The network for 'response to lipid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to lipid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.

Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.816
socs3a suppressor of cytokine signaling 3a 0.706
hnf1ba HNF1 homeobox Ba 0.621
cav1 caveolin 1 0.618
esr1 estrogen receptor 1 0.563
crabp2a cellular retinoic acid binding protein 2, a 0.536
gata3 GATA-binding protein 3 0.508
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.506
vcana versican a 0.505
ptgs2a prostaglandin-endoperoxide synthase 2a 0.473
id1 inhibitor of DNA binding 1 0.460
shha sonic hedgehog a 0.423
pcna proliferating cell nuclear antigen 0.401
smad9 MAD homolog 9 (Drosophila) 0.400
vasa vasa homolog 0.379
ptmaa prothymosin, alpha a 0.354
rxrab retinoid x receptor, alpha b 0.341
fgf3 fibroblast growth factor 3 0.329
ndr2 nodal-related 2 0.320
mapk3 mitogen-activated protein kinase 3 0.308
twist1a twist1a 0.302
th tyrosine hydroxylase 0.298
flh floating head 0.282
il1b interleukin 1, beta and interleukin 1, beta 0.273
notch1a notch homolog 1a 0.271
acvr2b activin receptor IIb 0.270
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.266
stc1l stanniocalcin 1, like 0.251
rag1 recombination activating gene 1 0.247
mkrn4 makorin, ring finger protein, 4 0.243
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.230
gata5 GATA-binding protein 5 0.226
fzd5 frizzled homolog 5 0.224
pycard PYD and CARD domain containing 0.223
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.219
ihha Indian hedgehog homolog a 0.217
jun jun proto-oncogene 0.208
robo3 roundabout homolog 3 0.204
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.202
apoeb apolipoprotein Eb 0.198
dld deltaD 0.196
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.187
bmp4 bone morphogenetic protein 4 0.182
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.180
cahz carbonic anhydrase 0.174
dlx4a distal-less homeobox gene 4a 0.174
efnb2a ephrin B2a 0.174
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.169
tbx16 T-box gene 16 0.163
ppargc1al peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like 0.162
otx5 orthodenticle homolog 5 0.162
fn1 fibronectin 1 0.161
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.160
tie1 endothelium-specific receptor tyrosine kinase 1 0.157
egr2b early growth response 2b 0.156
plcg1 phospholipase C, gamma 1 0.155
nkx1.2la NK1 transcription factor related 2-like,a 0.154
col5a1 procollagen, type V, alpha 1 0.153
krt15 keratin 15 0.151
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.150
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.148
tbx2b T-box 2b 0.146
dlc deltaC 0.145
msxa muscle segment homeobox A 0.144
kdrl kinase insert domain receptor like 0.144
esr2a estrogen receptor 2a 0.141
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.139
paqr7b progestin and adipoQ receptor family member VII, b 0.138
mcoln1 mucolipin 1 0.137
cry1a cryptochrome 1a 0.137
vtg3 vitellogenin 3, phosvitinless 0.133
pitx3 paired-like homeodomain transcription factor 3 0.132
col1a1a collagen, type I, alpha 1a 0.132
oxtl oxytocin-like 0.131
sulf1 sulfatase 1 0.131
ripk2 receptor-interacting serine-threonine kinase 2 0.131
avpl arginine vasopressin-like 0.130
junbl jun B proto-oncogene, like 0.129
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.128
igf3 insulin-like growth factor 3 0.128
fbn2b fibrillin 2b 0.127
snai1a snail homolog 1a (Drosophila) 0.124
ptges prostaglandin E synthase 0.124
ctsl1a cathepsin L, 1 a 0.123
hcrt hypocretin (orexin) neuropeptide precursor 0.123
slit3 slit (Drosophila) homolog 3 0.121
drl draculin 0.120
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.120
gamt guanidinoacetate N-methyltransferase 0.120
nkx2.5 NK2 transcription factor related 5 0.120
fgfrl1a fibroblast growth factor receptor-like 1a 0.120
wnt5b wingless-type MMTV integration site family, member 5b 0.117
cbr1l carbonyl reductase 1-like 0.117
wnt10a wingless-type MMTV integration site family, member 10a 0.116
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.114
bcl2l1 bcl2-like 1 0.114
sox9a SRY-box containing gene 9a 0.114
tmprss4a transmembrane protease, serine 4a 0.113
ptch2 patched 2 0.112
pomca proopiomelanocortin a 0.111
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.575
Egfr Epidermal growth factor receptor 0.484
ci cubitus interruptus 0.438
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.314
Rel Relish 0.306
nej nejire 0.251
EcR Ecdysone receptor 0.230
Fmr1 CG6203 gene product from transcript CG6203-RC 0.227
hep hemipterous 0.217
Sir2 CG5216 gene product from transcript CG5216-RA 0.207
caz cabeza 0.205
Ugt35a UDP-glycosyltransferase 35a 0.180
CG6283 CG6283 gene product from transcript CG6283-RA 0.170
sina seven in absentia 0.165
cg combgap 0.159
Cyp12a4 CG6042 gene product from transcript CG6042-RA 0.151
Ubx Ultrabithorax 0.146
usp ultraspiracle 0.135
shn schnurri 0.128
disco disconnected 0.127
wg wingless 0.125
ey eyeless 0.125
Mad Mothers against dpp 0.122
Iswi Imitation SWI 0.118
Moe Moesin 0.114
jeb jelly belly 0.111
Tequila CG4821 gene product from transcript CG4821-RE 0.106
ed echinoid 0.106
hth homothorax 0.097
InR Insulin-like receptor 0.097
Hop Hsp70/Hsp90 organizing protein homolog 0.092
da daughterless 0.092
trx trithorax 0.091
Mpk2 CG5475 gene product from transcript CG5475-RB 0.089
slmb supernumerary limbs 0.086
Akt1 CG4006 gene product from transcript CG4006-RA 0.082
ap apterous 0.079
slp1 sloppy paired 1 0.078
drk downstream of receptor kinase 0.077
Stat92E Signal-transducer and activator of transcription protein at 92E 0.076
odd odd skipped 0.075
ftz-f1 ftz transcription factor 1 0.073
pan pangolin 0.072
rg rugose 0.071
Pten CG5671 gene product from transcript CG5671-RB 0.067
scny scrawny 0.064
twi twist 0.063
babo baboon 0.060
Scm Sex comb on midleg 0.060
Lam Lamin 0.058
eve even skipped 0.058
Pink1 PTEN-induced putative kinase 1 0.058
Rac1 CG2248 gene product from transcript CG2248-RA 0.058
Bap60 Brahma associated protein 60kD 0.058
Pkc98E Protein C kinase 98E 0.056
CG16718 CG16718 gene product from transcript CG16718-RA 0.056
CG6543 CG6543 gene product from transcript CG6543-RA 0.056
cnc cap-n-collar 0.056
Nmdar1 NMDA receptor 1 0.055
bowl brother of odd with entrails limited 0.054
fusl fuseless 0.054
Tps1 Trehalose-6-phosphate synthase 1 0.053
dac dachshund 0.053
LamC Lamin C 0.053
lola longitudinals lacking 0.053
G9a CG2995 gene product from transcript CG2995-RA 0.052
sinah sina homologue 0.051
C15 CG7937 gene product from transcript CG7937-RA 0.051
os outstretched 0.051
CG13253 CG13253 gene product from transcript CG13253-RB 0.050
dome domeless 0.049
stck steamer duck 0.049
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.049
CG9394 CG9394 gene product from transcript CG9394-RA 0.047
en engrailed 0.047
Cat Catalase 0.046
Mtk Metchnikowin 0.046
ome omega 0.046
CG12672 CG12672 gene product from transcript CG12672-RA 0.046
Trh Tryptophan hydroxylase 0.046
mmd mind-meld 0.045
CG34400 CG34400 gene product from transcript CG34400-RD 0.045
gt giant 0.044
brm brahma 0.044
bi bifid 0.043
ari-2 ariadne 2 0.042
BG4 CG12297 gene product from transcript CG12297-RA 0.042
eya eyes absent 0.042
grh grainy head 0.041
argos CG4531 gene product from transcript CG4531-RA 0.041
cpa capping protein alpha 0.041
Mer Merlin 0.040
AttA Attacin-A 0.040
bab2 CG9102 gene product from transcript CG9102-RA 0.040
kni knirps 0.040
tin tinman 0.039
neb nebbish 0.039
slou slouch 0.039
CG13310 CG13310 gene product from transcript CG13310-RA 0.039
dib disembodied 0.039
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
CAV1 caveolin 1, caveolae protein, 22kDa 0.999
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.999
ESR1 estrogen receptor 1 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.998
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.996
MYD88 myeloid differentiation primary response gene (88) 0.991
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.991
CREBBP CREB binding protein 0.987
NCOR2 nuclear receptor corepressor 2 0.985
MAPK14 mitogen-activated protein kinase 14 0.982
TRAF2 TNF receptor-associated factor 2 0.982
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.980
TLR4 toll-like receptor 4 0.975
HDAC1 histone deacetylase 1 0.968
AR androgen receptor 0.966
SOCS3 suppressor of cytokine signaling 3 0.964
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.962
RARA retinoic acid receptor, alpha 0.946
ANXA1 annexin A1 0.936
SMAD3 SMAD family member 3 0.924
TAL1 T-cell acute lymphocytic leukemia 1 0.918
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.916
XIAP X-linked inhibitor of apoptosis 0.904
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.884
ARRB1 arrestin, beta 1 0.881
CCR1 chemokine (C-C motif) receptor 1 0.873
DUSP1 dual specificity phosphatase 1 0.866
SMAD4 SMAD family member 4 0.857
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.856
TRAF1 TNF receptor-associated factor 1 0.855
TP53 tumor protein p53 0.848
TGFB1 transforming growth factor, beta 1 0.834
CCR5 chemokine (C-C motif) receptor 5 0.829
IRAK2 interleukin-1 receptor-associated kinase 2 0.829
IL8 interleukin 8 0.827
IRAK1 interleukin-1 receptor-associated kinase 1 0.826
PRDX4 peroxiredoxin 4 0.825
TRAF6 TNF receptor-associated factor 6 0.824
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.824
EPOR erythropoietin receptor 0.824
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.822
JUN jun proto-oncogene 0.822
IL6 interleukin 6 (interferon, beta 2) 0.820
SMAD2 SMAD family member 2 0.818
MAPK1 mitogen-activated protein kinase 1 0.816
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.809
GSTM1 glutathione S-transferase mu 1 0.801
COL1A1 collagen, type I, alpha 1 0.801
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.799
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.792
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.786
MAPK8 mitogen-activated protein kinase 8 0.783
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.778
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.775
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.757
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.752
IL1B interleukin 1, beta 0.746
MED15 mediator complex subunit 15 0.741
PCGF2 polycomb group ring finger 2 0.740
SMAD1 SMAD family member 1 0.733
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.732
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.720
DHCR7 7-dehydrocholesterol reductase 0.698
SP1 Sp1 transcription factor 0.697
NCF1 neutrophil cytosolic factor 1 0.686
FAS Fas (TNF receptor superfamily, member 6) 0.682
THBS1 thrombospondin 1 0.681
KRT18 keratin 18 0.672
TLR2 toll-like receptor 2 0.672
S100A8 S100 calcium binding protein A8 0.669
ENG endoglin 0.665
NRP1 neuropilin 1 0.656
TRADD TNFRSF1A-associated via death domain 0.651
BMP2 bone morphogenetic protein 2 0.644
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.641
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.640
BIRC3 baculoviral IAP repeat containing 3 0.637
S100A9 S100 calcium binding protein A9 0.634
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.634
TNF tumor necrosis factor 0.631
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.630
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.629
SC4MOL sterol-C4-methyl oxidase-like 0.620
SYK spleen tyrosine kinase 0.619
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.618
GSK3B glycogen synthase kinase 3 beta 0.606
MET met proto-oncogene (hepatocyte growth factor receptor) 0.602
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.600
POU5F1 POU class 5 homeobox 1 0.598
RNF144B ring finger protein 144B 0.598
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.589
CXCL2 chemokine (C-X-C motif) ligand 2 0.589
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.588
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.581
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.580
CCND3 cyclin D3 0.575
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.571
RUNX1 runt-related transcription factor 1 0.568
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBP15 Ubp15p 0.025
CKS1 Cks1p 0.025
SLT2 Slt2p 0.021
SNF1 Snf1p 0.018
AQY2 Aqy2p 0.017
HOG1 Hog1p 0.017
ROM2 Rom2p 0.017
KDX1 Kdx1p 0.014
ERR2 Err2p 0.012
STE2 Ste2p 0.012