IMP

Process View

Homo sapiens

29 genes annotated in human

cellular response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to xenobiotic stimulus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to xenobiotic stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
GSTM1	glutathione S-transferase mu 1	0.999
GSTM2	glutathione S-transferase mu 2 (muscle)	0.999
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.997
S100B	S100 calcium binding protein B	0.990	Human
RARA	retinoic acid receptor, alpha	0.969
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.965
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.952
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.951
S100A4	S100 calcium binding protein A4	0.950	Human
RXRA	retinoid X receptor, alpha	0.948	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.941
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.932
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.913	Human Zebrafish Rat Fly
S100A1	S100 calcium binding protein A1	0.878	Human
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.850	Human
S100A16	S100 calcium binding protein A16	0.840	Human
S100A6	S100 calcium binding protein A6	0.811	Human
GSTM4	glutathione S-transferase mu 4	0.799
ANXA2	annexin A2	0.785
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.695
S100A14	S100 calcium binding protein A14	0.659	Human
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.559
MED25	mediator complex subunit 25	0.556
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.471
NCOR2	nuclear receptor corepressor 2	0.417
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.415	Fly
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.412
S100A11	S100 calcium binding protein A11	0.385	Human
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.313
HR	hairless homolog (mouse)	0.289
XIAP	X-linked inhibitor of apoptosis	0.243
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.237
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.226
NCOA1	nuclear receptor coactivator 1	0.223
ALS2CR12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	0.219
C6	complement component 6	0.205
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.199	Fly
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.191	Human
GLYAT	glycine-N-acyltransferase	0.178
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.178
GSTM3	glutathione S-transferase mu 3 (brain)	0.169
APAF1	apoptotic peptidase activating factor 1	0.156
SPOP	speckle-type POZ protein	0.154
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.146	Fly
AREG	amphiregulin	0.145
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.130
A1CF	APOBEC1 complementation factor	0.127
OTC	ornithine carbamoyltransferase	0.127
HIPK2	homeodomain interacting protein kinase 2	0.126
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.124	Human
AGER	advanced glycosylation end product-specific receptor	0.123
FKBP4	FK506 binding protein 4, 59kDa	0.108
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.103	Human Zebrafish Fly
TIMP2	TIMP metallopeptidase inhibitor 2	0.102
MASP2	mannan-binding lectin serine peptidase 2	0.097
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	0.096
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.094
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.092	Human
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.081
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.080
GSTM5	glutathione S-transferase mu 5	0.075	Human
KNG1	kininogen 1	0.072
S100A2	S100 calcium binding protein A2	0.071	Human
FMO4	flavin containing monooxygenase 4	0.071	Human
HRG	histidine-rich glycoprotein	0.071
ADH6	alcohol dehydrogenase 6 (class V)	0.068
FAM46A	family with sequence similarity 46, member A	0.067
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.063	Human
LGALS3	lectin, galactoside-binding, soluble, 3	0.063
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.062
F9	coagulation factor IX	0.062
ESR1	estrogen receptor 1	0.062
LGALS1	lectin, galactoside-binding, soluble, 1	0.061
TMSB10	thymosin beta 10	0.060
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.059
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.059
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.058
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.057
S100A8	S100 calcium binding protein A8	0.054	Human
XDH	xanthine dehydrogenase	0.054
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.054
S100A9	S100 calcium binding protein A9	0.054	Human
C8B	complement component 8, beta polypeptide	0.054
PROX1	prospero homeobox 1	0.052
AADAC	arylacetamide deacetylase (esterase)	0.051
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.051	Human
PGR	progesterone receptor	0.050
ALDOB	aldolase B, fructose-bisphosphate	0.050
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.049	Fly
FTL	ferritin, light polypeptide	0.049
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.047
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.047
C8A	complement component 8, alpha polypeptide	0.046
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.044
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.043	Human Fly
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.042
BHMT	betaine--homocysteine S-methyltransferase	0.041
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.040	Human
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.039	Human Fly
TM4SF4	transmembrane 4 L six family member 4	0.039
GSTA3	glutathione S-transferase alpha 3	0.039	Human Rat
MTTP	microsomal triglyceride transfer protein	0.039
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.038
HNF4A	hepatocyte nuclear factor 4, alpha	0.035
PON1	paraoxonase 1	0.034
IGSF21	immunoglobin superfamily, member 21	0.034
S100A12	S100 calcium binding protein A12	0.034
S100P	S100 calcium binding protein P	0.034	Human
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	0.032
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.032
APCS	amyloid P component, serum	0.030
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.029
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.028
UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	0.028
CAPG	capping protein (actin filament), gelsolin-like	0.028
CSTB	cystatin B (stefin B)	0.027
NPC2	Niemann-Pick disease, type C2	0.026
F13B	coagulation factor XIII, B polypeptide	0.026
F11	coagulation factor XI	0.026
TTPA	tocopherol (alpha) transfer protein	0.025
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.025
CA5A	carbonic anhydrase VA, mitochondrial	0.025
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.025
GLRX	glutaredoxin (thioltransferase)	0.024
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.024
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.024	Human Zebrafish Rat
S100A10	S100 calcium binding protein A10	0.024	Human
MEP1B	meprin A, beta	0.024
CCL16	chemokine (C-C motif) ligand 16	0.024
GC	group-specific component (vitamin D binding protein)	0.023
G6PC	glucose-6-phosphatase, catalytic subunit	0.023
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.022
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.022
TIMP1	TIMP metallopeptidase inhibitor 1	0.022
REG1A	regenerating islet-derived 1 alpha	0.022
TM4SF5	transmembrane 4 L six family member 5	0.022
PAH	phenylalanine hydroxylase	0.021
FABP1	fatty acid binding protein 1, liver	0.021
HGD	homogentisate 1,2-dioxygenase	0.021
LGALS4	lectin, galactoside-binding, soluble, 4	0.020
PML	promyelocytic leukemia	0.020
PPARA	peroxisome proliferator-activated receptor alpha	0.019	Human
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.019
NCOA3	nuclear receptor coactivator 3	0.019
PRKG2	protein kinase, cGMP-dependent, type II	0.019
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.019
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.019
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.019
HPD	4-hydroxyphenylpyruvate dioxygenase	0.019
ITIH2	inter-alpha (globulin) inhibitor H2	0.019
RARG	retinoic acid receptor, gamma	0.019
NADSYN1	NAD synthetase 1	0.019
EMP3	epithelial membrane protein 3	0.018
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.018	Human
HAL	histidine ammonia-lyase	0.018
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.018
CREBBP	CREB binding protein	0.018
CFHR4	complement factor H-related 4	0.018
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.018
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.017
PI3	peptidase inhibitor 3, skin-derived	0.017
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.017
LECT2	leukocyte cell-derived chemotaxin 2	0.017
AICDA	activation-induced cytidine deaminase	0.017	Human
AFM	afamin	0.017
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.017
IL1RN	interleukin 1 receptor antagonist	0.016
MAT1A	methionine adenosyltransferase I, alpha	0.016
DPYS	dihydropyrimidinase	0.016
TAT	tyrosine aminotransferase	0.016
S100G	S100 calcium binding protein G	0.016	Human
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.016	Human
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.016
AHR	aryl hydrocarbon receptor	0.015
RGN	regucalcin (senescence marker protein-30)	0.015
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.015
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.015
AHNAK	AHNAK nucleoprotein	0.015
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.015
S100A13	S100 calcium binding protein A13	0.015
USP2	ubiquitin specific peptidase 2	0.015
ACSM5	acyl-CoA synthetase medium-chain family member 5	0.015
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.015
DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.015
UBXN1	UBX domain protein 1	0.015
NSFL1C	NSFL1 (p97) cofactor (p47)	0.015
GIF	gastric intrinsic factor (vitamin B synthesis)	0.014
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.014	Human Zebrafish
C4BPA	complement component 4 binding protein, alpha	0.014
MIA2	melanoma inhibitory activity 2	0.014
CSTA	cystatin A (stefin A)	0.014
ANXA1	annexin A1	0.014
NCOA6	nuclear receptor coactivator 6	0.014
PON3	paraoxonase 3	0.014	Rat
FMO1	flavin containing monooxygenase 1	0.013	Human
TALDO1	transaldolase 1	0.013
ARIH2	ariadne homolog 2 (Drosophila)	0.013
PLG	plasminogen	0.013
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.013
SAA4	serum amyloid A4, constitutive	0.013
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.013
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.013
AMFR	autocrine motility factor receptor	0.013
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.013
DAO	D-amino-acid oxidase	0.013
UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.013	Human
ARNT	aryl hydrocarbon receptor nuclear translocator	0.012
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.012
HIPK3	homeodomain interacting protein kinase 3	0.012
RUNX1	runt-related transcription factor 1	0.012
GLA	galactosidase, alpha	0.012
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.012
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.012
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.012
ZG16	zymogen granule protein 16 homolog (rat)	0.012
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.012
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.012
SGK2	serum/glucocorticoid regulated kinase 2	0.012
LRRC31	leucine rich repeat containing 31	0.012
CNGA1	cyclic nucleotide gated channel alpha 1	0.012
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.011
ASPA	aspartoacylase	0.011
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.011
BCMO1	beta-carotene 15,15'-monooxygenase 1	0.011
DHPS	deoxyhypusine synthase	0.011
AGXT2	alanine--glyoxylate aminotransferase 2	0.011
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.011
C4BPB	complement component 4 binding protein, beta	0.011
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.011
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.011
IFNA16	interferon, alpha 16	0.011
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.011
CDA	cytidine deaminase	0.011
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
USP42	ubiquitin specific peptidase 42	0.011
A2M	alpha-2-macroglobulin	0.011
GYS2	glycogen synthase 2 (liver)	0.011
NAMPT	nicotinamide phosphoribosyltransferase	0.010
FMO5	flavin containing monooxygenase 5	0.010	Human
ANXA10	annexin A10	0.010
HNF1B	HNF1 homeobox B	0.010
KLF4	Kruppel-like factor 4 (gut)	0.010