The network for 'skeletal muscle fiber development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal muscle fiber development

The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

Danio rerio
Name Description Probability Func Analog Organism
actn3a actinin alpha 3a 0.995
myf5 myogenic factor 5 0.971
ptch2 patched 2 0.958
myog myogenin 0.892
myod1 myogenic differentiation 1 0.868
gli2a GLI-Kruppel family member GLI2a 0.863
ambra1 autophagy/beclin-1 regulator 1 0.814
lama2 laminin, alpha 2 0.801
unc45b unc-45 homolog B (C. elegans) 0.800
smyd1b SET and MYND domain containing 1b 0.747
dmd dystrophin 0.717
actn2 actinin, alpha 2 0.715
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.663
cdh2 cadherin 2, neuronal 0.643
jam3b junctional adhesion molecule 3b 0.642
gli1 GLI-Kruppel family member 1 0.602
bmp2b bone morphogenetic protein 2b 0.590
myf6 myogenic factor 6 0.579
hsp90a.1 heat shock protein 90-alpha 1 0.568
stac3 SH3 and cysteine rich domain 3 0.557
ryr1a ryanodine receptor 1a (skeletal) 0.532
tnni1al troponin I, skeletal, slow like 0.524
smyhc2 slow myosin heavy chain 2 0.516
tbx24 T-box 24 0.416
robo3 roundabout homolog 3 0.336
chsy1 chondroitin sulfate synthase 1 0.305
myhc4 myosin heavy chain 4 0.303
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.300
wu:fv91b12 wu:fv91b12 0.280
rx3 retinal homeobox gene 3 0.275
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.275
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.272
srf serum response factor 0.267
tnnc1b troponin C type 1b (slow) 0.258
lamb1a laminin, beta 1a 0.247
tcf12 transcription factor 12 0.220
smyhc1 slow myosin heavy chain 1 0.193
smyd1a SET and MYND domain containing 1a 0.191
tnni2a.4 troponin I, skeletal, fast 2a.4 0.185
apobec2a apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a 0.182
chrnd cholinergic receptor, nicotinic, delta polypeptide 0.180
runx2a runt-related transcription factor 2a 0.177
tbx18 T-box 18 0.173
hoxa13b homeo box A13b 0.172
ptch1 patched 1 0.169
grifin galectin related inter-fiber protein 0.167
lamb2 laminin, beta 2 (laminin S) 0.162
runx2b runt-related transcription factor 2b 0.158
mef2ca myocyte enhancer factor 2ca 0.153
hoxa9a homeo box A9a 0.150
wnt10a wingless-type MMTV integration site family, member 10a 0.150
zgc:113210 zgc:113210 0.149
actn1 actinin, alpha 1 0.149
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.147
epha4b eph receptor A4b 0.140
lamc1 laminin, gamma 1 0.138
shha sonic hedgehog a 0.133
tbx1 T-box 1 0.131
xirp1 xin actin-binding repeat containing 1 0.129
scinla scinderin like a 0.128
ret1 receptor tyrosine kinase 0.125
gpc4 glypican 4 0.124
ttna titin a 0.121
hoxa11a homeo box A11a 0.118
s1pr2 sphingosine-1-phosphate receptor 2 0.117
vgll2b vestigial like 2b 0.116
foxd5 forkhead box D5 0.116
lgi1b leucine-rich, glioma inactivated 1b 0.114
wt1b wilms tumor 1b 0.113
actn3b actinin alpha 3b 0.109
eya1 eyes absent homolog 1 0.108
cdh4 cadherin 4, retinal 0.108
neo1 neogenin 1 0.107
vax2 ventral anterior homeobox 2 0.102
hoxd3a homeo box D3a 0.101
sepn1 selenoprotein N, 1 0.100
LOC100149148 novel protein similar to myosin heavy chain 4 (myhc4) 0.098
fance Fanconi anemia, complementation group E 0.097
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.097
im:7146310 im:7146310 0.095
zp3 zona pellucida glycoprotein 3 0.094
il1b interleukin 1, beta and interleukin 1, beta 0.092
zgc:136878 zgc:136878 0.092
ndr2 nodal-related 2 0.092
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.089
acta1a actin, alpha 1a, skeletal muscle 0.087
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.085
lmo4a LIM domain only 4a 0.085
disp1 dispatched homolog 1 (Drosophila) 0.084
foxd3 forkhead box D3 0.084
brd4 bromodomain containing 4 0.084
gyltl1b glycosyltransferase-like 1b 0.083
mylz2 myosin, light polypeptide 2, skeletal muscle 0.083
ryr1b ryanodine receptor 1b (skeletal) 0.083
plagl2 pleiomorphic adenoma gene-like 2 0.078
lgals9l1 lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1 0.078
notch1a notch homolog 1a 0.076
nova2 neuro-oncological ventral antigen 2 0.075
mtm1 myotubularin 1 0.075
chd chordin 0.075
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
rho rhomboid 0.593
Pp2B-14D Protein phosphatase 2B at 14D 0.593
rst roughest 0.536
G-oalpha47A G protein oalpha 47A 0.523
ci cubitus interruptus 0.481
hth homothorax 0.472
htl heartless 0.410
vg vestigial 0.407
if inflated 0.332
Egfr Epidermal growth factor receptor 0.328
stumps CG31317 gene product from transcript CG31317-RC 0.303
stck steamer duck 0.295
Arp66B Actin-related protein 66B 0.293
myoglianin CG1838 gene product from transcript CG1838-RD 0.282
cora coracle 0.277
Mad Mothers against dpp 0.227
LanB1 CG7123 gene product from transcript CG7123-RA 0.221
mew multiple edematous wings 0.213
kirre kin of irre 0.190
InR Insulin-like receptor 0.185
sr stripe 0.183
Nrg Neuroglian 0.180
put punt 0.177
Rya-r44F Ryanodine receptor 44F 0.170
Pkc98E Protein C kinase 98E 0.167
Moe Moesin 0.166
Actn alpha actinin 0.156
slou slouch 0.153
gbb glass bottom boat 0.150
crb crumbs 0.146
nau nautilus 0.144
wg wingless 0.140
rols rolling pebbles 0.138
blow blown fuse 0.138
egh egghead 0.131
mys myospheroid 0.130
Tm2 Tropomyosin 2 0.129
how held out wings 0.123
Mmp1 Matrix metalloproteinase 1 0.123
Act87E Actin 87E 0.119
sina seven in absentia 0.117
dpp decapentaplegic 0.116
NetB Netrin-B 0.115
Gug Grunge 0.112
phyl phyllopod 0.111
hh hedgehog 0.105
Vrp1 Verprolin 1 0.103
pan pangolin 0.095
Wnt4 Wnt oncogene analog 4 0.094
LamC Lamin C 0.093
Mhc Myosin heavy chain 0.092
cpb capping protein beta 0.090
Rac2 CG8556 gene product from transcript CG8556-RA 0.088
en engrailed 0.088
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.086
spi spitz 0.086
wb wing blister 0.086
twi twist 0.085
Pde8 Phosphodiesterase 8 0.082
Vhl von Hippel-Lindau 0.082
byn brachyenteron 0.081
VAChT CG32848 gene product from transcript CG32848-RA 0.080
CaMKII Calcium/calmodulin-dependent protein kinase II 0.080
fng fringe 0.080
zfh1 Zn finger homeodomain 1 0.079
Cul-3 Cullin-3 0.077
CG5177 CG5177 gene product from transcript CG5177-RA 0.076
fry furry 0.075
Prm Paramyosin 0.075
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.075
SH3PX1 CG6757 gene product from transcript CG6757-RA 0.073
Imp IGF-II mRNA-binding protein 0.073
shn schnurri 0.069
sns sticks and stones 0.069
cher cheerio 0.067
fj four-jointed 0.066
CadN Cadherin-N 0.066
trx trithorax 0.066
Mekk1 CG7717 gene product from transcript CG7717-RB 0.066
CG32528 CG32528 gene product from transcript CG32528-RA 0.065
rost rolling stone 0.063
CG32810 CG32810 gene product from transcript CG32810-RB 0.063
bab2 CG9102 gene product from transcript CG9102-RA 0.062
Smr Smrter 0.061
Mnt CG13316 gene product from transcript CG13316-RD 0.061
GlyP Glycogen phosphorylase 0.060
Myo31DF Myosin 31DF 0.060
CG5168 CG5168 gene product from transcript CG5168-RB 0.058
ko knockout 0.057
in inturned 0.056
EndoGI Endonuclease G inhibitor 0.056
Akt1 CG4006 gene product from transcript CG4006-RA 0.055
Mlc2 Myosin light chain 2 0.055
kn knot 0.055
LanB2 Laminin B2 0.054
Dad Daughters against dpp 0.054
egg eggless 0.054
B-H1 BarH1 0.053
ft fat 0.051
sbb scribbler 0.051
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Homo sapiens
Name Description Probability Func Analog Organism
TTN titin 0.996
JAG1 jagged 1 0.981
HDAC4 histone deacetylase 4 0.976
TRIM63 tripartite motif containing 63 0.974
NOTCH1 notch 1 0.886
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.797
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.723
TCAP titin-cap (telethonin) 0.470
FN1 fibronectin 1 0.391
BCL6 B-cell CLL/lymphoma 6 0.381
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.370
BMPR1A bone morphogenetic protein receptor, type IA 0.369
MEF2C myocyte enhancer factor 2C 0.365
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.347
NEB nebulin 0.339
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.317
FSTL1 follistatin-like 1 0.264
BCL2L1 BCL2-like 1 0.254
