The network for 'dopaminergic neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dopaminergic neuron differentiation

The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.

Danio rerio
Name Description Probability Func Analog Organism
barhl2 BarH-like 2 0.980
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.952
sox2 SRY-box containing gene 2 0.723
pou3f1 POU class 3 homeobox 1 0.696
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.686
ascl1a achaete-scute complex-like 1a (Drosophila) 0.685
sox3 SRY-box containing gene 3 0.658
dla deltaA 0.642
foxp2 forkhead box P2 0.537
lhx5 LIM homeobox 5 0.501
nxph1 neurexophilin 1 0.456
ddc dopa decarboxylase 0.433
fzd7b frizzled homolog 7b 0.409
shha sonic hedgehog a 0.401
otx1b orthodenticle homolog 1b 0.399
dbx1a developing brain homeobox 1a 0.344
lef1 lymphocyte enhancer binding factor 1 0.343
nr4a2b nuclear receptor subfamily 4, group A, member 2b 0.333
pitx3 paired-like homeodomain transcription factor 3 0.317
dlx2a distal-less homeobox gene 2a 0.312
fzd8a frizzled homolog 8a 0.274
prox1 prospero-related homeobox gene 1 0.274
fezf2 FEZ family zinc finger 2 0.266
neurog1 neurogenin 1 0.261
hlx1 H2.0-like homeo box 1 (Drosophila) 0.227
gad1b glutamate decarboxylase 1b 0.216
lhx1a LIM homeobox 1a 0.215
dlb deltaB 0.211
phox2a paired-like homeobox 2a 0.210
bdnf brain-derived neurotrophic factor 0.204
adcyap1b adenylate cyclase activating polypeptide 1b 0.200
gfap glial fibrillary acidic protein 0.188
efnb2a ephrin B2a 0.182
emx2 empty spiracles homeobox 2 0.174
kal1a Kallmann syndrome 1a sequence 0.163
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.151
atoh1a atonal homolog 1a 0.149
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.146
nr2f1b nuclear receptor subfamily 2, group F, member 1b 0.145
nr4a2a nuclear receptor subfamily 4, group A, member 2a 0.142
ccdc151 coiled-coil domain containing 151 0.142
nkx2.2a NK2 transcription factor related 2a 0.119
nr4a1 nuclear receptor subfamily 4, group A, member 1 0.119
dlx5a distal-less homeobox gene 5a 0.098
adcyap1r1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.094
met met proto-oncogene (hepatocyte growth factor receptor) 0.094
hmgb1a high-mobility group box 1a 0.091
tfap2b transcription factor AP-2 beta 0.080
LOC555504 novel protocadherin protein 0.080
pcsk1nl proprotein convertase subtilisin/kexin type 1 inhibitor, like 0.079
gata2a GATA-binding protein 2a 0.078
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.074
otx2 orthodenticle homolog 2 0.070
zgc:103663 zgc:103663 0.069
zgc:110124 zgc:110124 0.067
mdkb midkine-related growth factor b 0.066
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.065
mpz myelin protein zero 0.065
robo2 roundabout homolog 2 0.063
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.062
pcdh17 protocadherin 17 0.059
pvrl1b poliovirus receptor-related 1b 0.059
crhbp corticotropin releasing hormone binding protein 0.058
si:dkey-24g18.2 si:dkey-24g18.2 0.058
clock3 clock homolog 3 (mouse) 0.058
barhl1.1 BarH-like 1.1 0.055
otpa orthopedia homolog a 0.055
mbp myelin basic protein 0.055
wu:fi18a01 wu:fi18a01 0.054
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.054
xbp1 X-box binding protein 1 0.051
dld deltaD 0.051
fabp7a fatty acid binding protein 7, brain, a 0.051
her4.2 hairy-related 4.2 0.050
fzd7a frizzled homolog 7a 0.049
nr4a3 nuclear receptor subfamily 4, group A, member 3 0.049
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.049
dlx1a distal-less homeobox gene 1a 0.049
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.048
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.048
nf1b neurofibromin 1b 0.047
lmo3 LIM domain only 3 0.046
adarb1 adenosine deaminase, RNA-specific, B1 0.046
gbx2 gastrulation brain homeo box 2 0.044
