeobox 0.016
TBX1 T-box 1 0.014
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.014
CIR1 corepressor interacting with RBPJ, 1 0.014
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Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Tbx3 T-box 3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Efnb2 ephrin B2 1.000
Gata4 GATA binding protein 4 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Pax2 paired box gene 2 0.999
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.999
Foxc2 forkhead box C2 0.999
Foxc1 forkhead box C1 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Tbx1 T-box 1 0.999
Bmp4 bone morphogenetic protein 4 0.998
Ntf3 neurotrophin 3 0.998
Gli2 GLI-Kruppel family member GLI2 0.997
Jag1 jagged 1 0.996
Tgfb2 transforming growth factor, beta 2 0.994
Hand1 heart and neural crest derivatives expressed transcript 1 0.992
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.991
Gata6 GATA binding protein 6 0.989
Notch1 Notch gene homolog 1 (Drosophila) 0.988
Pax3 paired box gene 3 0.987
Hoxa1 homeobox A1 0.986
Chrd chordin 0.986
Wnt3a wingless-related MMTV integration site 3A 0.985
Meox2 mesenchyme homeobox 2 0.983
Sox9 SRY-box containing gene 9 0.972
Hoxa13 homeobox A13 0.971
Prrx1 paired related homeobox 1 0.962
Fgf10 fibroblast growth factor 10 0.961
Ctnnb1 catenin (cadherin associated protein), beta 1 0.956
T brachyury 0.941
Tbx5 T-box 5 0.940
Fgfr1 fibroblast growth factor receptor 1 0.940
Nog noggin 0.934
Vangl2 vang-like 2 (van gogh, Drosophila) 0.899
Rxra retinoid X receptor alpha 0.895
Trp63 transformation related protein 63 0.889
Zfpm2 zinc finger protein, multitype 2 0.889
Twist2 twist homolog 2 (Drosophila) 0.888
Rarb retinoic acid receptor, beta 0.887
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.887
Fgfr3 fibroblast growth factor receptor 3 0.886
Hoxd11 homeobox D11 0.879
Ptch1 patched homolog 1 0.870
Psen1 presenilin 1 0.864
Nos3 nitric oxide synthase 3, endothelial cell 0.860
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.839
Smad6 MAD homolog 6 (Drosophila) 0.833
Foxf1a forkhead box F1a 0.816
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.807
Nodal nodal 0.800
Zeb1 zinc finger E-box binding homeobox 1 0.794
Hoxd13 homeobox D13 0.792
Tbx2 T-box 2 0.780
Apc adenomatosis polyposis coli 0.731
Tcf21 transcription factor 21 0.721
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.701
Msx2 homeobox, msh-like 2 0.696
Pitx1 paired-like homeodomain transcription factor 1 0.662
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.661
Fgf3 fibroblast growth factor 3 0.656
Rarg retinoic acid receptor, gamma 0.655
Gdf5 growth differentiation factor 5 0.653
Bdnf brain derived neurotrophic factor 0.641
Otx2 orthodenticle homolog 2 (Drosophila) 0.627
Hoxa11 homeobox A11 0.609
Tbx15 T-box 15 0.599
Pten phosphatase and tensin homolog 0.582
Gdnf glial cell line derived neurotrophic factor 0.578
Chd7 chromodomain helicase DNA binding protein 7 0.570
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.564
Gata5 GATA binding protein 5 0.544
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.540
Pou5f1 POU domain, class 5, transcription factor 1 0.530
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.528
Alx4 aristaless-like homeobox 4 0.528
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.525
Gsc goosecoid homeobox 0.516
Sall4 sal-like 4 (Drosophila) 0.513
Sox2 SRY-box containing gene 2 0.509
Acvr1 activin A receptor, type 1 0.492
Bmp5 bone morphogenetic protein 5 0.485
Pou3f3 POU domain, class 3, transcription factor 3 0.484
Gbx2 gastrulation brain homeobox 2 0.468
Msx1 homeobox, msh-like 1 0.464
Lhx1 LIM homeobox protein 1 0.455
Epha4 Eph receptor A4 0.454
Dlx5 distal-less homeobox 5 0.452
Vegfa vascular endothelial growth factor A 0.447
Gsk3b glycogen synthase kinase 3 beta 0.447
Lrp6 low density lipoprotein receptor-related protein 6 0.437
Egfr epidermal growth factor receptor 0.430
Mesp1 mesoderm posterior 1 0.421
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.419
Lmx1a LIM homeobox transcription factor 1 alpha 0.390
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.389
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100362824 caveolin 2-like 0.467
Cav1 caveolin 1, caveolae protein 0.400
