The network for 'ventricular cardiac muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ventricular cardiac muscle tissue development

The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.923
tal1 T-cell acute lymphocytic leukemia 1 0.873
ttna titin a 0.761
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.752
tnni1b troponin I, skeletal, slow b 0.744
tnnc1b troponin C type 1b (slow) 0.742
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.719
alcama activated leukocyte cell adhesion molecule a 0.673
smyhc2 slow myosin heavy chain 2 0.635
vmhc ventricular myosin heavy chain 0.562
tnni1al troponin I, skeletal, slow like 0.506
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.457
tnnt3a troponin T3a, skeletal, fast 0.453
gata5 GATA-binding protein 5 0.428
nkx2.5 NK2 transcription factor related 5 0.417
smyhc1l slow myosin heavy chain 1, like 0.408
actn3b actinin alpha 3b 0.408
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.398
cmlc1 cardiac myosin light chain-1 0.393
tnnt3b troponin T3b, skeletal, fast 0.360
smyd1b SET and MYND domain containing 1b 0.358
rbm24a RNA binding motif protein 24a 0.339
gata6 GATA-binding protein 6 0.333
lmo2 LIM domain only 2 (rhombotin-like 1) 0.328
foxc1a forkhead box C1a 0.320
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.314
myod1 myogenic differentiation 1 0.310
tbx20 T-box 20 0.310
tbx5a T-box 5a 0.299
tnni2a.4 troponin I, skeletal, fast 2a.4 0.285
hhex hematopoietically expressed homeobox 0.285
actc1b actin, alpha, cardiac muscle 1b 0.267
actc1a actin, alpha, cardiac muscle 1a 0.262
myl7 myosin, light polypeptide 7, regulatory 0.260
hand2 heart and neural crest derivatives expressed transcript 2 0.255
smyhc1 slow myosin heavy chain 1 0.238
tnnt2a troponin T2a, cardiac 0.216
ogg1 8-oxoguanine DNA glycosylase 0.188
wls wntless homolog (Drosophila) 0.186
unc45b unc-45 homolog B (C. elegans) 0.184
fn1 fibronectin 1 0.179
col11a1b collagen type XI alpha-1b and collagen, type XI, alpha 1b 0.176
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.171
dlc deltaC 0.156
hnf1ba HNF1 homeobox Ba 0.151
hsp90a.1 heat shock protein 90-alpha 1 0.150
bmp10 bone morphogenetic protein 10 0.146
tbx2b T-box 2b 0.145
fli1a friend leukemia integration 1a 0.141
tbx2a T-box gene 2a 0.139
tnnc2 troponin C type 2 (fast) 0.138
pdlim7 PDZ and LIM domain 7 0.136
aplnrb apelin receptor b 0.134
tmem88a transmembrane protein 88 a 0.131
ccm2 cerebral cavernous malformation 2 0.129
wu:fb01h12 wu:fb01h12 0.126
ckma creatine kinase, muscle a 0.123
fancd2 Fanconi anemia, complementation group D2 0.118
wnt11r wingless-type MMTV integration site family, member 11, related 0.110
rargb retinoic acid receptor, gamma b 0.107
gata2a GATA-binding protein 2a 0.106
mylk3 myosin light chain kinase 3 0.106
gata3 GATA-binding protein 3 0.105
wu:fb36d12 wu:fb36d12 0.104
tnnt1 troponin T1, skeletal, slow 0.102
ryr3 ryanodine receptor 3 0.100
rnasel1 ribonuclease like 1 0.098
hspa12b heat shock protein 12B 0.097
pax6b paired box gene 6b 0.096
etv2 ets variant gene 2 0.094
mef2cb myocyte enhancer factor 2cb 0.093
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.092
mef2ca myocyte enhancer factor 2ca 0.086
zgc:66286 zgc:66286 0.084
vmhcl ventricular myosin heavy chain-like 0.084
isl1 islet1 0.083
bcdo2l beta-carotene 15, 15-dioxygenase 2, like 0.082
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.081
her9 hairy-related 9 0.080
myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.080
cetn2 centrin, EF-hand protein, 2 0.079
srl sarcalumenin 0.079
robo4 roundabout homolog 4 0.073
ndr2 nodal-related 2 0.073
mybpc3 myosin binding protein C, cardiac 0.069
isl2a islet2a 0.067
fli1b friend leukemia integration 1b 0.066
cx36.7 connexin 36.7 0.066
tp63 tumor protein p63 0.065
tiparp TCDD-inducible poly(ADP-ribose) polymerase 0.064
LOC100149148 novel protein similar to myosin heavy chain 4 (myhc4) 0.063
ptprja protein tyrosine phosphatase, receptor type, J a 0.062
nppa natriuretic peptide precursor A 0.061
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.061
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.060
rxrga retinoid x receptor, gamma a 0.059
bmp3 bone morphogenetic protein 3 0.059
actn2 actinin, alpha 2 0.058
notch1b notch homolog 1b 0.058
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.058
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TNNC1 troponin C type 1 (slow) 0.995
TNNI1 troponin I type 1 (skeletal, slow) 0.991
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.974
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.940
TPM1 tropomyosin 1 (alpha) 0.896
DSP desmoplakin 0.717
TBX5 T-box 5 0.685
MYH9 myosin, heavy chain 9, non-muscle 0.678
TNNI2 troponin I type 2 (skeletal, fast) 0.678
TNNT2 troponin T type 2 (cardiac) 0.646
TPM2 tropomyosin 2 (beta) 0.631
SMYD1 SET and MYND domain containing 1 0.616
CKM creatine kinase, muscle 0.543
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.477
TNNT3 troponin T type 3 (skeletal, fast) 0.454
FGF1 fibroblast growth factor 1 (acidic) 0.423
ACVR1B activin A receptor, type IB 0.389
TAL1 T-cell acute lymphocytic leukemia 1 0.376
NOTCH1 notch 1 0.367
SFN stratifin 0.359
ACTA1 actin, alpha 1, skeletal muscle 0.328
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.326
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.287
TRIM63 tripartite motif containing 63 0.286
LDB3 LIM domain binding 3 0.278
JUP junction plakoglobin 0.275
GATA4 GATA binding protein 4 0.274
JAG1 jagged 1 0.268
SETD8 SET domain containing (lysine methyltransferase) 8 0.214
FGF10 fibroblast growth factor 10 0.209
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.206
MYBPC2 myosin binding protein C, fast type 0.190
KRT14 keratin 14 0.182
HNF4A hepatocyte nuclear factor 4, alpha 0.178
HAP1 huntingtin-associated protein 1 0.164
PSEN1 presenilin 1 0.147
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.145
RARA retinoic acid receptor, alpha 0.141
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.129
SMAD3 SMAD family member 3 0.116
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.114
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.114
TNNT1 troponin T type 1 (skeletal, slow) 0.112
PDLIM7 PDZ and LIM domain 7 (enigma) 0.104
PKP2 plakophilin 2 0.102
TNNC2 troponin C type 2 (fast) 0.098
FLNA filamin A, alpha 0.097
KRT18 keratin 18 0.085
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.083
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.079
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.078
GSK3B glycogen synthase kinase 3 beta 0.074
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.074
NOTCH3 notch 3 0.072
KRT8 keratin 8 0.064
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.064
ACTN1 actinin, alpha 1 0.061
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.059
MYBPC1 myosin binding protein C, slow type 0.054
MYOD1 myogenic differentiation 1 0.054
SMAD9 SMAD family member 9 0.053
CXXC5 CXXC finger protein 5 0.053
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.051
DES desmin 0.051
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.050
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.050
MAML1 mastermind-like 1 (Drosophila) 0.049
ACTN3 actinin, alpha 3 0.047
PDX1 pancreatic and duodenal homeobox 1 0.041
TGFBR1 transforming growth factor, beta receptor 1 0.041
MARK3 MAP/microtubule affinity-regulating kinase 3 0.040
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.040
MED25 mediator complex subunit 25 0.039
GATA2 GATA binding protein 2 0.038
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.036
MYBPH myosin binding protein H 0.035
CTBP2 C-terminal binding protein 2 0.034
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.033
CORO1C coronin, actin binding protein, 1C 0.030
ACTB actin, beta 0.030
TPM4 tropomyosin 4 0.029
ANK1 ankyrin 1, erythrocytic 0.028
SOX7 SRY (sex determining region Y)-box 7 0.028
SMAD6 SMAD family member 6 0.027
SLN sarcolipin 0.027
ACTC1 actin, alpha, cardiac muscle 1 0.026
TNNI3 troponin I type 3 (cardiac) 0.026
PTPRJ protein tyrosine phosphatase, receptor type, J 0.025
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.025
CDK19 cyclin-dependent kinase 19 0.024
PGAM2 phosphoglycerate mutase 2 (muscle) 0.024
RBBP4 retinoblastoma binding protein 4 0.023
MB myoglobin 0.021
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.021
FGF7 fibroblast growth factor 7 0.020
SKIL SKI-like oncogene 0.020
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.019
MYH4 myosin, heavy chain 4, skeletal muscle 0.019
CASQ2 calsequestrin 2 (cardiac muscle) 0.019
TGFB1 transforming growth factor, beta 1 0.019
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.998
Pitx2 paired-like homeodomain transcription factor 2 0.991
Hand2 heart and neural crest derivatives expressed transcript 2 0.991
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.986
Otx2 orthodenticle homolog 2 (Drosophila) 0.979
Hand1 heart and neural crest derivatives expressed transcript 1 0.973
Gata4 GATA binding protein 4 0.971
Fgfr2 fibroblast growth factor receptor 2 0.959
Isl1 ISL1 transcription factor, LIM/homeodomain 0.959
Notch1 Notch gene homolog 1 (Drosophila) 0.946
Tlx3 T-cell leukemia, homeobox 3 0.932
Gli3 GLI-Kruppel family member GLI3 0.931
Tbx3 T-box 3 0.909
Foxc1 forkhead box C1 0.895
Hoxd13 homeobox D13 0.883
Pax2 paired box gene 2 0.832
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.802
Bmp4 bone morphogenetic protein 4 0.793
Fgfr3 fibroblast growth factor receptor 3 0.784
Lhx3 LIM homeobox protein 3 0.778
Smad6 MAD homolog 6 (Drosophila) 0.766
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.702
Scn5a sodium channel, voltage-gated, type V, alpha 0.697
Tbx5 T-box 5 0.695
Tbx1 T-box 1 0.684
Jag1 jagged 1 0.649
Smad4 MAD homolog 4 (Drosophila) 0.644
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.614
Pitx1 paired-like homeodomain transcription factor 1 0.610
Foxc2 forkhead box C2 0.585
Gata6 GATA binding protein 6 0.569
Nog noggin 0.551
Sox2 SRY-box containing gene 2 0.544
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.542
Emx1 empty spiracles homolog 1 (Drosophila) 0.535
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.480
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.479
Pthlh parathyroid hormone-like peptide 0.473
Gsc goosecoid homeobox 0.436
Chd7 chromodomain helicase DNA binding protein 7 0.433
Kiss1 KiSS-1 metastasis-suppressor 0.413
Hoxa13 homeobox A13 0.400
Emx2 empty spiracles homolog 2 (Drosophila) 0.384
Klk1b5 kallikrein 1-related peptidase b5 0.373
Fgf8 fibroblast growth factor 8 0.371
Neurod1 neurogenic differentiation 1 0.345
Foxf1a forkhead box F1a 0.327
Foxa2 forkhead box A2 0.317
Neurod4 neurogenic differentiation 4 0.316
Dll4 delta-like 4 (Drosophila) 0.293
Col13a1 collagen, type XIII, alpha 1 0.290
Ptf1a pancreas specific transcription factor, 1a 0.288
Hmx3 H6 homeobox 3 0.288
Col1a1 collagen, type I, alpha 1 0.285
Nkx3-2 NK3 homeobox 2 0.280
Lmx1a LIM homeobox transcription factor 1 alpha 0.277
Nkx2-1 NK2 homeobox 1 0.271
Gli2 GLI-Kruppel family member GLI2 0.268
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.266
Rxra retinoid X receptor alpha 0.258
Col5a1 collagen, type V, alpha 1 0.254
Insm1 insulinoma-associated 1 0.252
En1 engrailed 1 0.252
Mesp1 mesoderm posterior 1 0.245
Pten phosphatase and tensin homolog 0.240
Atoh1 atonal homolog 1 (Drosophila) 0.240
She src homology 2 domain-containing transforming protein E 0.239
Neurog2 neurogenin 2 0.231
Myog myogenin 0.229
Dlx1 distal-less homeobox 1 0.216
Ctnnb1 catenin (cadherin associated protein), beta 1 0.214
Pax3 paired box gene 3 0.214
Meox2 mesenchyme homeobox 2 0.210
Art1 ADP-ribosyltransferase 1 0.207
Wt1 Wilms tumor 1 homolog 0.203
Sox7 SRY-box containing gene 7 0.202
Barx1 BarH-like homeobox 1 0.199
Hes1 hairy and enhancer of split 1 (Drosophila) 0.196
Casq2 calsequestrin 2 0.196
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.195
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.194
Mmp24 matrix metallopeptidase 24 0.192
Col2a1 collagen, type II, alpha 1 0.189
Efna2 ephrin A2 0.184
Col3a1 collagen, type III, alpha 1 0.181
Foxg1 forkhead box G1 0.179
Nodal nodal 0.178
Amhr2 anti-Mullerian hormone type 2 receptor 0.178
Phox2b paired-like homeobox 2b 0.177
Smad1 MAD homolog 1 (Drosophila) 0.177
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.174
Klk1b21 kallikrein 1-related peptidase b21 0.170
Nos3 nitric oxide synthase 3, endothelial cell 0.170
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.169
Klk1b26 kallikrein 1-related petidase b26 0.162
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.162
Pax6 paired box gene 6 0.161
Prox1 prospero-related homeobox 1 0.161
Zic1 zinc finger protein of the cerebellum 1 0.160
Pitx3 paired-like homeodomain transcription factor 3 0.159
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism