IMP

Process View

Homo sapiens

24 genes annotated in human

activin receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activin receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activin receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	1.000
SMAD7	SMAD family member 7	1.000
SMAD1	SMAD family member 1	0.999	Human
SMAD2	SMAD family member 2	0.998
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.993
TGFBR1	transforming growth factor, beta receptor 1	0.955	Human Fly
FKBP1A	FK506 binding protein 1A, 12kDa	0.928
BMP2	bone morphogenetic protein 2	0.904
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.902	Human
ACVR1B	activin A receptor, type IB	0.836
SMAD4	SMAD family member 4	0.787	Human
ADRB1	adrenergic, beta-1-, receptor	0.737
SIRT1	sirtuin 1	0.732
SMAD5	SMAD family member 5	0.635	Human
SKIL	SKI-like oncogene	0.605	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.543	Human
INSR	insulin receptor	0.534
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.468
ACVR1	activin A receptor, type I	0.433
CXXC5	CXXC finger protein 5	0.379
SMAD6	SMAD family member 6	0.371	Human
ENG	endoglin	0.287
GRB10	growth factor receptor-bound protein 10	0.282
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.280
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.217
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.175
IRS1	insulin receptor substrate 1	0.150	Fly
AR	androgen receptor	0.133
TGFB3	transforming growth factor, beta 3	0.131
CTBP2	C-terminal binding protein 2	0.125
NOG	noggin	0.123
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.111
MAPK8	mitogen-activated protein kinase 8	0.104
TGFB1	transforming growth factor, beta 1	0.099	Fly
PRKG1	protein kinase, cGMP-dependent, type I	0.087
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.076
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.074	Human
BMP4	bone morphogenetic protein 4	0.071
LGALS8	lectin, galactoside-binding, soluble, 8	0.064
SMAD9	SMAD family member 9	0.052	Human
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.049
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.047
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.046
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.044
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.042
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.041
ZFYVE9	zinc finger, FYVE domain containing 9	0.039
SOX7	SRY (sex determining region Y)-box 7	0.038
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.038
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.037
NRP1	neuropilin 1	0.035
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.034
EP300	E1A binding protein p300	0.032
NCOA6	nuclear receptor coactivator 6	0.030
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.030
DSCAML1	Down syndrome cell adhesion molecule like 1	0.030
IRS2	insulin receptor substrate 2	0.030	Fly
IGF1R	insulin-like growth factor 1 receptor	0.028
ADAM12	ADAM metallopeptidase domain 12	0.027
CTBP1	C-terminal binding protein 1	0.027
KAT2B	K(lysine) acetyltransferase 2B	0.026
WRN	Werner syndrome, RecQ helicase-like	0.025
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.025
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.024
VEZF1	vascular endothelial zinc finger 1	0.024
SOX13	SRY (sex determining region Y)-box 13	0.021
ZEB2	zinc finger E-box binding homeobox 2	0.021
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.021
ACVR2B	activin A receptor, type IIB	0.020
FHL2	four and a half LIM domains 2	0.020
ARHGAP5	Rho GTPase activating protein 5	0.019
FOXO3	forkhead box O3	0.019	Fly
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.019
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.019
MKL2	MKL/myocardin-like 2	0.018
CREBBP	CREB binding protein	0.018
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.018
TFPI2	tissue factor pathway inhibitor 2	0.018
NCOR1	nuclear receptor corepressor 1	0.017
ZEB1	zinc finger E-box binding homeobox 1	0.017
BMPR1B	bone morphogenetic protein receptor, type IB	0.017	Human
ACVR2A	activin A receptor, type IIA	0.017
PMEPA1	prostate transmembrane protein, androgen induced 1	0.017
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.016
EPAS1	endothelial PAS domain protein 1	0.016
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.016
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.016
MEST	mesoderm specific transcript homolog (mouse)	0.015
THBS1	thrombospondin 1	0.015
ZBED5	zinc finger, BED-type containing 5	0.015
YY1	YY1 transcription factor	0.014
HIC1	hypermethylated in cancer 1	0.014
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.013
KDM2A	lysine (K)-specific demethylase 2A	0.013
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.013
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.013
INHBB	inhibin, beta B	0.013
HOXC8	homeobox C8	0.013
TGFBR3	transforming growth factor, beta receptor III	0.012
COL2A1	collagen, type II, alpha 1	0.012
AXIN1	axin 1	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.012
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.012
FSTL1	follistatin-like 1	0.012	Human
RMND5B	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	0.011
FOXF2	forkhead box F2	0.011
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.011
NLK	nemo-like kinase	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.011
FZD7	frizzled homolog 7 (Drosophila)	0.011
MAST4	microtubule associated serine/threonine kinase family member 4	0.011
GDF5	growth differentiation factor 5	0.011	Human
ACACA	acetyl-CoA carboxylase alpha	0.011
MTMR10	myotubularin related protein 10	0.011
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.010
BGN	biglycan	0.010
MAPK7	mitogen-activated protein kinase 7	0.010
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.010
EVC2	Ellis van Creveld syndrome 2	0.010