Cdkn3 cyclin-dependent kinase inhibitor 3 0.292
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.236
Cav2 caveolin 2 0.172
Top2a topoisomerase (DNA) II alpha 0.163
Ube2c ubiquitin-conjugating enzyme E2C 0.163
Phkg1 phosphorylase kinase, gamma 1 0.121
Traf4af1 TRAF4 associated factor 1 0.106
Syt8 synaptotagmin VIII 0.105
Strn striatin, calmodulin binding protein 0.096
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.096
Nos3 nitric oxide synthase 3, endothelial cell 0.094
Ccnb2 cyclin B2 0.079
Gja3 gap junction protein, alpha 3 0.078
Pdc phosducin 0.066
Prrx1 paired related homeobox 1 0.063
Sqle squalene epoxidase 0.060
Fgf16 fibroblast growth factor 16 0.056
Pttg1 pituitary tumor-transforming 1 0.053
Kitlg KIT ligand 0.053
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.052
Fgfr2 fibroblast growth factor receptor 2 0.052
Prp15 proline-rich protein 15 0.050
Cdk1 cyclin-dependent kinase 1 0.050
Prl8a2 prolactin family 8, subfamily a, member 2 0.047
Ccnb1 cyclin B1 0.046
Ppy pancreatic polypeptide 0.043
Timp3 TIMP metallopeptidase inhibitor 3 0.040
Tacr2 tachykinin receptor 2 0.039
Fgf14 fibroblast growth factor 14 0.039
Tnni1 troponin I type 1 (skeletal, slow) 0.038
Rrm2 ribonucleotide reductase M2 0.037
Racgap1 Rac GTPase-activating protein 1 0.036
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.036
Oprd1 opioid receptor, delta 1 0.036
Prkca protein kinase C, alpha 0.036
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.035
Adarb2 adenosine deaminase, RNA-specific, B2 0.035
Dmd dystrophin 0.033
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.032
Musk muscle, skeletal, receptor tyrosine kinase 0.030
Smad7 SMAD family member 7 0.030
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.030
Synpo synaptopodin 0.029
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.029
Pcdhgc3 protocadherin gamma subfamily C, 3 0.029
Hpcal4 hippocalcin-like 4 0.029
Svs1 seminal vesicle secretory protein 1 0.029
Gfi1 growth factor independent 1 transcription repressor 0.029
Ehd2 EH-domain containing 2 0.028
Svs4 seminal vesicle secretory protein 4 0.027
Cks2 CDC28 protein kinase regulatory subunit 2 0.027
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.027
Met met proto-oncogene 0.026
Smad3 SMAD family member 3 0.026
Crybb2 crystallin, beta B2 0.025
Ncan neurocan 0.025
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.025
Mcam melanoma cell adhesion molecule 0.024
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.024
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.024
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.024
Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.024
Ldhc lactate dehydrogenase C 0.023
Lamc1 laminin, gamma 1 0.023
Foxi2 forkhead box I2 0.023
Chrm1 cholinergic receptor, muscarinic 1 0.023
Tpc1808 tropic 1808 0.022
Kifc1 kinesin family member C1 0.022
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.022
Ednra endothelin receptor type A 0.022
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.021
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.021
Prl prolactin 0.021
Ngf nerve growth factor (beta polypeptide) 0.021
Fam70b family with sequence similarity 70, member B 0.021
Notch2 Notch homolog 2 (Drosophila) 0.021
Galr2 galanin receptor 2 0.021
Dusp4 dual specificity phosphatase 4 0.020
Creb1 cAMP responsive element binding protein 1 0.020
Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.020
Olr837 olfactory receptor 837 0.020
Cdca3 cell division cycle associated 3 0.020
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.019
Igfbp5 insulin-like growth factor binding protein 5 0.019
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.019
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.019
Olfml2b olfactomedin-like 2B 0.018
Pnliprp1 pancreatic lipase-related protein 1 0.018
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.018
LOC689399 hypothetical protein LOC689399 0.018
Stx2 syntaxin 2 0.018
Stmn1 stathmin 1 0.017
Hspb2 heat shock protein beta 2 0.017
Cpxm2 carboxypeptidase X (M14 family), member 2 0.017
Dnah2 dynein, axonemal, heavy chain 2 0.017
Ghr growth hormone receptor 0.017
Il11 interleukin 11 0.017
Nrg1 neuregulin 1 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism