IMP
Process View
ubiquitin dependent smad protein catabolic process
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
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Click on a gene's description to view its network relationships with genes known to be involved in "ubiquitin dependent smad protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.999 | ||
| NCK2 | NCK adaptor protein 2 | 0.675 | ||
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | 0.646 | Human | |
| SMAD4 | SMAD family member 4 | 0.636 | ||
| RNF11 | ring finger protein 11 | 0.611 | ||
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.575 | ||
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.555 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.505 | ||
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.483 | Human | |
| XIAP | X-linked inhibitor of apoptosis | 0.414 | ||
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.407 | ||
| SMAD7 | SMAD family member 7 | 0.348 | ||
| ANKRD13A | ankyrin repeat domain 13A | 0.320 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.307 | ||
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.303 | ||
| ILK | integrin-linked kinase | 0.301 | ||
| FHL2 | four and a half LIM domains 2 | 0.248 | ||
| HOXA1 | homeobox A1 | 0.210 | ||
| TRIP6 | thyroid hormone receptor interactor 6 | 0.156 | ||
| SCNN1B | sodium channel, nonvoltage-gated 1, beta | 0.139 | ||
| RNF5 | ring finger protein 5 | 0.134 | ||
| LPXN | leupaxin | 0.130 | Human | |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.120 | Human | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.111 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.102 | Human | |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.096 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.081 | Human | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.080 | ||
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like | 0.067 | Human | |
| BAG1 | BCL2-associated athanogene | 0.065 | ||
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.064 | ||
| UBQLN2 | ubiquilin 2 | 0.050 | ||
| TRAF4 | TNF receptor-associated factor 4 | 0.047 | ||
| VCL | vinculin | 0.044 | ||
| SMAD5 | SMAD family member 5 | 0.043 | ||
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 0.042 | ||
| RNF168 | ring finger protein 168 | 0.040 | ||
| FAM173A | family with sequence similarity 173, member A | 0.039 | ||
| HSPB1 | heat shock 27kDa protein 1 | 0.036 | ||
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.034 | ||
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 0.033 | ||
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.032 | ||
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 0.031 | ||
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.031 | ||
| CCDC127 | coiled-coil domain containing 127 | 0.028 | ||
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 | 0.028 | ||
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.027 | ||
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.025 | ||
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.024 | ||
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.023 | ||
| ZYX | zyxin | 0.023 | ||
| NUBP2 | nucleotide binding protein 2 (MinD homolog, E. coli) | 0.023 | ||
| PARVA | parvin, alpha | 0.023 | ||
| HSF1 | heat shock transcription factor 1 | 0.023 | ||
| WNK1 | WNK lysine deficient protein kinase 1 | 0.023 | ||
| UBE4A | ubiquitination factor E4A (UFD2 homolog, yeast) | 0.022 | ||
| SNX9 | sorting nexin 9 | 0.022 | ||
| HSPA1B | heat shock 70kDa protein 1B | 0.020 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.019 | ||
| ARRDC3 | arrestin domain containing 3 | 0.019 | ||
| SMAD1 | SMAD family member 1 | 0.019 | ||
| ZNF426 | zinc finger protein 426 | 0.019 | ||
| PHF21A | PHD finger protein 21A | 0.018 | ||
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.017 | ||
| BFAR | bifunctional apoptosis regulator | 0.017 | ||
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.016 | ||
| BBS10 | Bardet-Biedl syndrome 10 | 0.015 | ||
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.015 | ||
| BAG3 | BCL2-associated athanogene 3 | 0.015 | ||
| ZNRF1 | zinc and ring finger 1 | 0.014 | ||
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.014 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.013 | ||
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.013 | ||
| PARVB | parvin, beta | 0.012 | ||
| RHOA | ras homolog gene family, member A | 0.012 | ||
| ERCC6 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | 0.012 | ||
| TP73 | tumor protein p73 | 0.011 | ||
| ING2 | inhibitor of growth family, member 2 | 0.011 | ||
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | 0.011 | ||
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 0.011 | ||
| SCNN1A | sodium channel, nonvoltage-gated 1 alpha | 0.010 | ||
| NDFIP2 | Nedd4 family interacting protein 2 | 0.010 |