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.043
gria2a glutamate receptor, ionotropic, AMPA 2a 0.042
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.042
sst1.1 somatostatin 1, tandem duplicate 1 0.042
fgfr2 fibroblast growth factor receptor 2 0.041
gria4b glutamate receptor, ionotropic, AMPA 4b 0.041
cx43 connexin 43 0.040
penka proenkephalin a 0.039
otpb orthopedia homolog b 0.039
dmbx1a diencephalon/mesencephalon homeobox 1a 0.039
gria4a glutamate receptor, ionotropic, AMPA 4a 0.038
irx7 iroquois homeobox protein 7 0.037
pax7a paired box gene 7a 0.037
tfap2a transcription factor AP-2 alpha 0.037
lrrtm1 leucine rich repeat transmembrane neuronal 1 0.037
cry2b cryptochrome 2b 0.037
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.564
EGLN1 egl nine homolog 1 (C. elegans) 0.448
NRP1 neuropilin 1 0.171
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.099
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.068
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.061
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.058
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.051
SDF2L1 stromal cell-derived factor 2-like 1 0.048
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.043
TCEAL5 transcription elongation factor A (SII)-like 5 0.041
PGF placental growth factor 0.037
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.037
EGLN3 egl nine homolog 3 (C. elegans) 0.033
LRRK2 leucine-rich repeat kinase 2 0.032
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.029
EPAS1 endothelial PAS domain protein 1 0.023
CRELD2 cysteine-rich with EGF-like domains 2 0.022
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.022
PDIA4 protein disulfide isomerase family A, member 4 0.022
EGR3 early growth response 3 0.021
MYOD1 myogenic differentiation 1 0.021
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.021
KAT2B K(lysine) acetyltransferase 2B 0.019
VHL von Hippel-Lindau tumor suppressor 0.018
ONECUT1 one cut homeobox 1 0.017
NBR1 neighbor of BRCA1 gene 1 0.016
TAL1 T-cell acute lymphocytic leukemia 1 0.015
CHN2 chimerin (chimaerin) 2 0.015
SSX4 synovial sarcoma, X breakpoint 4 0.015
GSC goosecoid homeobox 0.015
FZD1 frizzled homolog 1 (Drosophila) 0.015
SQSTM1 sequestosome 1 0.014
WNT3A wingless-type MMTV integration site family, member 3A 0.014
SH3RF1 SH3 domain containing ring finger 1 0.014
EGR1 early growth response 1 0.014
SEC13 SEC13 homolog (S. cerevisiae) 0.014
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.014
PTMA prothymosin, alpha 0.013
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.013
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.013
ARNT aryl hydrocarbon receptor nuclear translocator 0.013
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.013
LDLR low density lipoprotein receptor 0.012
NCOA6 nuclear receptor coactivator 6 0.012
TOLLIP toll interacting protein 0.012
NTF3 neurotrophin 3 0.012
AHR aryl hydrocarbon receptor 0.012
FGF8 fibroblast growth factor 8 (androgen-induced) 0.012
WNT1 wingless-type MMTV integration site family, member 1 0.011
TCF4 transcription factor 4 0.011
EPS8 epidermal growth factor receptor pathway substrate 8 0.011
GMPPB GDP-mannose pyrophosphorylase B 0.011
SPAG9 sperm associated antigen 9 0.011
LBX1 ladybird homeobox 1 0.011
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.011
LHX3 LIM homeobox 3 0.010
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.010
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.010
OTX2 orthodenticle homeobox 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 0.999
Shh sonic hedgehog 0.999
Gli3 GLI-Kruppel family member GLI3 0.998
Lmx1b LIM homeobox transcription factor 1 beta 0.997
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Foxc1 forkhead box C1 0.996
Pax8 paired box gene 8 0.994
Fgf8 fibroblast growth factor 8 0.989
Lhx1 LIM homeobox protein 1 0.989
Msx1 homeobox, msh-like 1 0.982
Pax3 paired box gene 3 0.969
Fgfr2 fibroblast growth factor receptor 2 0.968
Tbx1 T-box 1 0.966
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.957
Eya1 eyes absent 1 homolog (Drosophila) 0.929
Chrd chordin 0.929
Lhx3 LIM homeobox protein 3 0.926
Dlx5 distal-less homeobox 5 0.891
Pax6 paired box gene 6 0.891
Ctnnb1 catenin (cadherin associated protein), beta 1 0.872
Rarg retinoic acid receptor, gamma 0.865
Nog noggin 0.863
Foxc2 forkhead box C2 0.858
Hand2 heart and neural crest derivatives expressed transcript 2 0.841
Hand1 heart and neural crest derivatives expressed transcript 1 0.832
Bmp7 bone morphogenetic protein 7 0.829
Otx1 orthodenticle homolog 1 (Drosophila) 0.821
Gbx2 gastrulation brain homeobox 2 0.813
Pitx2 paired-like homeodomain transcription factor 2 0.796
Isl1 ISL1 transcription factor, LIM/homeodomain 0.790
Emx2 empty spiracles homolog 2 (Drosophila) 0.748
Gdnf glial cell line derived neurotrophic factor 0.740
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.740
Hoxa1 homeobox A1 0.727
Emx1 empty spiracles homolog 1 (Drosophila) 0.726
Wnt4 wingless-related MMTV integration site 4 0.723
Fgfr1 fibroblast growth factor receptor 1 0.713
Prrx1 paired related homeobox 1 0.713
Bmp4 bone morphogenetic protein 4 0.712
Fgf10 fibroblast growth factor 10 0.610
Prrx2 paired related homeobox 2 0.573
Sox9 SRY-box containing gene 9 0.534
Wnt3a wingless-related MMTV integration site 3A 0.520
Gli2 GLI-Kruppel family member GLI2 0.517
Tcfap2a transcription factor AP-2, alpha 0.508
Gsc goosecoid homeobox 0.498
Tgfb2 transforming growth factor, beta 2 0.496
Lmx1a LIM homeobox transcription factor 1 alpha 0.477
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.464
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.443
Dlx6 distal-less homeobox 6 0.426
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.426
Phox2b paired-like homeobox 2b 0.424
Id1 inhibitor of DNA binding 1 0.404
En1 engrailed 1 0.400
Tbx3 T-box 3 0.388
Msx2 homeobox, msh-like 2 0.374
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.362
Pax9 paired box gene 9 0.357
Ret ret proto-oncogene 0.324
Smo smoothened homolog (Drosophila) 0.322
Foxb1 forkhead box B1 0.320
Hmx1 H6 homeobox 1 0.318
Sox2 SRY-box containing gene 2 0.317
Foxg1 forkhead box G1 0.303
Hoxa2 homeobox A2 0.300
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.276
Foxa2 forkhead box A2 0.266
Rarb retinoic acid receptor, beta 0.257
Pou3f3 POU domain, class 3, transcription factor 3 0.251
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.248
Fgf15 fibroblast growth factor 15 0.247
Nkx2-1 NK2 homeobox 1 0.246
Hmx3 H6 homeobox 3 0.246
Onecut1 one cut domain, family member 1 0.239
Dlx2 distal-less homeobox 2 0.235
Foxd2 forkhead box D2 0.230
T brachyury 0.227
Wnt1 wingless-related MMTV integration site 1 0.222
Alx4 aristaless-like homeobox 4 0.212
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.211
Dlx1 distal-less homeobox 1 0.195
Nrtn neurturin 0.189
Tbx15 T-box 15 0.189
Lef1 lymphoid enhancer binding factor 1 0.167
Tgfa transforming growth factor alpha 0.165
Zeb1 zinc finger E-box binding homeobox 1 0.165
Hoxd3 homeobox D3 0.162
Kiss1 KiSS-1 metastasis-suppressor 0.161
Wt1 Wilms tumor 1 homolog 0.161
Alx3 aristaless-like homeobox 3 0.155
Hoxd9 homeobox D9 0.151
Twist2 twist homolog 2 (Drosophila) 0.150
Sox3 SRY-box containing gene 3 0.145
Hoxd11 homeobox D11 0.145
Pou3f1 POU domain, class 3, transcription factor 1 0.144
Sim2 single-minded homolog 2 (Drosophila) 0.139
Lhx9 LIM homeobox protein 9 0.138
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.133
Nos3 nitric oxide synthase 3, endothelial cell 0.128
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism