IMP
Process View
signal transduction involved in dna damage checkpoint
A signal transduction process that contributes to a DNA damage checkpoint.
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Click on a gene's description to view its network relationships with genes known to be involved in "signal transduction involved in dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| TP53 | tumor protein p53 | 0.998 | Mouse | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.930 | Human | |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.865 | ||
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.681 | ||
| APAF1 | apoptotic peptidase activating factor 1 | 0.665 | ||
| XIAP | X-linked inhibitor of apoptosis | 0.520 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.515 | ||
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.506 | ||
| NBN | nibrin | 0.488 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.487 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.373 | ||
| RB1 | retinoblastoma 1 | 0.336 | ||
| LRDD | leucine-rich repeats and death domain containing | 0.315 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.275 | ||
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.246 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.217 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.187 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.186 | ||
| IER3 | immediate early response 3 | 0.176 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.175 | ||
| BRCA1 | breast cancer 1, early onset | 0.173 | ||
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.138 | ||
| POU3F2 | POU class 3 homeobox 2 | 0.136 | ||
| DAXX | death-domain associated protein | 0.130 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.118 | ||
| BCL2 | B-cell CLL/lymphoma 2 | 0.112 | ||
| PAX3 | paired box 3 | 0.096 | ||
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.092 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.076 | ||
| BIRC2 | baculoviral IAP repeat containing 2 | 0.072 | ||
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.071 | ||
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.066 | ||
| CDC5L | CDC5 cell division cycle 5-like (S. pombe) | 0.054 | ||
| PLRG1 | pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) | 0.046 | ||
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.046 | Human | |
| FANCD2 | Fanconi anemia, complementation group D2 | 0.043 | ||
| SMAD7 | SMAD family member 7 | 0.043 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.036 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.033 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.030 | ||
| IFI16 | interferon, gamma-inducible protein 16 | 0.028 | ||
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.027 | ||
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.027 | Human | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.025 | Human | |
| H2AFX | H2A histone family, member X | 0.024 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.022 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.022 | ||
| NMI | N-myc (and STAT) interactor | 0.022 | ||
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.021 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.021 | Human | |
| CCND3 | cyclin D3 | 0.020 | ||
| BTBD2 | BTB (POZ) domain containing 2 | 0.020 | ||
| CHUK | conserved helix-loop-helix ubiquitous kinase | 0.020 | ||
| MEOX2 | mesenchyme homeobox 2 | 0.019 | ||
| SALL2 | sal-like 2 (Drosophila) | 0.019 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.019 | ||
| NOTCH1 | notch 1 | 0.018 | ||
| FOXD3 | forkhead box D3 | 0.018 | ||
| U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 0.018 | ||
| ATR | ataxia telangiectasia and Rad3 related | 0.017 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.016 | ||
| CCND1 | cyclin D1 | 0.014 | ||
| MED1 | mediator complex subunit 1 | 0.014 | ||
| TELO2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) | 0.014 | ||
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.013 | ||
| NOD1 | nucleotide-binding oligomerization domain containing 1 | 0.013 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.013 | ||
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.013 | ||
| RBL2 | retinoblastoma-like 2 (p130) | 0.013 | ||
| NUCB2 | nucleobindin 2 | 0.012 | ||
| BIRC3 | baculoviral IAP repeat containing 3 | 0.011 | ||
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.011 | ||
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.011 | ||
| BCAS2 | breast carcinoma amplified sequence 2 | 0.011 | ||
| GORAB | golgin, RAB6-interacting | 0.011 | ||
| DZIP1 | DAZ interacting protein 1 | 0.011 | ||
| TERF1 | telomeric repeat binding factor (NIMA-interacting) 1 | 0.011 | ||
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.010 | ||
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.010 | ||
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.010 |