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.249
TESK1 testis-specific kinase 1 0.247
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.239
IGF2 insulin-like growth factor 2 (somatomedin A) 0.203
UTRN utrophin 0.199
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.184
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.159
MEF2A myocyte enhancer factor 2A 0.146
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.132
ESR1 estrogen receptor 1 0.123
PARVA parvin, alpha 0.121
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.106
NOTCH3 notch 3 0.095
ACTN2 actinin, alpha 2 0.094
NCOR2 nuclear receptor corepressor 2 0.093
MTMR12 myotubularin related protein 12 0.089
JUND jun D proto-oncogene 0.089
JUN jun proto-oncogene 0.082
CNOT8 CCR4-NOT transcription complex, subunit 8 0.082
ENG endoglin 0.077
HDAC9 histone deacetylase 9 0.075
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.069
ATF3 activating transcription factor 3 0.067
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.066
IRS1 insulin receptor substrate 1 0.061
ITSN1 intersectin 1 (SH3 domain protein) 0.061
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.059
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.058
DLL1 delta-like 1 (Drosophila) 0.056
CXCL11 chemokine (C-X-C motif) ligand 11 0.056
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.056
MYOZ1 myozenin 1 0.054
ATXN1 ataxin 1 0.054
MAPK1 mitogen-activated protein kinase 1 0.053
INO80B INO80 complex subunit B 0.052
DMD dystrophin 0.051
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.051
PTCH1 patched 1 0.051
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.048
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.045
PTRF polymerase I and transcript release factor 0.044
FBLN1 fibulin 1 0.044
CTGF connective tissue growth factor 0.041
TMSB10 thymosin beta 10 0.040
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.038
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.036
FHL2 four and a half LIM domains 2 0.035
NCOR1 nuclear receptor corepressor 1 0.035
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.033
SMAD3 SMAD family member 3 0.031
ACTN3 actinin, alpha 3 0.030
IQGAP1 IQ motif containing GTPase activating protein 1 0.028
TGFB3 transforming growth factor, beta 3 0.027
DUSP1 dual specificity phosphatase 1 0.025
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.024
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.024
IGFBP5 insulin-like growth factor binding protein 5 0.023
ATF2 activating transcription factor 2 0.023
ZFYVE9 zinc finger, FYVE domain containing 9 0.023
ADAM12 ADAM metallopeptidase domain 12 0.023
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.022
CAV1 caveolin 1, caveolae protein, 22kDa 0.022
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.022
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.021
GATA4 GATA binding protein 4 0.021
COL1A1 collagen, type I, alpha 1 0.021
DBP D site of albumin promoter (albumin D-box) binding protein 0.019
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.019
MAPK8 mitogen-activated protein kinase 8 0.019
FUNDC2 FUN14 domain containing 2 0.019
PNRC1 proline-rich nuclear receptor coactivator 1 0.019
EP300 E1A binding protein p300 0.019
KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 0.018
ITGB1BP3 integrin beta 1 binding protein 3 0.018
PKNOX1 PBX/knotted 1 homeobox 1 0.018
VCL vinculin 0.017
NOTCH2NL notch 2 N-terminal like 0.017
TGFBR1 transforming growth factor, beta receptor 1 0.017
KCNE3 potassium voltage-gated channel, Isk-related family, member 3 0.017
MAML1 mastermind-like 1 (Drosophila) 0.017
MET met proto-oncogene (hepatocyte growth factor receptor) 0.017
JAG2 jagged 2 0.016
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Pax3 paired box gene 3 0.999
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.978
Actc1 actin, alpha, cardiac muscle 1 0.972
Pitx2 paired-like homeodomain transcription factor 2 0.971
Rarg retinoic acid receptor, gamma 0.962
Mef2d myocyte enhancer factor 2D 0.953
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.951
Ldb3 LIM domain binding 3 0.951
Gli3 GLI-Kruppel family member GLI3 0.931
Fgfr2 fibroblast growth factor receptor 2 0.916
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.914
Id3 inhibitor of DNA binding 3 0.905
Bcl2 B-cell leukemia/lymphoma 2 0.879
Fgfr1 fibroblast growth factor receptor 1 0.875
Mybph myosin binding protein H 0.861
Des desmin 0.849
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.847
Myf6 myogenic factor 6 0.847
Bmp4 bone morphogenetic protein 4 0.845
Nog noggin 0.840
Tcf3 transcription factor 3 0.837
Myod1 myogenic differentiation 1 0.814
Hrc histidine rich calcium binding protein 0.813
Id1 inhibitor of DNA binding 1 0.809
Tnni2 troponin I, skeletal, fast 2 0.801
Lta lymphotoxin A 0.799
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.797
Ccl2 chemokine (C-C motif) ligand 2 0.780
Hes1 hairy and enhancer of split 1 (Drosophila) 0.772
En1 engrailed 1 0.763
Otx2 orthodenticle homolog 2 (Drosophila) 0.762
Ccl12 chemokine (C-C motif) ligand 12 0.755
Prkce protein kinase C, epsilon 0.754
Ltb lymphotoxin B 0.744
Chrd chordin 0.735
Mapk14 mitogen-activated protein kinase 14 0.726
Srpk3 serine/arginine-rich protein specific kinase 3 0.702
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.700
Scn5a sodium channel, voltage-gated, type V, alpha 0.697
Csf1 colony stimulating factor 1 (macrophage) 0.691
Tbx5 T-box 5 0.682
Dmd dystrophin, muscular dystrophy 0.674
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.668
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.666
Tcfap2a transcription factor AP-2, alpha 0.666
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.662
Tbx3 T-box 3 0.647
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.643
Ccl7 chemokine (C-C motif) ligand 7 0.639
Homer1 homer homolog 1 (Drosophila) 0.637
Cxcl13 chemokine (C-X-C motif) ligand 13 0.630
Ncor2 nuclear receptor co-repressor 2 0.629
Msx1 homeobox, msh-like 1 0.623
Meox2 mesenchyme homeobox 2 0.592
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.587
Pax7 paired box gene 7 0.575
Nos1 nitric oxide synthase 1, neuronal 0.571
Runx2 runt related transcription factor 2 0.567
Socs1 suppressor of cytokine signaling 1 0.555
Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.553
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.542
Xirp1 xin actin-binding repeat containing 1 0.540
Ncoa2 nuclear receptor coactivator 2 0.540
Prrx2 paired related homeobox 2 0.509
Smad6 MAD homolog 6 (Drosophila) 0.506
Myl3 myosin, light polypeptide 3 0.499
Emx1 empty spiracles homolog 1 (Drosophila) 0.487
Ikzf1 IKAROS family zinc finger 1 0.485
Tnnt3 troponin T3, skeletal, fast 0.468
Vegfa vascular endothelial growth factor A 0.467
Sox4 SRY-box containing gene 4 0.461
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.461
Pitx1 paired-like homeodomain transcription factor 1 0.459
Il1b interleukin 1 beta 0.452
Cd40 CD40 antigen 0.452
Sox17 SRY-box containing gene 17 0.450
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.442
Hoxd13 homeobox D13 0.439
Actn3 actinin alpha 3 0.437
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.430
Ccl17 chemokine (C-C motif) ligand 17 0.426
Jag2 jagged 2 0.424
Fgf8 fibroblast growth factor 8 0.420
Bax BCL2-associated X protein 0.419
Popdc3 popeye domain containing 3 0.417
Otx1 orthodenticle homolog 1 (Drosophila) 0.417
Tnf tumor necrosis factor 0.414
Tbx15 T-box 15 0.404
Flt1 FMS-like tyrosine kinase 1 0.389
Pkd1 polycystic kidney disease 1 homolog 0.386
Tcfap2c transcription factor AP-2, gamma 0.382
Nf1 neurofibromatosis 1 0.380
Hspb2 heat shock protein 2 0.379
Kbtbd5 kelch repeat and BTB (POZ) domain containing 5 0.379
Ryr1 ryanodine receptor 1, skeletal muscle 0.378
Gja1 gap junction protein, alpha 1 0.374
Trp53 transformation related protein 53 0.351
Pou3f3 POU domain, class 3, transcription factor 3 0.341
Isl1 ISL1 transcription factor, LIM/homeodomain 0.330
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism