IMP

Process View

Homo sapiens

12 genes annotated in human

protein destabilization

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein destabilization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein destabilization" (in gray)

Name	Description	Probability	Func Analog Organism
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.973
BTRC	beta-transducin repeat containing	0.587
FBXW11	F-box and WD repeat domain containing 11	0.533
DAXX	death-domain associated protein	0.392
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.365
BMPR1A	bone morphogenetic protein receptor, type IA	0.286
PAX3	paired box 3	0.277
RB1	retinoblastoma 1	0.158
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.139
HIPK2	homeodomain interacting protein kinase 2	0.121
PML	promyelocytic leukemia	0.120
TRIM5	tripartite motif containing 5	0.097	Human
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.096
ZNF263	zinc finger protein 263	0.090
POU3F2	POU class 3 homeobox 2	0.082
TP53	tumor protein p53	0.073
SKP1	S-phase kinase-associated protein 1	0.070
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.059
CUL1	cullin 1	0.055
TRIM21	tripartite motif containing 21	0.052
TRIM39	tripartite motif containing 39	0.044	Human
SMAD7	SMAD family member 7	0.044
MED1	mediator complex subunit 1	0.035
ZNRF1	zinc and ring finger 1	0.033
GORAB	golgin, RAB6-interacting	0.031
RNF126	ring finger protein 126	0.031
XIAP	X-linked inhibitor of apoptosis	0.029
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.026
PRNP	prion protein	0.025
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.024
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.023
IRF2	interferon regulatory factor 2	0.021
SNCAIP	synuclein, alpha interacting protein	0.020
ZNF473	zinc finger protein 473	0.019
MED13	mediator complex subunit 13	0.019
MED29	mediator complex subunit 29	0.017
TRIM34	tripartite motif containing 34	0.017
TRIM17	tripartite motif containing 17	0.016	Human
MARCKSL1	MARCKS-like 1	0.015
TRIM26	tripartite motif containing 26	0.015
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.014
SOCS1	suppressor of cytokine signaling 1	0.014
SP100	SP100 nuclear antigen	0.013
MED26	mediator complex subunit 26	0.013
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.012
PDK2	pyruvate dehydrogenase kinase, isozyme 2	0.012
FAS	Fas (TNF receptor superfamily, member 6)	0.012
TRIM35	tripartite motif containing 35	0.012
COMMD3	COMM domain containing 3	0.012
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.012
CDK6	cyclin-dependent kinase 6	0.012
CSNK1A1	casein kinase 1, alpha 1	0.012
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.012
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.012
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.012
MTAP	methylthioadenosine phosphorylase	0.012
MAPK8	mitogen-activated protein kinase 8	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
ARIH2	ariadne homolog 2 (Drosophila)	0.011
MED10	mediator complex subunit 10	0.011
APC	adenomatous polyposis coli	0.011
BFAR	bifunctional apoptosis regulator	0.011
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.010
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.010
RNF38	ring finger protein 38	0.010