IMP

Process View

Homo sapiens

17 genes annotated in human

ketone biosynthetic process

The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ketone biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ketone biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.997	Human
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.996	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.955
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.949	Yeast
ZFYVE9	zinc finger, FYVE domain containing 9	0.911
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.762
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.654
BMPR1B	bone morphogenetic protein receptor, type IB	0.461
MYO6	myosin VI	0.416
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.279	Yeast
SMAD4	SMAD family member 4	0.250
FSTL1	follistatin-like 1	0.218
NOG	noggin	0.212
ZMYND11	zinc finger, MYND-type containing 11	0.170
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.157
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.145	Yeast
TGFBR1	transforming growth factor, beta receptor 1	0.116
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.082
ANKRD13A	ankyrin repeat domain 13A	0.081
FOXD3	forkhead box D3	0.079
FBXL15	F-box and leucine-rich repeat protein 15	0.072
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.068
CXXC5	CXXC finger protein 5	0.062
MAPK15	mitogen-activated protein kinase 15	0.060
SFRP1	secreted frizzled-related protein 1	0.052
FGF18	fibroblast growth factor 18	0.051
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.051	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.044
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.042	Fly
BMP2	bone morphogenetic protein 2	0.042
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.041
LRP6	low density lipoprotein receptor-related protein 6	0.040
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.039
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.034	Yeast
BMP4	bone morphogenetic protein 4	0.034	Human
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.034
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.031
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.030	Human
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.029
TG	thyroglobulin	0.027
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.026
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.026
ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	0.025
CAT	catalase	0.025
WNT4	wingless-type MMTV integration site family, member 4	0.025
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.025	Rat
WIF1	WNT inhibitory factor 1	0.024
AADAC	arylacetamide deacetylase (esterase)	0.024
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.024
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.023	Yeast
DUOX1	dual oxidase 1	0.023
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.022
SOX7	SRY (sex determining region Y)-box 7	0.021
COL2A1	collagen, type II, alpha 1	0.021
BHMT	betaine--homocysteine S-methyltransferase	0.021
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.020
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.020	Yeast
PEX7	peroxisomal biogenesis factor 7	0.019
TGFB3	transforming growth factor, beta 3	0.019
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.019
SMAD6	SMAD family member 6	0.019
IHH	Indian hedgehog	0.017
NRP1	neuropilin 1	0.016
SMAD7	SMAD family member 7	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
SMAD5	SMAD family member 5	0.015
AHSG	alpha-2-HS-glycoprotein	0.015
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.015
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.015
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.014
SRI	sorcin	0.014
ING2	inhibitor of growth family, member 2	0.014
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.014	Fly
WNT3	wingless-type MMTV integration site family, member 3	0.014	Human
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.014
WNK1	WNK lysine deficient protein kinase 1	0.014
ACAN	aggrecan	0.013
CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	0.013
DLX4	distal-less homeobox 4	0.013
FBLN1	fibulin 1	0.013
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.013
KLF5	Kruppel-like factor 5 (intestinal)	0.013
FGF4	fibroblast growth factor 4	0.013
DIO1	deiodinase, iodothyronine, type I	0.012
DEDD	death effector domain containing	0.012
WNT1	wingless-type MMTV integration site family, member 1	0.012	Human
NDFIP2	Nedd4 family interacting protein 2	0.012
PAX2	paired box 2	0.012
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.012
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.012
RDH16	retinol dehydrogenase 16 (all-trans)	0.012
FZD10	frizzled homolog 10 (Drosophila)	0.012
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.012
MMACHC	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	0.012
WNT11	wingless-type MMTV integration site family, member 11	0.012	Human
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.012
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.011
SMAD1	SMAD family member 1	0.011
CALCA	calcitonin-related polypeptide alpha	0.011
KLK10	kallikrein-related peptidase 10	0.011
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
MTMR4	myotubularin related protein 4	0.011
GAS1	growth arrest-specific 1	0.011
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.011
WNT10A	wingless-type MMTV integration site family, member 10A	0.011	Human
PITX2	paired-like homeodomain 2	0.011
HOXD10	homeobox D10	0.011
DOCK9	dedicator of cytokinesis 9	0.011
DTX1	deltex homolog 1 (Drosophila)	0.010
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.010	Fly
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.010
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.010	Human
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.010
GJB3	gap junction protein, beta 3, 31kDa	0.010
FOXF2	forkhead box F2	0.010
GLYAT	glycine-N-acyltransferase	0.010