The network for 'convergent extension' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

convergent extension

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.

Danio rerio
Name Description Probability Func Analog Organism
tbx16 T-box gene 16 0.958
wnt5b wingless-type MMTV integration site family, member 5b 0.923
igf1rb insulin-like growth factor 1b receptor 0.918
nkd1 naked cuticle homolog 1 (Drosophila) 0.903
smad5 MAD homolog 5 (Drosophila) 0.901
hnf1ba HNF1 homeobox Ba 0.893
tbx20 T-box 20 0.888
fn1 fibronectin 1 0.885
pkd2 polycystic kidney disease 2 0.881
col5a2l collagen, type V, alpha 2-like 0.864
flh floating head 0.851
mespa mesoderm posterior a 0.848
cnn2 calponin 2 0.838
map2k4a mitogen-activated protein kinase kinase 4a 0.819
wnt9b wingless-type MMTV integration site family, member 9B 0.814
smad9 MAD homolog 9 (Drosophila) 0.792
bmp2a bone morphogenetic protein 2a 0.786
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.758
sox2 SRY-box containing gene 2 0.754
fzd10 frizzled homolog 10 0.706
lft2 lefty2 0.704
fbln1 fibulin 1 0.703
spns2 spinster homolog 2 (Drosophila) 0.688
mmp2 matrix metalloproteinase 2 0.685
zeb2a zinc finger E-box binding homeobox 2a 0.681
lfng lunatic fringe homolog 0.679
cc2d2a coiled-coil and C2 domain containing 2A 0.675
fzd7a frizzled homolog 7a 0.663
chd chordin 0.643
fibin fin bud initiation factor 0.628
gata5 GATA-binding protein 5 0.626
sox17 SRY-box containing gene 17 0.597
bon bonnie and clyde 0.565
fzd7b frizzled homolog 7b 0.557
snai1b snail homolog 1b (Drosophila) 0.548
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.547
tbx1 T-box 1 0.545
lft1 lefty1 0.544
pcdh8 protocadherin 8 0.537
fzd2 frizzled homolog 2 0.524
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.519
gro1 groucho 1 0.517
vent ventral expressed homeobox 0.516
smad2 MAD homolog 2 (Drosophila) 0.509
wnt10a wingless-type MMTV integration site family, member 10a 0.498
dmbx1a diencephalon/mesencephalon homeobox 1a 0.490
ilk integrin linked kinase 0.488
col5a1 procollagen, type V, alpha 1 0.482
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.478
ttna titin a 0.473
aplp2 amyloid beta (A4) precursor-like protein 2 0.470
cdh2 cadherin 2, neuronal 0.466
snai1a snail homolog 1a (Drosophila) 0.451
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.449
wnt4a wingless-type MMTV integration site family, member 4a 0.447
irx4b iroquois homeobox protein 4b 0.446
emx3 empty spiracles homeobox 3 0.442
tpm4 tropomyosin 4 0.436
notum3 notum 3 0.430
fzd8b frizzled homolog 8b 0.430
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.423
bmp2b bone morphogenetic protein 2b 0.422
osr1 odd-skipped related 1 (Drosophila) 0.421
lhx1b LIM homeobox 1b 0.421
oep one-eyed pinhead 0.417
cfl2l cofilin 2, like 0.408
wnt11 wingless-type MMTV integration site family, member 11 0.408
ptpra protein tyrosine phosphatase, receptor type, A 0.404
spry4 sprouty (Drosophila) homolog 4 0.399
vox ventral homeobox 0.397
fgf17 fibroblast growth factor 17 0.392
tp53 tumor protein p53 0.385
ndr2 nodal-related 2 0.382
pmp22a peripheral myelin protein 22a 0.379
f2r coagulation factor II (thrombin) receptor 0.376
sp5l Sp5 transcription factor-like 0.375
fzd5 frizzled homolog 5 0.372
cdh1 cadherin 1, epithelial 0.369
boc brother of CDO 0.365
wnt10b wingless-type MMTV integration site family, member 10b 0.365
foxd5 forkhead box D5 0.357
zeb1 zinc finger E-box binding homeobox 1 0.356
hapln1a hyaluronan and proteoglycan link protein 1a 0.356
rnd3a Rho family GTPase 3a 0.351
dcn decorin 0.349
zgc:101761 zgc:101761 0.346
vangl2 vang-like 2 (van gogh, Drosophila) 0.344
postn periostin, osteoblast specific factor 0.343
fyna FYN oncogene related to SRC, FGR, YES a 0.342
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.339
myf5 myogenic factor 5 0.337
tph1b tryptophan hydroxylase 1b 0.337
lmo4a LIM domain only 4a 0.337
aplnra apelin receptor a 0.337
igf1ra insulin-like growth factor 1a receptor 0.335
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.332
ephb4b eph receptor B4b 0.323
ttc21b tetratricopeptide repeat domain 21B 0.322
tal1 T-cell acute lymphocytic leukemia 1 0.321
sesn1 sestrin 1 0.321
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
robo roundabout 0.805
smo smoothened 0.802
lea leak 0.585
arm armadillo 0.540
fz frizzled 0.484
not non-stop 0.401
pod1 CG4532 gene product from transcript CG4532-RF 0.293
CG14869 CG14869 gene product from transcript CG14869-RB 0.269
wb wing blister 0.257
wg wingless 0.248
trc tricornered 0.240
robo3 CG5423 gene product from transcript CG5423-RA 0.224
CycE Cyclin E 0.202
drpr draper 0.177
Wnt5 Wnt oncogene analog 5 0.175
kirre kin of irre 0.167
Klp64D Kinesin-like protein at 64D 0.159
fj four-jointed 0.146
hep hemipterous 0.145
ovo CG6824 gene product from transcript CG6824-RE 0.145
tutl turtle 0.138
Ptp69D Protein tyrosine phosphatase 69D 0.136
Wnt4 Wnt oncogene analog 4 0.135
Ephrin CG1862 gene product from transcript CG1862-RA 0.124
tkv thickveins 0.122
pan pangolin 0.118
dsh dishevelled 0.117
nkd naked cuticle 0.115
spi spitz 0.114
Src64B Src oncogene at 64B 0.113
ds dachsous 0.106
brk brinker 0.106
baz bazooka 0.100
stan starry night 0.099
sens senseless 0.095
hts hu li tai shao 0.094
sli slit 0.094
bab2 CG9102 gene product from transcript CG9102-RA 0.090
jumu jumeau 0.090
Btk29A Btk family kinase at 29A 0.084
ct cut 0.082
unc-5 CG8166 gene product from transcript CG8166-RA 0.078
Mtl Mig-2-like 0.077
rok Rho-kinase 0.076
rempA reduced mechanoreceptor potential A 0.076
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.068
usp ultraspiracle 0.067
csw corkscrew 0.064
mam mastermind 0.062
Met Methoprene-tolerant 0.061
put punt 0.060
ex expanded 0.060
arr arrow 0.059
Snoo Sno oncogene 0.059
cta concertina 0.056
VGlut Vesicular glutamate transporter 0.056
fz2 frizzled 2 0.056
Dscam Down syndrome cell adhesion molecule 0.054
rin rasputin 0.053
Mrtf Myocardin-related transcription factor 0.053
Akt1 CG4006 gene product from transcript CG4006-RA 0.053
SoxN SoxNeuro 0.052
fru fruitless 0.052
Tl Toll 0.051
mid midline 0.051
mew multiple edematous wings 0.050
Wnt2 Wnt oncogene analog 2 0.050
CG5146 CG5146 gene product from transcript CG5146-RA 0.050
Fas2 Fasciclin 2 0.050
akirin CG8580 gene product from transcript CG8580-RD 0.049
dgo diego 0.048
btv beethoven 0.048
sd scalloped 0.047
Hph HIF prolyl hydroxylase 0.047
stumps CG31317 gene product from transcript CG31317-RC 0.047
CSN3 COP9 complex homolog subunit 3 0.045
stwl stonewall 0.045
ey eyeless 0.044
por porcupine 0.043
Hrb87F Heterogeneous nuclear ribonucleoprotein at 87F 0.043
CG3194 CG3194 gene product from transcript CG3194-RB 0.042
bin biniou 0.041
Cby Chibby 0.040
RpLP1 Ribosomal protein LP1 0.040
Hop Hsp70/Hsp90 organizing protein homolog 0.039
CG33960 CG33960 gene product from transcript CG33960-RB 0.039
plexB plexin B 0.039
wts warts 0.039
Lim1 CG11354 gene product from transcript CG11354-RA 0.039
pygo pygopus 0.039
kek5 kekkon5 0.038
Sir2 CG5216 gene product from transcript CG5216-RA 0.037
Eb1 CG3265 gene product from transcript CG3265-RF 0.037
Sep2 Septin-2 0.037
D Dichaete 0.037
RpL22 Ribosomal protein L22 0.037
CadN Cadherin-N 0.036
pk prickle 0.036
nub nubbin 0.036
rib ribbon 0.036
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Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.924
MED28 mediator complex subunit 28 0.596
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.454
LRRK2 leucine-rich repeat kinase 2 0.413
APC adenomatous polyposis coli 0.364
BMPR1A bone morphogenetic protein receptor, type IA 0.300
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.297
BCAR1 breast cancer anti-estrogen resistance 1 0.254
FNBP1L formin binding protein 1-like 0.211
SMAD1 SMAD family member 1 0.208
CSNK1E casein kinase 1, epsilon 0.204
MBNL1 muscleblind-like (Drosophila) 0.178
DSG2 desmoglein 2 0.171
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.144
LUM lumican 0.139
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.125
FZD1 frizzled homolog 1 (Drosophila) 0.105
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.103
YAP1 Yes-associated protein 1 0.097
FYN FYN oncogene related to SRC, FGR, YES 0.095
TRIP6 thyroid hormone receptor interactor 6 0.094
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.091
BBS2 Bardet-Biedl syndrome 2 0.090
CEP164 centrosomal protein 164kDa 0.085
BMP1 bone morphogenetic protein 1 0.084
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.083
GSK3B glycogen synthase kinase 3 beta 0.081
BBS1 Bardet-Biedl syndrome 1 0.077
AXIN1 axin 1 0.074
AR androgen receptor 0.073
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.071
PCM1 pericentriolar material 1 0.064
FERMT2 fermitin family member 2 0.064
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.059
STAT2 signal transducer and activator of transcription 2, 113kDa 0.055
BBS10 Bardet-Biedl syndrome 10 0.055
SKI v-ski sarcoma viral oncogene homolog (avian) 0.054
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.054
BBS9 Bardet-Biedl syndrome 9 0.051
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.051
FSTL1 follistatin-like 1 0.050
COL6A1 collagen, type VI, alpha 1 0.048
CAV1 caveolin 1, caveolae protein, 22kDa 0.048
CHD4 chromodomain helicase DNA binding protein 4 0.047
SOCS1 suppressor of cytokine signaling 1 0.047
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.045
CFL1 cofilin 1 (non-muscle) 0.045
KLHL2 kelch-like 2, Mayven (Drosophila) 0.045
DST dystonin 0.044
ERBB2IP erbb2 interacting protein 0.044
SMAD4 SMAD family member 4 0.044
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.043
PTK2 PTK2 protein tyrosine kinase 2 0.043
SOCS3 suppressor of cytokine signaling 3 0.043
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.042
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.042
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.042
HDAC2 histone deacetylase 2 0.042
CTTN cortactin 0.042
IFNGR1 interferon gamma receptor 1 0.042
GJA1 gap junction protein, alpha 1, 43kDa 0.041
RGS2 regulator of G-protein signaling 2, 24kDa 0.041
SPTBN1 spectrin, beta, non-erythrocytic 1 0.040
FNBP1 formin binding protein 1 0.040
CAV2 caveolin 2 0.038
PSEN1 presenilin 1 0.038
TIMP2 TIMP metallopeptidase inhibitor 2 0.038
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.037
MCC mutated in colorectal cancers 0.036
TTC8 tetratricopeptide repeat domain 8 0.035
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.035
FRS2 fibroblast growth factor receptor substrate 2 0.035
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.035
LRP6 low density lipoprotein receptor-related protein 6 0.034
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.034
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.033
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.033
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.033
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.033
SULF1 sulfatase 1 0.033
HIPK2 homeodomain interacting protein kinase 2 0.033
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.032
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.032
GATA5 GATA binding protein 5 0.032
GLIS2 GLIS family zinc finger 2 0.031
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.031
MPDZ multiple PDZ domain protein 0.031
GAB1 GRB2-associated binding protein 1 0.031
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.031
TP53BP2 tumor protein p53 binding protein, 2 0.030
TBX5 T-box 5 0.030
CSNK1D casein kinase 1, delta 0.030
ACSL4 acyl-CoA synthetase long-chain family member 4 0.029
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.029
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.029
TGFB2 transforming growth factor, beta 2 0.028
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.028
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.028
SH2B1 SH2B adaptor protein 1 0.028
MAGEA2 melanoma antigen family A, 2 0.028
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Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 0.999
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.998
Gli3 GLI-Kruppel family member GLI3 0.990
Fgfr2 fibroblast growth factor receptor 2 0.952
Wnt3a wingless-related MMTV integration site 3A 0.948
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.902
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.841
Gli2 GLI-Kruppel family member GLI2 0.812
Shh sonic hedgehog 0.793
Ptk7 PTK7 protein tyrosine kinase 7 0.785
Fgf8 fibroblast growth factor 8 0.730
Fyn Fyn proto-oncogene 0.697
Fzd1 frizzled homolog 1 (Drosophila) 0.690
Ctnnb1 catenin (cadherin associated protein), beta 1 0.634
Lrp6 low density lipoprotein receptor-related protein 6 0.601
Foxc1 forkhead box C1 0.589
Fgfr1 fibroblast growth factor receptor 1 0.570
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.418
Slit3 slit homolog 3 (Drosophila) 0.366
Nodal nodal 0.366
Hes1 hairy and enhancer of split 1 (Drosophila) 0.326
Meox2 mesenchyme homeobox 2 0.319
Fzd8 frizzled homolog 8 (Drosophila) 0.302
Wnt5a wingless-related MMTV integration site 5A 0.302
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.285
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.282
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.282
Tbx3 T-box 3 0.255
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.252
Sfrp2 secreted frizzled-related protein 2 0.250
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.242
Sfrp1 secreted frizzled-related protein 1 0.233
Nog noggin 0.230
Twist2 twist homolog 2 (Drosophila) 0.225
Sox9 SRY-box containing gene 9 0.214
Dlg1 discs, large homolog 1 (Drosophila) 0.210
Pitx2 paired-like homeodomain transcription factor 2 0.202
Bbs2 Bardet-Biedl syndrome 2 (human) 0.200
Bmp4 bone morphogenetic protein 4 0.199
Fzd7 frizzled homolog 7 (Drosophila) 0.197
Smad1 MAD homolog 1 (Drosophila) 0.190
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.188
Egfr epidermal growth factor receptor 0.165
Fgfr3 fibroblast growth factor receptor 3 0.164
Smad6 MAD homolog 6 (Drosophila) 0.151
Msx1 homeobox, msh-like 1 0.149
Vangl1 vang-like 1 (van gogh, Drosophila) 0.135
Tbx2 T-box 2 0.133
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.126
Acvr1 activin A receptor, type 1 0.125
Prrx1 paired related homeobox 1 0.121
Gata6 GATA binding protein 6 0.117
Smo smoothened homolog (Drosophila) 0.112
Bmp7 bone morphogenetic protein 7 0.108
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.106
Wnt4 wingless-related MMTV integration site 4 0.104
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.099
Foxc2 forkhead box C2 0.098
Axin1 axin 1 0.097
Slit1 slit homolog 1 (Drosophila) 0.095
Efna4 ephrin A4 0.089
Robo2 roundabout homolog 2 (Drosophila) 0.088
Rbms1 RNA binding motif, single stranded interacting protein 1 0.088
Pax1 paired box gene 1 0.086
Rarb retinoic acid receptor, beta 0.081
Hand1 heart and neural crest derivatives expressed transcript 1 0.080
Dlg4 discs, large homolog 4 (Drosophila) 0.079
Tgfb2 transforming growth factor, beta 2 0.073
Rxra retinoid X receptor alpha 0.070
Rara retinoic acid receptor, alpha 0.069
Pax3 paired box gene 3 0.068
Gsk3b glycogen synthase kinase 3 beta 0.067
Jak2 Janus kinase 2 0.062
Gopc golgi associated PDZ and coiled-coil motif containing 0.062
Amhr2 anti-Mullerian hormone type 2 receptor 0.059
Tead2 TEA domain family member 2 0.058
Gas1 growth arrest specific 1 0.057
Foxh1 forkhead box H1 0.053
Trp63 transformation related protein 63 0.053
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.049
Lrp5 low density lipoprotein receptor-related protein 5 0.049
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.047
Fgf10 fibroblast growth factor 10 0.046
Gli1 GLI-Kruppel family member GLI1 0.045
Lhx1 LIM homeobox protein 1 0.045
Ptch2 patched homolog 2 0.044
Zfp185 zinc finger protein 185 0.043
Chrd chordin 0.041
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.041
Bmpr1a bone morphogenetic protein receptor, type 1A 0.040
Alx4 aristaless-like homeobox 4 0.040
Fzd2 frizzled homolog 2 (Drosophila) 0.040
Klf7 Kruppel-like factor 7 (ubiquitous) 0.037
Wdr1 WD repeat domain 1 0.036
Zfp503 zinc finger protein 503 0.035
Smad4 MAD homolog 4 (Drosophila) 0.034
Try10 trypsin 10 0.032
Invs inversin 0.032
Fzd10 frizzled homolog 10 (Drosophila) 0.032
Ptpre protein tyrosine phosphatase, receptor type, E 0.032
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism