IMP

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Homo sapiens

4 genes annotated in human

actin filament capping

The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "actin filament capping"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "actin filament capping" (in gray)

Name	Description	Probability	Func Analog Organism
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.967
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.950
TRIM63	tripartite motif containing 63	0.833
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.706
TTN	titin	0.634
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.569
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.547
MYPN	myopalladin	0.488
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.385
SOS1	son of sevenless homolog 1 (Drosophila)	0.290
CORO1C	coronin, actin binding protein, 1C	0.280
IQGAP1	IQ motif containing GTPase activating protein 1	0.237
MYH9	myosin, heavy chain 9, non-muscle	0.215
SVIL	supervillin	0.187
MAPK1	mitogen-activated protein kinase 1	0.150
FLNA	filamin A, alpha	0.150
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.148
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.135
TPM4	tropomyosin 4	0.126
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.126
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.124
ITSN1	intersectin 1 (SH3 domain protein)	0.114
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.099
ACTN1	actinin, alpha 1	0.096
RIPK3	receptor-interacting serine-threonine kinase 3	0.084
BZW1	basic leucine zipper and W2 domains 1	0.083
ABI1	abl-interactor 1	0.076
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.067
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.066
BAIAP2	BAI1-associated protein 2	0.060
SCYL2	SCY1-like 2 (S. cerevisiae)	0.058
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.055
KBTBD10	kelch repeat and BTB (POZ) domain containing 10	0.054
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.052
TEX11	testis expressed 11	0.051
ACTA1	actin, alpha 1, skeletal muscle	0.050
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.049
RAB11A	RAB11A, member RAS oncogene family	0.046
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.045
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.042
MRPL20	mitochondrial ribosomal protein L20	0.042
RHOA	ras homolog gene family, member A	0.041
EXOC5	exocyst complex component 5	0.040
WASF2	WAS protein family, member 2	0.038
MYL12B	myosin, light chain 12B, regulatory	0.036
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.035
SCP2	sterol carrier protein 2	0.035
GULP1	GULP, engulfment adaptor PTB domain containing 1	0.034
UEVLD	UEV and lactate/malate dehyrogenase domains	0.034
PEA15	phosphoprotein enriched in astrocytes 15	0.032
TOM1L1	target of myb1 (chicken)-like 1	0.032
LASP1	LIM and SH3 protein 1	0.032
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.029	Mouse Fly
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.029
PICALM	phosphatidylinositol binding clathrin assembly protein	0.028
PINK1	PTEN induced putative kinase 1	0.027
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.026
RAB10	RAB10, member RAS oncogene family	0.024
RASSF7	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	0.023
NCKIPSD	NCK interacting protein with SH3 domain	0.023
VCL	vinculin	0.023
ZYX	zyxin	0.022
ALDH7A1	aldehyde dehydrogenase 7 family, member A1	0.022
ADD1	adducin 1 (alpha)	0.022
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.022
GNG10	guanine nucleotide binding protein (G protein), gamma 10	0.022
ARRB1	arrestin, beta 1	0.021
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.021
GRB2	growth factor receptor-bound protein 2	0.021
TMEM123	transmembrane protein 123	0.020
MSN	moesin	0.020
CD164	CD164 molecule, sialomucin	0.020
CD2AP	CD2-associated protein	0.019
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.019
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.019
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.019
CNN2	calponin 2	0.018
ITGB5	integrin, beta 5	0.018
ACTB	actin, beta	0.018
RAP1B	RAP1B, member of RAS oncogene family	0.018
XIRP2	xin actin-binding repeat containing 2	0.017
PRSS8	protease, serine, 8	0.017
TAGLN2	transgelin 2	0.017
CFL1	cofilin 1 (non-muscle)	0.017
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.017
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.017
NCKAP1	NCK-associated protein 1	0.017
NPTN	neuroplastin	0.017
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.017
ALS2CL	ALS2 C-terminal like	0.016
MAP2K1	mitogen-activated protein kinase kinase 1	0.016
ACTG1	actin, gamma 1	0.016
CAPN3	calpain 3, (p94)	0.016
AP1M2	adaptor-related protein complex 1, mu 2 subunit	0.015
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.015
DUSP3	dual specificity phosphatase 3	0.015
PRMT2	protein arginine methyltransferase 2	0.015
MYH14	myosin, heavy chain 14, non-muscle	0.015
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.014
MRFAP1	Morf4 family associated protein 1	0.014
MAPK14	mitogen-activated protein kinase 14	0.014
C6orf136	chromosome 6 open reading frame 136	0.014
ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	0.014
ATP2C2	ATPase, Ca++ transporting, type 2C, member 2	0.014
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.014
CYB5R4	cytochrome b5 reductase 4	0.014
DSTYK	dual serine/threonine and tyrosine protein kinase	0.014
RPP14	ribonuclease P/MRP 14kDa subunit	0.014
ADAM9	ADAM metallopeptidase domain 9	0.014
FN1	fibronectin 1	0.014
RP2	retinitis pigmentosa 2 (X-linked recessive)	0.013
RAB1A	RAB1A, member RAS oncogene family	0.013
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.013
AIDA	axin interactor, dorsalization associated	0.013
PTPRR	protein tyrosine phosphatase, receptor type, R	0.013
ACTN4	actinin, alpha 4	0.013
TMOD3	tropomodulin 3 (ubiquitous)	0.013	Worm
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.013
NRBP1	nuclear receptor binding protein 1	0.013
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.013
VASP	vasodilator-stimulated phosphoprotein	0.013
OSTF1	osteoclast stimulating factor 1	0.012
ATN1	atrophin 1	0.012
ATP13A3	ATPase type 13A3	0.012
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.012
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.012
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.012
SLC25A24	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	0.012
BLNK	B-cell linker	0.012
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.012
RAB25	RAB25, member RAS oncogene family	0.012
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.012
NAGK	N-acetylglucosamine kinase	0.011
WSB2	WD repeat and SOCS box containing 2	0.011
COMMD8	COMM domain containing 8	0.011
SSH3	slingshot homolog 3 (Drosophila)	0.011
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.011
SKAP2	src kinase associated phosphoprotein 2	0.011
TRAK2	trafficking protein, kinesin binding 2	0.011
FKBP1A	FK506 binding protein 1A, 12kDa	0.011
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.011
AHNAK	AHNAK nucleoprotein	0.011
PLIN3	perilipin 3	0.011
CLIC4	chloride intracellular channel 4	0.010
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.010	Yeast Fly
TMPRSS2	transmembrane protease, serine 2	0.010
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.010
ESRP2	epithelial splicing regulatory protein 2	0.010